• Journal of Integrative Natural Science
• /
• v.9 no.2
• /
• pp.121-127
• /
• 2016

CXC chemokine receptor 2 (CXCR2) is a prominent chemokine receptor on neutrophils. The neutrophilic inflammation in the lung diseases is found to be largely regulated through CXCR2 receptor. Antagonist of CXCR2 may reduce the neutrophil chemotaxis and alter the inflammatory response. Hence, in the present study, ligand based Comparative molecular field analysis (CoMFA) was performed on a series of CXCR2 antagonist named pyrimidine-5-carbonitrile-6-alkyl derivatives. The optimum CoMFA model was obtained with statistically significant cross-validated coefficients ($q^2$) of 0.568 and conventional coefficients ($r^2$) of 0.975. The contour maps suggest the important structural modifications and this study can be used to guide the development of potent CXCR2 antagonist.

• Wind and Structures
• /
• v.9 no.6
• /
• pp.457-471
• /
• 2006

This paper is devoted to the non linear quasi-steady aerodynamic loading. A linear approximation is often used to compute the response of structures to buffeting forces. Some researchers have however shown that it is possible to account for the non linearity of this loading. This non linearity can come (i) from the squared velocity or (ii) from the shape of the aerodynamic coefficients (as functions of the wind angle of attack). In this paper, it is shown that this second origin can have significant implications on the design of the structure, particularly when the non linearity of the aerodynamic coefficient is important or when the transverse turbulence is important.

• The KSFM Journal of Fluid Machinery
• /
• v.1 no.1 s.1
• /
• pp.24-31
• /
• 1998

Aerodynamic performance tests and flow measurement were carried out for several radial impellers of NACA 65-810 airfoil. The data base obtained are to be used for verifying the methods of flow analysis and CFD codes. The effects of numbers and span of blades on the performances, efficiency and impeller exit flow are investigated in the present study. The flow rate on the performance curve is proportional to the span of the blade for the same value of fan pressure rise. The magnitude of radial velocity component at the impeller exit gradually decreases from the hub to shroud side. The magnitude of tangential velocity component gradually increases from the hub to shroud side. The way of variations of velocity is the same at the diffuser exit, however, becomes more uniform. The pressure rise performance increases with blade number at the small flow coefficients, however, decreases with the number of blade at the large flow coefficients. This shows that flow guidance in important at the low flow rate and the friction becomes significant at the high flow rate.

• Journal of KSNVE
• /
• v.7 no.6
• /
• pp.1015-1023
• /
• 1997

Rotordynamic analysis of a multistage turbine pump using finite element method is performed to investigate the effects of seal wear on its system behavior. Stiffness and damping coefficents of the 2-axial grooved bearing are obtained as functions of rotating speed. Stiffness and damping coefficients of plane annuler seals are calculated as functions of rotating speed as well as seal clearance of seals become larger, these stiffness and damping coefficients decrease drastically so that there can be significant changes in whirl natural frequencies and damping characteristics of the pump rotor system. Although a pump is designed to operate with a sufficient seperation margin from the 1st critical speed, seal wear due to long operation may cause a sudden increase in vibration amplitude by resonance shift and reduce seal damping capability.

• Journal of the Institute of Electronics and Information Engineers
• /
• v.50 no.7
• /
• pp.231-235
• /
• 2013

Lens distortions have a significant impact on captured or projected image geometry. This paper proposes a lens distortion correction with gradient components for wide-angle lenses. In most cases, distortion coefficients are estimated using a distortion model by point correspondences. Corrected images using only point correspondences can be compensated excessively, therefore, producing bended lines into the opposite direction near the corners. To curtail these phenomena, we propose to adopt the gradient components in addition to positions to obtain the distortion coefficients. We verified the improved accuracy and the straightness of the proposed method through experimentation.

