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Neuropeptide Regulation of Signaling and Behavior in the BNST

  • Kash, Thomas L.;Pleil, Kristen E.;Marcinkiewcz, Catherine A.;Lowery-Gionta, Emily G.;Crowley, Nicole;Mazzone, Christopher;Sugam, Jonathan;Hardaway, J. Andrew;McElligott, Zoe A.
    • Molecules and Cells
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    • v.38 no.1
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    • pp.1-13
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    • 2015
  • Recent technical developments have transformed how neuroscientists can probe brain function. What was once thought to be difficult and perhaps impossible, stimulating a single set of long range inputs among many, is now relatively straight-forward using optogenetic approaches. This has provided an avalanche of data demonstrating causal roles for circuits in a variety of behaviors. However, despite the critical role that neuropeptide signaling plays in the regulation of behavior and physiology of the brain, there have been remarkably few studies demonstrating how peptide release is causally linked to behaviors. This is likely due to both the different time scale by which peptides act on and the modulatory nature of their actions. For example, while glutamate release can effectively transmit information between synapses in milliseconds, peptide release is potentially slower [See the excellent review by Van Den Pol on the time scales and mechanisms of release (van den Pol, 2012)] and it can only tune the existing signals via modulation. And while there have been some studies exploring mechanisms of release, it is still not as clearly known what is required for efficient peptide release. Furthermore, this analysis could be complicated by the fact that there are multiple peptides released, some of which may act in contrast. Despite these limitations, there are a number of groups making progress in this area. The goal of this review is to explore the role of peptide signaling in one specific structure, the bed nucleus of the stria terminalis, that has proven to be a fertile ground for peptide action.

The Real-Time Determination of Ionospheric Delay Scale Factor for Low Earth Orbiting Satellites by using NeQuick G Model (NeQuick G 모델을 이용한 저궤도위성 전리층 지연의 실시간 변환 계수 결정)

  • Kim, Mingyu;Myung, Jaewook;Kim, Jeongrae
    • Journal of Advanced Navigation Technology
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    • v.22 no.4
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    • pp.271-278
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    • 2018
  • For ionospheric correction of low earth orbiter (LEO) satellites using single frequency global navigation satellite system (GNSS) receiver, ionospheric scale factor should be applied to the ground-based ionosphere model. The ionospheric scale factor can be calculated by using a NeQuick model, which provides a three-dimensional ionospheric distribution. In this study, the ionospheric scale factor is calculated by using NeQuick G model during 2015, and it is compared with the scale factor computed from the combination of LEO satellite measurements and international GNSS service (IGS) global ionosphere map (GIM). The accuracy of the ionospheric delay calculated by the NeQuick G model and IGS GIM with NeQuick G scale factor is analyzed. In addition, ionospheric delay errors calculated by the NeQuick G model and IGS GIM with the NeQuick G scale factor are compared. The ionospheric delay error variations along to latitude and solar activity are also analyzed. The mean ionospheric scale factor from the NeQuick G model is 0.269 in 2015. The ionospheric delay error of IGS GIM with NeQuick G scale factor is 23.7% less than that of NeQuick G model.

A STUDY ON BONE STRENGTH AND THE DEGREE OF CONVERSION OF DENTIN BONDING AGENTS (수종 상아질 접착제의 결합강도와 중합률에 관한 연구)

