• Journal of Korean Neurosurgical Society
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• 제62권1호
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• pp.35-45
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• 2019

Objective : To describe our experiences with a fully equipped high-end digital subtraction angiography (DSA) system within a hybrid operating room (OR). Methods : A single-plane DSA system with 3-dimensional rotational angiography, cone-beam computed tomography (CBCT), and real-time navigation software was used in our hybrid OR. Between April 2014 and January 2018, 191 sessions of cerebrovascular procedures were performed in our hybrid OR. After the retrospective review of all cases, the procedures were categorized into three subcategorical procedures : combined endovascular and surgical procedure, complementary rescue procedure during intervention and surgery, and frameless stereotaxic operation. Results : Forty-nine of 191 procedures were performed using hybrid techniques. Four cases of blood blister aneurysms and a ruptured posterior inferior cerebellar artery aneurysm were treated using bypass surgery and endovascular trapping. Eight cases of ruptured aneurysm with intracranial hemorrhage (ICH) were treated by partial embolization and surgical clipping. Six cases of ruptured arteriovenous malformation with ICH were treated by Onyx embolization of nidus and subsequent surgical removal of nidus and ICH. Two (5.4%) of the 37 cases of pre-mature rupture during clipping were secured by endovascular coil embolization. In one (0.8%) complicated case of 103 intra-arterial thrombectomy procedures, emergency surgical embolectomy with bypass surgery was performed. In 27 cases of ICH, frameless stereotaxic hematoma aspiration was performed using $XperGuide^{(R)}$ system (Philips Medical Systems, Best, the Netherlands). All procedures were performed in single sessions without any procedural complications. Conclusion : Hybrid OR with a fully equipped DSA system could provide precise and safe treatment strategies for cerebrovascular diseases. Especially, we could suggest a strategy to cope flexibly in complex lesions or unexpected situations in hybrid OR. CBCT with real-time navigation software could augment the usefulness of hybrid OR.

• Journal of Korean Neurosurgical Society
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• 제65권1호
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• pp.40-48
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• 2022

Objective : Placement of a single transverse stent via the nondominant A1 across the anterior communicating artery (AComA) into the contralateral A2 can provide sufficient neck coverage for wide-necked bifurcation AComA aneurysms. The authors described the feasibility, safety and long-term outcomes of this technique. Methods : Between January 2015 and February 2018, placement of a single transverse stent via the nondominant A1 was attempted in 17 wide-necked bifurcation AComA aneurysms. The authors reviewed the medical records and radiological studies. Results : The technical success rate was 94.1% (16/17). Periprocedural thromboembolic complications occurred in one patient (6.3%) without permanent neurological deficits. The mean clinical follow-up duration was 39.9±9.8 months. No deaths or delayed thromboembolic complications occurred. The mean angiographic follow-up duration was 38.9±9.8 months. The immediate and final follow-up complete occlusion rates were 87.4 and 93.7%, respectively. There was no recanalization during the follow-up period. Conclusion : Placement of a single transverse stent via the nondominant A1 across the AComA into the contralateral A2 is a feasible and relatively safe endovascular technique for the treatment of wide-necked bifurcation AComA aneurysms, with good long-term occlusion rates and a reasonable complication rate, if only the nondominant A1 is applicable.

• Journal of Korean Neurosurgical Society
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• 제58권3호
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• pp.184-191
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• 2015

