• Journal of Pharmacopuncture
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• v.21 no.3
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• pp.203-206
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• 2018

Objectives: There is an increasing number of complex diseases that are progressively more difficult to be controlled using the conventional "single compound, single target" approach as demonstrated in our current modern drug development. TCM might be the new cornerstone of treatment alternative when the current treatment option is no longer as effective or that we have exhausted it as an option. Orthogonal stimulus-response compatibility group study is one of the most frequently employed formulas to produce optimal herbal combination for treatment of multi-syndromic diseases. This approach could solve the relatively low efficacy single drug therapy usage and chronic adverse effects caused by long terms administration of drugs that has been reported in the field of pharmacology and medicine Methods: The present review was based on the Science Direct database search for those related to the TCM and the development of antihypertensive TCM herbal combination using orthogonal stimulus-response compatibility group studies approach. Results: Recent studies have demonstrated that the orthogonal stimulus-response compatibility group study approach was most frequently used to formulate TCM herbal combination based on the TCM principles upon the selection of herbs, and the resulting formulated TCM formula exhibited desired outcomes in treating one of global concerned complex multi-syndromic diseases, the hypertension. These promising therapeutic effects were claimed to have been attributed by the holistic signaling mechanism pathways employed by the crude combination of herbs. Conclusion: The present review could serve as a guide and prove the feasibility of TCM principles to be used for future pharmacological drug research development.

• The Research Journal of the Costume Culture
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• v.18 no.2
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• pp.261-276
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• 2010

The analysis of an art trend in the principle dimension starts by observing the object of work in the perspective of formative composition and recognizing it as a universal system. It can be said that it is consistent with an interpretation method for a form theory of formal history by Heinrich W$\ddot{o}$lfflin, a leading form critic in art criticism. Hence, the purpose of this study was to find out what are the formative principles in Renaissance Classicism as a design principle to be applicable to modern fashion by reviewing the formative characteristics of Renaissance Classicism Architecture with which W$\ddot{o}$lfflin directly dealt. As for the theoretical literature review, I used W$\ddot{o}$lfflin's theoretical framework and looked at the Renaissance Classicism Architecture that he studied and examined the possibility of utilizing his theory as a layout principle and the characteristics. As for analysis of design cases, I applied the aforementioned architecture layout principle to modern fashion and conducted case study analysis to delve into distinctive layout principles found in fashion. The study showed that the Renaissance Classicism Architectural Style is marked by linearity, planarity, closing and multiple unity: linearity was expressed in the observation form in fixed frontal view and an emphasis on a tangible silhouette homeogenous and definite line structures; planarity was achieved in the form of paralleled layers of frontal view element, planarity style, and identical and proportional repetition of various sizes.; closing signified the pursuit of complete and clear regularity, and architecture developed in a constructive phase through organizational inevitability and absolute invariability.; multiple unity was expressed in self-completedness and independent parallel of discrete forms and harmony of emphasized individual elements in a totality. Applying these layout characteristics of the Renaissance Classicism Architectural style and to see their individual expressive features, I found out that in adopting layout principles of the Renaissance Classicism Architecture to modern fashion, it turned out to be an emphasis of individual silhouettes, a flattened space, completed objects, organic harmony among independent parts: the emphasis of individual silhouettes was expressed in individual definitiveness of formative lines of clothes in accordance with body joints and an emphasis on formative lines of clothes; the flattened space was marked by single layer structure, planarity of elements of clothes, and listing arrangement by appropriate proportion.; the completedness of the objects was expressed by the stationary state where overall image is fixed, the construction of homogeneous and complete space, and absolute inevitability of internal layout in proportion; lastly, organic harmony of independent parts was stressed in independent completedness of each detail, and organic harmony of the whole. The expressive features would lead to a unique expression style of linear emphasis, proportion, constructive forms, and two-dimensional arrangement. The meaning of this study is follows: The characteristics of art school of thought are given shape by appling & analysing the architectural layout principles of historical art school of thought to modern fashion in the view point of formal construction dimension. The applied possibility of historical art school of thought as the source of inspiration about the fashion design is extended.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.38 no.3
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• pp.127-135
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• 2015

Universal design is defined as the design process of products and environments usable by all people to the greatest extent possible, without the need for adaptation or specialized design. The benefits of universal design have been promoted primarily through illustrative 'success stories' of public, residential and occupational environments and products. While case examples may be informative, they may unfortunately be limited in terms of generality to other designs or tasks. Therefore, design methods and criteria that can be applied systematically in a range of situations to encourage universal design are needed. In addition, the seven principles of universal design are intended to guide the design process. The principles provide a framework that allows a systematic evaluation of new or existing designs and assists in educating both designers and consumers about the characteristics of more usable products and environments. However, exactly how these principles are incorporated into the design process has beenleft up to the designer. Since the introduction of universal design, designers have become familiar with the principles of universal design, and they have developed many products based on universal design. However, the principles of universal design are qualitative, which means designers cannot quantitatively evaluate their designs. Some have worked to develop more systematic ways to evaluate products and environments by providing design guidelines for each of the principles. However, recommendations have not yet been made regarding how to integrate performance measures of universal design into the product design process before the product is mass produced. Furthermore, there are sets of requirements regarding each user group that has different age and ability. Consequently, there is an urgent need for design methods, based on a better understanding of age and ability related factors, which will lead to a universally designed product or environment. The authors have proposed the PSD (Preference Set-Based Design) method that can generate a ranged set of feasible solutions (i.e., robust and flexible solution set) instead of single point solution that satisfies changing sets of design targets. The objective of this paper is to develop a general method for systematically supporting the universal design process. This paper proposes the applicability of PSD method to universal design. Here, the proposed method is successfully illustrated with a universal design problem.

