• The Journal of Korean Medicine
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• v.24 no.1
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• pp.65-73
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• 2003

Objective: The aim of this study was to investigate the effect of scalp acupuncture on recovery from motor disorders in stroke patients. Methods: Twenty-two patients with post-stroke hemiplegia were randomized into two groups. Ten patients (test group) were treated by 2 methods: scalp acupuncture and general acupuncture. The other twelve patients (control group) were treated only with general acupuncture. The activity of daily living was measured with a National Institutes of Health stroke scale (NIHSS) and Modified Barthel Index (MBI). The therapy was performed once a day for 2 weeks. Results: In terms of NIHSS score, the test group showed statistically meaningful decrease after 2 weeks treatment, while the control group showed statistically meaningful decrease after 1 week (p<0.05). And in terms of score of MBI, the test group did not show statistically meaningful increase but the control group showed statistically meaningful increase after 1 week (p<0.05). There was no statistically meaningful difference after 1 and 2 weeks treatment between the groups. Conclusions: These results support that the test group has almost same the effectiveness compared with the control group in improvement of the activity of daily living of post-stroke hemiplegic patients.

• Journal of Korean Traditional Oncology
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• v.15 no.1
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• pp.105-110
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• 2010

Objective: This study reports one case of polycythemia vera patient treated with oriental medicine in conjunction with conventional medicine. Methods: One patient who was diagnosed with polycythemia vera was treated using different modalities of herbs, acupuncture, and pharmacopuncture. An herbal formula, Yongdamsagan-tang was given three times a day with daily acupuncture treatment session, in addition to Soyeom and Jahageo pharmacopuncture injection which were administered three times a week. After treatment, patient's symptoms and blood test results were observed and analyzed. Results: After ten days of treatment, the patient had shown improvements in symptoms of headache, dizziness, tinnitus, and itchiness. Two months later, laboratory findings continued to be kept within the normal range and the intervals of phlebotomy therapy has extended to three months. Conclusions: This case study shows minimum evidence of safety and efficacy of oriental medicine for managing symptoms of polycythemia vera. Considering this is only a short term, single case study, further research is needed to confirm these results.

• Clinical and Experimental Pediatrics
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• v.49 no.6
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• pp.581-588
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• 2006

Asthma is a chronic inflammation of the airway associated with increased bronchial hyperresponsiveness that leads to recurrent episodes of cough, wheezing, breathless, chest tightness. According the recent studies, repeated airway inflammation leads to structural changes so called 'airway remodeling' and associated with decreased pulmonary function. Airway remodeling begins form the early stage of asthma and the early diagnosis and management is very important to prevent airway remodeling. Medication for asthma can be classified into acute symptom reliever and chronic controller. Short acting beta2 agonist is a well-known reliever that reduced asthma symptoms within minutes. Controllers should be taken daily as a long-term basis to control airway inflammation. Inhaled corticosteroid(ICS) is the most effective controller in current use. However, in some patients ICS monotherapy is not sufficient to control asthma. In those cases, other medications such as long acting beta2 agonist, leukotriene modifier or sustained-release theophylline should be added to ICS, which called Add-on-Therapy. Combination inhaler devices are easy to use. Oral leukotriene modifier has a good compliance especially in children. Finally, as asthma is a chronic disease, the development of on-going partnership among health care professionals, the patients, and the patients' family is necessary for the effective management of asthma.

• Korean Journal of Adult Nursing
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• v.18 no.3
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• pp.416-425
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• 2006

Purpose: To evaluate the effects of a follow-up program for breast cancer patients after surgery. Method: A quasi-experimental design was used. The subjects were 56 breast cancer patients (experimental group: 27, control group: 29). The subjects of the experimental group participated in the Follow-up program of 7 sessions once a week, during 4 weeks including one telephone visit. The program consisted of health education of breast cancer, exercise, lymph edema prevention, diet education, theraband rehabilitation exercise, laugh therapy, and breast self examination. The obtained data were analysed by using the ANCOVA of SPSS. Results: There was a significant difference in the scores of physical wellbeing, symptom distress and mood state between the two groups. Conclusion: Considering these research results, short-term intervention could improve physical and emotional functioning abilities by helping better health. Nurses should establish and manage a proper program to provide multipurpose support and it must apply the program after surgery as soon as possible for breast cancer women.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.4
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• pp.1639-1642
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• 2014

The multidrug resistance phenotype is one of the major problems in development of cancer cell resistance to chemotherapy. Some natural compounds from medicinal plants have demonstrated promising capacity in enhancing anticancer effects in drug resistant cancer cells. We aimed to investigate whether mangiferin might have an ability to re-sensitize MCF-7 breast cancer cells previously treated with short-term doxorubicin in vitro, through the modulation of efflux transporters, P-glycoprotein (P-gp), MRP1 and BCRP. We exposed MCF-7 breast cancer cells pretreated with doxorubicin for 10 days to mangiferin (10, 25 or 50 ${\mu}M$) for 96 hours. Afterwards, we evaluated influence on cell viability and level of mRNA expression of P-gp, MRP1 and BCRP. Doxorubicin given in combination with mangiferin at low concentrations (10 and 25 ${\mu}M$) failed to give significant reduction in cell viability, while at the highest concentrations, the combination significantly reduced cell viability. The mRNA expression analysis of P-gp, MRP1 and BCRP showed that mangiferin had inhibitory effects on P-gp but no effects on MRP1 and BCRP. In conclusion, we suggest that mangiferin at high concentrations can be used as chemosensitizer for doxorubicin therapy. This effect might be attributed by inhibitory effects of mangiferin on P-glycoprotein expression.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2057-2060
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• 2014

