• Journal of Oriental Neuropsychiatry
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• v.14 no.1
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• pp.85-106
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• 2003

Studies have shown that both the psychomotor stimulant effects and rewarding properties of addictive drugs, including morphine, are sensitized by repeated drug administration and it is suggested that both of these effects are mediated by the same or closely overlapping dopamine systems. Specifically, the mesolimbic dopamine system has been implicated in the reinforcing and sensitizing properties of morphine. In oriental medicine, Shenmen (HT7) point on the heart channel has been used to treat mental and psychosomatic disorders. This study was designed to investigate the effect of acupuncture on acute and repeated morphine-induced changes in extracellular dopamine levels using in vivo microdialysis and morphine-induced behavioral changes. In the morphine sensitization experiment, male Sprague-Dawley rats were treated twice a day for three days with increasing doses of morphine (10, 20 and 40 mg/kg, s.c.) or with saline. After 15 days of withdrawal, rats were challenged with morphine hydrochloride (5mg/kg, s.c.). Acupuncture was applied at bilateral Shenmen (HT7) points for 1 min after the morphine challenge. In the acute experiment, rats also received acupuncture for 1 min after an injection of morphine hydrochloride (5 mg/kg, s.c.). Results showed that acupuncture at the specific acupoint HT7, but not at control points (tail) significantly decreased both dopamine release and behavior induced by a systemic morphine challenge or a single sc morphine injection in the acute animals. These results suggest that reduction in sensitization may be one mechanism whereby acupuncture alleviates morphine craving in addicts.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.27 no.7
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• pp.472-476
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• 2014

We report the characteristics of thin-film transistor (TFT) to make the bi-channel structure with stacked $Mg_{0.1}Zn_{0.9}O$ (Mg= 10 at.%) and ZnO. The ZnO and $Mg_{0.1}ZnO_{0.9}O$ thin films were deposited by radio frequency (RF) co-sputter system onto the thermally oxidized silicon substrate. A total thickness of active layer was 50 nm. Firstly, the ZnO thin films were deposited to control the thickness from 5 nm to 30 nm. Sequentially, the $Mg_{0.1}ZnO_{0.9}O$ thin films were deposited to change from 45 nm to 20 nm. The bi-layer TFT shows more improved properties than the single layer TFT. The field effect mobility and subthreshold slope for $Mg_{0.1}ZnO_{0.9}O$/ZnO-TFT are $7.40cm^2V^{-1}s^{-1}$ and 0.24 V/decade at the ZnO thickness of 10 nm, respectively.

• Journal of the Korea Convergence Society
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• v.11 no.2
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• pp.17-22
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• 2020

In this paper, we measured the user's EEG signal and classified the EEG signal using the Support Vector Machine algorithm and measured the accuracy of the signal. An experiment was conducted to measure the user's EEG signals by separating men and women, and a single channel EEG device was used for EEG signal measurements. The results of measuring users' EEG signals using EEG devices were analyzed using R. In addition, data in the study was predicted using a 80:20 ratio between training data and test data by applying a combination of specific vectors with the highest classifying performance of the SVM, and thus the predicted accuracy of 93.2% of the recognition rate. This paper suggested that the user's EEG signal could be recognized at about 93.2 percent, and that it can be performed only by simple linear classification of the SVM algorithm, which can be used variously for biometrics using EEG signals.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.17 no.8
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• pp.875-881
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• 2004

