• Molecular & Cellular Toxicology
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• v.5 no.4
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• pp.346-353
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• 2009

Drug metabolism is a critical determinant of the therapeutic and adverse effects of many psychotropic drugs. The metabolism depends on the pharmacokinetics of a drug, which includes its absorption, distribution, and elimination. Psychotropic drugs are metabolized mainly by cytochrome P450 (CYP) enzymes; about 20 of these enzymes exist and they are often responsible for the rate-limiting step of drug metabolism. CYP2D6 is the best-characterized P450 enzyme that exhibits polymorphism in humans. This study determined the relationship between the CYP2D6*10 (P34S) polymorphism and the response to mirtazapine in 153 Koreans with major depressive disorder (MDD). The genotype frequencies were compared using logistic regression analysis, and between-genotype differences in the decrease in the 21-item Hamilton Depression (HAMD21) score over the 12-week treatment period were analyzed using a linear regression analysis. The proportion of remitters was lower in patients with MDD possessing the S allele than in P allele carriers after 2 weeks of mirtazapine treatment. Similarly, the reductions in the HAMD21 and Clinical Global Impression (CGI) scores in S allele carriers were smaller than those in patients with the P allele after 2 weeks of mirtazapine treatment. In the analysis of depression symptoms, the sleep and delusion scores had smaller reductions in S allele carriers. Based on the Liverpool University Neuroleptic Side Effect Rating Scale (LUNSERS), the psychic adverse effects of mirtazapine were associated with CYP2D6 P34S, while weight gain was not. These results suggest that CYP2D6 P34S affects the outcome of mirtazapine treatment in patients with MDD, and that this polymorphism may be a good genetic marker for predicting the clinical outcome of mirtazapine treatment.

• The Korean Journal of Cytopathology
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• v.6 no.1
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• pp.41-47
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• 1995

Two hundred and twenty one consecutive patients with enlarged lymph nodes of the neck were diagnosed as metastatic carcinoma by fine needle aspiration. The metastatic carcinomas were most frequent in the supraclavicular lymph nodes (p<0.05). As a primary site, lung, stomach, upper respiratory tract and breast were commonly involved in descending order of frequency. Overall, squamous cell carcinoma was the most common in males (43%) while adenocarcinoma was the most common in females (72%) (p<0.05). While carcinomas of the esophago-gastro-intestinal tract showed a tendency to metastasize to the left supraclavicular lymph nodes, metastatic carcinomas of the lung and breast usually metastasized to the same side as that of the primary cancer with a predilection for the supraclavicular lymph nodes. The submandibular lymph nodes were frequently involved by carcinoma of the upper and lower respiratory tract, in which squamous cell carcinoma was the most prevalent cytologic type. Diagnosis by fine needle aspiration cytology is the first step in the workup of patients with nodal enlargement suspicious for malignancy, particularly in metastatic carcinoma.

• Journal of the Korean Society of Clothing and Textiles
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• v.40 no.2
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• pp.240-257
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• 2016

This study determines the effect of 3D compression pants and Kinesio taping on muscular function of the leg during knee joint flexion and extension. Eight males participated in the experiment, wearing basic pants (BP), Kinesio taping on bare skin (KT), 3D compression pants with (KTP) and without Kinesio taping (CP). The test protocol for isokinetic muscular function was composed of four sets at three angular velocities (60, 180, $240^{\circ}/sec$) using Cybex 660. Peak torque and work per repetition of the lower limbs of eight males were analyzed from the result of Cybex. Agility and power of the subjects were examined from side step and sergeant jump. Peak torque, average power, work per repetition, force decay time of subjects wearing CP and KTP were significantly better than BP or KT, especially at low angular velocity of $60^{\circ}/sec$. The time to generate peak torque of subjects wearing BP was the longest, while the force-decay time of BP was the shortest. The application of Kinesio tape on skin did not increase muscle peak torque, work and power, but did shorten the time to generate peak torque.

