• Korean Journal of Radiology
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• 제20권6호
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• pp.967-975
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• 2019

Objective: To evaluate whether the combination of magnetic resonance spectroscopy (MRS) and ¹¹C-methionine positron emission tomography (¹¹C-MET PET) could increase accurate diagnostic sensitivity for non-enhancing supratentorial gliomas. Materials and Methods: Between February 2012 and December 2017, 109 patients with non-enhanced supratentorial lesions on contrast-enhanced MRI were enrolled. Each patient underwent MRS and ¹¹C-MET PET before treatment. A lesion was considered to be a glioma when either the MRS or ¹¹C-MET PET results reached the diagnostic threshold. The radiological diagnosis was compared with the pathological diagnosis or medical diagnostic criteria. Results: The sensitivity and specificity were 60.0% and 50.0% for MRS and 75.8% and 50.0% for ¹¹C-MET PET, respectively. Upon combining the two modalities, the sensitivity and specificity of the imaging-based diagnosis prior to surgery reached 89.5% and 42.9%, respectively. Statistically significant differences in the sensitivities were observed between the combined and individual approaches (MRS alone, 89.5% vs. 60.0%, p < 0.001; ¹¹C-MET PET alone, 89.5% vs. 75.8%, p = 0.001). However, no significant differences in specificity were observed between the combined and individual modalities. Conclusion: The combination of MRS and ¹¹C-MET PET findings significantly increases accurate diagnostic sensitivity for non-enhancing supratentorial gliomas without significantly lowering the specificity. This finding suggests the potential of the combined MRS and ¹¹C-MET PET approach in clinical applications.

• 대한교통학회:학술대회논문집
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• 대한교통학회 1993년도 한-중 국제학술회의 발표논문
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• pp.139-151
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• 1993

• Nutrition Research and Practice
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• 제8권2호
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• pp.165-171
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• 2014

BACKGROUND: Groundwater is believed to possess many beneficial effects due to its natural source of various minerals. In this study, we examined the effects of natural Jeju groundwater S1 (Samdasoo$^{TM}$), S2 and S3 pumped up from different locations of Jeju Island, Korea, along with local tap water, on body weight gain, serum lipids and lipoproteins, and liver histopathology in high-fat diet-induced hyperlipidemic rats. MATERIALS/METHODS: Rats were randomly and equally divided into 6 groups. Different water samples were supplied to the hyperlipidemic rats as their daily drinking water and the widely-used anti-hyperlipidemic drug simvastatin was used as a positive control. Body weight, serum lipids and lipoproteins were measured weekly. Liver weight, liver index and liver histopathology were examined after the execution of the rats. RESULTS: After drinking Jeju groundwaters for two months, S2 but not S3 significantly reduced weight growth and serum triglycerides levels and increased high density lipoprotein-C (HDL-C) without affecting total cholesterol or LDL-C. S1 and particularly S2 significantly reduced the severity of liver hypertrophy and steatosis. All Groundwaters had much higher contents of vanadium (S3>S2>S1>>tap water) whereas S1 and S2 but not S3 markedly blocked autoxidation of ferrous ions. CONCLUSION: Jeju Groundwater S1 and particularly S2 exhibit protective effects against hyperlipidemia and fatty liver and hypothesize that the beneficial effect of Jeju Groundwaters may be contributed from blockade of autoxidation of ferrous ions rather than their high contents of vanadium.

• Journal of Ginseng Research
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• 제43권1호
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• pp.116-124
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• 2019

Background: Ginsenosides are known as the principal pharmacological active constituents in Panax medicinal plants such as Asian ginseng, American ginseng, and Notoginseng. Some ginsenosides, especially the 20(R) isomers, are found in trace amounts in natural sources and are difficult to chemically synthesize. The present study provides an approach to produce such trace ginsenosides applying biotransformation through Escherichia coli modified with relevant genes. Methods: Seven uridine diphosphate glycosyltransferase (UGT) genes originating from Panax notoginseng, Medicago sativa, and Bacillus subtilis were synthesized or cloned and constructed into pETM6, an ePathBrick vector, which were then introduced into E. coli BL21star (DE3) separately. 20(R)-Protopanaxadiol (PPD), 20(R)-protopanaxatriol (PPT), and 20(R)-type ginsenosides were used as substrates for biotransformation with recombinant E. coli modified with those UGT genes. Results: E. coli engineered with $GT95^{syn}$ selectively transfers a glucose moiety to the C20 hydroxyl of 20(R)-PPD and 20(R)-PPT to produce 20(R)-CK and 20(R)-F1, respectively. GTK1- and GTC1-modified E. coli glycosylated the C3-OH of 20(R)-PPD to form 20(R)-Rh2. Moreover, E. coli containing $p2GT95^{syn}K1$, a recreated two-step glycosylation pathway via the ePathBrich, implemented the successive glycosylation at C20-OH and C3-OH of 20(R)-PPD and yielded 20(R)-F2 in the biotransformation broth. Conclusion: This study demonstrates that rare 20(R)-ginsenosides can be produced through E. coli engineered with UTG genes.

