• Molecular & Cellular Toxicology
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• 제5권4호
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• pp.346-353
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• 2009

Drug metabolism is a critical determinant of the therapeutic and adverse effects of many psychotropic drugs. The metabolism depends on the pharmacokinetics of a drug, which includes its absorption, distribution, and elimination. Psychotropic drugs are metabolized mainly by cytochrome P450 (CYP) enzymes; about 20 of these enzymes exist and they are often responsible for the rate-limiting step of drug metabolism. CYP2D6 is the best-characterized P450 enzyme that exhibits polymorphism in humans. This study determined the relationship between the CYP2D6*10 (P34S) polymorphism and the response to mirtazapine in 153 Koreans with major depressive disorder (MDD). The genotype frequencies were compared using logistic regression analysis, and between-genotype differences in the decrease in the 21-item Hamilton Depression (HAMD21) score over the 12-week treatment period were analyzed using a linear regression analysis. The proportion of remitters was lower in patients with MDD possessing the S allele than in P allele carriers after 2 weeks of mirtazapine treatment. Similarly, the reductions in the HAMD21 and Clinical Global Impression (CGI) scores in S allele carriers were smaller than those in patients with the P allele after 2 weeks of mirtazapine treatment. In the analysis of depression symptoms, the sleep and delusion scores had smaller reductions in S allele carriers. Based on the Liverpool University Neuroleptic Side Effect Rating Scale (LUNSERS), the psychic adverse effects of mirtazapine were associated with CYP2D6 P34S, while weight gain was not. These results suggest that CYP2D6 P34S affects the outcome of mirtazapine treatment in patients with MDD, and that this polymorphism may be a good genetic marker for predicting the clinical outcome of mirtazapine treatment.

• 대한세포병리학회지
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• 제6권1호
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• pp.41-47
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• 1995

Two hundred and twenty one consecutive patients with enlarged lymph nodes of the neck were diagnosed as metastatic carcinoma by fine needle aspiration. The metastatic carcinomas were most frequent in the supraclavicular lymph nodes (p<0.05). As a primary site, lung, stomach, upper respiratory tract and breast were commonly involved in descending order of frequency. Overall, squamous cell carcinoma was the most common in males (43%) while adenocarcinoma was the most common in females (72%) (p<0.05). While carcinomas of the esophago-gastro-intestinal tract showed a tendency to metastasize to the left supraclavicular lymph nodes, metastatic carcinomas of the lung and breast usually metastasized to the same side as that of the primary cancer with a predilection for the supraclavicular lymph nodes. The submandibular lymph nodes were frequently involved by carcinoma of the upper and lower respiratory tract, in which squamous cell carcinoma was the most prevalent cytologic type. Diagnosis by fine needle aspiration cytology is the first step in the workup of patients with nodal enlargement suspicious for malignancy, particularly in metastatic carcinoma.

• 한국의류학회지
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• 제40권2호
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• pp.240-257
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• 2016

This study determines the effect of 3D compression pants and Kinesio taping on muscular function of the leg during knee joint flexion and extension. Eight males participated in the experiment, wearing basic pants (BP), Kinesio taping on bare skin (KT), 3D compression pants with (KTP) and without Kinesio taping (CP). The test protocol for isokinetic muscular function was composed of four sets at three angular velocities (60, 180, $240^{\circ}/sec$) using Cybex 660. Peak torque and work per repetition of the lower limbs of eight males were analyzed from the result of Cybex. Agility and power of the subjects were examined from side step and sergeant jump. Peak torque, average power, work per repetition, force decay time of subjects wearing CP and KTP were significantly better than BP or KT, especially at low angular velocity of $60^{\circ}/sec$. The time to generate peak torque of subjects wearing BP was the longest, while the force-decay time of BP was the shortest. The application of Kinesio tape on skin did not increase muscle peak torque, work and power, but did shorten the time to generate peak torque.

• 상하수도학회지
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• 제32권4호
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• pp.357-361
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• 2018

Forward osmosis (FO) process has been attracting attention for its potential applications such as industrial wastewater treatment, wastewater reclamation and seawater desalination. Particularly, in terms of fouling reversibility and operating energy consumption, the FO process is assumed to be preferable to the reverse osmosis (RO) process. Despite these advantages, there is a difficulty in the empirical step due to the lack of separation and recovery techniques of the draw solution. Therefore, rather than using FO alone, recent developments of the FO process have adapted a hybrid system without draw solution separation/recovery systems, such as the FO-RO osmotic dilution system. In this study, we investigated the performance of the hollow fiber FO module according to various operating conditions. The change of permeate flow rate according to the flow rates of the draw and feed solutions in the process operation is a factor that increases the permeate flow rate, one of the performance factors in the positive osmosis process. Our results reveal that flow rates of draw and feed solutions affect the membrane performance, such as the water flux and the reverse solute flux. Moreover, use of hydraulic pressure on the feed side was shown to yield slightly higher flux than the case without applied pressure. Thus, optimizing the operating conditions is important in the hollow fiber FO system.

