• Journal of Gastric Cancer
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• 제12권4호
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• pp.217-222
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• 2012

Purpose: We conducted this study to study the clinical correlation between the characteristics of gastric cancer and serum selenium and zinc levels. Materials and Methods: The following data were measured in the baseline serum selenium and zinc levels of 74 patients with curative gastrectomy subsequent to confirmed gastric cancer, from March 2005 to August 2012. Results: Among the 74 gastric cancer patients, 53 patients were male. Mean serum selenium and zinc levels were $118.7{\pm}33.1$ ug/L and $72.2{\pm}24.3$ ug/dl, respectively. Seven patients (9.5%) showed lower selenium level, and 33 patients (44.6%) showed lower zinc level. Serum Selenium level was $99.1{\pm}31.8$ ug/L in cardia cancer group (10 cases) and $121.8{\pm}32.4$ ug/L in non-cardia cancer group (64 cases)(P=0.044). According to tumor gross type, zinc level was $78.7{\pm}29.6$ ug/dl in early gastric cancer (33) and $66.9{\pm}17.8$ ug/dl in advanced gastric cancer (41) (P=0.064). Conclusions: The serum selenium level was highly correlated with the location of gastric cancer. The serum zinc level was lower in advanced gastric cancer.

• 한국식품영양과학회지
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• 제38권9호
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• pp.1174-1178
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• 2009

본 연구는 아연 공급 수준이 비만과 관련된 당대사 이상과 체내 무기질 함량에 미치는 영향을 알아보기 위하여 고지방식이 유도 비만쥐에게 아연을 요구량의 50%, 100%, 200% 수준으로 공급한 후 혈당, 인슐린 및 혈청 아연, 마그네슘, 크롬 함량을 측정하였다. 사료섭취량, 체중증가량, 사료효율 및 각 조직의 무게는 아연 공급 수준에 따른 유의적인 차이를 보이지 않았다. 그러나 혈당과 인슐린 농도는 아연 공급수준에 따라 유의적인 차이를 보여 혈당은 아연 과잉군이 결핍군과 적정군보다 유의적으로 낮게 나타났지만(p<0.05), 인슐린 농도는 아연 과잉군이 결핍군과 적정군보다 유의적으로 높았다(p<0.05). 혈청 아연과 크롬 함량은 아연 공급량에 따른 유의적인 영향을 받지 않았으나, 혈청 마그네슘 함량은 아연 결핍군이 다른 두 군보다 유의적으로 높게 나타났다(p<0.05). 결론적으로 비만군에서 아연 공급 수준에 따라 체내 당대사 및 그와 관련된 무기질 일부가 변화되는 것을 관찰할 수 있었다. 그러므로 비만군에게 아연을 보충 급여하면 인슐린 농도가 증가하며 그 결과 비만으로 발생될 수 있는 고혈당을 낮추는 효과가 있을 것으로 사료된다.

• Nutrition Research and Practice
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• 제7권5호
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• pp.380-384
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• 2013

Zinc may participate in blood pressure regulation and in the pathogenesis of hypertension. The study examined the relationship between zinc status and blood pressure in obese Korean women. Forty obese women (body mass index (BMI) ${\geq}25kg/m^2$) aged 19-28 years participated in this study. Zinc intake was estimated from one 24 hour recall and 2-day diet records. Serum and urinary zinc concentrations were determined by atomic absorbance spectrophotometry. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured using an automatic sphygmometer. Metabolic variables, such as waist circumference, triglyceride, high density lipoprotein (HDL) cholesterol, fasting glucose, and fasting insulin, were also measured. Dietary zinc intake of obese women was averagely 7.5 mg/day. Serum zinc and urinary zinc concentrations were $13.4{\mu}mol/L$ and $378.7{\mu}g/day$, respectively. Averages of SBP and DBP were 119 mmHg and 78 mmHg. Dietary zinc intake was negatively correlated with SBP after adjusting for energy intake (P < 0.05), but serum and urinary zinc concentrations were not found to be correlated with SBP or DBP. Multivariate linear regression analysis showed that dietary zinc intake was inversely associated with SBP in obese women after adjusting for body weight, energy intake and sodium intake (P = 0.0145). The results show that dietary zinc intake may be an independent risk factor of elevated SBP in obese Korean women.

