• Journal of Astronomy and Space Sciences
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• 제26권4호
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• pp.621-634
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• 2009

조선 초기의 보천가(步天歌)와 천문류초(天文類抄)에 대해 연구하였다. 이 연구에서는, 다음과 같은 근거로부터 이 보천가(步天歌)의 가결(歌訣)이 A.D. 1161년에 중국에서 출간된 통지(通志)에 실려 있는 보천가(步天歌)에 큰 영향을 받았음을 알았다. 두 보천가(步天歌)의 별자리들은 서술 순서가 같고, 태미원(太微垣)의 가결(歌訣)의 첫 구철이 일곱 글자가 아니라 다섯 글자로 되어 있으며, 특히 별자리들에 대한 은하수의 위치를 기술한 천하기몰(天河起沒)은 통지(通志)의 저자인 정초(鄭樵)가 특별히 작성하여 보충한 것인데 그것이 조선 보천가(步天歌)에 들어 있다는 점이 그 근거들이다. 통지(通志)는 A.D. 1364년에 고려에 들어왔으므로, 조선 초기의 보천가(步天歌)는 그 후에야 성립 될 수 있다. 조선 초기의 보천가(步天歌)는, 중국의 보천가(步天歌)들과 비교할 때, 그 가결(歌訣)에 별자리들의 색깔이 유난히 강조되어 있다. 이것은 석신(石申), 감덕(甘德), 무함(巫咸)으로부터 기원한 별자리를 색깔로 구분하려는 의도이다. 조선 초기에 출간된 보천가(步天歌)와 천상열차분야지도(天象列次分野之圖)의 성도(星圖)들은 별자리들의 이름, 별개수, 모양 등이 일치한다. 이 사설은 조선 보천가(步天歌)의 성도(星圖)가 천상열차분야지도(天象列次分野之圖)의 모본(母本)이나 천상열차분야지도(天象列次分野之圖) 자체에서 기원했음을 뜻한다. 천상열차분야지도(天象列次分野之圖)의 모본(母本)은 A.D. 1392년에 발견되어 A.D. 1396년에 비석에 새겨졌기 때문에, 보천가(步天歌)의 성립시기의 상한은 1392년이 된다. 천문류초(天文類抄)는 보천가(步天歌)에 중국의 점성술 문헌의 내용을 덧붙인 책이다. 이 책의 성립 시기는 그 저자인 이순지(李純之)의 생애 등을 근거로 A.D. 1440-1450년으로 추론되었다. 더군다나, 보천가(步天歌)는 A.D. 1430년에 관상감의 천문학자를 뽑는 취재(取才) 시험의 과목으로 선정되었다. 이러한 사설들로부터, 이 연구에서는 조선의 보천가(步天歌)가, 송(宋)의 선진 체제를 받아들임으로써 조선 왕조의 문화적 정치적 기초를 다지기 위해, A.D. 1392년에서 A.D. 1430 사이에 출간되었을 것으로 추론하였다.

• Journal of Astronomy and Space Sciences
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• 제26권4호
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• pp.603-620
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• 2009

1792년 조선에서 출간된 새로운 보천가(步天歌)는 기존 보천가(步天歌)의 가결(歌訣)을 약간 수정하고 여기에 중국의 새로운 항성 관측 자료를 바탕으로 성립된 성도(星圖)를 합하여 작성된 것이다. 기존의 조선(朝鮮) 보천가(步天歌)의 배열 순서는 송대(宋代)의 보천가(步天歌)를 따랐으나, 이 보천가(步天歌)는 명대(明代) 이후의 보천가(步天歌)를 따르고 있다. 이 보천가(步天歌)의 성도(星圖)에서 자미원(紫微垣)은 12차(次)와 12진(辰)를 사용하여 구획하고 있고, 28숙(宿)는 3개나 4개씩 묶어서 그리되 각 그룹은 12진(辰)으로도 영역을 표시하였다. 그러나 28숙(宿)의 가결(歌訣)에는 기존의 조선 성도(星圖)들과 마찬가지로 황도십이궁을 채용하고 있다. 각 성도(星圖)는 그 적경 범위 안에 들어있는 모든 별을 그린 것이 아니라 그 원(垣)이나 숙(宿)에 소속된 별자리만을 그렸다. 이 보천가(步天歌)는 의상지(義象志)를 활용했고, 그 주석(注釋)과 비슷한 내용을 1700년 무렵의 중국 문헌에서 찾을 수 있다. 이 문헌들은 1709년에 동시에 조선으로 수입되었다. 우리는 피휘, 참숙(參宿)와 자숙(宿)의 도치, 그리고 1791년에 운관절목(雲觀節目)을 개정할 때 기존의 보천가(步天歌)를 대신하여 이 보천가 취재(取才)에 사용된 사설 등으로부터 우리는 이 보천가(步天歌)의 작성 시기를 고찰해 보았다. 그 결과, 1792년에 출간된 보천가(步天歌)의 성도(星圖)와 주석(注釋)은 그 모본(母本)에 해당하는 것이 중국에서 작성되어 1709년에 조선으로 수입되었고, 1709년과 1791년 사이에 새로운 보천가(步天歌)로 작성되어 사용되다가, 1792년에 출간되었다고 추론하였다. 이러한 추론을 뒷받침하기 위해 필요한 추가 연구에 대해 토의하였다.