Objective : Anterior communicating artery (AcomA) aneurysms represent the most common intracranial aneurysms and challenging to treat due to complex vascularity. The purpose of this study was to report our experience of endovascular treatment of AcomA aneurysms. Methods : Between January 2003 and December 2013, we retrospectively reviewed the medical records of 134 AcomA aneurysm patients available more than 6 months conventional angiographic and clinical follow-up results. We focused on aneurismal or AcomA vascular characters, angiographic and clinical follow-up results, and retreatment. Results : The rate of ruptured cases was 75.4%, and the small (<10 mm) aneurysms were 96.3%. Based on the subtypes defined by dominance of A1, 79 patients (59%) had contralateral A1 hypoplasia or agenesis. The immediate post-procedural angiography confirmed complete occlusion in 75.4%, partial occlusion in 24.6%. Procedure related complications were observed in 25 (18.6%) patients. Most of the adverse events were asymptomatic. Follow-up conventional angiography at ${\geq}6$ months was performed in all patients (mean 16.3 months) and major recanalization was noted in 6.7% and regrowth in one case. The aneurysm size (p=0.016), and initial treatment results (p=0.00) were statistically significant risk factors related to aneurysm recurrence. An overall improvement in mRS was observed during the clinical follow-up period and no rebleeding episode occurred. Conclusion : This study demonstrated that endovascular treatment is an effective treatment modality for AcomA aneurysms with low morbidity. Patients should take long term clinical and angiographic follow-up in order to assess the recurrence and warrant retreatment, especially ruptured, large, and initially incomplete occluded aneurysms.

• 대한방사선기술학회지:방사선기술과학
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• 제32권1호
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• pp.61-67
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• 2009

연구목적 : poly-L-guluronic alginate(PGA) 겔이 혈관색전술에 적용가능한지 시뮬레이션을 통해 확인하고, PGA 겔이 혈관 내에서도 유용한지 혈관조영술을 통해 알아보고자 하였다. 연구방법 : 겔을 형성하는 PGA는 다시마에서 추출하여 생물학적 적합성 시험을 거쳤고, 단백질 불순물을 완전히 정제한 후 실험에 이용하였다. 유리 동맥류 모형을 이용하여 PGA가 겔을 형성하여 색전을 일으키는지 확인하였고, 가토의 신장 혈관에서도 PGA가 색전을 일으키는지 혈관조영술을 통해 확인하였다. 결 과 : 유리 동맥류 모형에서 PGA는 자동 주입기를 이용하여 카테타를 통해 주입한 후 염화칼슘($CaCl_2$)을 주입하니 유리 동맥류 모형 내에서 겔을 형성하며 색전을 일으켰다. 가토 실험에서는 우신 동맥과 대동맥을 결찰한 후 혈관조영술을 통해 좌신의 혈류를 확인하였다. 좌신동맥으로 PGA와 염화칼슘($CaCl_2$)을 동일한 카테터를 통해 순서대로 주입한 후 우신동맥과 대동맥의 결찰을 제거하였다. 혈관조영술을 다시 실시하여 좌신동맥의 혈류를 확인하니 좌신동맥이 보이지 않았다. 이는 좌신 혈관 내에세 PGA가 겔을 형성하여 혈류를 완전히 차단하였기 때문이었다. 결 론 : PGA는 혈관 내에서 혈관을 완전히 차단하고 색전을 일으킴을 확인하였다. 그러므로 PGA는 혈관 색전물질로 유용할 것이고, 혈관색전술과 조영술 적용에 상당히 효과적일 것이다.

• 한국융합학회논문지
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• 제10권1호
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• pp.339-351
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• 2019

본 연구는 2016년 1월부터 12월까지 뇌동맥류로 진단받고 치료를 받고 있는 환자의 일반적, 입원관련, 임상적, 뇌동맥류 자체 및 생활습관 특성 중 위험요인을 확인하고자 의무기록지 검토를 통해 후향적으로 이루어졌다. 로지스틱 회귀분석결과 2개 이상의 경고증상(14.14 (CI: 1.25-159.40))이 뇌동맥류 파열에 대한 오즈비가 가장 높았고, 다음으로 3점 이상의 두통(13.95 (CI: 3.68-52.83)), 응급실을 통한 입원(13.62 (CI: 4.85-38.26)), 배우자가 없는 경우(9.72 (CI: 2.22-42.49)), 부정맥이 있는 경우(3.70 (CI: 1.22-11.22)), 1 mmHg 수축기압 증가(1.04 (CI: 1.01-1.08)), 1점 GCS 증가 (0.58 (CI: 0.37-0.90)), 1세 나이 증가(0.95 (CI: 0.91-0.99))순이었다. 뇌동맥류 파열이 발생하기 전에 일상적인 평가를 포함한 예방 활동을 수행해야하며 뇌동맥류 환자발견 시 뇌동맥류파열 위험요인에 대한 신속한 사정이 필요하다.

