• Proceedings of the KSR Conference
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• 2009.05a
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• pp.2056-2062
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• 2009

Recent advances in computer technology have brought more dependence on software to train control systems. Hence, the safety assurance of the vital software running on the railway system is very critical task and yet, not many works have been done. While much efforts have been reported to improve electronic hardware's safety, not so much systematic approaches to evaluate software's safety, especially for the vital software running on board train controllers. In this paper, we have developed the static software testing tool for railway signaling, especially Fagan Inspection supporting tool. This static testing tool for railway signaling can be utilized at the assessment phase, and also usefully at the software development stage also. It is anticipated that it will be greatly helpful for the evaluation on the software for railway signalling system.

• Journal of the Korean Society of Systems Engineering
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• v.10 no.2
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• pp.43-50
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• 2014

The Centralized Traffic Control(CTC) System of Urban Railway is an element(subsystem) of the Urban Railway system to aim safety operation and efficient management of rolling stock in accordance with a train scheduling program in train operation ways. That's why the CTC System must be developed considering systematic and safety-guaranteed methods such as RAMS(Reliability, Availability, Maintainability, and Safety) refereed to IEC standards. The CTC System is consists of rolling stock, signaling, power supply, communication, and mechanical equipment and preforms control and remote monitoring functions. The technical activities considering safety process are very important at such an early stage of development in a railway project. This paper introduces RAMS activities and an independent safety assessment by $3^{rd}$ Party focused on a safety applied to a development of the CTC system of Urban Railway and proposes the experiences as well practices.

• BMB Reports
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• v.45 no.8
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• pp.427-432
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• 2012

Primary cilia, single hair-like appendage on the surface of the most mammalian cells, were once considered to be vestigial cellular organelles for a past century because of their tiny structure and unknown function. Although they lack ancestral motility function of cilia or flagella, they share common ground with multiciliated motile cilia and flagella on internal structure such as microtubule based nine outer doublets nucleated from the base of mother centrioles called basal body. Making cilia, ciliogenesis, in cells depends on the cell cycle stage due to reuse of centrioles for cell division forming mitotic spindle pole (M phase) and assembling cilia from basal body (starting G1 phase and maintaining most of interphase). Ciliary assembly required two conflicting processes such as assembly and disassembly and balance between these two processes determines the length of cilia. Both process required highly conserved transport system to supply needed substance to grow tip of cilia and bring ciliary turnover product back to the base of cilia using motor protein, kinesin and dynein, and transport protein complex, IFT particles. Disruption of ciliary structure or function causes multiple human disorder called ciliopathies affecting disease of diverse ciliated tissues ranging from eye, kidney, respiratory tract and brain. Recent explosion of research on the primary cilia and their involvement on animal development and disease attracts scientific interest on how extensively the function of cilia related to specific cell physiology and signaling pathway. In this review, I introduce general features of primary cilia and recent progress in understanding of the ciliary length control and signaling pathways transduced through primary cilia in vertebrates.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.3 no.1
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• pp.175-183
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• 1999

This paper describes the network configuration, No. 7 signaling IS-41.A protocol and basic operations for the RFC(Remote Feature Control) service which is one of the supplementary services provided in the mobile telephone network. In order to solve the protocol error occurred while providing the RFC service for analog system, this paper suggests three schemes and analyse detail signal algorithm for the proposed schemes. Through the simulations, it is verified the best choice of the proposed schemes without the signaling procedure error.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.23 no.5
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• pp.1397-1408
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• 1998

Service networks for the future communication networks will be combined by the B-ISDN networks. These service networks also will use SS No.7 as the signaling transport network for the control of user requriement service. Therefore, ITU-T recommended B-ISDN signaling layers for SS No.7 as a substitute for N-ISDN MTP signaling layer. In this paper, we propose the implementation structure and describe the characteristics and functions of each signaling layer of SS No.7, which are adapted to ATM switching system, and evaluate a performance. The structure of SSCOP transmission buffer using a linked list and an unit frame length is proposed for SAAL layer and the implementation structure and internal routing method according to the ATM switching system are also proposed for MTP-3b layer. Additionally, we propose the ISUP/B-ISUP level interworking structure using only associated mode, which are presented in the first stage of B-ISDN as the effective internatworking structure of SS No.7 for the circuit related signaling network between the existing N-ISDN networks and B-ISDN networks.

