• Nuclear Engineering and Technology
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• 제53권1호
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• pp.178-187
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• 2021

Dual-cooled annular fuel allows a significant increase in power density while maintaining or improving safety margins. However, the dual-cooled design brings much higher Zircaloy charge in reactor core, which could cause a great threaten of hydrogen explosion during severe accidents. Hence, an innovative fuel combined dual-cooled annular geometry and SiC cladding was proposed for the first time in this study. Capabilities of fuel design and behavior simulation were developed for this new fuel by the upgrade of FROBA-ANNULAR code. Considering characteristics of both SiC cladding and dual-cooled annular geometry, the basic fuel design was proposed and preliminary proved to be feasible. After that, a design optimization study was conducted, and the optimal values of as-fabricated plenum pressure and gas gap sizes were obtained. Finally, the performance simulation of the new fuel was carried out with the full consideration of realistic operation conditions. Results indicate that in addition to possessing advantages of both dual-cooled annular fuel and accident tolerant cladding at the same time, this innovative fuel could overcome the brittle failure issue of SiC induced by pellet-cladding interaction.

• Steel and Composite Structures
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• 제38권5호
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• pp.563-582
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• 2021

The present study experimentally and analytically investigated the push-out behaviour of H-shaped steel section embedded in ultrahigh-performance fibre-reinforced concrete (UHPFRC). The effect of significant parameters such as the concrete types, fibre content, embedded steel length, transverse reinforcement ratio and concrete cover on the bond stress, development of bond stress along the embedded length and failure mechanism has been reported. The test results show that the bond slip behaviour of steel-UHPFRC is different from the bond slip behaviour of steel-normal concrete and steel-high strength concrete. The bond-slip curves of steel-normal concrete and steel-high strength concrete exhibit brittle behaviour, and the bond strength decreases rapidly after reaching the peak load, with a residual bond strength of approximately one-half of the peak bond strength. The bond-slip curves of steel-UHPFRC show an obvious ductility, which exhibits a unique displacement pseudoplastic effect. The residual bond strength can still reach from 80% to 90% of the peak bond strength. Compared to steel-normal concrete, the transverse confinement of stirrups has a limited effect on the bond strength in the steel-UHPFRC substrate, but a higher stirrup ratio can improve cracking resistance. The experimental campaign quantifies the local bond stress development and finds that the strain distribution in steel follows an exponential rule along the steel embedded length. Based on the theory of mean bond and local bond stress, the present study proposes empirical approaches to predict the ultimate and residual bond resistance with satisfactory precision. The research findings serve to explain the interface bond mechanism between UHPFRC and steel, which is significant for the design of steel-UHPFRC composite structures and verify the feasibility of eliminating longitudinal rebars and stirrups by using UHPFRC in composite columns.

• Journal of Microbiology and Biotechnology
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• 제32권6호
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• pp.792-799
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• 2022

As a vital problem in reproductive health, recurrent spontaneous abortion (RSA) affects about 1% of women. We performed this study with an aim to explore the molecular mechanism of interleukin-23 (IL-23) and find optimal or effective methods to improve RSA. First, ELISA was applied to evaluate the expressions of IL-23 and its receptor in HTR-8/SVneo cells after IL-23 treatment. CCK-8, TUNEL, wound healing and transwell assays were employed to assess the proliferation, apoptosis, migration and invasion of HTR-8/SVneo cells, respectively. Additionally, the expressions of apoptosis-, migration-, epithelial-mesenchymal transition- (EMT-) and p38 MAPK signaling pathway-related proteins were measured by western blotting. To further investigate the relationship between IL-23 and p38 MAPK signaling pathway, HTR-8/SVneo cells were treated for 1 h with p38 MAPK inhibitor SB239063, followed by a series of cellular experiments on proliferation, apoptosis, migration and invasion, as aforementioned. The results showed that IL-23 and its receptors were greatly elevated in IL-23-treated HTR-8/SVneo cells. Additionally, IL-23 demonstrated suppressive effects on the proliferation, apoptosis, migration, invasion and EMT of IL-23-treated HTR-8/SVneo cells. More importantly, the molecular mechanism of IL-23 was revealed in this study; that is to say, IL-23 inhibited the proliferation, apoptosis, migration, invasion and EMT of IL-23-treated HTR-8/SVneo cells via activating p38 MAPK signaling pathway. In conclusion, IL-23 inhibits trophoblast proliferation, migration, and EMT via activating p38 MAPK signaling pathway, suggesting that IL-23 might be a novel target for the improvement of RSA.

