• 한국수산과학회지
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• 제55권1호
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• pp.17-22
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• 2022

Successful reproduction in vertebrates necessitates complex interactions along the brain-pituitary-gonad axis, it is determined by gonadotropin releasing hormone produced in the hypothalamus of the brain, gonadotropin synthesized in the pituitary gland, and sex hormone secreted by the gonads. The goal of this study was to secure and test technology for controlling (inhibiting) sexual maturation hormones such as maturation hormones through hormone regulation. We studied the effect on sexual maturation of zebrafish Danio rerio by tamoxifen, anastrozole, exemestane and dopamine 4 kinds of sexual maturation inhibitors to feed and after administration. As a result, 4 kinds of sexual maturation inducing substances were mixed with zebrafish feed, it could be concluded that all of them were effective in inhibiting sexual maturation by reducing mRNA levels of genetic materials related to sexual maturation.

• 여성건강간호학회지
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• 제24권2호
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• pp.219-228
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• 2018

Purpose: The purpose of this study is to evaluate sexual maturation, attitudes toward sexual maturity, and body esteem in the sexual development of Korean elementary-school boys and girls. Methods: A descriptive cross-sectional study was conducted with 399 fifth and sixth graders (192 boys and 207 girls). The data were analysed with a $x^2$ test, t-test, and Pearson correlation coefficients. Results: Among the 207 girls, 70.5% had pubic hair growth, 68.1% had breast development, and 56.0% had a menstrual period. In boys, 59.4% of the 192 subjects experienced the development of external genitalia and 52.6% had pubic hair growth. Sexual maturation was related to grade (boys, t=7.07, p=.008; girls, t=12.76, p<.001), age (t=-2.20, p=.030; t=-4.11, p<.001), height (t=-5.16, p<.001; t=-7.52, p<.001), and weight (t=-2.89, p=.004; t=-5.19, p<.001) in both boys and girls. Girls were more likely to have sexual maturity than boys ($x^2=22.29$, p<.001). Boys showed more positive attitudes toward sexual maturity (t=2.10, p=.036) and higher body esteem (t=2.12, p=.035) than girls. Conclusion: This study shows that sexual maturation, attitude toward sexual maturity, and body esteem in sexual development differ between boys and girls. The findings indicate that it is necessary to develop a tailored sex-education program according to the sex of elementary-school children.

• Journal of Nutrition and Health
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• 제40권1호
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• pp.58-68
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• 2007

The associations between dietary, body composition and sexual maturation were investigated among Korean girls of pubertal age in this study. Dietary intakes were collected by 3 day food records, body compositions were measured by bio-impedence analyzer and sexual maturation stages were determined with a self-administrated questionnaire using Tanner stages in 1,114 girls 9-13 years of age. Girls were divided into early maturation (EM) and late maturation (LM), based on the comparative maturation stages of breast and pubic hair among the same age groups by months. Subjects were excluded if their stage of maturation could not be divided into early and late groups. EM and LM groups consisted of 42.8% and 38.9% of subjects by breast stage and 67.4% and 22.8% by pubic hair stage. Girls in LM group had significantly lower in height, weight and bone mineral contents (p < 0.05). When nutrient densities of average daily intake of the two groups were compared, folate density was significantly higher among the LM group of breast stages (p < 0.01), and Ca, P, K, Vit. $B_1$, Vit. $B_2$ and folate densities were significantly higher among the LM group of pubic hair stages (p < 0.05). These results show that intakes of some micronutrients differ between children with faster and slower sexual maturation velocities at early pubertal stages. More longitudinal studies are needed to confirm whether such differences are consistent throughout the pubertal period.