• Proceedings of the IEEK Conference
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• 2003.07a
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• pp.569-572
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• 2003

The broadband wireless access industry, which provides high-tate network connections to stationary sites, has matured to the point at which it now has a standard for second-generation wireless metropolitan area networks. IEEE Standard 802.16, with its WirelessMAN air interface, set the stage for widespread and effective deployments worldwide. This paper presents an implementation of media access control that can be applied to BWA (Broadband Wireless Access) system. Medium access control (MAC) is a key issue in multi-access networks where a common channel is shared by many users. The designed MAC prototype roughly consists of MAC Hardware and MAC Software. The MAC Hardware part includes timing process, MAC transmission control, MAC reception control, and CRC/HCS process. The MAC Software part includes control of MAC signaling, network interface, and Physical (PHY) control. The designed MAC protocol will be integrated with the PHY of BWA in future and we can test overall system performance of MAC and PHY.

• Journal of Life Science
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• v.30 no.4
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• pp.402-409
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• 2020

Nervous necrosis virus (NNV) contains a bi-segmented viral genome, RNA1 (3.4 kb, RdRp), and RNA2 (1.4 kb, capsid protein) in a small particle (25 nm). Despite its extremely compact size, NNV has caused serious damage by infecting approximately 120 fish species worldwide since it was first reported in the late 1980s. In order to minimize the damage caused by NNV infection and develop effective vaccines, it is necessary to understand the intra cellular signaling system according to NNV infection. NNV infection induces cell cycle arrest at the G1 phase via the p53-dependent pathway to use the cellular system for its replication. Otherwise, host cells recognize NNV infection through the RIG-1-like receptor (RLR) signaling pathway to control the virus and infected cells, and then ISGs required for antiviral action are activated via the IFN signaling pathway. Moreover, apoptosis of infected cells is triggered by the unfolded protein response (UPR) through ER stress and mitochondria-mediated cell death. Cell signaling studies on the NNV infection mechanisms are still at an early stage and many pathways have yet to be identified. Understanding the various disease-specific cellular signaling systems associated with NNV infection is essential for rapid and accurate diagnosis and vaccine development.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7069-7074
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• 2013

Programmed cell death is a basic cellular process that is critical to maintaining tissue homeostasis. In contrast to apoptosis, necrosis was previously regarded as an unregulated and uncontrollable process. However, as research has progressed, necrosis, also known as necroptosis or programmed necrosis, is drawing increasing attention, not least becasu of its possible impications for cancer research. Necroptosis exhibits a unique signaling pathway that requires the involvement of receptor interaction protein kinases 1 and 3 (RIP1 and RIP3), mixed lineage kinase domain-like (MLKL), and phosphoglycerate mutase 5 (PGAM5) and can be specifically inhibited by necrostatins. Not only does necroptosis serve as a backup cell death program when apoptosis is inhibited, but it is now recognized to play a pivotal role in regulating various physiological processes and the pathogenesis of a variety of human diseases such as ischemic brain injury, immune system disorders and cancer. The control of necroptosis by various defined trigger factors and signaling pathways now offers the opportunity to target this cellular process for therapeutic purposes. The purpose of this paper is to review current findings concerning the connections between various trigger factors and the RIP1/RIP3 signaling pathway as it relates to necroptosis.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.53 no.11
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• pp.641-646
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• 2004

Computer system is widely used for controlling systems such as nuclear power plant, train speed control and air plane control. The failure of computerized controlling system can be arrived to catastrophic accident, so the safety ensuring of computerized controlling system is very important. This paper shows how to improve and ensure the safety of computerized systems. In this paper, we show how to identify, analyze hazards of the computerized system and to demonstrate risk of the system. Finally, we show how to adopt safety techniques for improving safety of the target system.

• Proceedings of the KSR Conference
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• 2011.05a
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• pp.377-383
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• 2011

The paper is to perceive accurately speed of the train through redundant processor operation. When Slip/slide is occurred at the axle, the train is applied brake force using the Tachometer and the Doppler sensor which assistance equipment. One of the main features of railway signaling system is that rolling stock is made stop to avoid collision with the rolling stock ahead when the rolling stock exceeds its maximum operating speed in line. In addition, in the case of the rolling stock with automatic train operation, it carries out activities such as braking and propulsion using the difference between its actual speed and target speed at the point. To perform these functions, it is essential to calculate the exact speed of the rolling stock in signaling equipment on vehicles. Train speed detection unit are composed of the Tachometer and the Doppler sensor, and speed information is sent to the SDU unit. The processor of SDU unit calculates the speed of the train using compare logic the received speed information. Even if there are Slip/Slide, signaling system is available to apply exact braking, to improve stop on position and to guarantee the safety of trains.