• Journal of Pharmaceutical Investigation
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• 제32권1호
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• pp.13-19
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• 2002

Water-lipid soluble multivitamin formulations were widely used to reduce the disease and stress of animals as husbandry has made a remarkable progress in recent. But the efficiency of these formulations is far from satisfactory. So, this study was attempted to develop the physically and chemically stable and useful multivitamin o/w emulsion. Multivitamin o/w emulsion composed of water, soybean oil (10%, v/v), vitamin A, D, E, K, $B_2,\;B_6,\;B_{12}$ and panthenol. To make a stable o/w emulsion, the egg lecithin (2%, w/v) and glycerin (2.5%, w/v) were used for emulsifier and thickening agent, respectively. The oil in water emulsion system was manufactured by microfluidizer and the physicochemical stability of this emulsion was evaluated. The average particle size and interfacial tension were measured. From the result of interfacial tension tested, critical micelle concentration of the egg lecithin was 0.5% (w/v) and optimal concentration for the preparation of emulsion was 2% (w/v). The mean particle size was about $0.6\;{\mu}m$ which was suitable for injections. Short-term accelerated stability as physical stability study was tested by centrifuging and freeze-thawing the emulsion samples. The additions of vitamins resulted in the increment of particle size and reduction of physical stability of emulsion. But it is not an enormous problem for the stability of emulsion. Also, we have performed the long-period preservation stability test for the vitamins. All vitamins were analysed by HPLC. The result of storage under $4^{\circ}C$ and dark conditions demonstrated that all vitamins were maintained stable at least 16 weeks, except for vitamin $B_{12}$.

• 대한원격탐사학회지
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• 제22권6호
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• pp.469-483
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• 2006

Terra 위성에 탑재된 MODIS 적외채널의 밝기온도 자료를 이용하여 한반도 지역에 대해 안정도 지수를 산출하는 알고리즘을 개발하였다. 안정도 지수는 정역학 평형 상태하에서 연직 변위에 대한 대기의 안정도로 정의되며, 대류성 폭풍우의 가능성을 나타내는 지수로 사용된다. RDAPS의 온도와 습도 연직분포 자료를 비선형 물리적 방법에 필요한 초기 추정 자료로 사용하여 KI, KO, LI, MB 지수를 산출하였고, RTTOV-7을 이용하여 물리적 복원 방법에 요구되는 긴 계산 시간을 단축하였다. 복사전달 모의를 통해 추정된 밝기온도는 관측값과 잘 일치하는 것으로 나타났다 단기 예보에 대한 유용성을 살펴보기 위해 안정도 지수 산출 알고리즘을 급격히 발달하는 대류성 폭풍우 사례에 적용하였다. RDAPS로부터 계산된 안정도 지수와 NASA에서 산출한 안정도_ 지수에 비해 대류운의 발달이 예상되는 지역을 보다 정확하게 예측하는 것으로 나타났다. 따라서 본 연구에서 개발된 알고리즘을 사용하여 순간 예보와 단기 예보를 향상시킬 수 있을 것으로 판단된다.

• 국제지역연구
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• 제15권3호
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• pp.215-237
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• 2011

한-중-일 3국간 무역형태는 각국의 산업구조 변화를 반영하여 무역수지가 고착화되고 또한 상호간 수출입 품목의 우선순위도 조정되어 왔다. 따라서 이와 같은 무역환경을 감안하여 새로운 형태의 무역정책을 수립 및 시행하는 것이 중요한 경제현안으로 부상하게 되었다. 본 연구는 공적분추정과 오차수정모형을 활용하여 한국, 중국, 및 일본간 수출입의 대체 보완성을 실증적으로 분석하려는 시도이다. 실증분석결과에 의하면 한-중-일 3국간 수출입의 경우 단기적으로는 보완관계를 유지하면서 상호간의 수출증대에 기여하는 측면이 있지만, 장기적으로는 한-중-일 3국 모두 대체관계를 형성하고 있어서 상호간의 수출을 감소시키는 것으로 나타났다. 따라서 향후 우리나라 무역정책의 경우 단기적으로는 시장에 의존하는 수출입 정책을 채택해도 무리가 없겠지만 장기적으로는 중국이나 일본과의 무역에서 대체관계에 따른 수출 감소에 대비할 수 있는 정책을 수행하여야 할 것이다. 즉, 한-중-일 3국간 무역에서 단기적으로는 기존의 산업구조를 바탕으로 시장에 영향을 미치는 환율정책이나 무역정책을 중심으로 운용해도 무리가 없겠지만 중장기적으로 무역구조에 영향을 미치는 산업구조의 개편이나 한-중-일 3국간 FTA 체결 등은 대체관계를 고려해서 추진하여야 할 것이다.