  • Kim, Byung-Hyun;Kwon, Hyuk-Choon
    • Restorative Dentistry and Endodontics
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    • v.23 no.1
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    • pp.68-93
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    • 1998
  • The physical properties of polymer are greatly influenced by the extent to which a resin cures. The presence of un reacted monomer can, have a plasticizing effect on the polymer, thereby altering the physical and mechanical properties of dentin bonding agent (DBA). If the DBA does not polymerize sufficiently, it will leave a weak bonding layer and lead to lower bond strength. The purpose of this study was to evaluate the shear bond strengths(SBS) and the degree of conversion (DC) of 4 commercialy avilable dentin bonding systems which are composed of 2 multi-bottle systems [Scotchbond Multi-Purpose (SMP), AeliteBond(AB)] and 2 onebottle systems [SingleBond(SB), One-Step(OS)]. For shear bond strength measurement, labial surfaces of freshly extracted bovine incisors were ground with # 600 grit SiC paper to expose dentin. Four different groups of samples were formed, with 10 samples. being made for each of the 4 commercial DBA in each group according to the curing sequences of DBA and overlayer thickness of composites: Group I (standard cure and 1mm thick composites) : The DBA was light cured and the composites of 1mm thickness was applied ; Group II (standard cure and 2mm thick composites) : The DBA was light cured and the composites of 2mm thickness was applied; Group III (simultaneous cure and 1mm thick composites) : The DBA was not light-cured and simultaneously cured with composites of 1mm thickness; Group N (simultaneous cure and 2mm thick composites) : The DBA was. not light-cured and simultaneously cured with composites of 2mm thickness. The SBS was measured immediately after the composites was bonded to the bovine dentin using an Instron machine. The DC of the DBA was examined in a thin film under simulated conditions of the experimental groups according to the curing sequences and overlayer thickness of composites in the SBS test. using a Fourier transform Infrared(FTIR) spectrometer. The following results were obtained from SBS tests and DC measurements 1. In SBS tests, the multi-bottle DBA(SMP, AB) had a generally higher bond strength values than the one bottle DBA(SB, OS). In DC measurements, the one bottle DBA(SB, OS) had a significantly higher DC than the multi-bottle DBA(SMP, AB). 2. In all DBAs except OS, there was no significant difference between the bond strength of group I (standard cure and 1mm thick composites) and that of group III (simultaneous cure and 1mm thick composites). SMP, SB in Group I had a significantly higher DC than those in group III, but AB, OS in group I had a significantly lower DC than those in group III 3. All DBAs in Goup II (standard cure and 2mm thick composites) had significantly higher bond strength and DC than those in Group N (simultaneous cure and 2mm thick composites). 4. In all DBAs, there was no significantly different SBS and DC between Group I and Group II, but all DBAs in Group III had significantly higher SBS and DC than those in Group IV.

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The basic experiments for the fabrication of the SPUDT type Inter using the SFIT type filter (SFIT형태를 이용한 SPUDT형 필터제작에 관한 기초실험)

  • You, Il-Hyun
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.11 no.10
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    • pp.1916-1923
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    • 2007
  • We have studied to obtain the SAW filter for the passband was formed on the Langasite substrate and was evaporated by Aluminum-Copper alloy and thin we performed computer-simulated by simulator. We cm fabricate that the block weighted type IDT as an input transducer of the filter and the withdrawal weighted type IDT as an output transducer of the filter from the results of our computer-simulation. Also, we have performed to obtain the properly design conditions about phase shift of the SAW filter for WCDMA. We have employed that the number of pairs of the input and output IDT are 50 pairs and the thickness and the width of reflector are $5000\;{\AA}$ and $3.6{\mu}m$ respectively. And we have employed that the distances from the hot electrode to the reflector are $2.0{\mu}m$, $2.4{\mu}m$ and the distance from the hot electrode to the ground is $1.5{\mu}m$ respectively. Frequency response of the fabricated SAW filter has the property that the center frequency is about 190MHz and bandwidth at the 3dB is probably 7,8MHz. And we could obtain that return loss is less then -18dB, ripple characteristics is probably 3dB and triple transit echo is less then -25dB after when we have matched impedance.

Analysis of Relationships between Features Extracted from SAR Data and Land-cover Classes (SAR 자료에서 추출한 특징들과 토지 피복 항목 사이의 연관성 분석)

  • Park, No-Wook;Chi, Kwang-Hoon;Lee, Hoon-Yol
    • Korean Journal of Remote Sensing
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    • v.23 no.4
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    • pp.257-272
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    • 2007
  • This paper analyzed relationships between various features from SAR data with multiple acquisition dates and mode (frequency, polarization and incidence angles), and land-cover classes. Two typical types of features were extracted by considering acquisition conditions of currently available SAR data. First, coherence, temporal variability and principal component transform-based features were extracted from multi-temporal and single mode SAR data. C-band ERS-1/2, ENVISAT ASAR and Radarsat-1, and L-band JERS-1 SAR data were used for those features and different characteristics of different SAR sensor data were discussed in terms of land-cover discrimination capability. Overall, tandem coherence showed the best discrimination capability among various features. Long-term coherence from C-band SAR data provided a useful information on the discrimination of urban areas from other classes. Paddy fields showed the highest temporal variability values in all SAR sensor data. Features from principal component transform contained particular information relevant to specific land-cover class. As features for multiple mode SAR data acquired at similar dates, polarization ratio and multi-channel variability were also considered. VH/VV polarization ratio was a useful feature for the discrimination of forest and dry fields in which the distributions of coherence and temporal variability were significantly overlapped. It would be expected that the case study results could be useful information on improvement of classification accuracy in land-cover classification with SAR data, provided that the main findings of this paper would be confirmed by extensive case studies based on multi-temporal SAR data with various modes and ground-based SAR experiments.

