• 제목/요약/키워드: Shim Yeon-Su

검색결과 45건 처리시간 0.028초

Cardamonin Inhibits the Expression of Inducible Nitric Oxide Synthase Induced by TLR2, 4, and 6 Agonists

  • Kim, Ah-Yeon;Shim, Hyun-Jin;Kim, Su-Yeon;Heo, Sung-Hye;Youn, Hyung-Sun
    • 대한의생명과학회지
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    • 제24권2호
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    • pp.102-107
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    • 2018
  • Toll-like receptors (TLRs) play an important role for host defense against invading pathogens. The activation of TLRs signaling leads to the activation of $NF-{\kappa}B$ and the expression of pro-inflammatory gene products such as cytokines and inducible nitric oxide synthase (iNOS). To evaluate the therapeutic potential of cardamonin, which is a naturally occurring chalcone from Alpinia species (zingiberaceous plant species), $NF-{\kappa}B$ activation and iNOS expression induced by MALP-2 (TLR2 and TLR6 agonist) or LPS (TLR4 agonist) were examined. Cardamonin inhibited the activation of $NF-{\kappa}B$ induced by MALP-2 or LPS. Cardamonin also suppressed the iNOS expression induced by MALP-2 or LPS. These results suggest that cardamonin has the specific mechanism for anti-inflammatory responses by regulating of TLRs signaling pathway.

ICP-MS에 의한 지하수 중의 Germanium 분석에 관한 연구 (Determination of Germanium in Spring Waters by Inductively Coupled Plasma Mass Spectrometry)

  • 박경수;송승연;심의섭;김선태
    • 분석과학
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    • 제11권2호
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    • pp.120-124
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    • 1998
  • 지하수 중의 극미량 germanium을 ICP-MS로 신속, 정확하게 분석할 수 있었으며 질량수 74를 분석하는 것이 가장 방해영향이 적음을 알 수 있었다. 지하수 중의 약 30%만이 $0.1{\mu}g/L$ 이상의 germanium을 함유하였고, 유기 germanium을 포함하는 지하수의 존재도 확인하였다.

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배주배양 없이 재배메밀(Fagopyrum esculentum)과 자식성 야생메밀(F. homotropicum)의 종간잡종 육성 I. 한국재래종 및 외국품종의 F. homotropicum과의 교잡친화성 (Interspecific Hybridization between Fagopyrum esculentum and F. homotropicum without ovule culture I. Crossability of Korean landraces and foreign varieties with F. homotropicum)

  • 박철호;김연복;최수용;이상용;허권;신영범;정찬선
    • 한국작물학회:학술대회논문집
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    • 한국작물학회 1999년도 춘계 학술대회지
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    • pp.174-175
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    • 1999
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Antioxidants Stimulated by UV-B Radiation in Rice Seedling

  • Sung, Jwa-Kyung;Lee, Seung-Hwan;Lee, Su-Yeon;Shim, Myung-Bo;Kim, Tae-Wan;Song, Beom-Heon
    • 한국작물학회지
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    • 제49권2호
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    • pp.116-120
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    • 2004
  • In order to investigate low molecular antioxidants synthesized by enhanced UV-B radiation, we used the seedlings of two rice varieties. Woonjangbyeo, UV-tolerant, and Hwajoongbyeo, UV-susceptible, were subjected under supplemental UV-B irradiation. When rice seedlings were irradiated with UV light for short period, biosynthesis of total phenolic compound, ascorbate and glutathione were momently reduced. With an increase of UV-B radiation, however, those were slightly synthesized. The content of lipid peroxides in UV-challenged rice leaves was considerably increased after 12 hrs of UV-B treatment. Lipoxygenase activity under supplemental UV-B radiation was differently responded on rice varieties.

葛根解肌湯을 투여하여 치료한 단독 환자에 대한 임상보고 3례 (A Case Report for Three Cases of Erysipelas Applied Galgunhaegitang.)

  • 심상희;정동환;유미경;박수연;최정화;김종한;위통순
    • 한방안이비인후피부과학회지
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    • 제17권3호
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    • pp.174-180
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    • 2004
  • Erysipelas is a type of cellulitis in skin infection generally caused by group A ${\beta}$-hemolytic streptococci. An erysipelas skin lesion typically has a raised border that is sharply demarcated from normal skin. The underlying skin is painful, intensely red, hardened, swollen, and warm. Objectives: We reviewed three cases of erysipelas patients who hospitalized in Dongshin Univ. Suncheon Oriental medicine hospital from June 2001 to June 2002. Methods : We treated them with Galgunhaegitang(葛根解肌湯) for interior diease of Taeumin(太陰人) and also used acupuncture and cupping therapy. Results and Conclusions ; We had significant effects of Galgunhaegitang(葛根解肌湯) for three cases of erysipelas patients. So if the patient were a Taeumin(太陰人), we can consider using Galgunhaegitang(葛根解肌湯) for erysipelas. We can also use antibiotics properly in case there are high fever or open wounds.