• 한국물환경학회지
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• 제25권2호
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• pp.306-310
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• 2009

Packed-bed reactor for removing ammonia was tested at different loading rates. Nitrifiers for ammonia removing was encapsulated in gel media which consisted of polyethlene glycol, alginate and activated carbon. The removal efficiency was nearly 100% when ammonia loading was $12g/m^3/hr$, and the maximum elimination capacity (EC) achieved on this study was $18g/m^3/hr$. The initial microbial portion of nitrifiers in the media was about 82% and it was increased to more than 90% at the end of the operation. Short-term shock loading test was carried out to survey the stability of the media. The inlet loading rates were varied from 2 to $20g/m^3/hr$. The packed-bed reactor overcame the shock loading i.e. removal efficiency recovered rapidly from about 80% to almost 100% within 6 hrs. The results of Live/Dead cell test showed that nitrifiers maintained there activity in the encapsulated media during the test and also against ammonia shock load.

• 한국도로학회논문집
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• 제16권6호
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• pp.19-25
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• 2014

PURPOSES : This study was performed to evaluate the possibility of Indirect Tensile Strength (ITS) as a testing method that can predict cracking on pavement. METHODS : Three asphalt binders and one kind of aggregate were used in this study, and all asphalt mixtures were produced using Gyratory Compactor followed asphalt mix design. The ITS test was performed for the mixture which are artificially short-term aged using the oven. The ITS properties were analyzed by air void, compaction temperature, asphalt content, and asphalt binder. RESULTS : The results of this study indicated that (1) the compaction temperature did not show relationship with the ITS test; (2) there was no specific trend between the asphalt content and the ITS test; (3) the ITS could reveal the property of kinds of asphalt binders; (4) the asphalt mixture that were produced at optimum temperature suggested by manufacturer did not exhibit optimum result for all asphalt binder. CONCLUSIONS : The possibility of ITS was confirmed from this study for replacement of the Marshall Stability method. However, it needs to perform in further studies of aggregate and compaction property to suggest a new ITS standard value.

• Journal of electromagnetic engineering and science
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• 제9권3호
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• pp.118-123
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• 2009

This paper discusses the design and fabrication of a reference signal generator for a naval radar system, including the vibration environment test. The transmit signals of the S-band radar system are synthesized by the reference signal and the phase noise must lower than - 130 dBc/Hz at a 10 kHz offset frequency. To achieve this specification, the phase noise of the reference signal needs to be less than -165 dBc/Hz at a 10 kHz offset. For achieving very low phase noise performance by the reference signal generator, the phase locked loop technique is applied with a 10 Hz loop bandwidth. Also, this reference signal generator has ${\pm}0.35\;ppb$ short-term stability to minimize instant phase errors and high vibration sensitivity against a ship's shaking, unbalanced rotating of antennas and so on.

• 한국콘텐츠학회논문지
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• 제22권3호
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• pp.81-93
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• 2022

주식 투자는 가장 널리 알려진 재테크 방법들 중 하나지만 실제 투자를 통해 수익을 얻기는 쉽지 않기 때문에 과거부터 효과적이고 안정적인 투자 수익을 얻기 위한 다양한 투자 전략들이 고안되고 시도되어 왔다. 그중 변동성 돌파 전략(Volatility Breakout)은 일일 단위로 일정 수준 이상의 범위를 뛰어넘는 강한 상승세를 돌파 신호로 파악하여 상승하는 추세를 따라가며 일 단위로 빠르게 수익을 실현하는 전략으로 널리 쓰이고 있는 단기 투자 전략들 중 하나이다. 그러나 주식 종목마다 가격의 추이나 변동성의 정도가 다르며 동일한 종목이라도 시기에 따라 주가의 흐름이 일정하지 않아 주가를 예측하고 정확한 매매 시점을 찾아내는 것은 매우 어려운 문제이다. 본 논문에서는 단순히 종가 또는 장기간에 걸친 수익률을 예측하는 기존 연구 방법들과는 달리 단기간에 수익을 실현할 수 있는 주식과 같은 시계열 데이터 분석에 적합한 양방향 장단기 메모리 심층 신경망을 이용하여 변동성 돌파 전략 기반 매매 시의 수익률을 예측하여 주식을 매매하여 방법을 제안한다. 이렇게 학습된 모델로 테스트 데이터에 대하여 실제 매매를 가정하여 실험한 결과 기존의 장단기 메모리 심층 신경망을 이용한 종가 예측 모델보다 수익률과 안정성을 모두 상회하는 결과를 확인할 수 있다.

