• Journal of Mechanical Science and Technology
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• 제20권2호
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• pp.197-204
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• 2006

The purpose of this study is to evaluate the AE characteristics for the basemetal, PWHT (post-weld heat treatment) and weldment specimens of SA-516 steel during fracture testing. Four-point bending and AE tests were conducted simultaneously. AE signals were emitted in the process of plastic deformation. AE signal strength and amplitude of the weldment was the strongest, followed by PWHT specimen and basemetal. More AE signals were emitted from the weldment samples because of the oxides, and discontinuous mechanical properties. AE signal strength and amplitude for the basemetal or PWHT specimen decreased remarkably compared to the weldment because of lower strength. Pre-cracked specimens emitted even lower event counts than the corresponding blunt notched specimens. Dimple fracture from void coalescence mechanism is associated with low-level AE signal strength for the basemetal or PWHT. Tearing mode and dimple formation were shown on the fracture surfaces of the weldment, but only a small fraction produced detectable AE.

• 전기의세계
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• 제18권6호
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• pp.33-45
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• 1969

The purpose of this paper is design the most important part of sequential control systems, that is, command-treatment part, from the signal-transformation point of view. An orderly procedure is developed by which for sequential control systems the experimental design method can be reduced to the rational design method. Important in this procedure are: 1. To make total block diagram of sequential control systems by determining input and output signals of command-treatment part. 2. To partition over-all block diagram by observing each output signal. 3. To design concretely minimum block diagram by using the operational block diagram. By applying the method for partitioning the circuit to the design, the design method for sequential control systems is organized and done rationally without the aid of experiece.

• Journal of Korean Neurosurgical Society
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• 제44권4호
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• pp.262-264
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• 2008

Discal cysts are rare lesions that can cause radiating leg pain. Because they are very rare, their natural history and the details of the therapeutic guidelines for the treatment of these cysts are still unknown. A 30-year-old male patient presented to our institute with radiating pain in his left leg and mild back pain. Magnetic resonance imaging (MRI) revealed an intraspinal extradural cystic mass with low signal intensity on T1-weighted images and high signal intensity on T2-weighted images at the L5-S1 level. The partial hemilaminectomy and cyst resection were performed. We report a patient with low back pain and radiating leg pain caused by a lumbar discal cyst and discuss the treatment of this cyst.

• 정보학연구
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• 제9권1호
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• pp.9-19
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• 2006

Medications or conitive-behavior methods have been mainly used as a treatment of alcoholism. lately the virtualy technology has been applied to the kink of alcoholic disorders. A virtual environment makes him having avility to over come the drink. In this study, we were implemented by making panorama images and 3D object modules using 3D MAX, VRML, JAVA. And the BAR stimulator that composed with a position sensor, head mount display, and audio system, is suggested. To illustrate the physiological difference between a person who has a alcoholism and without a liquor bottle, heart rate was measured during experiment, and also measured a person's HR after the virtual reality training. The system measures the Physiological signals such as ECG, Temperature, analyzes those data automatically. The system has two parts, one is physiological data acquisition part which gets the body signal, and the other one is mobile nuit which includes signal processing and transmission functions, And Bluetooth allows two parts to communicate with each other. we demonstrated the subjective effectiveness of virtual reality psychotherapy through the clinical experiment.

• Journal of Ginseng Research
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• 제20권2호
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• pp.159-167
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• 1996

To study the effects of ginseng saponin components on the signal transduction in the ac tivation of murine macrophages, phagocytosis and Intracellular calcium concentration of peritoneal exuded mouse macrophages were examined. The phagocytosis was increased significantly after treatment with total saponin, diol-saponin, $Rg_1$ and $Rg_2$, but triol-saponin was unable to increase phagocytosis. The phagocytosis were increased when H7, a PKC inhibitor, was pretreated and increased significantly by saponin fractions except total saponin. Pertussis toxin, which inactivates G-protein, decreased the phagocytosis. But the phagocytosis was restored to the control level by saponin fractions and the phagocytosis was increased significantly by $Rg_2$ and $Rg_2$. The triol saponin increased phagocytosis approximately by 2-fold as compared with the TMB-8 treated group. Peritoneal exuded macrophages displayed a prominent rise in cytosolic calcium following treatment with triol-saponin, $Rg_1$, $Rg_2$ and $Rg_2$. Incubation of macrophages with PT resulted in an inhibition of cytosolic calcium mobilization, but increased cytosolic calcium mobilization with saponin fraction.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.156.1-156.1
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• 2003

Cerarmide acts as a lipid second messenger in the cellular signal transduction and is involved in mediating a variety of cell functions such as proliferation, differentiation, growth arrest, and apoptosis. In the present study, we have investigated the effect of ceramide on cellular cytotoxity and reactive oxygen species (ROS) to understand the relationship between them. Ceramide treatment significantly increased cell death in RAW 264.7 murine macrophages activated with lipopolysaccharide (LPS) and interferon-g (IFN-g). (omitted)

