• BMB Reports
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• 제55권10호
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• pp.512-517
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• 2022

Traumatic brain injury (TBI) is brain damage which is caused by the impact of external mechanical forces. TBI can lead to the temporary or permanent impairment of physical and cognitive abilities, resulting in abnormal behavior. We recently observed that a single session of early exercise in animals with TBI improved their behavioral performance in the absence of other cognitive abnormalities. In the present study, we investigated the therapeutic effects of continuous exercise during the early stages of TBI in rats. We found that continuous low-intensity exercise in early-stage improves the locomotion recovery in the TBI of animal models; however, it does not significantly enhance short-term memory capabilities. Moreover, continuous early exercise not only reduces the protein expression of cerebral damage-related markers, such as Glial Fibrillary Acid Protein (GFAP), Neuron-Specific Enolase (NSE), S100β, Protein Gene Products 9.5 (PGP9.5), and Heat Shock Protein 70 (HSP70), but it also decreases the expression of apoptosis-related protein BAX and cleaved caspase 3. Furthermore, exercise training in animals with TBI decreases the microglia activation and the expression of inflammatory cytokines in the serum, such as CCL20, IL-13, IL-1α, and IL-1β. These findings thus demonstrate that early exercise therapy for TBI may be an effective strategy in improving physiological function, and that serum protein levels are useful biomarkers for the predicition of the effectiveness of early exercise therapy.

• Journal of Trauma and Injury
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• 제33권3호
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• pp.175-180
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• 2020

Resuscitative endovascular balloon occlusion of the aorta (REBOA) is widely performed as an adjunct to resuscitation or bridge to definitive control of non-compressible torso hemorrhage in patients with hemorrhagic shock. It is a crucial adjunct for the maintenance of cerebral and coronary perfusion during resuscitation. However, in polytrauma patients with concomitant neurotrauma, such as traumatic brain injury (TBI) or spinal cord injury, the physiological effects of REBOA are unclear. In this report on REBOA performed in a clinical setting for polytrauma patients with spinal cord injury or TBI, the physiological effects of REBOA in neurotrauma are reviewed.

• Journal of Chest Surgery
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• 제23권4호
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• pp.736-744
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• 1990

From Jan. 1985 to Sep. 1989, four hundred and ten patients were admitted to the department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine with a diagnosis of nonpenetrating chest trauma. The most common cause of injury were motor vehicle accidents(75.1%) with the prevalent age group being their forties. The four most common findings were rib fracture(83.4%), hemothorax(50.7%), pneumothorax(24.6%) and clavicle fracture(12.0%), Fifty piratory insufficiency and the ventilation time was correlated with 6 fators : 1) shock 2) endotracheal intubation or tracheostomy 3) hemothorax 4) clavicle fracture 5) flail chest 6) more than three combined injuries or combined head injury. Ventilatory care was also related with mortality and complications such as pneumonia sepsis and empyema thoracis(p<0.05). The most common organism of post-traumatic infection were Pseudomonas and Staphylococcus.

• Journal of Trauma and Injury
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• 제34권3호
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• pp.198-202
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• 2021

Super-selective renal artery embolization is an increasingly popular technique for the management of traumatic, low-grade renal trauma. When performed in distal arterial branches, this intervention enables tissue preservation and arrest of hemorrhage, but it may not be practical in cases of multifocal, high-grade renal injuries. In such cases, surgical nephrectomy remains the more common treatment modality to ensure hemodynamic control. We present the unique case of a patient who presented in hemorrhagic shock following a major trauma that resulted in a grade 5 renal injury treated with complete renal artery embolization using Gelfoam, resulting in hemodynamic stabilization. Interestingly, imaging 1 month after embolization revealed residual enhancement of the inferior pole of the kidney, suggesting reconstitution of flow and partial renal salvage. Ultimately, transcatheter "nephrectomy" with careful selection of a temporary embolic agent may serve as a safe and efficient alternative to surgical nephrectomy with the added possibility of preserving partial renal perfusion and function in the emergent setting.

• Journal of Trauma and Injury
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• 제34권1호
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• pp.61-65
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• 2021

A Morel-Lavallée lesion is a closed degloving injury caused by traumatic separation of the skin and subcutaneous tissue from the underlying fascia. However, since physicians tend to focus on treating the bone fracture, hemodynamic instability accompanying a Morel-Lavallée lesion can sometimes be overlooked. We report the case of a hemodynamically unstable 73-year-old man who had a Morel-Lavallée lesion of the thigh, but no femur fracture. Angiography showed active bleeding from the muscular branch of the right deep femoral artery, which was then successfully embolized.

• Journal of Trauma and Injury
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• 제19권2호
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• pp.201-205
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• 2006

Tension viscerothorax (gastrothorax) is rare life-threatening disease which is caused by air trapped in viscera. A distended viscera in the hemi-thorax shifts the mediastinal structures and causes extra-cardiac obstructive shock. A defective diaphragm is caused by abdominal trauma or a congenital anomaly. Traumatic diaphragmatic injury can be missed until herniation develops several years after blunt trauma. In our case, a 10-year old boy developed hemodynamic compromise in the emergency department. Three years earlier, he had suffered blunt abdominal trauma during a pedestrian traffic accident, but there was no evidence of diaphragmatic injury at that time. He was successfully resuscitated by gastric decompression and an emergent thoracic operation. The operation finding revealed a traumatic diaphragmatic injury. Tension viscerothorax is a rare, but catastrophic, condition, so we suggest that addition of tension viscerothorax to the Advanced Trauma and Life Support (ATLS) guidelines may be helpful.

