• 대한의용생체공학회:의공학회지
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• 제13권4호
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• pp.353-362
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• 1992

The stress distribution of bone is altered by the rigid bone plate, sometimes resulting in unfavorable osteoporosis. The rigidity and the biocompatibility are important factors for the design of prosthesis. However, it is also necessary to consider the effect on the bone remodeling. In this paper, it is attempted to establish an approximate and simple method to predict the trend of the configuration of surface bone remodeling for the case of a bone plate using stress analysis. Thus, three dimensional finite element model of plated-human femur is generated and simulated. In addition. the stress difference method (SDM) is introduced and attempted to demonstrate the configuration of surface bone remodeling of the plated-human femur. The results are compared with those of invivo tests and the feasibility of the stress difference method is discussed.

• 대한의용생체공학회:의공학회지
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• 제3권1호
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• pp.9-16
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• 1982

Removal of urea and vitamin B12 was simulated using two pool models with closed loop dialysis, open loop dialysis, and hemodiafiltrations with predilution and postdilulion. It was found that urea removal was limited by dialyzer clearance, however B12 removal was limited both by the resistance between ECF and ICF and by dialyzer clearance. Open loop dialysis was better than closed loop dialysis in terms of dialysate requirement and removal efficiency. Residual renal function plays an important role in removing vitamin B12. Dialysis frequency more than twice/wide does not have great effect on removal efficiency, but has the effect of reducing the difference between maximum and minimum cancentrations during dialysis period.

• 대한의용생체공학회:의공학회지
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• 제30권4호
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• pp.341-346
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• 2009

Cutaneous electrogastrography is the measurement of electrical activity of the stomach on the abdominal surface. The validity of cutaneous electrogastrography is dependent upon the quality of the recording technique. The locations of electrodes are an important issue. We examined the influences of the inter-electrode distance of bipolar leads on electrogastrography measurements. The sensitivity distributions of EGG leads were calculated based on a 2D body fat model and evaluated according to the region of interest sensitivity ratio (ROISR). We simulated the ROISR of the inter-electrode distance in relation to various body fat thicknesses. The distance between the electrodes was proportional to the distance between the ROI and the surface of the abdomen. The results imply that inter-electrode distance can be applied in electrogastrography according to human body fat thickness.

• 대한의용생체공학회:의공학회지
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• 제18권2호
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• pp.179-186
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• 1997

Steady and physiological flows of a Newtonian fluid and blood in the abdominal gorta/iliac artery bifurcation are numerically simulated to understand the etiology and pathogenesis of atherosclerosis. Distributions of velocity, pressure, and wall shear stress in the bifurcated arterial vessel model are calculated to investigate the differences of flow characteristics between steady and physiological flows and to compare flow characteristics of blood with that of a Newtonian fluid For the given Reynolds number the flow characteristics of physiological flows for a Newtonian fluid and blood in the bifurcated arterial vessel are quite different from thcse of steady flows. No flow separation or flow reversal in the bifurcated region appears downstream of a stenosis during the acceleration phase. However, during the deceleration phase the flow exhibits flow separation in the outer walls of daugtlter branches, which extends to the entire wall region.

• 한국수산과학회지
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• 제35권4호
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• pp.386-394
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• 2002

패류 양식 해역의 서식 환경과 양식 생물간의 상호 관계를 파악하고 지속적인 생산 방안을 위하여 굴 성장과 관련된 생리 대사 과정인 섭이, 소화, 배설, 호홉 등의 제 인자를 수식화하여 기존에 개발된 생태계모델 (EUTRP2)에 연계하여 환경용량 산정 모델을 구축하였다. 구축된 모델이 굴 성장과 서식환경과의 상호관계를 재현함에 있어 타당성 여부를 검정한 결과, 굴 성장에 따른 서식환경 중 식물플랑크톤 현존량이 감소하고 영양염 농도가 증가하는것으로 보아, 패류양식해역의 생태계 환경관리를 위한 도구로 사용할 수 있는 것으로 나타났다. 그리고, 생태계 구성 요소에 영향을 미치는 생물 인자에 대한 민감도 분석 결과, 구성 요소들은 식물플랑크톤의 증식 속도와 높은 민감도를 보였고, 굴 성장의 경우 동물플랑크톤 최대 섭이 속도와는 민감도가 낮은 반면, 식물플랑크톤 증식 속도, 사멸 속도와 굴의 먹이 흡수 효율에 매우 민감하였다.

• 한국농공학회논문집
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• 제59권4호
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• pp.1-15
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• 2017

Eutrophication of surface waters is of concern worldwide, because it can result in many undesirable water-quality and ecological problems, such as hypoxic 'dead' zones and harmful algal blooms, both associated with considerable economic costs. In this study, we used LSM (Land Surface Model) to simulate nitrogen in five major rivers in the Southern Korean Peninsula. The main objective of this research was to enhance nitrogen data for input of LM3V model in South Korea. Input data for nitrogen fluxes were categorized into three sections including agriculture fertilizer, livestock manure, atmosphere deposition, biological fixation, and sewage pollutants were used as the nitrogen input. For using LM3V model, the nitrogen input data were regenerated by considering states of agriculture and industry in South Korea at a $1/8^{\circ}$ resolution. Then, we simulated stream/river flows and N loads throughout the entire drainage networks in South Korea at a $1/8^{\circ}$ resolution. By using the same parameters for the entire country ($100,210km^2$), composed of 5 river basins with varying climate and land use, the model simulates spatial (11 sites) and temporal (1999~2010) patterns of flows and nitrate-N loads are resonable by comparing observed flow and nitrate-N loads. The r (Pearson's linear correlation) for water temperature, flow and nitrate-N at river were 080~0.93, 0.62~0.92 and 0.5~0.9 respectively. Based on enhanced N input data and model results, we find that LM3V model as land surface model can be applied in South Korea with interaction of atmosphere and land conditions.

