• 한국임상수의학회지
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• 제28권1호
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• pp.154-158
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• 2011

A 8-year-old female Shih-tzu dog (weighting 4.5 kg) with history of both hindlimb lameness and cervical mass was presented to Veterinary Teaching Hospital, Gyeongsang National University. In physical examination, ataxia, kyphosis, back pain and cervical mass were identified. Marked periosteal new bone formation of the fourth lumbar vertebra and soft tissue opacity mass of cervical region were observed in survey radiographs. Transverse computed tomography (CT) scan obtained at the lumbar and cervical lesions shown a well defined multilobulated bony mass and partially destructive lytic lesions the fourth lumbar vertebral body and a enlarged retropharyngeal lymph node with heterogeneous contrast enhancement and moderately enhancing left tonsillar mass. Neoplastic squamous epithelium which have developed vessel and lymphocyte infiltration in surrounding tissue were confirmed based on histopathologic examination. Based on the diagnostic findings the dog was diagnosed as a cervical lymph node metastases of tonsillar squamous cell carcinoma.

• 한국임상수의학회지
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• 제26권1호
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• pp.48-53
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• 2009

4 년령 시쭈개 (체중 5.4 kg)가 심잡음과 운동불내성으로 내원하였다. 진단검사상 심한 폐동맥협착증으로 진단되었다 (우심실 유출로의 peak velocity of 6.4 m/s, 압력구배 165 mmHg). 본 환견은 3 cm (길이) ${\times}$ 1.5 cm (직경)의 Palmaz biliary stent를 이용하여 치료하였다. 시술후 환견의 폐동맥 협착증은 상당히 많이 개선되었다 (우심실 유출로의 of peak velocity가 3.0 m/s로 감소). 내원전 보였던 임상증상은 더 이상 보이지 않았지만 경미한 폐동맥 패쇄부전이 관찰되었다. 본 증례는 우리나라에서 최초로 시도된 스텐트를 이용한 폐동맥 협착증 증례이다.

• 한국임상수의학회지
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• 제27권4호
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• pp.440-444
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• 2010

5.2 kg의 7살령 중성화 된 수컷 시추가 심각한 신경증상(paddling, 무의식, 실명, 발작)으로 내원하였다. 내원 당시 ECG 상에 심실 유래의 심박동 약 140회의 가속성 심실 고유박동(AVIR)이 지속적으로 나타났다. 이 환축은 자기공명영상법(MRI)과 뇌척수액검사(CSF)를 통해 파종성 육아종성 뇌수막염(GME)로 잠정 진단 내려졌다. 신경증상은 스테로이드제와 항경련제, 이뇨제, 항생제, 20% 만니톨 정맥 주사 등으로 호전 되었으며 부정맥은(AIVR) mexiletin으로 통제되었다. 신경학적인 문제에 대한 응급 처치 후 증상의 호전에도 불구하고 항부정맥제 처치 없이는 심장의 리듬이 불안정 했기 때문에 항부정맥 처치는 신경증상이 완전히 소실 될 때까지 유지되었다.

• 한국임상수의학회지
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• 제35권3호
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• pp.103-106
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• 2018

A 12-year-old castrated male Shih Tzu presented with suspected hearing loss. The patient had no history of head trauma or exposure to ototoxic drugs. The results of neurologic and physical examinations were normal. An otoscopic examination showed that both the tympanic membranes and the external ear canals had a normal appearance. However, the results of brainstem auditory evoked response tests confirmed sensorineural deafness in the right ear and indicated conduction disturbances and brainstem abnormalities in the left ear. Magnetic resonance imaging was performed to confirm the causes of the conduction disturbances and brainstem abnormalities. Inflammatory changes in the left middle ear were highly suspected to be responsible for the findings in the left ear. The results of these examinations confirmed complete hearing loss in the right ear and indicated otitis media in the left ear, which could have been the cause of the conduction disturbances.

• 한국임상수의학회지
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• 제32권4호
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• pp.356-358
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• 2015

큰 크기의 각막천공에 안내용물 손상이 된 눈을 안구적출술을 시도하지 않고, 안구내용물적출술과 실리콘볼 삽입후 각막이식을 적용하여 치료하여 안구적출술보다 미용상 만족한 눈의 외관을 얻은 증례를 소개 하였다.

• 한국임상수의학회지
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• 제28권5호
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• pp.506-509
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• 2011

본 실험은 임상적으로 건강한 시츄 견 36 두, 비글 견 16 두에서 컴퓨터단층촬영을 이용하여 비중격의 해부학적 차이와 편위 정도를 평가하고자 실시되었다. 비중격의 편위 정도는 비중격 편위의 각도 및 거리 측정에 의해 평가되었다. 비중격 편위의 각도 및 거리는 비글 견보다 시쮸 견에서 유의적으로 높은 수치를 나타냈다. 시츄, 비글견 두 품종에서 체중 및 나이는 비중격 편위의 각도 및 거리와 모두 유의적인 관계는 관찰되지 않았다. 이 결과에 기초하여 비중격의 편위는 임상적으로 건강한 개에서도 관찰 가능하며, 특히 시츄 견에서 쉽게 관찰되는 것으로 생각된다.