• Proceedings of the IEEK Conference
• /
• 2002.07b
• /
• pp.1240-1243
• /
• 2002

In this paper, we propose an adaptive digital image watermarking algorithm using successive subband quantization (SSQ) and perceptual model based on wavelet domain. The watermark is embedded into the perceptually significant coefficients (PSCs) of image. The PSCs in the baseband are selected according to the amplitude of the coefficients and the high frequency subbands are selected by SSQ. To embed the watermark, we use perceptual model. The perceptual model is based on the computation of the noise visibility function (NVF) and embed at the texture and edge region stronger embedded watermarks.

• Journal of the Korean Home Economics Association
• /
• v.33 no.4
• /
• pp.49-64
• /
• 1995

The purpose of this study was to develop the Daily Hassles Scale for children in Korea. The subject were 444 children of 184 fourth graders and 260 sixth graders selected form five elementary schools in Seoul(217 male and 227 female). A questionnaire consisting of 90-item daily hassles scale, demographic questions, and some additional questions was used as a methodological instrument. statistics used for data analysis were X2, cramer's V, factor analysis, multi-regression, Pearson's r, Cronbach's α. The major findings of this study were as follows. 1) 87 items of the 90-item scale were acceptible through item discriminant method. The discriminant coefficients of the items(Cramer's V) ranged form .28 to .73. 2) 6 factors(parents, home environment, friends, studies, teachers & school, the surroundings) were extracted from factor analysis. Multi-regression analysis conducted to reduce the length of scale have drawed 42 items for 'the Daily Hassles Scale for Children in Korea'. The correlation between this scale and the Quality of Life Scale(Olson & Barnes, 1982) was conducted to test the criterion-related validity, and the coefficient was significant(r=-.52, p<.001).3) Finally, reliability coefficients(Cronbach'α) of this scale was. 85.

• International Journal of Air-Conditioning and Refrigeration
• /
• v.9 no.3
• /
• pp.1-9
• /
• 2001

In this study, condensation heat transfer coefficients (HTCs) of nonazeotropic refrigerant mixtures of HFC32/HFC 134a and HCFC123 at various compositions were measured on a horizontal smooth tube. All data were taken at the vapor temperature of 39$^{\circ}C$ with a wall subcooling of 3~8K. Test results showed that HTCs of tested mixtures were 11.0~85.0% lowed than the ideal values calculated by the mass fraction weighting of the HTCs of the pure components. Thermal resistance due to the diffusion vapor film was partly responsible for the significant reduction of HTCs with these nonazeotropic mixtures. The measured data were compared against thc predicted ones by Colburn and Drew's film model and a good agreement was observed within a deviation of 15%.

• MALSORI
• /
• no.45
• /
• pp.35-45
• /
• 2003

Laryngeal diseases cause significant changes in the quality of speech production. Automatic detection of laryngeal diseases by voice is attractive because of its nonintrusive nature. In this paper, we apply speech recognition techniques to detection of laryngeal cancer, and investigate which feature parameters and classification methods are appropriate for this purpose. Linear Predictive Cepstral Coefficients (LPCC) and Mel-Frequency Cepstral Coefficients (MFCC) are examined as feature parameters, and parameters reflecting the periodicity of speech and its perturbation are also considered. As for classifier, multilayer perceptron neural networks and Gaussian Mixture Models (GMM) are employed. According to our experiments, higher order LPCC with the periodic information parameters yields the best performance.

• The Journal of the Acoustical Society of Korea
• /
• v.15 no.3E
• /
• pp.37-44
• /
• 1996

A new method for efficient modeling of the Head-Related Transfer Functions(HRTF's) without loss of any directional information is proposed. In this paper, the HRTF's were empirically measured in a real room and modeled as the ARMA models with common AR coefficients and different MA coefficients. To assess the validity of the proposed ARMA model, psychophysical tests show that the proposed ARMA model, in comparison with the conventional MA model, requires a small number of parameters to represent empirical HRTF's and improves the back-to-front confusions in sound-field localization. Thus, significant simplifications in the implementations of sound-field synthesis systems could be obtained by using the proposed ARMA model.