• Korean Journal of Pharmacognosy
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• v.30 no.4
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• pp.404-408
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• 1999

SH2 domains and their associated catalytic or noncatalytic proteins constitute critical signal transduction targets for drug discovery. Grb2 associates with phosphotyrosine sites of the activated receptors or Shc via their SH2 domain to link receptor tyrosine kinases to ras signalling. Blocking of the Grb2-Shc complex may be to intervene the oncogenic signal transduction pathways and to develop a new antitumor drug. In the search for blockers of Grb2 SH2-Shc interaction, Lutein, a family of carotenoids, was isolated from the extract of the leaf of Agastache rugosa O. Kuntze as SH2 domain antagonists. The $IC_{50}$ of Lutein against Grb2-Shc binding was $6.8\;{\mu}M$.

• International conference on construction engineering and project management
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• 2015.10a
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• pp.540-543
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• 2015

Solar energy is one of the most important alternative energy sources which have been shown to meet high levels of heating and cooling demands in buildings. However, the efficiencies to satisfy these demands using solar energy significantly vary based on the characteristics of individual building. Therefore, this paper is focused on developing the methodology which can help to design optimal solar system for heating and cooling to be in cooperated within the existing buildings according to their load profiles. This research has established the Solar Heating and Cooling (SHC) system which is composed of collectors, absorption chiller, boiler and heat storage tank. Each component of SHC system is analyzed and made by means of Modelica Language and Pistache tool is verified the results. Sequential approximate optimization (SAO) and meta-models determined to 15 design parameters to optimize SHC system. Finally, total coefficient of performance (COP) of the entire SHC system is improved approximately 7.3% points compared to total COP of the base model of the SHC system.

• Korean Journal of Microbiology
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• v.38 no.3
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• pp.168-172
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• 2002

Budding yeasts maintain an effective system to regulate intracellular pH in response to environmental pH fluctuation. In a previous study we reported that SHC1 plays a role in cell growth at alkaline condition, not at acid pH. We constructed a null mutant deleted an entire open reading frame for SHC1. To test whether the retardation in cell growth was caused by the absence of intracellular pH buffering capacity, we measured intracellular pH with a pH-sensitive fluorescent dye, C.SNARE. The intracellular pH of the mutant cell was much higher than that of wild-type cells, indicating that the mutant cells lack some types of buffering capacity. We also investigated the level of $Na^＋ and K^＋$ content with atomic mass spectroscopy after alkali shock. Wild-type cell showed a higher level of intracellular K^＋$ content, whereas there was no difference in $Na^＋$ level. The result suggested that K^＋$ is more important in the regulation of intracellular pH in yeasts.

• The Korean Journal of Mycology
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• v.22 no.2
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• pp.190-195
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• 1994

Studies were conducted to determine the potential of sodium hypochlorite(SHC) on the control of bacterial yellow blotch in cultivated oyster mushroom, Pleurotus ostreatus. SHC at the concentration of 80 ppm was effective on the control of Pseudomonas agarici causing yellow blotch in oyster mushroom except number 916 isolate. In vitro the mycelial growth was slightly inhibited at the concentration higher than 100 ppm of sodium hypochlorite, but retardation of the mycelial growth was soon recovered. Spray of SHC solution at the concentration of 40-50 ppm per day significantly reduced the incidence of the yellow blotch without impairing the growth of oyster mushroom in field culture. However, the higher concentration of SHC(67 ppm) induced yellow brown or dark gray in color and deformed cap and elongated stripe in morphology of fruiting body. Results indicate that periodical spray of sodium hypochlorite seems to be the recommendable method for protection against bacterial yellow blotch disease in oyster mushroom without reducing food quality.

• Korean Journal of Pharmacognosy
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• v.30 no.2
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• pp.202-206
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• 1999

The MeOH extracts obtained from the leaves of Eucommia ulmoides were solvent-fractionated with EtOAc, n-BuOH, and $H_20$, successively. From the EtOAc extract showing Grab2-Shc inhibitory activity, a flavonol and a lignan compounds were isolated through repeated silica gel column chromatographies. By interpretation of several spectral data and adaptation of acetylation method, the chemical structures of the compounds were determined as 5,7,3',4'-tetrahydroxy-flavonol (quercetin), and 4,4',8',9-tetrahydroxy-3,3'-dimethoxy-7,9'-cyclolignan {(-)-olivil)}, respectively. The compounds exhibited $IC_{50}$ values in Grb2-Shc inhibitory activity to be 93 and $210\;{\mu}mole/l$, respectively.

