• 생명과학회지
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• 제15권3호
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• pp.387-396
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• 2005

The aims of the study were to establish a short-term screening test for detecting testicular toxicity of chemicals in rats and to determine whether a 2-week administration period is sufficient to detect testicular toxicity of 2-bromopropane (2-BP) as an example. Male Sprague-Dawley rats were subcutaneously administered with 1000 mg/kg/day of 2-BP or its vehicle for 2 weeks. Ten male rats each were sacrificed on days 3, 7 and 14 after the initiation of treatment. Parameters of testicular toxicity included genital organ weights, testicular sperm head counts, epididymal sperm counts, motility and morphology, and qualitative and quantitative histopathologic examinations. The early histopathological changes observed on day 3 of treatment included degeneration of spermatogonia and spermatocytes, multinuclear giant cells, mature spermatid retention, vacuolization of Sertoli cells, and decreased number of spermatogonia in stages II and V. On day 7 of treatment, atrophy of seminiferous tubules, exfoliation of germ cells, degeneration of spermatogonia and spermatocytes, multinuclear giant cells, mature spermatid retention, vacuolization of Sertoli cells, decreased number of spermatogonia in stages II and V, and decreased number of spermatocytes in stages VII and XII. On day 14 after treatment, a significant decrease in the weights of testes and seminal vesicles was found. Atrophy of seminiferous tubules, exfoliation of germ cells, degeneration of spermatogonia and spermatocytes, mature spermatid retention, vacuolization of Sertoli cells, decreased number of spermatogonia in stages II and V, and decreased number of spermatocytes in all spermatogenic stages were also observed. In addition, a slight non-significant decrease in testicular sperm head counts, daily sperm production rate and epididymal sperm counts was found. The results showed that 2 weeks of treatment is sufficient to detect the adverse effects of 2-BP on male reproductive organs. It is considered that the short-term testicular toxicity study established in this study can be a useful tool for screening the testicular toxic potential of new drug candidates in rats.

• 한국수산과학회지
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• 제45권1호
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• pp.11-16
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• 2012

In coastal areas that are affected by continuous, seasonal or occasional pollution sources, bivalves accumulate biological contaminants such as pathogenic bacteria. We investigated the effect of natural seawater relaying and electrolyzed seawater depuration on the bacteriological quality of artificially contaminated oysters Crassostrea gigas and short-necked clams Ruditapes philippinarum to suggest an alternative method of shellfish sanitation control.When artificially contaminated oysters and short-necked clams (fecal coliform level 1,700 MPN/100 g) were relayed into a sea area of safe bacteriological water quality, the fecal coliform level dropped to below 110 MPN/100 g after 1 day. The bacteriological quality of oysters and short-necked clams that are contaminated at a fecal coliform level of 1,700 MPN/100 g could be improved, and become appropriate for raw consumption by a single day relay under proper environmental conditions. When artificially contaminated oysters (fecal coliform level 330 MPN/100 g) were depurated with electrolyzed seawater, 94% of fecal coliform was eliminated after 12 h and fecal coliform was undetectable after 24 h. After 24 h depuration with electrolyzed seawater, the fecal coliform level of short-necked clams with initial fecal coliform of 2,400 MPN/100 g was below 20 MPN/100 g. However, the fecal coliform level of short-necked clams with initial fecal coliform of 17,000 MPN/100 g was relatively high, at 790 MPN/100 g, even after 24 h of depuration with electrolyzed seawater, because of the repeated cycle of excretion and accumulation of fecal coliform in shellfish tissue under the closed depuration environment. Such natural seawater relaying and electrolyzed seawater depuration can be restrictively applied to improve or secure the bacteriological quality of oysters and short-necked clams in accordance with safety levels for bivalves for raw consumption.

• Journal of Acupuncture Research
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• 제24권6호
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• pp.207-213
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• 2007

Objectives : This study was designed to investigate the effect of SAAM-Acupuncture and GamigungguitangGaNokyong(GMGGTN) on Ankle Fracture. Methods : SAAM-Acupuncture was administered once daily. The following points were selected: $SP_3$(太白), $LU_9$(太淵), $LI_{11}$(曲池). After short leg casting, GMGGTN was taken 3 times per a day from March 28th to April 30th. We evaluated the patient using the Visual Analogue Scale(VAS) and Ankle Range of Motion(ROM). Results : After about 3 weeks of treatment, the patient's short leg cast was removed a week earlier than expected and the patient could walk without crutches and physical therapy. Their VAS changed from 10 to 1. And after added treatment for 2 weeks, there was no pain and limitation of ROM. Conclusions : According to the results, SAAM-Acupuncture and GMGGTN may have rapid effects on ankle fractures. But further studies are required to confirm this effect.