• 한국수정란이식학회지
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• 제30권2호
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• pp.83-89
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• 2015

The sexual maturation occurred by the changes of steroid hormones was known to sex-dependently and/or age-dependently regulate the lipid metabolism in various animal species. Our current study demonstrates that lipid and its functional fatty acids can be changed depending on the status of sexual maturation. Of the functional fatty acids, ${\gamma}$-linolenic acid (GLA; 18:3n-6) is an important factor for maintaining human health. The purpose of our study was to investigate the level of GLA in mice with different stages of sexual maturation. To this end, the longissimus muscle (LM) of immature (3-week-old) and mature (7-week-old) female mice was analysed for the fatty acid composition by gas chromatography. Furthermore, both gene and protein level of ${\Delta}6$ desaturase (FADS2) which is involved in GLA metabolism by real time PCR and Western blotting, respectively. Mature females showed greater (P<0.05) serum $17{\beta}$-estradiol (E2) level and LM GLA contents than immature group. The mRNA and protein levels of FADS2, which converts precursor linoleic acid into GLA, were higher (P<0.05) in mature female mice than in immature mice. In conclusion, these results show that sexual maturation of female mice induces GLA and FADS2 contents in LM.

• 지역사회간호학회지
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• 제23권4호
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• pp.405-414
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• 2012

Purpose: The purpose of this study was to examine the sexual maturation, body image, and self-esteem of Korean elementary school girls with symptoms of precocious puberty compared to those with no symptoms of precocious puberty. Methods: The subjects were 309 girls of lower grades in elementary school. Tanner's Sexual Maturation Rating (SMR), Self Image Scale, and Self-esteem Scale were utilized to determine the presence of symptoms of precocious puberty, body image, and self esteem. Collected data were analyzed by Chi-square test, independent t-test, and one-way ANOVA using the SPSS/WIN 17.0 program. Results: The percentage of the girls with breast development was 14.9%. Breast development usually began in the third grade (56.5%). Of the subjects, 0.3% were experiencing menstruation. Breast development was related to grade, age, height, weight, and a cause of worry. There was a significant difference of body image between girls with breast development in the first grade and in the second grade. Conclusion: An effective intervention that can improve the self-image of children with symptoms of precocious puberty should be developed to prevent and treat physical and mental problems related to sexual maturation.

• 생명과학회지
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• 제27권10호
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• pp.1097-1103
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• 2017

뱀장어(Anguilla japonica)의 인공종묘생산은 연어뇌하수체추출물(SPE, salmon pituitary extract)을 암컷 뱀장어에게 지속적인 투여를 하고 인위적으로 성성숙을 유도로 얻은 난과 정자를 인공수정을 하고 부화 시켜 생산한다. 하지만 SPE를 반복적으로 복강에 주사하는 방법은 암컷 뱀장어에게 많은 스트레스를 주며, 결국 스트레스로 인하여 완전한 성성숙을 하지 못하고 폐사에 이르게 되거나 배란한 난의 질이 좋지 않아 부화율과 자어의 생존율이 떨어지는 문제점을 갖고 있다. 본 연구에서는 뱀장어의 성성숙 유도에 유효하다고 알려진 호르몬이 주입된 osmotic pump를 복강에 삽입 후 암컷 뱀장어의 성성숙 유도를 하였다. 본 연구결과 SPE를 투여한 실험어의 GSI가 hCG, GnRHa, MT를 각각 또는 함께 투여한 실험구 보다 유의하게 증가하였으며 조직학적 분석결과에서도 난소의 난모세포가 핵이동기 단계로 발달되었음을 관찰할 수 있었다. 본 결과를 통해 osmotic pump를 이용한 암컷 뱀장어 인위적 성성숙 유도 방법으로 이용 가능할 것으로 생각된다.

• Asian-Australasian Journal of Animal Sciences
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• 제20권1호
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• pp.19-24
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• 2007

