• Biomolecules & Therapeutics
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• 제22권2호
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• pp.161-165
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• 2014

The main purpose of this study was to develop a novel, in situ gel system for sustained delivery of ranitidine hydrochloride. Ranitidine in situ gels at 0.2%, 0.5%, and 1.0% gellan gum concentration (w/v) were prepared, respectively, and characterized in terms of preparation, viscosity and in vitro release. The viscosity of the gellan gum formulations in solution increased with increasing concentrations of gellan gum. In vitro study showed that the release of ranitidine from these gels was characterized by an initial phase of high release (burst effect) and translated to the second phase of moderate release. Single photon emission computing tomography technique was used to evaluate the stomach residence time of gel containing $^{99m}Tc$ tracer. The animal experiment suggested in situ gel had feasibility of forming gels in stomach and sustained the ranitidine release from the gels over the period of at least 8 h. In conclusion, the in situ gel system is a promising approach for the oral delivery of ranitidine for the therapeutic effects improvement.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제12권8호
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• pp.3911-3925
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• 2018

This paper proposes a novel steganography method to hide secret data during the generation of tangle patterns. Different from the traditional steganography based on modifying natural images, we propose to construct stego images according to the secret messages. We first create a model to group a selected image contour, and define some basic operations to generate various pattern cells. During data hiding, we create a cell library to establish the relationships between cells and secret data. By painting the cell inside the image contour, we create a dense tangle pattern to carry secret data. With the proposed method, a recipient can extract the secret data correctly. Experimental results show that the proposed method has a flexible embedding capacity. The constructed stego tangle image has good visual effects, and is secure against adversaries. Meanwhile, the stego tangle pattern is also robust to JPEG compression.

• Experimental and Molecular Medicine
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• 제50권11호
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• pp.11.1-11.12
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• 2018

USP15 has been shown to stabilize transcription factors, to be amplified in many cancers and to mediate cancer cell survival. However, the underlying mechanism by which USP15 regulates multiple myeloma (MM) cell proliferation and apoptosis has not been established. Here, our results showed that USP15 mRNA expression was upregulated in MM patients. USP15 silencing induced MM cell proliferation inhibition, apoptosis, and the expression of nuclear and cytoplasmic NF-${\kappa}Bp65$, while USP15 overexpression exhibited an inverse effect. Moreover, in vivo experiments indicated that USP15 silencing inhibited MM tumor growth and NF-${\kappa}Bp65$ expression. PDTC treatment significantly inhibited USP15 overexpression-induced cell proliferation, apoptosis inhibition, and NF-${\kappa}Bp65$ expression. USP15 overexpression promoted NF-${\kappa}Bp65$ expression through inhibition of its ubiquitination, whereas NF-${\kappa}Bp65$ promoted USP15 expression as a positive regulator. Taken together, the USP15-NF-${\kappa}Bp65$ loop is involved in MM tumorigenesis and may be a potential therapeutic target for MM.

• Journal of the Korean Ceramic Society
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• 제49권4호
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• pp.295-300
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• 2012

SiC-based ceramic matrix composites show many advantages over their monolithic ceramic counterparts, which makes them potential candidates for applications in various fields. Depending strongly on the chemical composition and microstructure of the fiber reinforcement, matrix as well as the fiber/matrix interphase in the material, the properties of ceramic matrix composites(CMCs) are highly tailorable. In this paper, the latest progresses in the interphase design, matrix modification and fiber reinforcement decoration of CMCs are reviewed, their effects on the properties of the CMCs are introduced.

• Korean Journal of Radiology
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• 제20권6호
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• pp.939-946
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• 2019

Objective: To report our initial experience of percutaneous sacroplasty (PSP) with an interpedicular approach for treating painful sacral metastases involving multiple sacral vertebral bodies. Materials and Methods: This study prospectively enrolled 10 consecutive patients (six men and four women; mean age, 56.3 ± 13.8 years) who underwent PSP for painful sacral metastases involving multiple sacral vertebral bodies from March 2017 to September 2018. Visual analogue scale (VAS) scores, Oswestry disability index (ODI) values, and the number of opioids prescribed to the patients were assessed before and after PSP. The procedure duration, length of hospitalization, and complications were also recorded. Results: Mean VAS and ODI declined significantly from 6.90 ± 1.20 and 74.40 ± 5.48 before the procedure to 2.70 ± 1.34 and 29.60 ± 14.57 after the procedure, respectively (p < 0.01). The median number of opioids prescribed per patient decreased from 2 (interquartile range [IQR] 1-3) pre-procedure to 1 (IQR 0-3) post-procedure (p < 0.01). Nine of the 10 patients showed no or decreased opioid usage, and only 1 patient showed unchanged usage. The mean procedure duration was 48.5 ± 3.0 minutes. The average length of hospitalization was 4.7 ± 1.7 days. Extraosseous cement leakage occurred in three cases without causing any clinical complications. Conclusion: PSP with an interpedicular approach is a safe and effective treatment in patients with painful sacral metastases involving multiple sacral vertebral bodies and can relieve pain and improve mobility.