• Journal of Korean Society of Water and Wastewater
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• v.32 no.4
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• pp.357-361
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• 2018

Forward osmosis (FO) process has been attracting attention for its potential applications such as industrial wastewater treatment, wastewater reclamation and seawater desalination. Particularly, in terms of fouling reversibility and operating energy consumption, the FO process is assumed to be preferable to the reverse osmosis (RO) process. Despite these advantages, there is a difficulty in the empirical step due to the lack of separation and recovery techniques of the draw solution. Therefore, rather than using FO alone, recent developments of the FO process have adapted a hybrid system without draw solution separation/recovery systems, such as the FO-RO osmotic dilution system. In this study, we investigated the performance of the hollow fiber FO module according to various operating conditions. The change of permeate flow rate according to the flow rates of the draw and feed solutions in the process operation is a factor that increases the permeate flow rate, one of the performance factors in the positive osmosis process. Our results reveal that flow rates of draw and feed solutions affect the membrane performance, such as the water flux and the reverse solute flux. Moreover, use of hydraulic pressure on the feed side was shown to yield slightly higher flux than the case without applied pressure. Thus, optimizing the operating conditions is important in the hollow fiber FO system.

• Journal of Advanced Navigation Technology
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• v.22 no.5
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• pp.420-428
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• 2018

In this paper, represented uninterruptible power supply (UPS) equipment maintaining constant output voltage, the proposes a photovoltaic system constructed with a step up boosting chopper and single phase pulse width modulation (PWM) voltage source inverter. as power source disconnection, voltage variation and output current variation with load variation. This system is driven by being synchronized voltage fed inverter and AC source, and in the steady state of power source charge battery connected to DC side with solar cell using a Photovoltaic that it was so called constant voltage charge. It can be results of saving electric power, and through a normal operation of energy storage system (ESS), the system operated the LED a calling on signal changes at the airport in an efficient manner. In addition, better output waveform was generated because of PWM method, and it was proved to test by experiment maintained constant output voltage regardless of AC source disconnection, load variation, and voltage variation of AC power source.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 1998.04a
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• pp.163-185
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• 1998

The purpose of this study was to analyze the physiology changes by circuit weight training(CWT). The subject of this study consists of 16 student on ship(experimental groups(SE) N=8, control group(SCa) N=8) and 16 students on land (experimental groups(LE) n=8, control groups(LCb) N=8). The items of measurement were the changes of CWT time and heart rate per week, musclear functino and cardiopulmonary function. The conclusions are as follows : 1. Muscular fuction 1) Back strength in SE and LE group was increased significantly (p<.01, p<.05, 8.86% and 7.08%).Grip strength was increased slightly in 4 groups but there was no significance. 2) In push-ups, all 4 groups were increased significantly (p<.05, p<.01), sit-ups also were increased significantly in SE and LE group (p<.05, 6.71% and 9.62%). 3) In SE and LE group , standing long jump was in significantly (p<.01, p<.05, 4.49% and 6.09%), but only in LE group , side step was increased significantly (p<0.1, 5.84%). 2. Cardiopulmonary function 1) HRrest was decreased slightly in all 4 groups but was not significant changes. HRmax was increased only in LE group significantly (p<.05, 2.81%), treadmill running time was increased significantly in SE and LE group respectively (p<.01, p<.05, 10.78% and 11.07%). 2) VEmax was increased significantly in SE and LE group(p<.05, p<.01, 10.59% and 13.68%), but only in LE group Rfmax was increased significantly (p<.01, 4.83%). 3) In VO2max, LCb group was increased significantly (p<.05, 6.835), but SCa group was decreased significantly (p<.05, 4.32). VO2max/kg$.$min was increased significantly in LE and LCb group respectively (p<.01 p<.05. 4.75% and 3.98%).