• 한국태양에너지학회:학술대회논문집
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• 한국태양에너지학회 2011년도 추계학술발표대회 논문집
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• pp.105-110
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• 2011

The objective of this study is to analyze the characteristic of radiation environment in the urban and rural through the field observation in the summer. The radiation balance was compared through the measurement of the shortwave radiation and long-wave radiation in the urban, sub-urban, and rural. The following conclusion could be obtained from this research. (1) In the results of observation including the rain-day, it was found that the short wave radiance in the urban is lower about 10% than the rural. (2) The upper part of atmosphere layers in the urban area absorb much short wave radiation energies compared with the rural relatively. It can increase the temperature of the upper part of atmosphere layers and the emittance of long wave radiation. (3) The ratio of the downward short wave radiation to the downward long wave radiation was 1.24 for the urban, 1.28 for sub-urban and1.35 for rural. It can be estimated that the atmosphere condition of the rural is better than that of other areas.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 학술회의 논문집 정보 및 제어부문 B
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• pp.588-591
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• 2003

This paper presents a new short-term load forecasting system using data mining. Since the electric load has very different pattern according to the day, it definitely gives rise to the forecasting error if only one forecasting model is used. Thus, to resolve this problem, the fuzzy model-based classifier and predictor are proposed for the forecasting of the hourly electric load. The proposed classifier is the multi-input and multi-output fuzzy system of which the consequent part is composed of the Bayesian classifier. The proposed classifier attempts to categorize the input electric load into Monday, Tuesday$\sim$Friday, Saturday, and Sunday electric load, Then, we construct the Takagi-Sugeno (T-S) fuzzy model-based predictor for each class. The parameter identification problem is converted into the generalized eigenvalue problem (GEVP) by formulating the linear matrix inequalities (LMIs). Finally, to show the feasibility of the proposed method, this paper provides the short-term load forecasting example.

• Physical Therapy Rehabilitation Science
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• 제5권2호
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• pp.78-83
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• 2016

Objective: The purpose of this study was to investigate whether the intrinsic foot muscle training method can improve the medial longitudinal arch in patients with chronic ankle injury and with pronated feet, as well as to investigate for the most effective exercise method for these patients. Design: Randomized controlled trial. Methods: Thirty men and women with pronated feet had participated in this study and were allocated to either the short foot exercise group (SFEG) or the towel curl exercise group (TCEG) randomly. SFEG and TCEG underwent exercises three times a week for 8 weeks, with three sets per day, totalling up to 5 minutes per day. The navicular drop test (NDT) was used in order to assess for changes in the medial longitudinal arch and the Cumberland ankle instability tool (CAIT) was used to assess for ankle instability of the chronic ankle sprain patients. Results: There was a significant increase in CAIT scores in the SFEG (p<0.05) and a significant difference between groups was presented (p<0.05). The NDT scores were significantly decreased in both groups (p<0.05). In the SFEG, the NDT scores were more decreased than in the TCEG (p<0.05). Conclusions: These results suggest that short foot exercises are more effective in providing intrinsic foot muscle training for patients with pronated feet among chronic ankle sprain patients. Furthermore, short foot exercises may be used to provide ankle stability.

• 조명전기설비학회논문지
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• 제16권2호
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• pp.98-103
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• 2002

전력수요를 예측할 경우 가장 중요한 문제 중의 하나가 특수일 부하의 처리문제이다. 따라서 본 연구에서 길고(구정, 추석) 짧은(식목일, 현충일 등) 특수일 피크 부하를 신경회로망과 회귀모형을 이용하여 예측하는 방법을 제시한다. 신경회로망 모형의 특수일 부하 처리는 패턴 변환비를 이용하며, 4차의 직교 다항 회귀모형은 과거의 10년 (1985∼1994)간의 특수일 피크부하 자료를 이용하여 길고 짧은 특수일 부하를 예측한다. 특수일 피크 부하를 예측한 결과, 신경회로망 모형의 주간 평균 예측 오차율과 직교 다항 회귀모형의 예측 오차율을 분석한 결과 1∼2[%]대로 두 모형 모두 양호한 결과를 얻었다. 또한 4차의 직교 다항 회귀 모형의 수정결정계수 및 F 검정을 분석한 결과 구성한 예측 모형의 타당성을 확인하였다. 두 모형의 특수일 부하를 예측한 결과를 비교해 보면 긴 특수일 부하를 예측할 때는 패턴 변환비를 이용한 신경회로망 모형이 보다 더 효과적이었고, 짧은 특수일 부하를 예측할 경우에는 두 방법 모두 유효하였다.