• 대한영상의학회지
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• 제84권6호
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• pp.1339-1349
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• 2023

목적 단일 기관에서 7년간의 장골 분지 장치 사용 경험을 바탕으로 그 효과와 안전성을 확인하고 효용성 및 한계를 고찰하고자 하였다. 대상과 방법 이 연구는 단일 기관에서 총장골동맥류에 장골 분지 장치 삽입술을 받은 환자들을 대상으로 시행했다. 추적 컴퓨터단층촬영 스캔을 분석하고, 내장골동맥의 개방성 및 장골분지 장치 사용과 관련된 합병증을 검토했다. 후향적 분석을 시행하였으며 전체 생존율과 재시술이 필요 없는 환자의 비율을 Kaplan-Meier method에 따라 분석했다. 결과 38명의 총장골동맥류가 있는 환자들 중에서 10명의 환자(12개의 총장골동맥류)만이 해부학적으로 장골 분지 장치 사용에 적합했다. 5명의 환자는 반대측 내장골동맥 색전술과 함께 장골 분지 장치 삽입술을 받았으며, 이 중 3명의 환자(60%)는 합병증으로 파행을 보였으나 모두 6개월 만에 증상이 호전되었다. 또한 7년 후 장골 분지 장치 사용 관련 재시술이 필요없는 환자의 비율은 77.8%였으며 시술과 관련된 사망은 없었다. 결론 장골 분지 장치는 높은 기술적 성공률과 장기 개통률을 보이지만, 아시아인의 경우 해부학적 요인으로 인해 적용이 제한되는 경우가 많다. 또한 단측 내장골동맥 색전술을 시행한 경우에도 경미한 합병증과 좋은 예후를 보였으므로, 해부학적으로 복잡한 총장골동맥류에서 단측 장골 분지 장치 삽입술 및 반대측 내장골동맥 색전술을 선택하여 시행할 수 있다.

• Journal of Korean Neurosurgical Society
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• 제49권6호
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• pp.329-333
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• 2011

Objective : As medical advances have increased life expectancy, it has become imperative to develop specific treatment strategies for intracranial aneurysms in the elderly. We therefore analyzed the clinical characteristics and outcomes of the treatment of unruptured intracranial aneurysms in patients older than 70 years. Methods : We retrospectively reviewed the medical records and results of neuroimaging modalities on 54 aneurysms of 48 consecutive patients with un ruptured intracranial aneurysms. ($mean{\pm}SD$ age, $72.11{\pm}1.96$ years; range, 70-78 years) who underwent surgical clipping over 10 years (May 1999 to June 2010). Results : Of the 54 aneurysms, 22 were located in the internal carotid artery, 19 in the middle cerebral artery, 12 in the anterior cerebral artery, and 1 in the superior cerebellar artery. Six patients had multiple aneurysms. Aneurysm size ranged from 3 mm to 17 mm ($mean{\pm}SD$, $6.82{\pm}3.07$ mm). Fifty of the 54 aneurysms (92.6%) were completely clipped. Three-month outcomes were excellent in 50 (92.6%) aneurysms and good and poor in 2 each (3.7%), with 1 death (2.0%). Procedure-related complications occurred in 7 aneurysms (13.0%), with 2 (3.7%) resulting in permanent neurological deficits, including death. No postoperative subarachnoid hemorrhage occurred during follow-up. The cumulative rates of stroke- or death-free survival at 5 and 10 years were 100% and 78%, respectively. Conclusion : Surgical clipping of unruptured intracranial aneurysms in elderly group could get it as a favorable outcome in well selected cases.