Purpose: To assess the effect and safety of lobaplatin combinated floxuridine /pirarubicin in transcatheter hepatic arterial chemoembolization(TACE) of unresectable primary liver cancer. Patients and Methods: TACE combined with the chemotherapy regimen was used to treat 34 unresectable primary liver cancer patients. DSA/MRI/CT/blood routine examinations were used to evaluate short term activity and toxicity after 4-5 weeks, the process being repeated if necessary. Results: Among the 34 cases, 1 (2.9%) showed a complete response, 21 (61.7%) a partial response, 8 (23.5%) stable disease, and 4 progressive disease, with a total effective rate of 67.6%. The content of alpha fetoprotein dropped by over 50% in 20 cases (58.8%). The rate of recovery was hepatalgia (88.2%), ascites (47.1%), appetite (55.9%), Performance Status(30.4%). The median follow-up time (MFT) was 281 days (63-558 days), and median progression-free survival was 118.5 days (95%, CI:88.8-148.2days). Adverse reactions (III-IV grade) were not common, with only 4 cases of vomiting and 2 cases of thrombocytopenia (III grade). Conclusions: Lobaplatin-based TACE is an effective and safe treatment for primary liver cancer.

• Journal of Oriental Neuropsychiatry
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• v.14 no.2
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• pp.145-154
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• 2003

Objective : The aims of this study were to show the clinical state and to investigate depression and anxiety by BDI and STAI scale in tension headache patients. Method : The patient group was consisted of the 20 patients with Tension Headache who were treated in Department of Neuropsychiatry, Daejeon University Oriental Hospital from 3 March 2003 to 30 September 2003. The control group was consisted of the 20 patients on physical therapy with cerebaral vascular disorder in the Daejeon University Cheonan Oriental Hospital. The patient group was investigated by various characteristics, and compared with the control group by BDI and STAI scores. Result : 1. The ratio of female was higher, the 40 aged were higher frequence, in distribution of the period of the clinical history, short term within 1 week was the most.. 2. Tension headache was most frequent at whole portion, neck stiffness, shoulder pain, general body weakness were mainly coexited, and the prescription invigorating spleen supplementing qi and tonifying qi and blood. 3. The BDI score was higher in patient group, but there was no significant difference 4. The STAI score was higher in patient group, but there was no significant difference.

• Clinics in Shoulder and Elbow
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• v.16 no.2
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• pp.141-147
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• 2013

A 57-year-old man who simultaneously underwent an operation for repair of rotator cuff and a revision operation for nonunion of a Pilon fracture presented with osteomyelitis of the humeral head on the $19^{th}$ day after surgery due to MRSA (Methicillin-resistant Staphylococcus aureus) infection. Infection was controlled after administration of appropriate intravenous antibiotic therapy and performance of several surgical procedures. However, devastating defects at the humeral head and the rotator cuff remained. No case of short term MRSA induced osteomyelitis has been reported.

• Journal of the Korean Society for Precision Engineering
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• v.27 no.6
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• pp.75-81
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• 2010

The purpose of this study was to investigate the short-term effects of electrical massager on stress-related parameters including heart rate variability (HRV), heart rate (HR) using the photoplethysmogram (PPG) signal with motion artifact correction. Twenty healthy subjects were randomly allocated to receive a 15-min section of three types ((1) resting mode (control group), (2) light massage mode, (3) strong massage mode). Results indicated that self-report, VAS (Visual Analog Scale) significantly decreased for two massage modes after massage except control group. In strong massage mode, it was associated with significant increases in HF, but significant decreases in LF and LH/HF ratio compared with the light massage mode. For all outcomes, similar changes were not observed in the control group. Also, the result founded that mean HR of all groups decrease. We conclude that electrical massager reduces perceived stress and improves adaptive autonomic response to stress in healthy adults.

• Journal of Korean Medicine for Obesity Research
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• v.3 no.1
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• pp.1-6
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• 2003

Background: Recently, Obesity has become a social problem in all over the world including Korea. Dietary regulation, exercise and behavior modification therapy are used in the treatment of obesity, but until now, there have been many difficulties in treating it. Objectives: To examine in obese pre-menopausal Korean females the short-term efficacy for weight loss of an herbal formula (Slim-diet). Design: A 6-week longituidinal evaluation of a herbal formula (Slim-diet) in 35 pre-menopausal females (baseline age $31.6\;{\pm}\;6.1$) with body mass index > $25kg/m^2$. Body composition was measured using bioimpedence analysis (BIA) and dual energy X-ray absorptiometry (DXA). Anthropometry was done by same observer. Total cholesterol, total lipid, triglyceride, and LDL-cholesterol were measured. Results: Herbal formula (Slim-diet) treatment produced significant loss of weight (P < 0.001), percent of body fat (P < 0.001, both BIA and DXA) and waist circumference (P < 0.001). It also produced significant reduction of total cholesterol and total lipid levels (P < 0.05).