• Journal of the Korean housing association
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• v.18 no.6
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• pp.83-91
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• 2007

The purpose of this study is to understand the present housing condition of the suburban housing complex, and the residents' preferences to make their living condition better in Yong-in and Yang-pyeong, Pocheon, Kwang-ju and Kimpo in Kyung-Ki province, Korea. Questionnaire survey has been carried out to figure out the current status and residents' preferences of the Suburban housing complexes (hereafter SHC). The study showed the present status and the demands of people for their houses as a result like the below. First, currently the SHCs are managed by a joint control type, and the preferences of the residents' showed the similar way. Because of this status, the SHC planning is supposed to have the self-governing management and community space to support the activity of their community. Second, most SHCs doesn't have many public facility, in contrast, each house has various exteriors. This result shows the residents want more to develop their own houses' exterior than that of the SHC's public facility. Prior to plan the SHC, a program should be considered to give better understanding to residens what is the complexed life and make them choose what they really want to have. Third, the studied SHCs' renovation activities are commonly focussed on the exteriors. This shows the residents' life style is focussed more on the out-door life. The planning for the future SHC is supposed to have the points that could follow up the out-door friendly situations.

• Journal of the Korea Society for Simulation
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• v.14 no.3
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• pp.109-118
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• 2005

The purpose of this paper is to analyze transport ability of AGV(Automated Guided Vehicle) and SHC(SHuttle Carrier). The main difference between two types of transport vehicles is that AGV depends on container crane or transfer crane to do loading/unloading container, but SHC is very independent to it. Therefore, the transport ability of SHC is expected to be higher than AGV. So, in this paper, we established simulation model to evaluate two types of transport vehicles and analyzed the results. Simulation model was established to automated container terminal with perpendicular yard layout, and applied closed loop operation of transport vehicle between apron and stacking yard. In the result, SHC showed very superior than AGV aspect of container crane productivity and vehicle fleets.

• Proceedings of the Korea Society for Simulation Conference
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• 2005.05a
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• pp.57-63
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• 2005

The purpose of this paper is to analyze transport ability of AGV(Automated Guided Vehicle) and SHC(SHuttle Carrier). The main difference between two types of transport vehicles is that AGV depends on container crane or transfer crane to do loading/unloading container, but SHC is very independent to it. Therefore, the transport ability of SHC is expected to be higher than AGV, So, in this paper, we established simulation model to evaluate two types of transport vehicles and analyzed the results. Simulation model was established to automated container terminal with perpendicular yard layout, and applied closed loop operation of transport vehicle between apron and stacking yard. In the result, SHC showed very superior than AGV aspect of container crane productivity and vehicle fleets,

• KIEAE Journal
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• v.4 no.1
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• pp.11-20
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• 2004

Innovative daylighting systems in buildings in various climatic zones around the world have been developed under the IEA SHC Task21. The performance assessment were obtained by monitoring the most systems using full-scale test model rooms or actual buildings under real sky conditions. This study aims to analyze the configuration and monitoring system of the nine Mock-up models of the IEA SHC Task21 comparatively. For the purpose, the geometry of the test rooms (length, width, height, window area, glazed area and occupied), reflectance of walls, floor and ceiling, transmittance of glazing (transmittance for hemispherical irradiation, normal irradiation and U-value) were compared. And equipment for measurement (manufacturer, range, calibration, maximum calibration error, cosine response error, fatigue error), and data acquisition system (manufacturer, type, number of differential analogue input channels, A/D converter resolution in bits, data acquisition software) were also analyzed comparatively. Some findings of these experimental methodology of standard monitoring have been proven to be a valuable one for future assessment of advanced daylighting systems in our country.

• The Korean Journal of Physiology and Pharmacology
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• v.4 no.6
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• pp.507-513
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• 2000

ErbB3/HER3 is a cell surface receptor which belongs to the ErbB/HER subfamily of receptor protein tyrosine kinases. When expressed in NIH/3T3 cells, ErbB3 can form heterodimeric coreceptor with endogenous ErbB2. Among known intracellular effectors of the ErbB2/ErbB3 are mitogen-activated protein kinase (MAPK) and phosphoinositide (PI) 3-kinase. In the present study, we studied relative contributions of above two distinct signaling pathways to the heregulin-induced mitogenic response via activated ErbB3. For this, clonal NIH-3T3 cell lines expressing wild-type ErbB3 and ErbB3 mutants were stimulated with $heregulin{\beta}_1$. While cyclin D1 level was markedly high and further increased by treatment of heregulin in cells expressing wild-type ErbB3, the elimination of either Shc binding or PI 3-kinase binding lowered both levels. This result was supported by the reduction of cyclin $D_1$ expression by preteatment with MAPK kinase inhibitor or PI 3-kinase inhibitor before stimulation with heregulin. In accordance with the cyclin $D_1$ expression, elimination of either Shc binding or PI 3-kinase binding reduced the heregulin-induced DNA synthesis and cell growth rate. Our results obtained by the comparison of wild-type and ErbB3 mutants indicate that the full induction of the cell cycle progression through $G_1/S$ phase by ErbB3 activation is dependent on both Shc/MAPK and PI 3-kinase signal transduction pathways.