• Journal of Korean Ophthalmic Optics Society
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• v.18 no.2
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• pp.93-99
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• 2013

Purpose: The aim of this study was to develop a dry eye test method using a paper based microfluidic device that improves inaccuracy caused by using one of current point-of-care dry eye tests such as Shirmer's. Methods: Wax printed hydrophilic chromatography papers were dyed with anthocyanin extracts to detect colorimetric display of liquid samples with varying pH. Fluid distribution rates were measured using artificial tears and human tears directly from 32 subjects. Results: With Shirmer's, fluid distribution rates with small amount of samples (less than $0.5{\mu}l$) were not displayed. However, with paper based microfluidic device, fluid imbibition distances over time were clearly showed. Also clinical results of dry eye from newly developed paper based microfluidic device showed correlation with the results from tear break up time tests. Conclusions: The newly developed paper based microfluidic devices were easy to use and exhibited more accurate clinical results than current dry eye point of care tests such as Shirmer's.

• Journal of Korean Ophthalmic Optics Society
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• v.5 no.2
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• pp.91-98
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• 2000

To investigate the distribution of dry eye and to accept diagnosis methods of dry eye in ophthalmic shop, this study was performed on 81 persons(male : 49, female : 32). 1. We divided two group for diagnosing dry eye by dry eye screening questionnaire : one was dry eye symptom group(49.3%) and the other was non-dry eye symptom group(50.7%). 2. Non-invasive break-up time(NIBUT) which was measured by using Tear $scope^{(R)}$ (Killer. co)was longer than invasive break-up time(IBUT). 3. A blink rate in dry eye symptom group(10%) was measured lesser than 10 cycle/min, in non-dry eye symptom group(14.9%). 4. In shirmer test there were lesser than 10mm/5min in dry eye symptom group(67.5%), in non-dry eye symptom group(39%). 5. Cornea and conjunctival staining by rose bengal represented Mild 25%, medium 36.25%, extreme 38.75% in dry eye symptom group. Non-dry eye symptom group was showed Mild 19.51%, medium 14.63%, extreme 12.19%. 6. These results showed that the patient showed dry eye symptom in 3 items of eye examination was 22.5%, 4 items 25%, 5 items 30%, 6 items 15%.