• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 1998.03a
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• pp.53-57
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• 1998

In order to investigate the effects of the variables during the stamping process upon the side wall curl behavior, experiments and finite element analyses were done using a 90 degree draw-bending test. The variables considered were the die radius, the forming speed, the restraint force, the lubrication and the sheet grade. The experiments and simulation conditions were selected according to the design of experiment (DOE) approach. The effects of the restraint force, the lubrication and the forming speed were the same for both high strength and mild steels, but the effects of the die radius on the side wall curl were dependent on the magnitude of the die radius and the sheet grade. A straight side wall was observed for both high strength and mild steels when the die radius was about 2∼3 times of the sheet thickness. It was recommended that the restraint force, the forming speed and the friction be increased in order to reduce the side wall curl.

• Journal of Digestive Cancer Research
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• v.3 no.2
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• pp.76-81
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• 2015

Gastrointestinal side effects including nausea and vomiting, diarrhea, constipation, oral mucositis and colitis, and hepatotoxicity are common occurrence during chemotherapy. Often they result in unplanned admission and interruption of scheduled therapy. Additionally they have a negative influence on patient's therapeutic outcome and quality of life. The assessment of gastrointestinal side effects is dependent on clinician assignment of a grade established by the National Cancer Institute Common Terminology Criteria for Adverse Events. Continued interest of gastrointestinal side effects has allowed identifying patients at higher risk and providing effective treatments to relieve painful symptom. Finally, proper prevention and management of chemotherapy-induced gastrointestinal side effects will be needed to improve patient's survival and quality of life.

• Ocean Systems Engineering
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• v.3 no.4
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• pp.275-294
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• 2013

Side-by-side offloading operations are widely utilized in engineering practice. The hydrodynamic interactions between two vessels play a crucial role in safe operation. This study focuses on the coupled effects between two floating bodies positioned side-by-side as a shuttle tanker-FPSO (floating production, storage and offloading) system. Several wave directions with different side-by-side distances are studied in order to obtain the variation tendency of the horizontal hydrodynamic coefficients, motion responses and mean drift forces. It is obtained that the coupled hydrodynamics between two vessels is evidently distinguished from the single body case with shielding and exaggerating effects, especially for sway and yaw directions. The resonance frequency and the peak amplitude are closely related with side-by-side separation distance. In addition, the horizontal hydrodynamics of the shuttle tanker is more susceptible to coupled effects in beam waves. It is suggested to expand the gap distance reasonably in order to reduce the coupled drift forces effectively. Attention should also be paid to the second peaks caused by hydrodynamic coupling. Since the horizontal mean drift forces are the most mainly concerned forces to be counteracted in dynamic positioning (DP) system and mooring system, prudent prediction is beneficial in saving consumed power of DP system and reducing tension of mooring lines.

• Journal of Information Display
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• v.13 no.3
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• pp.125-130
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• 2012

In this paper, a new precharging method without any side effects is proposed to overcome image degradation caused by insufficient charging times. This work explains why the precharging method can compensate for short charging times. However, side effects of the precharging method in the form of horizontal line artifacts are addressed, wherein line artifact-compensating precharging (LCP) is presented to mitigate the side effects. Behavioral modeling is employed to investigate the side effects by estimating transient responses of a liquid crystal display. The LCP proves that it can dramatically reduce line artifacts caused by precharging because the brightness difference of adjacent pixels does not exceed 1.0.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.24 no.1
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• pp.181-191
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• 2011

Backgrounds : Pompholyx is a distinctive reaction pattern presenting as symmetric vesicular hand and foot dermatitis. Other than acute symptoms like itching and vesicles, chronic changes with scaling, fissure and pain may follow. As patients are treated by steroid for a long period, it tends to present side effects after quitting steroid treatment. Objectives : This study was carried out to investigate the effect of carbon arc lamp therapy and oriental medical therapy that venesection therapy, ointments and herbal medicine on chronic plantar pompholyx including steroids side effects. Methods : We treated one case of chronic plantar pompholyx which had continued about 10 years, including steroids side effects with venesection therapy, carbon arc lamp therapy, ointments and herbal medicine. To evaluate the results of this treatment, we categorized symptoms into six items which are vesicles, itching, fissures, pain, erosions and scales. Results : Except mild itching, vesicles and scales in a small area, all the symptoms were subsided. Conclusions : It is considered that various kinds of oriental medical therapy including carbon arc lamp therapy could replace steroid therapy which has many side effects.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.5
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• pp.596-603
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• 2003