• Journal of Microbiology and Biotechnology
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• 제20권4호
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• pp.678-682
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• 2010

The deletion of sti from the Streptomyces plasmid pIJ101 made its derivative pHZ1358 an efficient vector for gene disruption and replacement. Here, pHZ1358 was further optimized by the construction of a derivative plasmid pJTU1278, in which a cassette carrying multiple cloning sites and a lacZ selection marker were introduced for convenient plasmid construction in E. coli. In addition, the oriT region of pJTU1278 was also deleted, generating a vector (pJTU1289) that can be used specifically for PCR-targeting. The efficient usage of these vectors was demonstrated by the deletion of the gene involved in avermectin biosynthesis in S. avermitilis.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권3호
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• pp.1363-1376
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• 2020

An improved clustering scheme based on user group is proposed. Every two users are grouped among N-users in the allowed system according to their link gain from large to small. Each user group is numbered sequentially. Two user clusters are obtained according to the principle of maximizing link gain difference for the users in the first and last user groups. The remaining user groups are added to the two existing user clusters according to the parity of the group number. The clustering should be clustered again among the users in either user cluster if the throughput summation of a user cluster in NOMA is less than that of these users in orthogonal multiple access. The simulation results show that the proposed clustering scheme can increase the system throughput by about 8% compared with the hybrid clustering scheme when the number of users requiring service is 12.

• 한국축산식품학회지
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• 제37권6호
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• pp.847-854
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• 2017

A rapid, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of four barbiturates (phenobarbital, pentobarbital, amobarbital and secobarbital) in raw milk. The barbiturates were extracted using liquid-liquid extraction, ultrasonication and centrifugation, and purified on an SPE column. Analytes were separated by HPLC on a CSH C18 column eluted using an acetonitrile-water system with a linear gradient dilution programme, and detected by MS/MS. The recoveries of the barbiturates were 85.0-113.5%, and the intra- and inter-assay RSDs were less than 9.8% and 7.3%, respectively. The limit of detection was 5 ng/mL for all four of the barbiturates. The analytical method exhibited good linearity from 10 to 1000 ng/mL; the correlation coefficient ($r^2$) was greater than 0.9950 for each barbiturate. This method was also applied to the determination of barbiturates in real milk samples and was found to be suitable for the determination of veterinary drug residues in raw milk.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권9호
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• pp.3412-3431
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• 2015

This paper considers the effect of co-channel interference on hybrid satellite-terrestrial relay network. In particular, we investigate the problem of amplify-and-forward (AF) relaying in hybrid satellite-terrestrial link, where the relay is interfered by multiple co-channel interferers. The direct link between satellite and terrestrial destination is not available due to masking by surroundings. The destination node can only receive signals from satellite with the assistance of a relay node situated at ground. The satellite-relay link is assumed to follow the shadowed Rice fading, while the channels of interferer-relay and relay-destination links experience Nakagami-m fading. For the considered AF relaying scheme, we first derive the analytical expression for the moment generating function (MGF) of the output signal-to-interference-plus-noise ratio (SINR). Then, we use the obtained MGF to derive the average symbol error rate (SER) of the considered scenario for M-ary phase shift keying (M-PSK) constellation under these generalized fading channels.

• International Journal of Automotive Technology
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• 제7권6호
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• pp.645-652
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• 2006

This paper is concerned with an experimental study of a turbocharged diesel engine operating on dimethyl ether(DME). The combustion and emission characteristics of DME engine were investigated. The results showed that the maximum torque and power with DME could achieve a greater level compared to diesel operation, particularly at low speeds; the brake specific fuel consumption with DME was lower than the diesel at low and middle engine speeds. The injection delay of DME was longer than that of diesel. However, the maximum cylinder pressure, maximum pressure rise rate and combustion noises of DME engine were lower than those of diesel. The combustion velocity of DME was faster than that of diesel, resulting in a shorter combustion duration of DME. Compared with the diesel engine, $NO_x$ emissions of the DME engine were reduced by 41.6% on ESC data. The DME engine was smoke free at all operating points of the engine.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권10호
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• pp.5130-5143
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• 2019

Football (soccer) is one of the most popular sports in the world. A huge number of people watch live football matches by TV or Internet. A football match takes 90 minutes, but viewers may only want to watch a few highlights to save their time. As far as we know, there is no such a product that can be put into use to achieve intelligent highlight extraction from live football matches. In this paper, we propose an intelligent editing system for live football matches. Our system can automatically extract a series of highlights, such as goal, shoot, corner kick, red yellow card and the appearance of star players, from the live stream of a football match. Our system has been integrated into live streaming platforms during the 2018 FIFA World Cup and performed fairly well.