• 한국식품영양과학회지
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• 제19권1호
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• pp.80-86
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• 1990

This experiment was conducted to study the effects of dietary zinc and ethanol on the zinc content of serum and tissues. Eight male rats of Sprague-Dawley strain with average weight of 80$\pm$5g were divided into five groups such as C group: ad libitum control diet(100 ppm Zn) plus isocaloric sucrose solution CE group ; ad libitum control diet plus 25% ethanol solution PF group ; pair fed control to zinc deficient diet(5ppm Zn) plus isocaloric sucrose solution ZD grop ; ad libitum zinc deficient diet plus isocaloric sucrose solution and ZDE group ; ad libitum zinc deficient diet plus 25% ethanol solution. The rats were sacrificed after 4 and 7 weeks of feeding periods. The liver weights of ZD and ZDF groups were increased however the weight of testis was decreased in the same groups The content of serum zinc was infiuenced by the dietary zinc level and the amount was significantly decreased in the ZD group. The content of liver zinc was influnced by the dietary zinc level and the amount was decreased by ethanol feeding. The content of testis zinc was significantly low in the ZDE group. The zinc level of feces to be increased by the ethanol feeding.

• Journal of Nutrition and Health
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• 제17권2호
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• pp.137-144
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• 1984

Due to the fact that blood gathering is not readily accepted by people, it has been difficult to make a full-scale study on zinc through blood analysis. For that reason, in this paper, a correlation of zinc contents in serum and hair was studied to find out whether only hair, which is relatively easy to collect, can be used for a measurement of zinc content. The subjects were 47 healthy female collegians selected at random whose average age was 22, mean height 159.1cm and average weight 49.7kg. The mean zinc value in serum of subjects was ${107.1}\pm{29.0}{\mu}g{/100ml}$, while the mean value in hair was ${150.2}\pm{42.7}ppm$. Correlation analysis shows that there was a significant correlation in zinc contents of serum and hair ( p<0.01). The results shows that measuring zinc level by using only hair samples would be satisfactory. But the use of hair sample for a measurement of zinc level has one demerit. That is, the method is more likely to be subjected to contamination because it makes more complicated procedures in sample preparation than the method of using blood sample.

• 환경위생공학
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• 제12권2호
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• pp.37-42
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• 1997

The toxic and detoxifying effects of cadmium and zinc on rat plasma ACTH and serum cortisol levels were investigated in rats. Rats were injected by i.p. with saline (0.9%), cadmium chloride (0.25 or 0.5mg/kg body weight) and pretreated with zinc chloride (4mg/kg body weight) before cadmium chloride treatment 1 or 2 weeks, respectively. The ACTH levels were no significant differences in cadmium 0.25mg/kg-treated group, but were significantly decreased in cadmium 0.5mg/kg-treated group compared with normal group. The ACTH levels after zinc pretreatment for 1 week were significantly increased but zinc pretreatment for 2 week were no difference. The serum cortisol levels of cadmium treated rats were significantly decreased, but were increased in zinc pretreated rats. The results showed that the zinc have some protective effect on cadmium toxicity in rats.

• 생명과학회지
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• 제18권7호
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• pp.947-951
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• 2008

아연은 많은 생리학적인 기능을 가지는 필수미량 원소로, 특히 성기능에 있어서 중요한 역할을 하는 것으로 잘 알려져 있다. 열대 과일 Rambutan으로부터 분리된 아연 고함유 효모의 미네랄 성분은 아연 306 ppm, K 28,640 ppm, Mg 2,342, Na 1,048 ppm, Ca 366 ppm, Fe 236 ppm 및 Mn 4 ppm이 함유되어 있었다. 혈청 중 성호르몬인 테스토스테론(testosterone) 농도는 정상군에 비해 에탄올 급여 실험군에서 감소 경향을 나타내었다. 에탄올 급여에 의한 성호르몬 테스토스테론의 농도 감소는 아연 고함유 효모 투여로 현저하게 증가하였다. 또한, 혈청 중 아연 함량에 에탄올 급여 실험군에서 감소경향을 보였고, 이러한 감소는 아연 고함유 효모 투여로 현저하게 증가하였다. 따라서, 에탄올 투여에 의한 혈중 아연 및 테스토스테론 농도의 감소효과는 아연 고함유 효모 투여로 상쇄되는 것으로 나타나 본 실험에 사용된 아연 고함유 효모는 성기능 관련 건강기능식품의 소재로서 산업적으로 유용하게 사용될 것으로 사료되어 진다.