• 한국산학기술학회논문지
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• 제17권7호
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• pp.301-310
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• 2016

본 연구는 만성요통을 호소하는 여성노인을 대상으로 뜸 요법을 중재 방법으로 적용하여 일상생활기능장애 및 수면 양상을 효율적으로 관리 할 수 있는지 그 효과를 규명하기 위해 시도된 비동등성 대조군 전후 실험연구이다. G시에 거주하는 여성노인(실험군 30명, 대조군 30명)으로 2015년 3월 15일부터 5월 31일까지 뜸 요법을 12주간 주 1회 총 12회 뜸 요법을 적용하였고, 추후조사는 사후조사 2주후에 실시하였다. 뜸 요법은 요혈인 신수(腎諭)와 아시혈, 대장수(大腸兪), 요양관(腰陽關), 요수(腰兪)을 취혈하였다. 무극보양뜸 7혈인 족삼리(足三里) 곡지(谷地), 중완(中脘), 중극(中極)과 수도(水道), 폐수(肺愈), 고황과 천추(天樞), 위중(委中)부위에 각각 5장씩 뜸처치를 실시하였다. 연구도구는 요통정도를 사정하기 위해 Scott & Huskisson(1979)이 개발한 시각적 상사척도(Visual Analog Scale ; VAS)를 사용하였고, 일상생활기능장애 측정 도구는 Fairbank 등(1980)이 개발하고 임현술 등(1998)이 번역 수정한 Oswestry Disability Index를 이용하여 측정하였다. 수면양상 측정 도구는 오진주, 송미순, 김신미(1998)가 개발한 수면 측정 도구를 이용하였다. 자료분석은 SPSS/WIN 18.0을 사용하였으며 Chi-square test, t-test, repeated measures ANOVA를 실시하였다. 대조군에 비해 뜸 요법을 제공받은 여성노인의 통증점수(F=2510.32, p<.001), 일상생활기능장애 점수(F=1937.82, p<.001), 수면양상점수((F=15.54, p<.001)가 유의한 차이로 나타났다. 따라서 뜸요법은 통증과 일상생활기능장에를 감소시키고, 수면의 질을 향상시키는데 긍정적인 기여를 하는 것으로 나타나 향후 뜸요법이 만성요통을 호소하는 노인에게 간호중재로 활용할 필요가 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4603-4608
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• 2015

