• Proceedings of the Korean Nutrition Society Conference
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• 2002.11a
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• pp.73-82
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• 2002

The low molecular weight zinc-binding protein metallothionein (U) contains 32% cysteine and has been shown to efficiently scavenge hydroxyl radicals in vitro. MT expression is induced by oxidative stress and an antioxidant role for this protein has therefore been proposed. This review mainly focuses on the evidence for this role arising from studies using genetically modified animals and cells which either over- or under-express MT. Despite some considerable disparity of results in the literature, reported studies do generally support an antioxidant role. Nevertheless, oxidant stress at non-physiological treatment levels has been the preferred experimental model and there is little information about the role of MT in physiological oxidative stress. Although it is presumed that the mechanism by which MT has an antioxidant effect involves oxidation of cysteinal thiols, it is possible that zinc release from MT is in itself an important signalling factor.

• The Transactions of the Korea Information Processing Society
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• v.6 no.7
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• pp.1909-1918
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• 1999

The terrestrial/satellite hybrid network may replace or supply the terrestrial network in some areas or certain applications. For example, it may play a major role in global B-ISDN or in certain areas where the deployment of optical cable is not feasible, especially at the early stage of implementing terrestrial B-ISDN. Furthermore, it can play an important role in the development of B-ISDN due to their features of flexible wide coverage, independent of ground distances and geographical constraints, multiple access and multipoint broadcast. Also, satellite have the capability to supply terrestrial B-ISDN/ATM with flexible links for access networks as well as trunk networks. This paper describes the design and verification of the interworking protocol between terrestrial B-ISDN뭉 satellite network. For the verification, the designed interworking protocol is modeled by Petri-net and the model is analyzed by reachability tree.

• Journal of Integrative Natural Science
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• v.11 no.2
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• pp.93-100
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• 2018

Caspases, a family of cysteinyl aspartate-specific proteases plays a central role in the regulation and the execution of apoptotic cell death. Caspase-3 has been proven to be an effective target for reducing the amount of cellular and tissue damage because the activation of caspases-3 stimulates a signalling pathway that ultimately leads to the death of the cell. In this study, Hologram based Quantitative Structure Activity Relationship (HQSAR) models was generated on a series of Caspase-3 inhibitors named 3, 4-dihydropyrimidoindolones derivatives. The best HQSAR model was obtained using atoms, bonds, and hydrogen atoms (A/B/H) as fragment distinction parameter using hologram length 61 and 3 components with fragment size of minimum 5 and maximum 8. Significant cross-validated correlation coefficient ($q^2=0.684$) and non cross-validated correlation coefficients ($r^2=0.754$) were obtained. The model was then used to evaluate the eight external test compounds and its $r^2_{pred}$ was found to be 0.559. Contribution map show that presence of pyrrolidine sulfonamide ring and its bulkier substituent's makes big contributions for improving the biological activities of the compounds.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.5
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• pp.892-900
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• 1994

Recently, ITU-TSS recommends a service specific connection oriented protocol (SSCOP) which assures the successful transmission of signalling information for B-ISDN. In the SSCOP, there is a mechanism to exchange periodically status informations for both error and flow controls. In this paper, we analyze the SSCOP with a discrete-time queueing model. We consider two cases for link-by-link and end-to-end controls. As the performance measures, we investigate delay, throughput, and buffer size of the receiver. The average values of these measures are analyzed with respect to the loss probability of messages, the traffic load, and the exchange period of status information. We also verify the accuracy of this model with simulations.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.11
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• pp.2168-2174
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• 2009

Electrical railway system consists of rolling stock, track, signal and streetcar line system. Track circuit system is a vital system due to checking the location of trains. Track circuits are divided by using frequency and isolated electrically. Currently, there is not a regulation for the distance between track circuits using identical frequency. In case of installing additional track circuits in large stations or marshalling yard, the problem which is that the signal is not exactly transmitted to the track circuit occurs due to the mutual interference. In other words, the track circuit properly is not operated on account of wrong induction current by the mutual inductance between track circuits. In this paper, we suggest the electrical model between track circuits and numerically calculate demanded parameters in electrical model. The distance between track circuits satisfying the mutual inductance which does not happen to the mutual interference phenomenon is presented about the distance of track circuit. It is proved by using Matlab and PSpice program as the amplitude of mutual induced current.