Present study has been conducted to see the relative effects of adding N: to fuel-side and air-side on flame structure, soot formation and NOx emissions. Experiments were carried out to ascertain to what degree chemical kinetics and/or molecular transport effects can explain the differences in soot formation and NOx emission by studying laminar diffusion flames. Direct photograph was taken to see the flame structure. CARS techniques was used to get the flame temperature profiles. And spatial distribution of soot could be obtained by PLII method. CHEMKIN code was also used to estimate the global residence time to predict NOx emissions at each condition. Results from these studies indicate that fuel-side dilution is more effective than air-side dilution in view of NOx emissions. However, air-side dilution shows greater effectiveness over fuel-side dilution in soot formation. And turbulent mixing and heat transfer problems were thought to be considered in practical applications.

• Journal of the korean academy of Pediatric Dentistry
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• v.47 no.2
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• pp.109-119
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• 2020

This retrospective study assessed the effectiveness and side effects of conscious sedation using chloral hydrate, hydroxyzine, and N₂O/O₂ in the sedation of 149 pediatric patients over 188 sedation sessions, and to identify associated variables. The effectiveness of the sedation was evaluated using the Houpt scale, and was considered effective for scale categories of excellent or good. Effectiveness and side effects were assessed every 15 minutes. The effectiveness decreased and side effects increased over time. The effectiveness of sedation during 60 minutes was 57.4%, and one or more side effects occurred in 18.1% of sessions. Effectiveness of sedation increased with body mass index (BMI). When patients were sedated at the beginning of the procedure, the effectiveness was greater. Side effects increased with patient age. When sedation was divided into two sessions, the number of sedation did not affect the effectiveness or side effects. It can be suggested that sedation should be performed over two separate sessions, as a single prolonged session may lead to reduced effectiveness and increased side effects. To maximize effectiveness and minimize side effects, several variables such as BMI, whether to sedate at the beginning of the procedure and age should be considered thoroughly before sedation.

• Journal of the Korea Society of Computer and Information
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• v.21 no.1
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• pp.115-123
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• 2016

In this study, we collect various side effect pairs which are appeared frequently at many drugs, and select side effect pairs that have higher severity. For every selected side effect pair, we extract common genetic networks which are shared by side effects' genes and drugs' target genes based on PPI(Protein-Protein Interaction) network. For this work, firstly, we gather drug related data, side effect data and PPI data. Secondly, for extracting common genetic network, we find shortest paths between drug target genes and side effect genes based on PPI network, and integrate these shortest paths. Thirdly, we develop a classification model which uses this common genetic network as a classifier. We calculate similarity score between the common genetic network and genetic network of a drug for classifying the drug. Lastly, we validate our classification model by means of AUC(Area Under the Curve) value.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.4
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• pp.945-949
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• 2005

The objective of this study is to investigate the inhibitor effects of an traditional oriental herb, Sophora flavescens on the pancreatic & cardiac side effects of chemotherapy were studied by using Bl6-BL6 melanoma-injected C57BL6 mouse tumor model. In this study, the effects of an traditional oriental herb, Sophora flavescens, on the side effects of chemotherapy were studied using B16 melanoma-injected C57BL6 mouse tumor model. Anticancer drugs widely used in clinical situation. Sophora flavescen has significant effect on the reduction of the side effects of chemotherapy. Water extract of Sophora flavescens significantly inhibited cisplatin-induced increase of amylase (AMY) which is a good indicator of pancreatic toxicity. Sophora flavescens extract does not decrease the anti-tumor activity of cisplatin showing that it can selectively inhibit side effects of anticancer drugs preserving beneficial effect. Theses results suggest a possibility that Sophora flavescens extract can be used for cancer patients for the reduction of the side effects and improving the quality of life during chemotherapy of cancer patients.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.13
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• pp.5433-5436
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• 2014

Conventional chemotherapy against hepatocellular carcinoma typically causes various side effects. Our previous study showed that cecropin of Musca domestica can induce apoptosis in human hepatocellular carcinoma BEL-7402 cells in vitro. However, whether cecropin inhibits BEL-7402 cell in vivo and the question of possible side effects remained undentified. The present study confirmed tumor-inhibitory effects of cecropin in vivo, and furthermore strongly suggested that cecropin cytotoxicity in BEL-7402 cells in vivo may be mainly derived from its pro-apoptotic action. Specifically, we found that cecropin exerted no obvious side effects in tumor-bearing mice as it had no significant hematoxicity as well as visceral toxicity. Therefore, cecropin may be a potential candidate for further investigation as an antitumor agent against hepatocellular carcinoma.