Background: To determine the potential value of serum tumor markers in predicting pCR (pathological complete response) during neoadjuvant chemotherapy. Materials and Methods: We retrospectively monitored the pro-, mid-, and post-neoadjuvant treatment serum tumor marker concentrations in patients with locally advanced breast cancer (stage II-III) who accepted pre-surgical chemotherapy or chemotherapy in combination with targeted therapy at Fudan University Shanghai Cancer Center between September 2011 and January 2014 and investigated the association of serum tumor marker levels with therapeutic effect. Core needle biopsy samples were assessed using immunohistochemistry (IHC) prior to neoadjuvant treatment to determine hormone receptor, human epidermal growth factor receptor 2(HER2), and proliferation index Ki67 values. In our study, therapeutic response was evaluated by pCR, defined as the disappearance of all invasive cancer cells from excised tissue (including primary lesion and axillary lymph nodes) after completion of chemotherapy. Analysis of variance of repeated measures and receiver operating characteristic (ROC) curves were employed for statistical analysis of the data. Results: A total of 348 patients were recruited in our study after excluding patients with incomplete clinical information. Of these, 106 patients were observed to have acquired pCR status after treatment completion, accounting for approximately 30.5% of study individuals. In addition, 147patients were determined to be Her-2 positive, among whom the pCR rate was 45.6% (69 patients). General linear model analysis (repeated measures analysis of variance) showed that the concentration of cancer antigen (CA) 15-3 increased after neoadjuvant chemotherapy in both pCR and non-pCR groups, and that there were significant differences between the two groups (P=0.008). The areas under the ROC curves (AUCs) of pre-, mid-, and post-treatment CA15-3 concentrations demonstrated low-level predictive value (AUC=0.594, 0.644, 0.621, respectively). No significant differences in carcinoembryonic antigen (CEA) or CA12-5 serum levels were observed between the pCR and non-pCR groups (P=0.196 and 0.693, respectively). No efficient AUC of CEA or CA12-5 concentrations were observed to predict patient response toward neoadjuvant treatment (both less than 0.7), nor were differences between the two groups observed at different time points. We then analyzed the Her-2 positive subset of our cohort. Significant differences in CEA concentrations were identified between the pCR and non-pCR groups (P=0.039), but not in CA15-3 or CA12-5 levels (p=0.092 and 0.89, respectively). None of the ROC curves showed underlying prognostic value, as the AUCs of these three markers were less than 0.7. The ROC-AUCs for the CA12-5 concentrations of inter-and post-neoadjuvant chemotherapy in the estrogen receptor negative HER2 positive subgroup were 0.735 and 0.767, respectively. However, the specificity and sensitivity values were at odds with each other which meant that improving either the sensitivity or specificity would impair the efficiency of the other. Conclusions: Serum tumor markers CA15-3, CA12-5, and CEA might have little clinical significance in predicting neoadjuvant treatment response in locally advanced breast cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.8003-8008
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• 2015

Background: The aim of this study was to investigate whether family history of cancer is associated with head and neck cancer risk in a Chinese population. Materials and Methods: This case-control study included 921 cases and 806 controls. Recruitment was from December 2010 to January 2015 in eight centers in East Asia. Controls were matched to cases with reference to sex, 5-year age group, ethnicity, and residence area at each of the centers. Results: We observed an increased risk of head and neck cancer due to first degree family history of head and neck cancer, but after adjustment for tobacco smoking, alcohol drinking and betel quid chewing the association was no longer apparent. The adjusted OR were 1.10 (95% CI=0.80-1.50) for family history of tobacco-related cancer and 0.96 (95%CI=0.75-1.24) for family history of any cancer with adjustment for tobacco, betel quid and alcohol habits. The ORs for having a first-degree relative with HNC were higher in all tobacco/alcohol subgroups. Conclusions: We did not observe a strong association between family history of head and neck cancer and head and neck cancer risk after taking into account lifestyle factors. Our study suggests that an increased risk due to family history of head and neck cancer may be due to shared risk factors. Further studies may be needed to assess the lifestyle factors of the relatives.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6047-6052
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• 2014

Background: Weight loss during chemotherapy has not been exclusively investigated. Macrophage inhibitory cytokine-1 (MIC-1) might play a role in its etiology. Here, we investigated the prognostic value of weight loss before chemotherapy and its relationship with MIC-1 concentration and its occurrence during chemotherapy in patients with advanced esophageal squamous cell carcinoma (ESCC). Materials and Methods: We analyzed 157 inoperable locally advanced or metastatic ESCC patients receiving first-line chemotherapy. Serum MIC-1 concentrations were assessed before chemotherapy. Patients were assigned into two groups according to their weight loss before or during chemotherapy:>5% weight loss group and ${\leq}5%$ weight loss group. Results: Patients with weight loss>5% before chemotherapy had shorter progression-free survival period (5.8 months vs. 8.7 months; p=0.027) and overall survival (10.8 months vs. 20.0 months; p=0.010). Patients with weight loss >5% during chemotherapy tended to have shorter progression-free survival (6.0 months vs. 8.1 months; p=0.062) and overall survival (8.6 months vs. 18.0 months; p=0.022), and if weight loss was reversed during chemotherapy, survival rates improved. Furthermore, serum MIC-1 concentration was closely related to weight loss before chemotherapy (p=0.001) Conclusions: Weight loss both before and during chemotherapy predicted poor outcome in advanced ESCC patients, and MIC-1 might be involved in the development of weight loss in such patients.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.945-950
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• 2014