• 시스템엔지니어링워크숍
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• s.4
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• pp.70-80
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• 2004

Most rail system related simulations currently used are designed to simulate only one discipline system. This obviously assunes the other discipline system are running regularly not being affected by the system being simulated. In this paper a multi discipline simulator is proposed and its design concept is presented.A multi discipline simulator is the simultor in which major subsystems with different technical discipline are simulated simultaneously. The advantage of the simulator is in that it makes it possible to analyze the systems behavior while other discipline system vary. With this we can identify the possible to analyze the systems ehavior find their solutions. A proto type simulator has bee developed using object oriented programming. Object concept was judged best suitable to model the various multi-discipline self-controlling railway subsystems. It was applied to the target system, which is under development by the Korea Railroad Research institute. The test results show it is very useful in design verification. It could also be a good tool in research and development work to make to improe the system.

• Journal of the Korean Society for Railway
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• v.6 no.4
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• pp.221-231
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• 2003

Most rail system related simulators currently used are designed to simulate only one discipline system. This obviously assumes the other discipline systems are running regularly not being affected by the system being simulated. In this paper a multi discipline simulator is proposed and its design concept is presented. A multi discipline simulator is the simulator in which major subsystems with different technical discipline are simulated simultaneously. The advantage of the simulator is in that it makes it possible to analyze the systems behavior while other discipline system vary. With this we can identify the possible multi-discipline problems and even find their solutions. A proto type simulator has been developed using object oriented programming. Object concept was judged best suitable to model the various multi-discipline self-controlling railway subsystems. It was applied to the target system, which is under development by the Korea Railroad Research Institute. The test results shows it is very useful in designn verification. It could also be a good tool in research and development work to improve the system.

• Proceedings of the KIEE Conference
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• 1998.07c
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• pp.908-910
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• 1998

Modern AC electric car has PWM(Pulse Width Modulation) -controlled converters, which give rise to higher harmonics. The current harmonics injected from AC electric car is propagated through power feeding circuit. As the feeding circuit is a distributed constant circuit composed of RLC, the capacitance of the feeding circuit and the inductance on the side of power system cause a parallel resonance and a magnification of current harmonics at a specific frequency. The magnified current harmonics usually brings about various problems. That is, the current harmonics makes interference in the adjacent lines of communications and the railway signalling system. Furthermore, in case it flows on the side of power system, not only overheating and vibration at the power capacitors but also wrong operation at the protective devices can occur. Therefore, the exact assessment of the harmonic current flow must be undertaken at design and planning stage for the electric traction systems. From these point of view, this study presents an approach to model and to analyse traction power feeding system focused on the amplification of harmonic current. The proposed algorithm is applied to a standard AT(Auto-transformer)-fed test system in which electric car with PWM-controlled converters is running.

• Proceedings of the KSR Conference
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• 1999.11a
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• pp.318-325
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• 1999

Modern AC electric car has PWM(Pulse Width Modulation)-controlled converters, which give rise to higher harmonics. The current harmonics injected from AC electric car is propagated through power feeding circuit, As the feeding circuit is a distributed constant circuit composed of RLC, the capacitance of the feeding circuit and the inductance on the side of power system cause a parallel resonance and a magnification of current harmonics at a specific frequency. The magnified current harmonics usually brings about various problems. That is, the current harmonics makes interference in the adjacent lines of communications and the railway signalling system. Furthermore, in case it flows on the side of power system, not only overheating and vibration at the power capacitors but also wrong operation at the protective devices can occur. Therefore, the exact assessment of the harmonic current flow must be undertaken at design and planning stage for the electric traction systems. From these point of view, this study presents an approach to model and to analyse traction power feeding system focused on the amplification of harmonic current The proposed algorithm is applied to a standard AT(Auto-transformer)-fed test system in which electric car with PWM-controlled converters is running.

• Journal of Korean Neurosurgical Society
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• v.64 no.3
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• pp.329-339
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• 2021

It has been recognised for over a century that the events of gastrulation are fundamental in determining, not only the development of the neuraxis but the organisation of the entire primitive embryo. Until recently our understanding of gastrulation was based on detailed histological analysis in animal models and relatively rare human tissue preparations from aborted fetuses. Such studies resulted in a model of gastrulation that neurosurgeons have subsequently used as a means of trying to explain some of the congenital anomalies of caudal spinal cord and vertebral development that present in paediatric neurosurgical practice. Recent advances in developmental biology, in particular cellular biology and molecular genetics have offered new insights into very early development. Understanding the processes that underlie cellular interactions, gene expression and activation/inhibition of signalling pathways has changed the way embryologists view gastrulation and this has led to a shift in emphasis from the 'descriptive and morphological' to the 'mechanistic and functional'. Unfortunately, thus far it has proved difficult to translate this improved knowledge of normal development, typically derived from non-human models, into an understanding of the mechanisms underlying human malformations such as the spinal dysraphisms and anomalies of caudal development. A paediatric neurosurgeons perspective of current concepts in gastrulation is presented along with a critical review of the current hypotheses of human malformations that have been attributed to disorders of this stage of embryogenesis.