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http://dx.doi.org/10.7314/APJCP.2014.15.13.5433

Cecropin Suppresses Human Hepatocellular Carcinoma BEL-7402 Cell Growth and Survival in vivo without Side-Toxicity  

Jin, Xiao-Bao (School of Basic Courses, Guangdong Pharmaceutical University)
Wang, Ying-Jiao (School of Basic Courses, Guangdong Pharmaceutical University)
Liang, Lu-Lu (School of Basic Courses, Guangdong Pharmaceutical University)
Pu, Qiao-Hong (School of Basic Courses, Guangdong Pharmaceutical University)
Shen, Juan (School of Basic Courses, Guangdong Pharmaceutical University)
Lu, Xue-Mei (School of Basic Courses, Guangdong Pharmaceutical University)
Chu, Fu-Jiang (School of Basic Courses, Guangdong Pharmaceutical University)
Zhu, Jia-Yong (School of Basic Courses, Guangdong Pharmaceutical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.13, 2014 , pp. 5433-5436 More about this Journal
Abstract
Conventional chemotherapy against hepatocellular carcinoma typically causes various side effects. Our previous study showed that cecropin of Musca domestica can induce apoptosis in human hepatocellular carcinoma BEL-7402 cells in vitro. However, whether cecropin inhibits BEL-7402 cell in vivo and the question of possible side effects remained undentified. The present study confirmed tumor-inhibitory effects of cecropin in vivo, and furthermore strongly suggested that cecropin cytotoxicity in BEL-7402 cells in vivo may be mainly derived from its pro-apoptotic action. Specifically, we found that cecropin exerted no obvious side effects in tumor-bearing mice as it had no significant hematoxicity as well as visceral toxicity. Therefore, cecropin may be a potential candidate for further investigation as an antitumor agent against hepatocellular carcinoma.
Keywords
Cecropin; hepatocellular carcinoma; side effects; cytotoxicity;
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