Purpose: To explore the value of systemic inflammatory markers as independent prognostic factors and the extent these markers improve prognostic classification for patients with inoperable advanced or metastatic gastric cancer (GC) receiving palliative chemotherapy. Methods: We studied the prognostic value of systemic inflammatory factors such as circulating white blood cell count and its components as well as that combined to form inflammation-based prognostic scores (Glasgow Prognostic Score (GPS), Neutrophil-Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Prognostic Index (PI) and Prognostic Nutritional Index (PNI)) in 384 patients with inoperable advanced or metastatic gastric cancer (GC) receiving first-line chemotherapy. Univariate and multivariate analyses were performed to examine the impact of inflammatory markers on overall survival (OS). Results: Univariate analysis revealed that an elevated white blood cell, neutrophil and/or platelet count, a decreased lymphocyte count, a low serum albumin concentration, and high CRP concentration, as well as elevated NLR/PLR, GPS, PI, PNI were significant predictors of shorter OS. Multivariate analysis demonstrated that only elevated neutrophil count (HR 3.696, p=0.003) and higher GPS (HR 1.621, p=0.01) were independent predictors of poor OS. Conclusion: This study demonstrated elevated pretreatment neutrophil count and high GPS to be independent predictors of shorter OS in inoperable advanced or metastatic GC patients treated with first-line chemotherapy. Upon validation of these data in independent studies, stratification of patients using these markers in future clinical trials is recommended.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5839-5843
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• 2014

Objective: The Zhejiang Provincial Cancer Prevention and Control Office collected cancer registration data during 2000 to 2009 from 6 cancer registries in Zhejiang province of China in order to analyze the cancer incidence. Methods: Descriptive analysis included cancer incidence stratified by sex, age and cancer site group. The proportions and cumulative rates of 10 common cancers in different groups were also calculated. Chinese population census in 1982 and Segi's population were used for calculating age-standardized incidence rates. The log-linear model was used for fitting to calculate the incidence trends. Results: The 6 cancer registries in Zhejiang province in China covered a total of 60,087,888 person-years during 2000 to 2009 (males 30,445,904, females 29,641,984). The total number of new cancer cases were 163,104 (males 92,982, females 70,122). The morphology verified cases accounted for 69.7%, and the new cases verified only by information from death certification accounted for 1.23%. The crude incidence rate in Zhejiang cancer registration areas was $271.5/10^5$ during 2000 to 2009 (male $305.41/10^5$, female $236.58/10^5$), age-standardized incidence rates by Chinese standard population (ASIRC) and by world standard population (ASIRW) were $147.1/10^5$ and $188.2/10^5$, the cumulative incidence rate (aged from 0 to 74) being 21.7%. The crude incidence rate was $209.6/10^5$ in 2000, and it increased to $320.20/10^5$ in 2009 (52.8%), with an annual percent change (APC) of 4.51% (95% confidence interval, 3.25%-5.79%). Age-specific incidence rate of 80-84 age group was achieved at the highest point of the incidence curve. Overall with different age groups, the cancer incidences differed, the incidence of liver cancer being highest in 15-44 age group in males; the incidence of breast cancer was the highest in 15-64 age group in females; the incidences of lung cancer were the highest in both males and females over the age of 65 years. Conclusions: Lung cancer, digestive system malignancies and breast cancer are the most common cancers in Zhejiang province in China requiring an especial focus. The incidences of thyroid cancer, prostate cancer, cervical cancer and lymphoma have increased rapidly. Prevention and control measures should be implemented for these cancers.

