• 한국산업융합학회 논문집
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• 제23권5호
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• pp.799-807
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• 2020

This paper deals with identification of probabilistic design using reliability based robust optimization in structure design of automatic salt collector. The thickness sizing variables of main structure member in the automatic salt collector were considered the random design variables including the uncertainty of corrosion that would be an inevitable hazardousness in the saltern work environment. The probabilistic constraint functions were selected from the strength performances of the automatic salt collector. The reliability based robust optimum design problem was formulated such that the random design variables were determined by minimizing the weight of the automatic salt collector subject to the probabilistic strength performance constraints evaluating from reliability analysis. Mean value reliability method and adaptive importance sampling method were applied to the reliability evaluation in the reliability based robust optimization. The three sigma level quality was considered robustness in side constraints. The probabilistic optimum design results according to the reliability analysis methods were compared to deterministic optimum design results. The reliability based robust optimization using the mean value reliability method showed the most rational results for the probabilistic optimum structure design of the automatic salt collector.

• 한국강구조학회 논문집
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• 제17권6호통권79호
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• pp.649-660
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• 2005

강박스거더교 다이아프램의 맨홀은 지금까지 경험적으로 설계하여, 강교제작에 과도한 비용을 유발시키는 한 요인이 되고 있다. 다이아프램 맨홀 제작의 경제성과 효율성을 제고시키기 위해서는 다이아프램 맨홀부의 정확한 거동분석을 통한 검토가 필요하다. 본 논문에서는 강상자형교 지점부의 다이아프램 맨홀의 거동 분석을 위해 현장실측과 구조해석이 수행되었다. 여러 가지 맨홀 형상들에 대한 상세 구조해석을 통하여, 강박스거더교의 지점부 다이아프램 맨홀의 적절한 보강방법에 대하여 제안하였다.

• BMB Reports
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• 제28권2호
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• pp.138-142
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• 1995

An anticoagulant/fibrinolytic protease was purified to homogeneity from the earthworm Lumbricus rubellus. The protein was a single chain glycoprotein of 32 kDa that exhibited strong proteolytic activity on human thrombin and fibrin clots. Proteolytic degradation of these plasma proteins by the purified enzyme occurred at a neutral pH range. Among several human plasma proteins tested as possible substrates for the protease reaction, the 32 kDa enzyme specifically hydrolyzed both thrombin and fibrin polymers without affecting other proteins, such as serum albumin, immunoglobulin, and hemoglobin. Treatment of the purified enzyme at neutral pH with either phenylmethylsulfonylfluoride or soybean trypsin inhibitor resulted in a loss of catalytic activity. The enzyme hydrolyzed the chromogenic substrate H-D-Phe-L-Pipecolyl-L-Arg-p-nitroanilide with a $K_m$ value of 1.1 ${\mu}M$ at a neutral pH. These results suggest that the anticoagulant/fibrinolytic enzyme from Lumbricus rubellus is a member of the serine protease family having a trypsin-like active site, and one of the potential clevage sites for the enzyme is the carbonyl side of arginine residues in polypeptide chains.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.153-158
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• 2013

This paper reports on part of a large study to identify competencies of oncology nurses in Malaysia. It focuses on oncology nurses' communications-related competency. As an important cancer care team member, oncology nurses need to communicate effectively with cancer patients. Literature shows that poor communication can make patients feel anxious, uncertain and generally not satisfied with their nurses' care. This paper deliberates on the importance of effective communication by oncology nurses in the context of a public hospital. Four focus group discussions were used in this study with 17 oncology/cancer care nurses from Malaysian public hospitals. The main inclusion criterion was that the nurses had to have undergone a post-basic course in oncology, or have work experience as a cancer care nurse. The findings indicated that nurses do communicate with their patients, patients' families and doctors to provide information about the disease, cancer treatment, disease recurrence and side effects. Nurses should have good communication skills in order to build relationships as well as to provide quality services to their patients. The paper concludes by recommending how oncology nursing competencies can be improved.

• 한국농촌건축학회논문집
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• 제18권1호
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• pp.29-37
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• 2016

This research is studied changes of outdoor lavatories in use of detached houses in rural areas. Out of 40 houses studied in a 1995 survey, 23 houses were performed again in 2015. Number of lavatories installed in indoor and outdoor both in 1995 are more than in 2015. However, number of indoor lavatories in 2015 are more because outdoor lavatories were demolished. Among 23 houses, 15 outdoor lavatories have been installed in 13 houses. Out of these 15 lavatories, eight have been used continuously from 1995 through 2015. Currently four are used for other purposes, and five have demolished. Outdoor lavatories tend to be built in the rear of the housing site. Those located in rear tend to be demolished rather than in front side because of decreasing in use. In rural areas, outdoor lavatories not only serve as spaces to fulfill basic human needs, but are used to store agricultural tools. Changes of family composition and member also exert an influence. When family members were decreased, outdoor lavatories tended to be demolished. However, although family members were decreased, the reason that outdoor lavatories have been used continually is for exterior work or farming and temporarily increasing family members in holiday and family events. The more family members used, the more outdoor lavatories are managed well. The more houses where the aged reside in, the more outdoor lavatories are not improved.