• Advances in nano research
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• 제12권3호
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• pp.301-317
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• 2022

Many studies have shown that Mg-Nd-Zn-Zr (abbreviated as JDBM) alloy has good biocompatibility and biodegradability as well as promotion of cell adhesion, proliferation and differentiation, and Wnt/β-catenin signaling pathway may play a unique role in joint tissue by controlling the function of chondrocytes, osteoblasts and synoviocytes. However, it is not clear whether the JDBM alloy induces osteochondral repair through Wnt/β-catenin signaling pathway. This study aims to verify that JDBM alloy can repair osteochondral defects in rats, which is realized by Wnt/β-catenin signaling pathway. In this study, the osteochondral defect model of the right femoral condyle non-weight-bearing area in rats was established and randomly divided into three groups: Control group, JDBM alloy implantation group and JDBM alloy implantation combined with signaling pathway inhibitor drug ICRT3 injection. It was found that after JDBM alloy implantation, the bone volume fraction (BVF) became larger, the bone trabeculae were increased, the relative expression of osteogenesis gene Runx2, Bmp2, Opn, Ocn and chondrogenesis gene Collagen II, Aggrecan were increased, and the tissue repair was obvious by HE and Masson staining, which could be inhibited by ICRT3.

• 국제학술발표논문집
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• The 7th International Conference on Construction Engineering and Project Management Summit Forum on Sustainable Construction and Management
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• pp.321-327
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• 2017

China is experiencing the urbanization at an unprecedented speed and scale in human history. The continuing growth of China's big cities, both in city land and population, has already led to great challenges in China's urban planning and construction activities, such as the continuous increase of construction and demolition (C&D) waste. Therefore, how to characterize cities' construction activities, particularly dynamically quantify the flows of building materials and construction debris, has become a pressing problem to alleviate the current shortage of resources and realize urban sustainable development. Accordingly, this study is designed to employ 4D-GIS (four dimensions-Geographic Information System) and Internet Plus to offer new approach for accurate but dynamic C&D waste management. The present study established a spatio-temporal pattern and material metabolism evolution model to characterize the geo-distribution of C&D waste by combing material flow analysis (MFA) and 4D-GIS. In addition, this study developed a mobile application (APP) for C&D waste trading and information management, which could be more effective for stakeholders to obtain useful information. Moreover, a cloud database was built in the APP to disclose the flows of C&D waste by the monitoring information from vehicles at regional level. To summarize, these findings could provide basic data and management methods for the supply and reverse supply of building materials. Meanwhile, the methodologies are practical to C&D waste management and beyond.

• 한국분말야금학회:학술대회논문집
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• 한국분말야금학회 2006년도 Extended Abstracts of 2006 POWDER METALLURGY World Congress Part 1
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• pp.453.1-453.1
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• 2006

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10949-10955
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• 2015

Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.

• Structural Monitoring and Maintenance
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• 제5권1호
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• pp.1-13
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• 2018

The Zhuhai Opera House has an external structure consisting of a type of spatial steel, where the stress of steel elements varies with the ambient temperature. A structural health monitoring system was implemented at Zhuhai Opera House, and the temperatures and stresses of the structures were monitored in real time. The relationship between the stress distribution and temperature variations was analysed by measuring the temperature and stresses of the steel elements. In addition to measurements of the structure stresses and temperatures, further simulation analysis was carried out to provide the detailed relationship between the stress distributions and temperature variations. The limited temperature measurements were used to simulate the structure temperature distribution, and the stress distributions of all steel elements of the structure were analysed by building a finite element model of the Zhuhai Opera House spatial steel structure. This study aims to reveal the stress distributions of steel elements in a real-world project based on temperature variations, and to supply a basic database for the optimal construction time of a spatial steel structure. This will not only provide convenient, rapid and safe early warnings and decision-making for the spatial steel structure construction and operation processes, but also improve the structural safety and construction accuracy of steel space structures.

• Structural Engineering and Mechanics
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• 제67권4호
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• pp.317-326
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• 2018

The iterative decomposition coupling formulation of the precise integration finite element method (FEM) and the time domain boundary element method (TD-BEM) is presented for elstodynamic problems. In the formulation, the FEM node and the BEM node are not required to be coincident on the common interface between FEM and BEM sub-domains, therefore, the FEM and BEM are independently discretized. The force and displacement converting matrices are used to transfer data between FEM and BEM nodes on the common interface between the FEM and BEM sub-domains, to renew the nodal variables in the process of the iterations for the un-coincident FEM node and BEM node. The iterative coupling formulation for elastodynamics in current paper is of high modeling accuracy, due to the semi-analytical solution incorporated in the precise integration finite element method. The decomposition coupling formulation for elastodynamics is verified by examples of a cantilever bar under a Heaviside-type force and a harmonic load.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권7호
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• pp.3558-3577
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• 2017

In 2D-to-3D video conversion process, the virtual left and right view can be generated from 2D video and its corresponding depth map by depth image based rendering (DIBR). The depth map plays an important role in conversion system, so the copyright protection for depth map is necessary. However, the provided virtual views may be distributed illegally and the depth map does not directly expose to viewers. In previous works, the copyright information embedded into the depth map cannot be extracted from virtual views after the DIBR process. In this paper, a new copyright protection scheme for the depth map is proposed, in which the copyright information can be detected from the virtual views even without the depth map. The experimental results have shown that the proposed method has a good robustness against JPEG attacks, filtering and noise.