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전처리 방법과 인공지능 모델 차이에 따른 대전과 부산의 태양광 발전량 예측성능 비교: 기상관측자료와 예보자료를 이용하여 (Comparison of Solar Power Generation Forecasting Performance in Daejeon and Busan Based on Preprocessing Methods and Artificial Intelligence Techniques: Using Meteorological Observation and Forecast Data)

  • 심채연;백경민;박현수;박종연
    • 대기
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    • 제34권2호
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    • pp.177-185
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    • 2024
  • As increasing global interest in renewable energy due to the ongoing climate crisis, there is a growing need for efficient technologies to manage such resources. This study focuses on the predictive skill of daily solar power generation using weather observation and forecast data. Meteorological data from the Korea Meteorological Administration and solar power generation data from the Korea Power Exchange were utilized for the period from January 2017 to May 2023, considering both inland (Daejeon) and coastal (Busan) regions. Temperature, wind speed, relative humidity, and precipitation were selected as relevant meteorological variables for solar power prediction. All data was preprocessed by removing their systematic components to use only their residuals and the residual of solar data were further processed with weighted adjustments for homoscedasticity. Four models, MLR (Multiple Linear Regression), RF (Random Forest), DNN (Deep Neural Network), and RNN (Recurrent Neural Network), were employed for solar power prediction and their performances were evaluated based on predicted values utilizing observed meteorological data (used as a reference), 1-day-ahead forecast data (referred to as fore1), and 2-day-ahead forecast data (fore2). DNN-based prediction model exhibits superior performance in both regions, with RNN performing the least effectively. However, MLR and RF demonstrate competitive performance comparable to DNN. The disparities in the performance of the four different models are less pronounced than anticipated, underscoring the pivotal role of fitting models using residuals. This emphasizes that the utilized preprocessing approach, specifically leveraging residuals, is poised to play a crucial role in the future of solar power generation forecasting.

남북한 치주과학 용어의 비교 (Comparison of Periodontology Terminology between South and North Korea)

  • 권태연;김범수;김재영;심상수;허진영
    • Journal of Periodontal and Implant Science
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    • 제32권4호
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    • pp.711-719
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    • 2002
  • Background : Terminology is a good index of reflections in conceptional imaginations, trends and technological advances in the field of their own. The purpose of this study is to compare the similarity and difference of terms in periodontology to evaluate the communicability between South and North Korea. These result may be particularly helpful for making glossary, academic communication and social unity at the time of reunion. Methods : This study was carried out by searching northern periodontology terminologies used in literatures published in North Korea and comparing those terms with the southern terms. The standard northen terms were not able to be distinguished, so the terms used frequently were chosen as the standard northern terms. Results : The South and North both use terms that stem from Chinese characters, but this tendency is stronger in the South. The main differences between the South and North are due to the North Korea's effort in converting terms into the native languages. There are also some differences in inscription of foreign language, spelling and spacing, and so on. Conclusion : The terminology using in South and North Korea in the field of periodontology is somewhat different but both side can be capable of communication. Now the basic efforts in both parts must be taken, such as establishing new terms, in order to relieve these differences.

Up-regulation of Idh3α causes reduction of neuronal differentiation in PC12 cells

  • Cho, Sun-A;Seo, Min-Ji;Ko, Je-Yeong;Shim, Jung-Hee;Yoo, Jin;Kim, Jung-Hee;Kim, Se-Yoon;Ryu, Na-Kyung;Park, Eun-Young;Lee, Han-Woong;Lee, Yeon-Su;Bahk, Young-Yil;Park, Jong-Hoon
    • BMB Reports
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    • 제43권5호
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    • pp.369-374
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    • 2010
  • The PC12 is the widely used cell line to study neuronal differentiation. We had extensively investigated the details of protein expression in differentiated PC12 cells by proteomic analysis. The cells were incubated at the presence of nerve growth factor. We had analyzed the expression changes in the differentiating PC12 cells by 2-dimensional electrophoresis and the identification of the proteins using MALDI-TOF MS. By comparing expression pattern in the time course, we identified the candidate genes which are associated with neuronal differentiation. Among these genes, we performed real-time PCR analysis to validate $Idh3{\alpha}$ expression by the time course. To identify the function of $Idh3{\alpha}$ in neuronal differentiation stage, the transfection of $Idh3{\alpha}$ to PC12 cells was performed. As a result, we proved that up-regulation of $Idh3{\alpha}$ causes reduction in neural differentiation of PC12 cells. Based on these data, we suggest that $Idh3{\alpha}$ plays a role to the neuronal differentiation.