• The Journal of Korean Medicine
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• v.35 no.2
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• pp.28-33
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• 2014

Background: Samul-tang (Si-Wu-Tang, SMT) is a traditional herbal formula, which has been widely used to treat various diseases such as menstrual irregularity, bleeding and leucorrhea. Although many studies have investigated the pharmacological properties of SMT, its toxicity information has not yet been fully elucidated. Methods: Five Sprague Dawley (SD) rats of each sex were given a single dose (5000 mg/kg) of SMT by gavage; control rats received the vehicle only. After the single administration, mortality, clinical signs, body weight changes and gross findings were monitored for 15 days in accordance with Good Laboratory Practice (GLP) principles. Results: In a single oral dose toxicity study, there was no adverse effect on mortality, clinical sign, body weight change or gross finding in any treatment group. Conclusions: The results indicate that SMT did not induce toxic effects at a dose level up to 5000 mg/kg in rats and its median lethal dose ($LD_{50}$) was considered to be over 5000 mg/kg/day body weight for both genders.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.7
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• pp.2570-2578
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• 2010

This paper presents a digital-controlled single-phase power-factor correction (PFC) converter operating in critical current conduction mode. The proposed converter utilizes the DC-DC boost converter topology for the PFC and operates the inductor current in critical conduction mode. Because the proposed converter is controlled digitally using a micom, its control circuit is simplified and the converter operates more effectively. This paper first explains the operational principles of the proposed converter and then analyzes the converter circuit. And this paper explains the implementation method of proposed converter with a detail design example, which is divided into software and circuit design parts. Also, it is shown through the experimental results of the prototype converter by the designed circuit parameters that the proposed converter has good performance as a single-phase PFC converter.

• Proceedings of the KIEE Conference
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• 1990.11a
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• pp.184-187
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• 1990

This paper presents the self-matched line pulse generator and the concerned principles on its operation and characteristics are mentioned. The circuit consists of a charged transmission line and a high speed switch, and it generates a square wave pulse with the very fast rise time. The generated waveform depends on the load resistance. As the load resistance is infinite, a single rectangular wave pulse is generated and its efficiency is nearly unity.

• 제어로봇시스템학회:학술대회논문집
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• 1988.10a
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• pp.206-209
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• 1988

For feedback control of a linear dynamic system the optimum linear slace regulator (OLSR) can be implemented only if all state are available for feedback. This work demonstrates that when only the output state is available for feedback, a nonlinear controllers can be improved performance over that obtained by a proportional controller. This paper found the optimal control law by well-known dynamic programming and principles of optimality. Thus, performance of both proportional and nonlinear controllers is compared with performance of optimum linear state regulator.

• Journal of the Korean Mathematical Society
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• v.50 no.3
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• pp.607-625
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• 2013

It is well-known that the ordinary single-parameter Wiener space exhibits a reflection principle. In this paper we establish a reflection principle for a generalized one-parameter Wiener space and apply it to the integration of a class of functionals on this space. We also discuss several notions of a reflection principle for the two-parameter Wiener space, and explore whether these actually hold.

• Proceedings of the Optical Society of Korea Conference
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• 2008.07a
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• pp.273-274
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• 2008

We present a quantitative phase microscopy for live cells. This method uses the principles of common path inteferometry and single shot phase image. This system has the ability to measure live cells quantitatively with subnanometer path length stability and millisecond scale aquisition time.

• Progress in Superconductivity
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• v.4 no.1
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• pp.1-9
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• 2002

Transferring single flux quanta across a Josephson junction at an exactly determined rate has made highly precise voltage measurements possible. Making use of self-shunted Nb-based SINIS junctions, programmable fast-switching DC voltage standards with output voltages of up to 10 V were produced. This development is now extended from fundamental DC measurements to the precise determination of AC voltages with arbitrary waveforms. Integrated RSFQ circuits will help to replace expensive semiconductor devices for frequency control and signal coding. Easy-to-handle AC and inexpensive quantum voltmeters of fundamental accuracy would be of interest to industry. In analogy to the development in the flux regime, metallic nanocircuits comprising small-area tunnel junctions and providing the coherent transport of single electrons might play an important role in quantum current metrology. By precise counting of single charges these circuits allow prototypes of quantum standards for electric current and capacitance to be realised. Replacing single electron devices by single Cooper pair circuits, the charge transfer rates and thus the quantum currents could be significantly increased. Recently, the principles of the gate-controlled transfer of individual Cooper pairs in superconducting A1 devices in different electromagnetic environments were demonstrated. The characteristics of these quantum coherent circuits can be improved by replacing the small aluminum tunnel Junctions by niobium junctions. Due to the higher value of the superconducting energy gap ($\Delta_{Nb}$ ＝ $7\Delta_{Al}$), the characteristic energy and the frequency scales for Nb devices are substantially extended as compared to A1 devices. Although the fabrication of small Nb junctions presents a real challenge, the Nb-based metrological devices will be faster and more accurate in operation. Moreover, the Nb-based Cooper pair electrometer could be coupled to an Nb single Cooper pair qubit which can be beneficial for both, the stability of the qubit and its readout with a large signal-to-noise ratio..