Fundamental results obtained from an atomic force microscope (AFM) chemically-induced direct nano-lithography process are presented, which is regarded as a simple method for fabrication nm-scale devices such as superconducting flux flow transistors (SFFTs) and single electron tunneling transistors (SETs). Si cantilevers with Pt coating and with 30 nm thick TiO coating were used as conducting AFM tips in this study. We observed the surfaces of superconducting strip lines modified by AFM anodization' process. First, superconducting strip lines with scan size 2 ${\mu}{\textrm}{m}$${\times}$2 ${\mu}{\textrm}{m}$ have been anodized by AFM technology. The surface roughness was increased with the number of AFM scanning, The roughness variation was higher in case of the AFM tip with a positive voltage than with a negative voltage in respect of the strip surface. Second, we have patterned nm-scale oxide lines on ${YBa}-2{Cu}_3{O}_{7-x}$ superconducting microstrip surfaces by AFM conductive cantilever with a negative bias voltage. The ${YBa}-2{Cu}_3{O}_{7-x}$ oxide lines could be patterned by anodization technique. This research showed that the critical characteristics of superconducting thin films were be controlled by AFM anodization process technique. The AFM technique was expected to be used as a promising anodization technique for fabrication of an SFFT with nano-channel.

• Journal of the Korea Convergence Society
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• v.10 no.12
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• pp.43-52
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• 2019

360 Virtual Reality(VR) service is getting attention in the domestic streaming market as 5G era is upcoming. However, existing IPTV-based 360 VR video services use upto 4K 360 VR video which is not enough to satisfy customers. It is generally required that over 8K resolution is necessary to meet users' satisfaction level. The bit rate of 8K resolution video exceeds the bandwidth of single QAM channel(38.817mbps), which means that it is impossible to provide 8K resolution video via the IPTV broadcast network environment. Therefore, we suggest and implement the edge streaming system for low-latency streaming to the display devices in the local network. We conducted experiments and confirmed that 360 VR streaming with a viewport switching delay less than 500ms can be achieved while using less than 100mbps of the network bandwidth.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.2
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• pp.75-83
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• 2016

Since a turbomachine has complex flow characteristics, which are caused by adverse pressure gradient and high speed motion, an elaborate turbulence model is needed to accurately predict the flow. Some turbulence models such as an algebraic or a two-equation eddy viscosity model have been used for in-house RANS-code, but it is difficult to obtain good result for several complex flows. In this study, Durbin's V2-F turbulence model, which has been known for better prediction for severe flow separation, is applied to T-Flow. It was validated for simple cases such as channel and compressor cascade, and its applicability to turbomachinery was shown by analyzing internal flow of a single rotor. As a result, the V2-F turbulence model shows better blade surface pressure distribution than the one-and-two equation turbulence model.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2001.11a
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• pp.94-94
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• 2001

Prostaglandin endoperoxide H synthase (PGHS) catalyzes the committed step in prostaglandins and thromboxane A$_2$-- oxygenation of arachidonic acid to the hydroperoxy endoperoxide PGG$_2$, followed by reduction PGG$_2$to the alcohol PGH$_2$. The two reactions by PGHS -- cyclooxygenase and peroxidase -- occur at distinct but structurally and functionally interconnected sites. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. Initially a peroxide reacts with the heme group, yielding Compound I and an alcohol derived from the oxidizing peroxide. Compound I next undergoes an intramolecular reduction by a single electron traveling from Tyr385 along the peptide chain to the proximal heme ligand, His388, and finally to the heme group. Following the binding of arachidonic acid, Tyr385 tyrosyl radical initiates the cyclooxygenase reaction by abstracting the 13-pro(5) hydrogen atom to give an arachidonyl radical, which sequentially reacts with two molecules of oxygen to yield PGG$_2$. In order to characterize PGHS peroxidase active site, we examined various lipid peroxides with purified recombinant ovine PGHS proteins and determined the rate constants. The results have shown that twenty-carbon unsaturated fatty acid hydroperoxides have similar efficiency in peroxidation by PGHS, irrespective of either the location of hydroperoxy group or the number of double bonds. It was also confirmed by the subsequent study with PGHS peroxidase active site mutants.