• 천문학회보
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• 제42권2호
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• pp.56.4-57
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• 2017

The GMT-Consortium Large Earth Finder (G-CLEF) is the very first light instrument of the Giant Magellan Telescope (GMT) to be commissioned in 2022. The instrument is a fiber feed, optical band echelle spectrograph that is capable of extremely precise radial velocity measurement. Korea Astronomy and Space Science Institute (KASI) has been involved in the development of the G-CLEF as one member of the international consortium consisted of five astronomical institutes including Smithsonian Astrophysical Observatory (SAO), Observatories of the Carnegie Institution of Washington (OCIW). It is scheduled to have KASI side Critical Design Review in December 2017. In this presentation we will report the recent progress on the critical design activities for the G-CLEF Flexure Control Camera (FCC).

• BMB Reports
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• 제47권4호
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• pp.215-220
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• 2014

Molecular-targeted therapy has gained attention because of its high efficacy and weak side effects. Previously, we confirmed that transmembrane 4 superfamily member 5 protein (TM4SF5) can serve as a molecular target to prevent or treat hepatocellular carcinoma (HCC). We recently extended the application of the peptide vaccine, composed of CpG-DNA, liposome complex, and TM4SF5 peptide, to prevent colon cancer in a mouse model. Here, we first implanted mice with mouse colon cancer cells and then checked therapeutic effects of the vaccine against tumor growth. Immunization with the peptide vaccine resulted in robust production of TM4SF5-specific antibodies, alleviated tumor growth, and reduced survival rate of the tumor-bearing mice. We also found that serum levels of VEGF were markedly reduced in the mice immunized with the peptide vaccine. Therefore, we suggest that the TM4SF5-specific peptide vaccine has a therapeutic effect against colon cancer in a mouse model.

• 한국기계가공학회지
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• 제13권2호
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• pp.55-63
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• 2014

Fractures and wrinkles are two major defects frequently found in the sheet metal forming process. The process has several noise factors that cannot be ignored when determining the optimal process conditions. Therefore, without any countermeasures against noise, attempts to reduce defects through optimal design methods have often led to failure. In this study, a new and robust design methodology that can reduce the possibility of formation of fractures and wrinkles is presented using decision-making theory. A two-attribute value function is presented to form the design metric for the sheet metal forming process. A modified complex method is adopted to isolate the optimal robust design variables. One of the major limitations of the traditional robust design methodology, which is based on an orthogonal array experiment, is that the values of the optimal design variables have to coincide with one of the experimental levels. As this restriction is eliminated in the complex method, a better solution can be expected. The procedure of the proposed method is illustrated through a robust design of the sheet metal forming process of a side member of an automobile body.

• 대한기계학회논문집A
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• 제32권6호
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• pp.533-539
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• 2008

An high frequency induction hardening technology of vehicle body press-formed of thin sheet steel has been developed to increase the strength of vehicle body parts locally by high frequency induction heating, thereby eliminating the need for reinforcements. And this technique for increasing the tensile strength of sheet steel was practically applied to the front floor cross member and center pillar reinforcement of a passenger car. The side impact behavior has been investigated when induction hardening technology is applied to the conventional low-carbon steel and weight reduction of an automotive body is expected. In this paper, basic experiments were performed for the hat-shaped specimen under high frequency induction heating process. Martensitic transformation was found in the heating zone through microscopic observation which showed higher hardness. In addition, the hardness and strength of the center-pillar specimen made of boron steel increased remarkably by high frequency induction heating.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2008년도 춘계 학술논문 발표대회
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• pp.67-71
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• 2008

The study analyzed on fire resistance of high strength concrete followed by thickness of fireproof plaster board and change of adhesive method. In spalling characteristics after fire resistance test, all four-side covering concretes were left out of testing screens. Thus, serious spalling was happened by exposing their internal reinforcing rods. in partial testing screens, spalling was happened till the internal concrete of main reinforcing rod. Only, temperature history didn't have special differences among changes of adhesive method. However, thickness of fireproof plaster board is very important. Namely, mock member reinforcing 25mm general adhesive + Bending was 583℃ in the highest temperature of surface part and 479℃ in the highest temperature of the main reinforcing rod, which was relatively good temperature history.