• 한국임상수의학회지
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• 제39권5호
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• pp.258-263
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• 2022

An eight-year-old, intact female, Shih-Tzu, weighing 4.5 kg presented with complaints of anorexia, pale mucous membrane, and vomiting for the past 5 days. On physical examination, nausea, abdominal pain, and melena were noted. On hematologic examination, severe anemia and thrombocytosis were identified. On radiographs examination, soft tissue opacity with small faint mineral opacity mass in the mid-abdomen and two mineral opacity regions in the cranial aspect of mass were identified. Ultrasonographic findings showed thickening of descending duodenal wall with loss of layering and mineralization within the duodenal wall and mesentery adjacent to the duodenal lesion. Computerized tomography showed circumferential wall thickening of descending duodenum with mineralization. Mineralization of the mesentery and mesenteric lymph nodes was identified. Based on the diagnostic imaging, the tentative diagnosis was descending duodenal tumor with dystrophic mineralization. Endoscopy revealed mucosal hemorrhage and erythema within the descending duodenum and stomach. Surgery was performed, and mineralization in the pancreatic tail to duodenum and mesentery was found. Resection of the duodenum, regional lymph node, and mineralized pancreatic region and the duodenal anastomosis were performed. The histologic examination revealed a high-grade undifferentiated duodenal carcinoma with metastases to the regional lymph node and mesentery. The patient was managed with supportive therapy for 8 days and discharged. The patient was followed up for 5 months and there were no complications.

• 한국임상수의학회지
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• 제40권2호
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• pp.158-163
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• 2023

A 9-year-old spayed female Shih-Tzu was presented with a mass on the upper eyelid of the right eye (OD). The eyelid mass continued to enlarge along the eyelid margin and the eyelid skin. Throughout the follow-up examinations, the mass did not affect the palpebral conjunctiva OD. Until 9 months since the mass was first identified, the dog did not show any clinical signs related to the mass. However, after 11 months, the owner complained of the dog's discomfort on OD and decided on surgical excision of the mass. There were no abnormalities in the complete blood count and serum chemistry profiles. The pentagonal resection was performed to completely remove the mass in the eyelid. There were no suspicious findings of metastasis on whole-body computed tomography scan immediately before the surgery. On histopathology and immunohistochemistry for multiple myeloma oncogene-1, the eyelid mass was diagnosed as extramedullary plasmacytoma (EMP). Surgical margin of the mass was clearly cut. No recurrence was observed during the 5-month follow-up. EMPs on the eyelid have rarely been reported in dogs. Although EMP is a benign tumor, the mass showed invasive growth and grew toward the skin rather than the palpebral conjunctiva. No recurrence occurred when surgically removed with clean margins.

• Molecules and Cells
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• 제26권4호
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• pp.396-403
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• 2008

The first ORF of the ARV S1133 S1 segment encodes the nonstructural protein p10, which is responsible for the induction of cell syncytium formation. However, p10-dependent signaling during syncytium formation is fully unknown. Here, we show that dominant negative RhoA, Rho inhibitor C3 exoenzyme, ROCK/Rho-kinase inhibitor Y-27632 and Rac1 inhibitor NSC23766 inhibit p10-mediated cell fusion. p10 over-expression is concomitant with activation and membrane translocation of RhoA and Rac1, but not cdc42. RhoA and Rac1 downstream events, including JNK phosphorylation and transcription factor AP-1 and $NF-{\kappa}B$ activation, as well as MLC expression and phosphorylation are simultaneously activated by p10. p10 point mutant T13M possessed 20% fusion-inducing ability and four p10 fusion-deficient mutants V15M, V19M, C21S and L32A reduced or lost their ability to activate RhoA and Rac1 signaling. We conclude that p10-mediated syncytium formation proceeds by utilizing RhoA and Rac1-dependent signaling.

• 한국임상수의학회지
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• 제29권1호
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• pp.38-42
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• 2012

To determine the prevalence of the primary glaucoma (PG) and occurrence of primary glaucoma in initially non-affected normal eye. Medical records of 7751 dogs presented to the Veterinary Medical Teaching Hospital (VMTH) of Seoul National University (SNU) between January 2006 and December 2009 were examined. Among 7751 dogs, forty three dogs (0.55%) developed PG. The following breeds were included in the study: 18 American Cocker Spaniels, 17 Shih Tzus, 3 Mixed Breeds, 2 Malteses, 2 Pekingeses, and 1 Chow Chow. The mean onset age of PG in the first eyes was $7.1{\pm}2.3$ years in the all breeds. Compared with Mixed Breed (0.54%), American Cocker Spaniel (3.16%, p = 0.004) and Chow Chow (20%, p = 0.001) had a higher risk of developing glaucoma. Twenty six of 43 dogs (60.1%) were females with male-to-female ratio of 1:1.53. Twenty nine of 33 eyes (87.9%) developed glaucoma in the fellow eye within mean ${\pm}SD$ time of $17.5{\pm}2.7$ months. From this study, American Cocker Spaniel and Shih Tzu were the most frequent PG breed in Korea. Also, unilateral PG dogs developed glaucoma in the non-affected normal eye within approximately 17 months. The results indicate that prophylactic medical therapy with antiglaucoma agents should be considered to delay or prevent developing glaucoma in non-affected normal eye.