• Biomolecules & Therapeutics
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• v.1 no.1
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• pp.1-8
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• 1993

It has been known that calcium antagonists also inhibit the radioligand binding to muscarinic and $\alpha$-adrenergic receptors and, in case of verapamil, these inhibitions may play a role in the effects of verapamil on the heart. In this study, the effects of nicardipine, nifedipine, nimodipine, diltiazem and verapamil on the binding of [$^3H$]dihydroalprenolol (DHA) to dog cardiac ${\beta}$-adrenergic receptors were examined. A single uniform [$^3H$]DHA binding site ($K_D/= 5nM\;and\;B_{max}=2600$ fmol/mg protein) was identified in dog cardiac sarcolemma. [$^3H$]DHA binding was not affected by the usual therapeutic concentrations of these calcium antagonists (nanomolar range) but in the "nonspecific"concentration ranges ($28-180{\mu}m$) these drugs inhibited [$^3H$]DHA binding to $\beta$-adrenergic receptors. Nicardipine, nifedipine, nimodipine and diltiazem competed for [$^3H$]DHA binding to ${\beta}$-adrenergic receptors with dissociation constants ($K_i$) of $28{\mu}m,\' 74{\mu}m, 39{\mu}m \;and \;35{\mu}m,$ respectively. Verapamil ($K_i=176.5 {\mu}m$) was less potent inhibitor than other drugs and this inhibition was noncompetitive; the maximal binding capacity ($B_{max}$) $300 {\mu}m$ verapamil without change in the apparent dissociation constant (4K_D$) for DHA. These results indicate that the inhibitory action of calcium antagonists at high concentrations on ${\beta}$-adrenergic receptors is not involved in the therapeutic effects of these drugs by the calcium channel blocking action.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.25 no.11
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• pp.1640-1649
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• 2001

The present study investigates the effects of various rib arrangements on heat/mass transfer in the cooling passage of gas turbine blades. A complex flow structure occurs in the cooling passage with rib turbulators which promote heat transfer on the wall. It is important to increase not only the heat transfer rates but also the uniformity of heat transfer in the cooling passage. A numerical computation is performed using a commercial code to calculate the flow structures and experiments are conducted to measure heat/mass transfer coefficients using a naphthalene sublimation technique. A square channel (50 mm $\times$ 50 mm) with rectangular ribs (4 mm $\times$ 5 mm) is used fur the stationary duct test. The experiments focus on the effects of rib arrangements and gap positions in the discrete ribs on the heat/mass transfer on the duct wall. The rib angle of attack is 60°and the rib-to-rib pitch is 32 mm, that is 8 times of the rib height. With the inclined rib angle of attack (60°), the parallel rib arrangements make a pair of counter rotating secondary flows in the cross section, but the cross rib arrangements make a single large secondary flow including a small secondary vortex. These secondary flow patterns affect significantly the heat/mass transfer on the ribbed wall. The heat/mass transfer in the parallel arrangements is 1.5 ∼2 times higher than that in the cross arrangements. However, the shifted rib arrangements change little the heat/mass transfer from the inline rib arrangements. The gap position in the discrete rib affects significantly the heat/mass transfer because a strong flow acceleration occurs locally through the gap.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.10a
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• pp.693-696
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• 2008

The systems for mobile communication services of fourth generation use OFDM (Orthogonal Frequency Division Multiplexing) scheme that ran transmit large amounts of data to support the multimedia services, and consist of several types of cell, such as Macro Cell, Pico Cell, Femto Cell to improve the qualify of service. According to subdivision of communication region, superposition of cells in co-channel different from conventional single cell is used, but it cause inter band interference between systems. In particular, an OFDM signal consists of a number of independently modulated subcarriers, and superposition of these subcarriers causes a problem that ran give a large PAPR. Increased PAPR induces signal distortion passing through components such as power amplifier so that inter band interference is caused by out-of-band spectrum radiation. In order to minimize the inter band interference, this paper applies PAPR reduction scheme and analyzes the out-of-band spectrum radiation when the signal passes through nonlinear components such an power amplifier.