Fusion of Aerosol Optical Depth from the GOCI and the AHI Observations (GOCI와 AHI 자료를 활용한 에어로졸 광학두께 합성장 산출 연구)

  • Kang, Hyeongwoo;Choi, Wonei;Park, Jeonghyun;Kim, Serin;Lee, Hanlim
    • Korean Journal of Remote Sensing
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    • v.37 no.5_1
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    • pp.861-870
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    • 2021
  • In this study, fused Aerosol Optical Depth (AOD) data were produced using AOD products from the Geostationary Ocean Color Imager (GOCI) onboard Communication, Oceanography and Meteorology Satellite (COMS)satellite and the Advanced Himawari Imager (AHI) onboard Himawari-8. Since the spatial resolution and the coordinate system between the satellite sensors are different, a preprocessing was first preceded. After that, using the level 1.5 AOD dataset of AErosol RObotic NETwork (AERONET), which is ground-based observation, correlations and trends between each satellite AOD and AERONET AOD were utilized to produce more accurate satellite AOD data than the originalsatellite AODs. The fused AOD were found to be more accurate than the originalsatellite AODs. Root Mean Square Error (RMSE) and mean bias of the fused AODs were calculated to be 0.13 and 0.05, respectively. We also compared errors of the fused AODs against those of the original GOCI AOD (RMSE: 0.15, mean bias: 0.11) and the original AHI AOD (RMSE: 0.15, mean bias: 0.05). It was confirmed that the fused AODs have betterspatial coverage than the original AODsin areas where there are no observations due to the presence of cloud from a single satellite.

Study on Manufacturing Techniques of Bracket Mural Paintings of Daeungbojeon Hall in Naesosa Temple (내소사 대웅보전 포벽화 제작기법 연구)

  • Lee, Hwa Soo;Lee, Na Ra;Han, Gyu-Seong
    • Journal of Conservation Science
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    • v.34 no.6
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    • pp.557-568
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    • 2018
  • The manufacturing techniques were studied by investigating a precise analysis on wall structure, features of materials and the painting layer of the bracket mural paintings at Daeungbojeon Hall in Naesosa temple. The wall frame is a single-branch structure, and The mural paintings are composed of 3 layers which are a support layer, a finishing layer and a painting layer. The support layer and the finishing layer are an earth wall that sand and clay such as Quartz, Feldspar, and etc. are mixed. The support and the finishing layers have a combination of medium particle sand and smaller than fine particle sand in the approximate ratios of 0.8:9.2 and 6:4, respectively. Therefore, the aforementioned ratio of sand with medium or large particles is relatively higher in the finishing layer than the support layer. As a result of a precise analysis on the painting layer, it has a relatively thick ground layer for painting which is maximum $456.15{\mu}m$ by using Celadonite or Glauconite and the paintings were colored by using pigments such as Atacamite, Kaolinite or Halloysite, Oxidized steel, and etc. on it. The manufacturing style and the painting techniques of an earth wall are included in the category of the Joseon Dynasty style that have been studied up to now, but the facts that the finishing layer has a high content of sand and a middle layer and chopped straw have not been identified. These are remarkable points in terms of structure and materials, and can be crucial in the evaluation of the state of conservation of mural paintings or preparation of a conservation plan.