• Journal of Trauma and Injury
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• 제25권3호
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• pp.72-78
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• 2012

Purpose: Clinical observation and research findings show that acute traumatic coagulopathy (ATC) is a major factor that must be addressed in the early care of severe trauma patients. ATC is associated with increased transfusion requirements and poor clinical outcomes. This study aimed to correlate the early predictable factors of ATC with the outcomes in severe trauma patients. Methods: Retrospective data from the trauma registry on severe trauma patients (Injury Severity Score (ISS) ${\geq}16$) were used to identify variables independently associated with coagulopathy. Univariate associations were calculated, and a multivariable logistic regression analysis was used to determine variables independently associated with ATC. Results: Patients were mostly male, aged $51.9{\pm}17.8$ years, with an injury severity score of $24.1{\pm}12.4$. ATC, as diagnosed in the emergency department (ED), occurred in 17% of the severe trauma patients. Using a multivariable logistic regression analysis, early predictable variables independently associated with ATC were base deficit (odds ratio (OR): 13.03; 95% confidence interval (CI): 3.47-48.93), acute liver injury (OR: 4.24; 95% CI: 1.06-17.00), and transfer from another hospital (OR: 21.00; 95% CI: 3.23-136.60). Conclusion: ATC is associated with mortality in severe trauma patients, and some variables associated with trauma and shock are an independent predictors of ATC. These variables contribute to the early recognition and management of coagulopathy, which may improve the outcome from trauma resuscitation.

• Journal of Chest Surgery
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• 제30권4호
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• pp.402-407
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• 1997

1986년 3월부터 1995년 3월까지 본 마산삼성 병원 흉부외과에서 경험한 총 28례의 외상성 횡 경 막 손상 환자를 분석 하였다. 들상에 의한 경우가 20례, 자상인 경우가 8례로서 둔상인 경우 1)례가 좌측, 자상인 경우 5례가 좌측으로 전반적으로 좌측이 우측보다 많았다. 대부분 다발성 손상을 동반하였으며 모든 예에서 흉통, 호흡곤란, 복통 등의 소견을 관찰할 수 있었고 내원당시 응급실에서 횡경막 파열을 의심할 수 있었던 경우는총25례로서 흉부X선 20례 UGI 3례, 폐쇄식 흉관 삽관식 손가락으로 파열공의 직접 확인이 2례 였다. 수술적 접근은둔상의 경우개흉술이 16례,개흉복술이 1례,개복술이 I례며,관통상의 경우는개흉술 3례, 개복술이 5례로서 수상후부 터 수술까지의 경과시간은 5시간 이내가 19례였다. 좌측 손상시 12례에서 위장이 늑막강내로 올라가 있었으며, 모든 결손은 비홉수성 봉합사를 사용하여 직접 단순 봉합을 하였으며, 술후 5례에서 패혈증, 저혈성 쇽크, 두부손상, 신부전 으로 술후 3일이내 사 망하였다.

• Journal of Chest Surgery
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• 제29권11호
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• pp.1257-1262
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• 1996

연세대학교 원주의과대학 흉부외과학교실에서는 1989년 1월부터 1996년 2월까지 외상성 횡격막 파열로 진단되어 수술을 시행하였던 환자 50례를 대상으로 하였으며, 남녀 성비는 4:1이였다. 연령 분포는 2세부터 80세까지로 평균 연령은 37세 였다. 외상의 종류로는 둔상이 39례였고 관통상이 11례로서, 둔상인 경우 교통사고가 29례, 추락사고 7례, 경운기 사고가 3례였으며, 관통상인 경우에는 자상 9례, 총상 1례, 유리에 찔린 경우가 1례 였다. 가장 빈번한 증상은 호흡곤란, 흉통 및 복통이었고, 파열 부위는 둔상인 경우 좌측이 30례, 우측이 9례였으며, 관통상인 경우에는 좌측이 8례, 우측이 3례였다. 수술 접근 방법은 18례에서 개흉술을 시행하였고 3례는 개흉 및 개복술을, 29례는 개복술을 시행하였다. 수술후 합병증은 15례로서 둔상인 경우에는 창상 감염이 5례, 호흡 부전이 3례 ,수흉 및 장폐쇄가 각각 2례였으며 농흉, 신부전 및 패혈증이 각각 1례였다. 관통상인 경우는 창상 감염이 2례, 농흉이 1례였다. 사망은 3례로서 사망 원인은 패혈성 쇼크, 뇌손상 및 호흡 부전이 각각 1례였다.

• 한국심리학회지 : 문화 및 사회문제
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• 제28권3호
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• pp.441-481
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• 2022

본 연구는 코로나 19 시기 워킹맘의 일과 가정의 균형과 관련된 경험을 탐색하고자 하였다. 이를 위해 1명 이상의 초등학생 이하의 자녀를 둔 시간제와 전일제 워킹맘 17명을 연구 대상자로 모집하여 심층면접을 실시하였다. 심층면담 내용을 근거이론 방법으로 분석한 결과 106개의 개념, 50개의 하위범주, 24개의 범주가 도출되었다. 코로나 19 시기에 워킹맘이 일과 가정을 양립하는 과정에서 경험하는 중심현상은 '신체적, 정서적 소진', '역할 갈등 상황에서의 불안감과 죄책감', '워킹맘이 겪는 일자리 위기', '가족 갈등 심화'로 나타났다. 워킹맘이 시간의 흐름에 따라 중심현상을 극복하여 일과 가정의 양립을 이루는 과정은 '충격과 혼란 단계', '고군분투 단계', '적극적 대처와 타협 단계', '수용 단계', '외상 후 성장 단계'의 5단계로 파악되었다. 이러한 연구 결과를 바탕으로 코로나 19 시기 워킹맘의 일과 가정의 양립 경험에 대한 논의와 후속 연구를 위한 제언을 서술하였다.