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.23 no.5
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• pp.335-344
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• 2011

A curvilinear non-hydrostatic free surface model is developed to investigate nonlinear wave interactions in a circular channel. The proposed model solves the unsteady Navier-Stokes equations in a three-dimensional domain with a pressure correction method, which is one of fractional step methods. A hybrid staggered-grid layout in the vertical direction is implemented, which renders relatively simple resulting pressure equation as well as free surface closure. Numerical accuracy with respect to wave nonlinearity is tested against the fifth-order Stokes solution in a two-dimensional numerical wave tank. Numerical applications center on the evolution of nonlinear waves including diffraction and reflection affected by the curvature of side wall in a circular channel comparing with linear waves. Except for a highly nonlinear bichrmatic wave, the model's results are in good agreement with superimposed analytical solution that neglects nonlinear effects. Through the numerical simulation of the highly nonlinear bichramatic wave, the model shows its capability to investigate the evolution of nonlinear wave groups in a circular channel.

• Archives of design research
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• v.13 no.1
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• pp.237-245
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• 2000

The designer get through a doorstep of ideation to obtain a design concept, which consequently achieves the successful design. However, the ideation with creativeness may not always be given as much as an effort is made. It is readily recognized as the ideation released is naturally limited to a resonable and logical frame structure. Conversely, the successful ideation can be obtained through illogical thought given in a while. The thinking method suggested in effect preview can thus satisfy the demand of lateral thinking, which can lead to the creativeness as a thinking model as well as amenably advertising concept in a final step of advertising plan. Finally, it is concluded that from the brain function theory, the unique role of each side of brain can not practically influence on an art work performance successfully achieved.

• Journal of Korean Foot and Ankle Society
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• v.7 no.1
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• pp.109-114
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• 2003

Purpose: The purpose of this study is to evaluate the effectiveness and indications of the modified Essex-Lopresti reduction in calcaneal fractures. Materials and Methods: We reviewed retrospectively 41 cases of displaced intraarticular calcaneal fractures. The fracture was reduced with Essex-Lopresti technique with modification in compression of the lateral wall with the specially designed compression device instead of the operator's hands. We evaluated the results of treatment by AOFAS scale and the radiographic parameters including the Bohler's angle, calcaneal width, calcaneofibular distance and the congruency of the posterior facet. Results: Boler's angle was restored from 11 to 29.6 degrees on average, heel width was reduced to 112% of contralateral value, the calcaneofibular gap was restored up to 87.9% of contralateral side, and the articular surface of the posterior facet was restored less than 2 mm of step off and less than 2 mm of gap. AOFAS scale averaged 87 points. The quality of reduction was best in Sander's type II fractures. Small sized fragments in type III fractures could not be reduced. The results were better when the reductions were performed within 24 hours of injury. Conclusion: The modified Essex-Lopresti reduction was less invasive, easy to perform, and the results of treatment were similar to those of open reduction; it seemed to be a reasonable alternative for the selected intraarticular calcaneal fractures.

• The Journal of Korean Physical Therapy
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• v.24 no.4
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• pp.253-261
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• 2012

Purpose: In this study, the following experiment was conducted to see how to apply the sprinter pattern in proprioceptive neuromuscular facilitation (PNF) and functional weight bearing exercise affected balance capabilities and weight bearing among chronic stroke patients. Methods: The subjects included 27 subjects who had been diagnosed with hemiplegia due to stroke. A total of 12 sessions was held, 3 sessions a week over 4 weeks, were provided to the groups. The control group received general rehabilitation program, and the experimental group performed sprinter pattern in PNF or functional weight bearing exercise. The weight bearing capability and static balance capability test was implemented by using Good-Balance System and Frailty and Injuries Cooperative Studies of Intervention Techniques, while the dynamic balance capability test was carried out by using Four Square Step Test and Timed "Up and Go". Results: The paretic/nonparetic side weight bearing by application of each exercise showed that there were no significant differences in variation among each groups on before exercise, after exercise, 2 weeks after exercise. Static balance test by application of each exercise showed that there were significant differences after exercise and 2 weeks after exercise. Dynamic balance test by application of each exercise showed that there were significant differences after exercise and 2 weeks after exercise. Conclusion: To put the results together, the application of sprinter pattern and functional weight bearing exercise was effective in improving static and dynamic balance capabilities. Therefore, these exercises are helpful to improve balance in patients with stroke.