Detecting Surface Changes Triggered by Recent Volcanic Activities at Kīlauea, Hawai'i, by using the SAR Interferometric Technique: Preliminary Report (SAR 간섭기법을 활용한 하와이 킬라우에아 화산의 2018 분화 활동 관측)

  • Jo, MinJeong;Osmanoglu, Batuhan;Jung, Hyung-Sup
    • Korean Journal of Remote Sensing
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    • v.34 no.6_4
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    • pp.1545-1553
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    • 2018
  • Recent eruptive activity at Kīlauea Volcano started on at the end of April in 2018 showed rapid ground deflation between May and June in 2018. On summit area Halema'uma'u lava lake continued to drop at high speed and Kīlauea's summit continued to deflate. GPS receivers and electronic tiltmeters detected the surface deformation greater than 2 meters. We explored the time-series surface deformation at Kīlauea Volcano, focusing on the early stage of eruptive activity, using multi-temporal COSMO-SkyMed SAR imagery. The observed maximum deformation in line-of-sight (LOS) direction was about -1.5 meter, and it indicates approximately -1.9 meter in subsiding direction by applying incidence angle. The results showed that summit began to deflate just after the event started and most of deformation occurred between early May and the end of June. Moreover, we confirmed that summit's deflation rarely happened since July 2018, which means volcanic activity entered a stable stage. The best-fit magma source model based on time-series surface deformation demonstrated that magma chambers were lying at depths between 2-3 km, and it showed a deepening trend in time. Along with the change of source depth, the center of each magma model moved toward the southwest according to the time. These results have a potential risk of including bias coming from single track observation. Therefore, to complement the initial results, we need to generate precise magma source model based on three-dimensional measurements in further research.

Automatic Geo-referencing of Sequential Drone Images Using Linear Features and Distinct Points (선형과 특징점을 이용한 연속적인 드론영상의 자동기하보정)

  • Choi, Han Seung;Kim, Eui Myoung
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.37 no.1
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    • pp.19-28
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    • 2019
  • Images captured by drone have the advantage of quickly constructing spatial information in small areas and are applied to fields that require quick decision making. If an image registration technique that can automatically register the drone image on the ortho-image with the ground coordinate system is applied, it can be used for various analyses. In this study, a methodology for geo-referencing of a single image and sequential images using drones was proposed even if they differ in spatio-temporal resolution using linear features and distinct points. Through the method using linear features, projective transformation parameters for the initial geo-referencing between images were determined, and then finally the geo-referencing of the image was performed through the template matching for distinct points that can be extracted from the images. Experimental results showed that the accuracy of the geo-referencing was high in an area where relief displacement of the terrain was not large. On the other hand, there were some errors in the quantitative aspect of the area where the change of the terrain was large. However, it was considered that the results of geo-referencing of the sequential images could be fully utilized for the qualitative analysis.

A Study of Evaluating Streetscape Green Environments to Improve Urban Street Green Spaces - A Case Study of Jeonju City - (도시가로녹지의 개선을 위한 녹화환경평가 연구 -전주시를 대상으로-)

  • Jeong, Moon-Sun;Lim, Hyun-Jeong
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.22 no.3
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    • pp.55-71
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    • 2019
  • The purpose of this study is to propose an evaluation method to assess green environments of streetscapes to improve urban street green spaces in Jeonju City. Through a rapid assessment of urban street green spaces, we suggest an objective basis for expanding street green space as well as for adopting sustainable maintenance and improvement measures. We choose 12 sections of streetscapes (roads and sidewalks) to investigate existing street conditions which have more than four lanes and function as major road axes. Six large roads and six medium roads of Jeonju City center area are investigated as pilot assessment study sites. Site inventory checklists consist of environmental characteristics of streetscape, street tree status, and planting condition evaluation. Environmental characteristics of streetscapes are composed of physical and neighborhood factors. For instance, items for physical factors are types and width of road/sidewalks, paving materials, tree protection materials, and green strip. And surrounding landuse is a neighborhood factor. Assessment items for street tree status are street plant names (tree/shrubs/ground cover), size, and planting intervals. Planting condition evaluation items are tree shape, damage, canopy density, and planting types with existence of adjacent green space. Evaluation results are classified into three levels such as A(maintain or repair), B(greening enhancement), and C(structural improvement). In case of grade A, streetscapes have enough sidewalk width for maintaining green strip and a multi-layered planting(in large road only) with fairly good growing conditions of street trees. For grade B and C, streetscapes have a moderate level of sidewalk width with a single street tree planting. In addition, street tree growing conditions are appeared poor so that green enhancement or maintenance measures are needed. For median, only grade B and C are found as its planting growing foundations are very limited in space. As a result, acquiring enough sidewalk space is essential to enhance ecological quality of urban street green. Especially, it is necessary to have green strip with reasonable widths for plant growing conditions in sidewalks. In addition, we need to consider native species with multi-layer plant compositions while designing street green.