• 한국항행학회논문지
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• 제22권5호
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• pp.420-428
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• 2018

본 논문은 태양광 발전시스템을 승압쵸퍼와 단상 펄스폭변조 전압형인버터를 사용하여 전원차단 경우나 전압변동 및 부하변동에 의한 출력전류 변화에도 일정한 출력전압을 유지하는 무정전 전원 공급장치(UPS)를 구성하였다. 본 시스템은 전압형인버터를 교류전원과 동기 시켜서 운전하고 정상상태에서는 전원으로부터 운전하고 정상상태에서는 전원으로부터 직류 측에 연결된 축전지를 태양전지를 이용한 광기전력효과와 함께 일정전압을 충전하며, 전원의 차단, 전원의 전압변동 및 부하전류의 변화에도 일정한 전압을 유지하도록 하였다. 에너지 저장장치 (ESS; energy storage system)를 상시 운영하여 공항의 기상 변화에 따른 파장별 LED 항공 유도신호 등을 효율적으로 운용하는 시스템을 구성 하였고, 전력절감효과를 얻을 수 있는 에너지절약 전원복합형 전력변환장치로 구성되어 있다. 출력은 PWM방식에 의하여 양호한 파형이 되도록 하고 전원차단과 부하의 상태의 변화 및 전원 전압 변동에도 일정한 전압으로 출력됨을 실험을 통하여 확인 할 수 있었다.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 1998년도 춘계학술발표회 논문집
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• pp.163-185
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• 1998

The purpose of this study was to analyze the physiology changes by circuit weight training(CWT). The subject of this study consists of 16 student on ship(experimental groups(SE) N=8, control group(SCa) N=8) and 16 students on land (experimental groups(LE) n=8, control groups(LCb) N=8). The items of measurement were the changes of CWT time and heart rate per week, musclear functino and cardiopulmonary function. The conclusions are as follows : 1. Muscular fuction 1) Back strength in SE and LE group was increased significantly (p<.01, p<.05, 8.86% and 7.08%).Grip strength was increased slightly in 4 groups but there was no significance. 2) In push-ups, all 4 groups were increased significantly (p<.05, p<.01), sit-ups also were increased significantly in SE and LE group (p<.05, 6.71% and 9.62%). 3) In SE and LE group , standing long jump was in significantly (p<.01, p<.05, 4.49% and 6.09%), but only in LE group , side step was increased significantly (p<0.1, 5.84%). 2. Cardiopulmonary function 1) HRrest was decreased slightly in all 4 groups but was not significant changes. HRmax was increased only in LE group significantly (p<.05, 2.81%), treadmill running time was increased significantly in SE and LE group respectively (p<.01, p<.05, 10.78% and 11.07%). 2) VEmax was increased significantly in SE and LE group(p<.05, p<.01, 10.59% and 13.68%), but only in LE group Rfmax was increased significantly (p<.01, 4.83%). 3) In VO2max, LCb group was increased significantly (p<.05, 6.835), but SCa group was decreased significantly (p<.05, 4.32). VO2max/kg$.$min was increased significantly in LE and LCb group respectively (p<.01 p<.05. 4.75% and 3.98%).

• 한국해안·해양공학회논문집
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• 제23권5호
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• pp.335-344
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• 2011

곡면의 경계를 가지는 수로에서 비선형 파랑의 상호작용을 모의하기 위한 비정수압 자유수면 모형이 개발되었다. 제안된 모형은 비선형의 3차원 Navier-Stokes 방정식을 곡선좌표 영역에서 계산단계 분리법의 일종인 압력수정법에 의하여 수치적으로 해석된다. 특히, 연직방향으로 변형된 형태의 엇갈린 격자를 이용하여 상대적으로 간단하게 압력방정식과 자유수면 경계조건을 구성하였다. 개발된 모형의 수치해석 정확도는 2차원의 수치 파수조에서 파랑의 비선형 정도에 대하여 5차의 스토스우크스 해석해와 비교하였다. 본 모형의 실제적 적용은 원형의 수로에서 회절과 반사에 의해 변형되는 비선형 파의 변형에 초점을 맞추어 수행하였다. 두개의 파를 중첩한 고비선형의 파에 대한 경우를 제외하고 수치해석 결과는 비선형적인 영향을 고려하지 않은 해석해의 선형적인 중첩과 일치하였다. 두개의 파를 중첩한 고비선형의 파에 대한 모의를 통하여 본 모형은 원형의 수로에서 비선형 군파의 변형에관한 수치적인 모의 가능성을 제시하였다.