• Journal of Yeungnam Medical Science
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• 제36권3호
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• pp.208-218
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• 2019

Background: The anatomy of middle cerebral artery (MCA) aneurysms has been noted to be unfavorable for endovascular treatment. The purpose of this study was to assess the feasibility and efficacy of coiling for MCA aneurysms. Methods: From January 2004 to December 2015, 72 MCA aneurysms (38 unruptured and 34 ruptured) in 67 patients were treated with coils. Treatment-related complications, clinical outcomes, and immediate and follow-up angiographic outcomes were retrospectively analyzed. Results: Aneurysms were located at the MCA bifurcation (n=60), 1st segment (M1, n=8), and 2nd segment (M2, n=4). Sixty-nine aneurysms (95.8%) were treated by neck remodeling techniques using multi-catheter (n=44), balloon (n=14), stent (n=8), or combination of these (n=3). Only 3 aneurysms were treated by single-catheter technique. Angiographic results were 66 (91.7%) complete, 5 (6.9%) remnant neck, and 1 (1.4%) incomplete occlusion. Procedural complications included aneurysm rupture (n=1), asymptomatic coil migration to the distal vessel (n=1), and acute thromboembolism (n=10) consisting of 8 asymptomatic and 2 symptomatic events. Treatment-related permanent morbidity and mortality rates were 4.5% and 3.0%, respectively. There was no bleeding on clinical follow-up (mean, 29 months; range, 6-108 months). Follow-up angiographic results (mean, 26 months; range, 6-96 months) in patients included 1 major and 3 minor recanalizations. Conclusion: Coiling of MCA aneurysms could be a technically feasible and clinically effective treatment strategy with acceptable angiographic and clinical outcomes. However, the safety and efficacy of this technique as compared to surgical clipping remains to be ascertained.

• Journal of Korean Neurosurgical Society
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• 제64권2호
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• pp.217-228
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• 2021

Objective : Given the high risk of rebleeding and recurrence of blood blister-like aneurysms (BBAs), we treated ruptured BBAs of the internal carotid artery (ICA) with stent-assisted coil embolization (SAC). This study aimed to evaluate the efficacy and safety of SACs. Methods : We retrospectively reviewed clinical and radiological data from eight patients with ruptured BBAs of the supraclinoid ICA. The modified Rankin Scale (mRS) was used to assess clinical outcomes, while radiological outcomes were evaluated on angiographs. For a pooled analysis, data from literature reporting the outcomes of ruptured BBAs treated with SAC were collected and analyzed in conjunction with our data. Results : In our cohort, the mean Raymond classification score was 1.57±0.53 immediately after initial endovascular treatment. There were no perioperative complications or rebleeding events during the follow-up period. The mean mRS score at patient discharge was 1.00±0.81 and improved to 0.28±0.48 by the last follow-up day. The recurrence rate was 25% with an asymptomatic presentation and successful treatment with multiple stent insertion. Pooled analysis of 76 cases of SAC revealed a complete occlusion rate immediately after treatment of 54.8%, rebleeding rate 7.94%, and recurrence rate 24.2%. Good clinical outcomes with mRS score 0-2 were observed in 89.9% by the last clinical follow-up. Total mortality rate was 7.7%. Conclusion : This treatment appears to not only minimize the hemodynamic burden on the fragile dome specific to this type of aneurysm, but also provides an opportunity for safe and effective treatment in recurrent cases.

• Journal of Chest Surgery
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• 제28권2호
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• pp.183-187
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• 1995

This is a report of successful management of a patient with complicated native valvular endocarditis. Initially stable patient showed sudden collapse at the end of 4th week of antibiotics coverage. Echocardiography revealed that previous vegetation at the Aorto-mitral Fibrous Skeleton[AMFS developed into a false aneurysm, perforated to left atrium and caused fistulous communication between left ventricle and left atrium. Extensive debridement was performed including part of the ascending aorta, aortic cusps, the AMFS, anterior mitral cusp and roof of the left atrium. Reconstruction of the AMFS with tailored single piece of autologous pericardium enabled the implantation of mechanical valves at the aortic and the mitral position. Ascending aorta and roof of the left atrium were repaired with autologous pulmonary artery patch graft and another autologous pericardial patch. The patient was discharged on postoperative 16th day and followed - up till now without any residuae or sequelae.