• Journal of Ginseng Research
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• 제29권2호
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• pp.94-99
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• 2005

In the previous study, we reported that the in viかo inhibitory effect of ginsenosides, active ingredient of Panax ginseng, on $5-HT_{3A}$ receptor channel activity is coupled to in vivo anti-vomiting and anti-nausea effect. In the present study, we further investigated that the inhibitory effect of ginsenosides, active ingredient of Panax ginseng, on 5-HT3A receptor channel activity is also coupled to attenuation of irritable bowel syndrome (IBS), which is induced by colorectal distention (CRD) and $0.6\%$ acetic acid treatment. The CRD-induced visceral pains induced by CRD and acetic acid treatment are measured by frequency of contractions of the external oblique muscle in conscious rats. Treatment of GTS significantly inhibited CRD-induced visceral pain with dose-dependent manner. The $EC_{50}$ was $5.5{\pm}4.7$ mg/kg ($95\%$ confidence intervals: 1.2-15.7) and the antinociceptive effect of GTS on visceral pain was persistent for 4 h. We also compared the effects of protopanaxadiol (PD) ginsenosides and protopanaxatriol (PT) ginsenosides with saline on acetic acid-and CRD-induced visceral pain, and found that protopanaxatriol (PT) ginsenosides was much more potent than PD ginsenosides in attenuating CRD-induced visceral pain. These results indicate that U ginsenosides of Panax ginseng are components far attenuation of experimentally CRD-induced visceral pains.

• 미생물학회지
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• 제31권3호
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• pp.203-207
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• 1993

Five different secretion vectors were constructed by varying the signal sequences and .alpha.-antitrypsin (.alpha.1-AT) a numan secretory protein, was produced from yeast cells. The signal sequences used are those of acid phosphatase (PH05) and .alpha.-factor (M f.alphal1) of Saccharomyces cerevisiae, glucoamylase (STA1) of Saccharomyces diastaticus, and human .alpha.1-AT. Four vectors directed the efficient secretion of .alpha.1-AT ito the culture media. The secretion vector carrying the glucoamylase signal sequence (pGAT11) showed the highest efficiency of secretion. About 70% of .alpha.1-AT produce dwere secreted into the media. The endo H treatment of partially purified .alpha.1-AT indicates that the secreted .alpha.1-AT appeared to be glycosylated. This glycosylation pattern was altered when amino acid substitution mutations were introduced at the three glycosylation sites of .alpha.-AT.

• BMB Reports
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• 제32권1호
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• pp.28-32
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• 1999

Annexin I (also called lipocortin 1), a 37-kDa member of the annexin family of proteins, has been implicated in the mitogenic signal transduction by epidermal growth factor (EGF). Annexin I is phosphorylated by the EGF signal, however, the role of annexin I in the EGF signal transduction is still unknown. To transduce extracellular signals into the intracellular targets, selective translocation of the signaling molecules to their targets would be necessary. In this study, we examined the subcellular locations of annexin I during EGF signal transduction. Treatment of A549 cells with EGF resulted in the translocation of cytoplasmic annexin I to the nucleus and perinuclear region as determined by Western blot and immunofluorescent staining. The nuclear translocation of annexin I was inhibited by tyrphostin AG 1478 and genistein, the inhibitors of EGF receptor kinase and downstream tyrosine kineses, respectively. Pretreatment of cells with cyclohexamide did not inhibit the nuclear translocation. The results suggest that nuclear translocation of annexin I is controlled by a series of kinase dependent events in the EGF receptor signaling pathway and may be important in tranducing the signals by EGF.

• 한국의류학회지
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• 제43권2호
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• pp.297-309
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• 2019

This study investigated EEG signal, subjective fragrance sensation, and the preference of differently colored cotton knit treated with Citrus unshiu oil containing microcapsules as well as examined their relationships for providing regression models on subjective fragrance preference. Color variables combining 2-level hue (Yellow and Green) and 3-level tone (strong, pale, and grayish) were applied by dyeing prior to microcapsule treatment. We invited 28 female college students aged 20's for EEG signal experiments and subjective fragrance sensations with fragrant knit by rubbing. EEG signals at $mid-{\alpha}$, $fast-{\alpha}$, and $low-{\beta}$ showed significant differences depending on color; Green had more relative power values and grayish tone did more at $low-{\beta}$. Even though subjective sensation showed no significant differences depending on color, some of them such as Fresh, Comfort, and Natural showed significant correlations with EEG signal at $low-{\beta}$, which means that the fragrance sensations of Citrus unshiu fragrance are concerned with attention and alertness for Koreans. Fragrance preference was regressed significantly using some EEG signals and subjective sensation. The results could be utilized to value up fragrant textiles by Citrus unshiu oil.