• Journal of Pharmaceutical Investigation
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• 제37권2호
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• pp.79-84
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• 2007

This study was aimed to establish analytical method of Bi to develop a guideline of the bioequivalence test of tripotassium dicitrato bismuthate (TDB). For this purpose, a simple, specific and sensitive inductively coupled plasma-mass spectrometry (ICP/MS) method were developed and validated in human plasma. Various concentrations of bismuth standard solution (0-25ng/mL) were prepared with distilled water and human blank plasma. To 10mL of the volumetric flasks, 2mL of blank plasma was added with 8ml of distilled water. Bi standard solution was added to prepare the calibration samples and injected into ICP-MS. The plasma samples obtained from volunteers given 3 tablets of bismuth (total 900mg as TDB) were analyzed as described above. As a result, the coefficients of variation were <20% in quantitation limit (0.2 ng/mL) and <15% at the rest of concentrations. The stability test by repeated freezing-thawing cycles showed that the samples were stable only for 24hr. The stability tested for samples with a short-term period of storage at room temperature and pre-treatment prior to the analysis showed very stable over 24hr. In 8 healthy Korean subjects received Denol tablets at the dose of 900mg bismuth, AUC, $C_{max},\;T_{max}$ and half-life $(t_{1/2})$ were determined to be $198.33{\pm}173.78 ng{\cdot}hr/mL,\;64.48{\pm}27.06 ng/mL,\;0.52{\pm}0.21 hr,\;and\;5.15{\pm}2.67 hr$, respectively, from the plasma bismuth concentration-time curves. In conclusion, the method was suitable for the determination of bismuth in human plasma samples and could be applied to bioequivalence test of bismuth tablet.

• The Journal of Asian Finance, Economics and Business
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• 제8권10호
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• pp.239-247
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• 2021

Central Bank authorities should carefully manage inflation rate uncertainties to achieve economic growth and development not only in the short-run but also in the long-run. Since inflation is a key macroeconomic variable, an increased understanding about its behavior is undoubtedly important. Thus, paper employs unit root with breakpoints to examine the mean reverting behavior of inflation rate in the Philippines using monthly data from 2002 to 2020. Empirically, the unit root breakpoint innovational and additive outlier tests favor the stationarity or mean reverting behavior of inflation in the Philippines. Also, results of standard unit root tests, ADF, PP, GLS-Dickey-Fuller, KPSS and NP, provide strong evidence of mean reverting processes. The mean reverting behavior of inflation rate reveals that the monetary policy using inflation targeting framework has succeeded in reducing chronic inflation persistence in the Philippines. Thus, this research supports inflation targeting policy that aims to maintain general price level stability for the Philippine economy's long-term growth and development prospects. The findings of this research remain important for the central bankers for not only providing them better understanding about the behavior of inflation rate, but also helping them formulate and implement policy reforms related to money, credit and banking.

• 한국운동역학회지
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• 제14권3호
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• pp.67-82
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• 2004

The purpose of this study was to evaluate the function and the safety of an additional weight shoe developed for the improvement of aerobic capacity, and to improve some problems found by subject's test for an additional weight shoe. The subjects employed for this study were 10 college students. 4 video cameras, AMTI force platform and Pedar insole pressure distribution measurement device were used to analyze foot motions. The results of the study were as follows: 1 The initial achilles tendon angle and initial rearfoot pronation angle of an additional weight shoe during walking were 183.7 deg and 2.33 deg, respectively, and smaller than a barefoot condition. Maximum achilles tendon angle and the angular displacement of achilles tendon angle were 185.35 deg and 4.21 deg respectively, and smaller than barefoot condition. Thus rearfoot stability variables were within the permission value for safety. 2. Maximal anterior posterior ground reaction force of additional weight shoe was appeared to be 1.01-1.2 B.W., and was bigger than a barefoot condition. The time to MAPGRF of an additional weight shoe was longer than a barefoot condition. Maximal vertical ground reaction force of additional weight shoe was appeared to be 2.3-2.7 B.W., and was bigger than a barefoot condition in propulsive force region. But A barefoot condition was bigger in braking force region. The time to MVGRF of an additional weight shoe was longer than a barefoot condition. 3. Regional peak pressure was bigger in medial region than in lateral region in contrast to conventional running shoes. The instant of regional peak pressure was M1-M2-M7-M4-M6-M5 -M3, and differed form conventional running shoes. Regional Impulse was shown to be abnormal patterns. There were no evidences that an additional weight shoe would have function and safety problems through the analysis of rearfoot control and ground reaction force during walking. However, There appeared to have small problem in pressure distribution. It was considered that it would be possible to redesign the inner geometry. This study could not find out safety on human body and exercise effects because of short term research period. Therefore long term study on subject's test would be necessary in the future study.