• Clinical and Experimental Reproductive Medicine
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• 제41권3호
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• pp.125-131
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• 2014

Objective: Under estrogen deficiency, blastocysts cannot initiate implantation and enter dormancy. Dormant blastocysts live longer in utero than normal blastocysts, and autophagy has been suggested as a mechanism underlying the sustained survival of dormant blastocysts during delayed implantation. Autophagy is a cellular degradation pathway and a central component of the integrated stress response. Reactive oxygen species (ROS) are produced within cells during normal metabolism, but their levels increase dramatically under stressful conditions. We investigated whether heightened autophagy in dormant blastocysts is associated with the increased oxidative stress under the unfavorable condition of delayed implantation. Methods: To visualize ROS production, day 8 (short-term dormancy) and day 20 (long-term dormancy) dormant blastocysts were loaded with $1-{\mu}M$ 5-(and-6)-chloromethyl-2', 7'-dichlorodihydrofluorescein diacetate, acetyl ester (CM-$H_2DCFDA$). To block autophagic activation, 3-methyladenine (3-MA) and wortmannin were used in vivo and in vitro, respectively. Results: We observed that ROS production was not significantly affected by the status of dormancy; in other words, both dormant and activated blastocysts showed high levels of ROS. However, ROS production was higher in the dormant blastocysts of the long-term dormancy group than in those of the short-term group. The addition of wortmannin to dormant blastocysts in vitro and 3-MA injection in vivo significantly increased ROS production in the short-term dormant blastocysts. In the long-term dormant blastocysts, ROS levels were not significantly affected by the treatment of the autophagy inhibitor. Conclusion: During delayed implantation, heightened autophagy in dormant blastocysts may be operative as a potential mechanism to reduce oxidative stress. Further, ROS may be one of the potential causes of compromised developmental competence of long-term dormant blastocysts after implantation.

• Nutrition Research and Practice
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• 제4권5호
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• pp.393-399
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• 2010

Enteral nutritional support has been used via tube feeding for dysphagic stroke patients. We performed long and short term trials to evaluate the effects of commercial enteral nutritional supports on nutrition and health in stroke patients (mRS = 3~5) and quality of life in their caregivers. For a long term study, we recruited chronic (${\geq}$ 1 yrs) stroke patients (n = 6) and administered them 6 cans/day (1,200 kcal) of the commercial enteral formula N for 6 months according to IRB-approved protocol. We collected peripheral blood at 0, 2, 4 and 6 months. For a short term study, we recruited acute (${\leq}$ 3 months) stroke patients (n = 12) and randomly administered them two different commercial enteral formulas, N or J, for 2 weeks. We collected their blood at 0, 4, 7 and 14 day of the administration. Blood samples were analyzed to quantify 19 health and nutritional biomarkers and an oxidative stress biomarker, malondialdehyde (MDA). In order to evaluate quality of life, we also obtained the sense of competence questionnaire (SCQ) from all caregivers at 'before' and 'after trials'. As results, the enteral formula, N, improved hemoglobin and hematocrit levels in the long term trial and maintained most of biomarkers within normal ranges. The SCQ levels of caregivers were improved in the long term treatment (P < 0.05). In a case of the short term study, both of enteral formulas were helpful to maintain nutritional status of the patients. In addition, MDA levels were decreased in the acute patients following formula consumption (0.05 < P < 0.1). Most of health and nutrition outcomes were not different, even though there is a big difference in price of the two products. Thus, we evaluate the formula N has equal nutritional efficacy compared to the formula J. In addition, long term use of enteral formula N can be useful to health and nutrition of stroke patients, and the quality of life for their caregivers.

• 대한한방소아과학회지
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• 제33권4호
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• pp.37-46
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• 2019

Objectives The purpose of this study is to confirm the efficacy and safety of the treatment of with fermented oyster extract on height growth in children with short stature. Methods A total of 100 people, between 6 and 11 years old, will be participated in a randomized, double-blind, and placebo-controlled human study. The fermented oyster group will take 500 mg of fermented oyster extract once a day for 24 weeks. The placebo group will take 3400 mg of fructooligosaccharide as placebo once a day for 24 weeks. The outcomes of the intervention will be measured at the baseline, 6 week, 12 week, 18 week, and 24 week. The primary outcome is the changes in height from the baseline. The secondary outcomes are growth rate, height SDS, bone age, GH, IGF-1, IGFBP-3, osteocalcin, BALP, DPD, and LH. Results This trial was approved by the institutional review board of Pusan National University Korean Medicine Hospital (registry number: PNUKHIRB-2019002). Recruitment of the research participants will be opened from May 2019 till December 2019. Conclusions This study will provide clinical information to determine the efficacy and safety of the treatment with fermented oyster extract on height growth in children with short stature.