• 대한예방한의학회지
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• 제8권2호
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• pp.141-156
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• 2004

Objectives : JianTeng-Yuan(交藤圓) is said to be a prescription for preservation of health in ${\ulcorner}$HuaTuo ZhongZangJing(華陀 中藏經)${\lrcorner}$. It is known to have the effect of Bu-Shen(補腎: strengthening kidney) and Yi-Shou(益壽: prolonging the span of one's life). This study investigates whether JTY is effective on inhibition of oxidation stress. Methods : Sprague-Dawley Rats(12-week-old, weight $300{\pm}20g$) were divided into 3 groups. Normal group(n=8) was injected PBS(1ml/body, s.c) at the back neck's skin. Control group(n=8) was injected D-galactose(50mg/kg, 1ml PBS/body, s.c) to induce pathological animals. JTY group was injected the same treatment for the Control group, and fed containing JTY(10%). The whole groups were treated 1 time per day for 6 weeks. After rats were sacrificed and anti-oxidant enzyme(SOD, CAT, G-px) activity, GSH quantity of RBC and tissue(heart, liver and kidney), plasma Vit-C quantity were examined. Besides, the MDA levels of liver and kidney, lipofuscin of heart and endurance of erythrocyte membrane were measured. Results : In the JTY group, RBC's SOD activity decline was halted by 21% of the normal level, compared to the control group ; G-px activity(unit/g of Hb) increased significantly, compared to the normal group ; and the level of Vit-C in plasma increased by 16%. Heart's SOD activity was kept at the same level as that of the normal group ; and CAT activity decline was halted by 26%. Kidney's CAT and G-px activities were kept at the same level as that shown in the normal group, implying the existence of halting effect. Liver also showed a slight halting effect against the decline of anti-oxidant ability, but the effect was not significant(a=0.05). A comparison between the levels of peroxide in SD rats showed that the level of TBARS in plasma increased significantly in the control group and that it was normal in the JTY group. The livers in the JTY group, compared to those in the control group, showed 36% halting effect of the normal level while their kidney's indicated the level significantly lower than the normal level. Heart's lipofuscin increased significantly in the control group, but was alike in both the JTY and the normal groups. Endurance of erythrocyte membrane(%) decreased significantly in the control group while it was kept at the similar level in both the JTY and the normal groups, indicating the halting effect. Conclusions : This study suggests that JTY is effective to defend oxidation stress caused by D-galactose in the animals. It showed that the anti-oxidant ability was maintained and strengthened. On the other hand, it reduced the level of peroxide in animals. In sum, JTY appeared to have the equilibrium normal physiological function in SD rat.

• 생약학회지
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• 제43권4호
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• pp.328-337
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• 2012

In order to investigate anti-inflammatory, anti-allergic and anti-obesity activities of Samchulkunbi-tang (SCT; Shen zhu jian pi-tang) water and 70% ethanol (EtOH) extracts, in vitro inhibitory activities against nitric oxide (NO), prostaglandin $E_2$ $PGE_2$), interleukin (IL)-6 and tumor necrosis factor (TNF)-${\alpha}$ production in lipopolysaccharide-stimulated RAW 264.7 cells, and macrophage-derived chemokine (MDC/CCL22) and regulated on activation of normal T-cell-expressed and -secreted (RANTES/CCL5) production in TNF-${\alpha}$/interferon-${\gamma}$-stimulated HaCaT and BEAS-2B cells as well as glycerol-3-phosphate dehydrogenase (GPDH) activity and leptin production in 3T3-L1 cells were determined. A HPLC was used for quantification of the seven marker components (albiflorin, paeoniflorin, liquiritin, naringin, hesperidin, poncirin and glycyrrhizin) of SCT water and 70% EtOH extracts. SCT showed inhibitory effects against MDC and RANTES production in HaCaT cells, as well as RANTES production in BEAS-2B cells. In addition, SCT reduced not only NO, $PGE_2$, IL-6 and TNF-${\alpha}$ production in RAW 264.7 cells, but also GPDH activity and leptin production in 3T3-L1 cells. Furthermore, the biological activities and the contents of six compounds (except paeoniflorin) were higher in 70% EtOH extract than water extract. These results suggest that SCT has anti-inflammatory, anti-allergic and anti-obesity activities. These efficacies of 70% EtOH extract are relatively higher than that of water extract.