• 대한의용생체공학회:의공학회지
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• 제22권5호
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• pp.393-402
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• 2001

전체 심혈관계의 혈류역학적 특성을 분석할 수 있는 수치해석 방법을 개발하였다. 이는 12개의 요소들로 구성된 lumped parameter모델에 기초하고 있으며 인체의 신경계에 의한 자율조절기능을 모사하기 위해 주로 혈압의 단기적 조절을 위한.baroreflex system뿐 아니라 cardiopulmonary reflex 메커니즘가지도 구현하여 모델에 포함시켰다. 또한 교감 및 부교감 신경에 의한 자극-반응 전달을 구현함에 있어 생리학적 데이터에 기초한 방법을 사용하였다. 본 연구의 수치해석 코드를 검증하기 위하여 우선 보통 상태의 심혈관계에 대하여 혈류역학적 계산 결과를 기존의 참고문헌들에서의 값들과 비교 검토하였다. 심혈관계 모델의 혈류역학적 자극에 대한 반응 결과를 조사하기 위하여. 20% 출혈이 발생하는 경우와 LBNP(Lower Body Negative Pressure) 모사를 수행하였다. 두 경우 모두. 비교적 실험치와 잘 일cl하고 있음을 확인할 수 있었다. 특히 LBNP 수행 시, 외부압력의 크기가 커질수록 baroreflex만을 포함하고 있는 방법은 baroreflex와 cardiopulmonary reflex 모두를 포함하고 있는 방법에 비하여 다소 부정확한 결과를 보여주고 있는데. 이는 cardiopulmonary reflex 메커니즘의 중요성을 보여주고 있다.

• 한국농공학회논문집
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• 제60권5호
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• pp.29-40
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• 2018

Even if a small amount of arsenic (As) is entering to small agricultural reservoir from upper streams, small agricultural reservoir becomes sensitive to changes in arsenic concentration depending on the water level in case of accumulation continuously because of its scale. If we want to manage arsenic concentration in small agricultural reservoir, it is very important to understand arsenic changes in agricultural reservoir. In spite of the fact that modeling is the most accurate method for analyzing arsenic concentration changes in small agricultural reservoirs, but, it is difficult to monitor arsenic change everyday. So, if data is prepared for modeling arsenic changes, water quality modeling is more effective than monitoring. Therefore, in this study, arsenic concentration changes was simulated and arsenic concentration change mechanism in small reservoir was analyzed using hydrological and water quality monitoring data and by conducting EFDC (Environment Fluid Dynamics Code)-WASP (Water Quality Analysis Simulation Program) linkage. EFDC-WASP coupling technique was very useful for modeling arsenic changes because EFDC can consider hydrodynamic and WASP can perform arsenic concentration simulation, separately. As a results of this study, during dry season, As concentration was maintained relatively high arsenic concentrations. Therefore, water level control will be needed for managing As concentration of reservoir.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2000년도 춘계학술발표대회
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• pp.370-373
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• 2000

In this work, an extractive membrane bioreactor containing coulture broth of Burkholderia cepacia G4 PR1 constitutively expressing the TCE-degrading enzyme, tolune-ortho-monooxygenase(TOM), was used for the degradation of TCE. The membrane bioreactor operates by seperating the TCE-containing waste gas from the aerated biomedium, by which the air-stripping of TCE without degradation was overcome that could occur in conventional aerobic biological treatments of TCE-contaminated waste gases. This was achieved by a silicone rubber membrane which was coiled around a perspex draft tube. TCE from the gas phase diffuses across the silicone rubber membrane into microbial culture broth that was continuously fed from a separate aerobic CSTR. Therefore, TCE degradation occured without the TCE being directly exposed to the aerating gas stream. Of the TCE supplied to the membrane bioreactor, 72.6% was biodegraded during the operation of this system. To construct a mathematical model for this system, parameters describing microbial growth kinetics on TCE were determined using a CSTR bioreactor. Else parameters used for numerical simulation were determined from either indepedent experiments or values reported in the literature. The model was compared with the experimental data, and there was a good agreement between the predicted and the measured TCE concentrations in the system. To achieve a higher treatment efficiency, various operating conditions were simulated as well.

• Environmental Engineering Research
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• 제25권2호
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• pp.205-211
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• 2020

Chlorhexidine digluconate (CHD) in the aquatic environment causes irreversible change to microbes, making them resistant to biodegradation, which needs remediation other than biological process. Adsorption study was performed for the removal of CHD on fly ash (FA) as a function of pH and ionic strength. Experimental result has been validated by characterization using Scanning electron microscopy, Fourier Transform-Infrared Spectroscopy and Brunauer-Emmett-Teller. CHD adsorption with FA showed an increasing trend with an increase in pH. Variation in pH proved to be an influential parameter for the surface charge of adsorbent and the degree of ionization of the CHD molecules. The adsorption capacity of CHD decreased from 23.60 mg g-1 to 1.13 mg g-1, when ionic strength increased from to M. The adsorption isotherms were simulated well by the Freundlich isotherm model having R2 = 0.98. The Lagergren's model was incorporated to predict the system kinetics, while the mechanistic study was better explained by pseudo-second order for FA. On the basis of operational conditions and cost-effectiveness FA was found to be more economical as an adsorbent for the adsorption of CHD.