• Journal of the Korean Society of Food Culture
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• 제20권6호
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• pp.744-753
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• 2005

This study was carried out to investigate Chinese in Beijing and Shanghai perception and preference for Korean Kimchi. The results were as follows: A questionnaire was examined on male 145(45.7%) and female 172(54.3%) of residing in Beijing, and on male 139(49.5%) and female 142(50.5%) of residing in Shanghai. In foods of eating with Kimchi resulted the highest Chinese foods 40.3% on male, and Korean. Chinese foods 25.3% on female in Beijing(p< .05), Korean, Chinese foods 26.7% and 25.3% on male respectively, and Korean foods 50.7% on female in Shanghai. In Kimchi used dishes Beijing resulted high Kimchi Ramyon 61.5%, Kimchi Kuk 51.3%, and Kimchi Chigae 44.9%, and Shanghai were Kimchi Ramyon 51.2%, Kimchi Kuk 41.3%, and Kimchi Fried Rice 22.4% in order. In evaluation by kinds of Kimchi, the taste resulted high onion juice Kimchi(M=6.55) of the third days, and overall acceptability resulted high onion juice Kimchi(M=6.18) of the third days, similary in Beijing, and Kimchi added in shrimp(M=5.70) of two days, and overall acceptability resulted high Kimchi added in shrimp(M=5.70) of the third days, similary in Shanghai. In Sensory evaluation by used Kimchi, the taste resulted high in the order of Kimchi Fried Rice and Chinese style Kimchi Fried Pork(M=6.27), and overall acceptability resulted Kimchi Fried Udong(M=6.40), Chinese style Kimchi Fried Pork(M=6.27), Kimchi Dumpling(M=6.20) in Beijing, and Kimchi Chige(M=6.70), Kimchi Fried Rice(M=6.67) and Kimchi Pancake(M=6.44), and overall acceptability resulted Kimchi Fried Udong, Kimchi Chige(M=6.50), Kimchi Fried Rice and Kimchi Pancake(M=6.44) in Shanghai.

• Journal of Photoscience
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• 제9권2호
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• pp.391-393
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• 2002

Effects of illumination with xenon or sulfur lamp on growth of tomato seedlings were studied. Results showed no obvious differences in net photosynthetic rate and apparent quantum efficiency. In comparison with xenon lamp, illumination with sulfur lamp slightly reduced ChI a and ChI b content in leaves, relatively shortened epicotyl and hypocotyl length, but significantly increased anthocyanin content of leaves and promoted root growth of tomato seedling plants.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권7호
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• pp.3231-3244
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• 2016

As processor design has been transiting from homogeneous multicore processor to heterogeneous multicore processor, traditional Amdahl's law cannot meet the new challenges for asymmetric multicore system. In order to further investigate the impact factors related to the Overhead of Data Preparation (ODP) for Asymmetric multicore systems, we evaluate an asymmetric multicore system built with CPU-GPU by measuring the overheads of memory transfer, computing kernel, cache missing and synchronization. This paper demonstrates that decreasing the overhead of data preparation is a promising approach to improve the whole performance of heterogeneous system.

• International Journal of Fluid Machinery and Systems
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• 제3권4호
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• pp.292-300
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• 2010

This study strives to develop an effective strategy to inhibit cavitation inception on hydrofoils by using local cooling technique. By setting up a temperature boundary condition and cooling a small area on the upper surface of a hydrofoil, the fluid temperature around the cooling surface will be decreased and thereby the corresponding liquid saturation pressure will drop below the lowest absolute pressure within the flow field. Hence, cavitation can never occur. In this paper, a NACA0015 hydrofoil at $4^{\circ}$ angle of attack was numerically investigated to verify the effectiveness of the proposed technique. The CFD results indicate that the cooling temperature and the cooling surface roughness are the critical factors affecting the success of such technique used for cavitation suppression.

• Nuclear Engineering and Technology
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• 제51권7호
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• pp.1822-1827
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• 2019

Mechanical responses and failure behaviors of advanced C/C composite tube are very important for structural component design in nuclear reactor. In this study, an experimental investigation was conducted to study mechanical properties of C/C composite tube. Quasi-static compression loading was applied to a type of advanced composite tube to determine the response of the quasi-static load displacement curve during progressive damage. Acoustic emissions (AE) signals were captured and analyzed to characterize the crack formation and crack development. In addition, the crack propagation of the specimens was monitored by imaging technique and failure mode of the specimen was analyzed. FEM is appled to simulate the stress distribution. Results show that advanced C/C composite tube exhibits considerable energy absorption capability and stability in load-carrying capacity.