Covariance components and genetic parameters of weekly live body weight from hatching to six weeks of age and age of sexual maturation were estimated in a laying type Japanese quail line. The univariate and bivariate animal model analysis included hatching group and sex as fixed effects. Each trait was analysed with animal as random effect to fit the additive direct effect. Additional random effects incorporated in the models were changed according to the trait examined. The best model for a trait was chosen based on a likelihood ratio test, comparing the models with and without maternal additive genetic and maternal permanent environmental effects. Heritability estimates of live-weight at hatch and one to six weeks of age with their standard errors were 0.22${\pm}$0.088, 0.39${\pm}$0.099, 0.31${\pm}$0.086, 0.38${\pm}$0.056, 0.46${\pm}$0.055, 0.50${\pm}$0.059, and 0.56${\pm}$0.062, respectively. Direct heritability value of age of sexual maturation was moderate (0.24${\pm}$0.055). The variances due to permanent environmental effect of dam after one week of age and maternal genetic effect after two weeks of age were not important sources of variation. The correlations between direct and maternal genetic effects were negative and ranged from high to moderate values (-0.21 to -0.83). Among the weekly live weights, genetic correlations were generally high between not only successive but also early and late weightings. It suggests that selection for final weight may be based on early weight records. Genetic correlations between age of sexual maturation and live weights were low, favourable but had high standard errors. These results indicate that selection for high weight will potentially result in lower age of sexual maturation only with accurate determination of breeding values.

• 한국양식학회지
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• 제16권4호
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• pp.245-251
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• 2003

2000년 1월부터 12월까지 남해안 한산만 해역에서 채집한 홍합의 생식소 발달과 생식주기에 관하여 조직학적 방법을 이용하여 조사하였다. 홍합은 자웅이체이며, 생식소는 암 수 모두 다수의 배우자형성소낭으로 이루어져 있었다. 생식소지수(GI)는 2월(3.40)에 가장 높았으며, 8월(1.18)에 가장 낮았다. 비만도(CI)는 생식소지수(GI)와 유사하게 변화하였다. 홍합의 주 산란기는 2∼3월이며, 생식주기는 휴지기(8∼11월), 분열증식기(11∼12월), 성장기(12∼1월), 성숙기(1∼2월), 부분방출기(2∼4월), 완전방출 및 퇴화흡수기(4∼7월)로 구분할 수 있었다. 성비(암:수)는 1:0.96으로 조사되었다.

• 한국해양생명과학회지
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• 제1권1호
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• pp.41-49
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• 2016

Kisspeptin (Kiss) and its cognate receptor, kisspeptin receptor (KissR; G protein coupled receptor 54, GPR54), have recently been recognized as potent regulators of reproduction in teleosts. Additionally, leptin plays an important role in energy homeostasis and reproductive function in teleosts. The purpose of this study was to examine differences in the concentration of the hormones of the Kiss/KissR system and leptin and the expression of their underlying genes, all of which are involved in the sexual maturation of female goldfish, Carassius auratus, following treatment with Kiss. The expression levels of KissR increased after the Kiss injection. Furthermore, the peptide hormone leptin also increased after the injection (in vivo and in vitro). Additionally, the expression of GnRH and GTHs (GTHα, FSHβ, and LHβ) increased in the brain and pituitary (in vitro and in vitro). These results support the hypothesis that Kiss plays important roles in the direct regulation of the hypothalamus-pituitary-gonad axis and leptin in goldfish. Therefore, we suggest that Kiss system gene expression is correlated with energy balance and reproduction.

• 한국어병학회지
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• 제16권2호
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• pp.125-129
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• 2003

Conncxin (Cx) is an important and essential protein induction of oocyte maturation, which is present in almost all mammalian tissucs except cirulating blood cells and adult skeletal museles. In this study, goldfish Cx43 cDNA sequence is available in GenBank under the accession number AB078505. Homology analyses using the GenBank and EMBL general database searches indicated that goldfish Cx43 cDNA has a high homology with carp Cx43 (95.1% identity), zebrafish Cx43 (90.5% identity), and chicken Cx43 (81.9% identity). Goldfish Cx43 is similar to the Cx family in its general features, and all the typical Cx consensus sequences are also found. Moreover, significantly increased Cx43 transcrpts were observed in mature goldfish (GSI; 18.3-21.7) pituitary and ovary when compared with immature goldfish (GSI; 4.9-6.0). Cx43 transeripts were weakly detectrd in both liver and kidney of immature and mature goldfish. There is possible that Cx43 nctivity was relation to oocyte maturation in the goldfish.