• 디자인학연구
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• 제13권1호
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• pp.237-245
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• 2000

디자이너라면 누구나 디자인의 결과물을 얻어내는 과정의 첫 단계로서 디자인의 컨셉을 만족시킬 수 있는 발상의 단계를 거치게 될 것이다. 그러나 새로움을 요구하는 발상은 누구에게나 노력하는 정도만큼 비례하여 얻어지는 속성을 지니고 있지 않다. 왜냐하면 인간이 노력하여 얻어낼 수 있는 합리적이고 논리적인 사고의 틀 속에는 새로운 것이 존재하지 않기 때문이다. 그러므로 좋은 발상의 핵심은 어떻게 하면 비논리적 사고영역에 자기 자신을 원하는 시간 동안 머물 수 있게 하는가에 있다고 말할 수 있다. 본고에서 제시하고 있는 "결과미리보기"의 사고법은 광고기획서에서 최종 단계에서 제시되고 있는 광고컨셉을 만족시키면서도 최종 단계에서 제시되고 있는 광고컨셉을 만족시키면서도 수평적사고의 영지에 인간의 사고활동을 일정 시간 묶어 둘 수 있는 발상모델이 될수 있다고 생각한다. 뇌기능이론에서, 우뇌나 좌뇌의 활동지수의 높고 낮음이 실제 작품제작에 미치는 영향은 유의할 정도가 아니라는 사실이 연구결과 드러났다.연구결과 드러났다.

• 대한족부족관절학회지
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• 제7권1호
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• pp.109-114
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• 2003

Purpose: The purpose of this study is to evaluate the effectiveness and indications of the modified Essex-Lopresti reduction in calcaneal fractures. Materials and Methods: We reviewed retrospectively 41 cases of displaced intraarticular calcaneal fractures. The fracture was reduced with Essex-Lopresti technique with modification in compression of the lateral wall with the specially designed compression device instead of the operator's hands. We evaluated the results of treatment by AOFAS scale and the radiographic parameters including the Bohler's angle, calcaneal width, calcaneofibular distance and the congruency of the posterior facet. Results: Boler's angle was restored from 11 to 29.6 degrees on average, heel width was reduced to 112% of contralateral value, the calcaneofibular gap was restored up to 87.9% of contralateral side, and the articular surface of the posterior facet was restored less than 2 mm of step off and less than 2 mm of gap. AOFAS scale averaged 87 points. The quality of reduction was best in Sander's type II fractures. Small sized fragments in type III fractures could not be reduced. The results were better when the reductions were performed within 24 hours of injury. Conclusion: The modified Essex-Lopresti reduction was less invasive, easy to perform, and the results of treatment were similar to those of open reduction; it seemed to be a reasonable alternative for the selected intraarticular calcaneal fractures.

• The Journal of Korean Physical Therapy
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• 제24권4호
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• pp.253-261
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• 2012

Purpose: In this study, the following experiment was conducted to see how to apply the sprinter pattern in proprioceptive neuromuscular facilitation (PNF) and functional weight bearing exercise affected balance capabilities and weight bearing among chronic stroke patients. Methods: The subjects included 27 subjects who had been diagnosed with hemiplegia due to stroke. A total of 12 sessions was held, 3 sessions a week over 4 weeks, were provided to the groups. The control group received general rehabilitation program, and the experimental group performed sprinter pattern in PNF or functional weight bearing exercise. The weight bearing capability and static balance capability test was implemented by using Good-Balance System and Frailty and Injuries Cooperative Studies of Intervention Techniques, while the dynamic balance capability test was carried out by using Four Square Step Test and Timed "Up and Go". Results: The paretic/nonparetic side weight bearing by application of each exercise showed that there were no significant differences in variation among each groups on before exercise, after exercise, 2 weeks after exercise. Static balance test by application of each exercise showed that there were significant differences after exercise and 2 weeks after exercise. Dynamic balance test by application of each exercise showed that there were significant differences after exercise and 2 weeks after exercise. Conclusion: To put the results together, the application of sprinter pattern and functional weight bearing exercise was effective in improving static and dynamic balance capabilities. Therefore, these exercises are helpful to improve balance in patients with stroke.