• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.12
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• pp.2395-2400
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• 2016

Conventional drug carriers such as liposomes, nanoparticles, polymer micelles, polymeric conjugate and lipid microemulsion for cancer chemotherapy shield normal tissues from toxic drugs to treat cancer cells in tumors. However, inaccurate tumor targeting uncontrolled drug release from the carriers and unwanted accumulation in healthy sites can limit treatment efficacy with current conventional drug carriers with insufficient concentrations of drugs in the tumors and unexpected side effects as a result. Sickle red blood cells show natural tumor preferential accumulation without any manipulation due to the adhesive interaction between molecular receptors on the membrane surface and counter-receptor on endothelial cells. In addition, structural changes of microvascular in tumor sites enhances polymerization of sickle red blood cells. In this research, we examined the use of sickle red blood cells as a new drug carrier with novel tumor targeting and controlled release properties to quantify its therapeutic effects.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.05a
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• pp.715-717
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• 2016

Conventional drug carriers such as liposomes, nanoparticles, polymer micelles, polymeric conjugate and lipid microemulsion for cancer chemotherapy shield normal tissues from toxic drugs to treat cancer cells in tumors. However, inaccurate tumor targeting uncontrolled drug release from the carriers and unwanted accumulation in healthy sites can limit treatment efficacy with current conventional drug carriers with insufficient concentrations of drugs in the tumors and unexpected side effects as a result. In this research, we examined the use of sickle red blood cells as a new drug carrier with novel tumor targeting and controlled release properties. Sickle red blood cells show natural tumor preferential accumulation without any manipulation and controlled drug release is possible using a hemolysis method with photosensitizers.

• Journal of the Korean Society of Radiology
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• v.17 no.2
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• pp.223-230
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• 2023

This study attempted to concider the morphological change of red blood cells after whole body irradiation. Blood samples used red blood cells of white mice and mouse after irradiation. Transmission electron microscope observation results, Anisocytosis was observed in red blood cells 20 days after 5 Gy irradiation. Triangle and tetrapod were observed for small red blood cell types. Poikilocytosis, sickle-shaped Drepanocyte, and Acantocyte were observed in general-sized red blood cells. Schizocyte was observed in red blood cells 20 days after 7 Gy irradiation. Scanning electron microscope observation results, Dacryocyte was observed with microcytes. It was also confirmed that red blood cells were get tangled with each other. In addition, polygonal shapes and half-moon shapes were also observed. In conclusion, it is judged that the modified form of pathological study is more important than the numerical change in the study of red blood cells by radiation exposure. In conclusion, it was confirmed that modified morphological studies are more important than numerical changes in the study of red blood cells by radiation exposure.

• Journal of the Korea Society of Computer and Information
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• v.19 no.12
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• pp.219-225
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• 2014

A Gompertz modeling, sigmoid in shape, is a widely used application for social science, natural science, engineering, and medical research to allow confident approximation and accurate analysis and has been applied to estimate an elderly population on aging of population. Due to the high toxicity of currently available drug delivery vehicles, various efforts have been made to reduce side-effects in clinical fields, but its application to preclinical and clinical studies is limited and there are some difficulties to optimize the parameters of Gompertz modeling applicable to preclinical studies. Therefore, in this study, we demonstrated the ability of sickle red blood cells loaded by hypotonic dialysis then photosensitized and light-activated ex vivo for controlled release and simultaneously optimized Gompertz function to evaluate controlled drug release properties of photosensitized sickle red blood cells to reduce pain-related treatments in cancer patients.