• 한국식품영양과학회지
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• 제25권4호
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• pp.601-607
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• 1996

Nineteen non-insulin-dependent diabetic(NIDD) and healthy control women were investigated to study the relationship between glycemic control and the level of calcium, zinc, and magnesium in the serum and urine. Urinary calcium, zinc and magnesium levels in the NIDD women were significantly higher(p<0.01) than those of the control women. There were no difference in serum magnesium and zinc levels between the two groups, but se겨m calcium level was lower(p<0.01) in the NIDD women compared to that of the control group. In the NIDD women, serum magnesium was negatively related to fasting blood glucose(r=-0.533 : p<0.05), urinary glucose(r=-0.767 ; P<0.001), urinary protein(r=-0.476 : p<0.05), and urine volume(r=-0.571 : p<0.05). The levels of zinc in both serum (r=0.515, p<0.05) and urine(r=0.623 : p<0.01) were related to urinary protein but only urinary zinc level(r=0.570 : p<0.01) was related to serum albumin. Urinary magnesium, not calcium was correlated with the urinary glucose(r=0.563 : p<0.05) and urinary protein(r=0.568 ; p<0.05). Fasting blood glucose was positively correlated with duration of diabetes, as well as dietary fat and calorie intake. The results of this study suggest that NIDD alters all magnesium, zinc, and calcium utilization, particularly magnesium is involved in glycemic control in this condition.

• Journal of Nutrition and Health
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• 제22권6호
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• pp.539-546
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• 1989

This study was carried out to investigate the effect of addition of cellulose in the diet on the metabolism in rat fed high and low level of zinc. The experimental animals were consisted of 24 male weaning rats of Sprague-Dawley strain(mean weight 72.3g), and they were devided into 4 groups of 6 rats and fed experimental diets for four weeks. Dietary zinc levels used were 10 ppm, and 300ppm and cellulose levels were 2.5% and 10% of diet by weight. Throughout the experimental period, feed consumption and body weight gain were measured and feed efficiency ratio was calculated. The weight of live, kidney and spleen were measured, and the contents of zinc in feces, urine, liver, kidney, spleen and serum were determined. The results obtained are summarized as following ; 1. Body weight gain in high zinc-adequate cellulose group was significantly higher than the other groups. Feed consumptions were significantly higher in high zinc groups and no significant difference was found with dietary cellulose levels. 2. Fecal zinc excretions of four groups were not different at the first week, but at the end of fourth week, high zinc groups experince significantly more zinc excretion than low zinc groups, and also high cellulose groups had higher zinc contents in the feces than the adequate ones within the same zinc levels(p<0.05). There was no significant difference in the urinary zinc excretion. 3. The weights of liver, kidney and spleen were heavier in the high zinc groups than the lower ones, and higher in the high cellulose groups(p<0.05). The liver zinc contents were significantly lower in the low zinc and high cellulose groups. However zinc contents in the kidney and serum were not influenced by dietary zinc level but by cellulouse level. High cellulose diet lowered serum and kidney zinc concentrations(p<0.05).

• Journal of Nutrition and Health
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• 제33권8호
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• pp.848-856
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• 2000

The study was designed to assess the zinc nutritional status by gestational age of pregnant women visiting in public health centers in Ulsan. The subjects were divided into 3 trimester by last menstrual period(LMP). Interview for dietary zinc intake and general characteristics of each subjects was given and biochemical analysis of blood and urine was performed. Serum zinc concentration and urinary zinc excretion were analyzed by Flame Atomic Absorption Spectrophotometer, and alkaline phosphatase(ALP) activity was analyzed by Bowers & McComb\\`s method with Schimadzu automatic analyser. Also urinary creatinine was analyzed by Hawk\\`s method. Mean intake of zinc was 6.61${\pm}$1.57mg and did not meet the RDA(44.1% of RDA) for pregnant women by gestational age. Zn intake of 3rd trimester was significantly increased but dietary zinc was almost supplied with cereal and grain (47.30%) which were reported with low zinc availability due to phytate. Mean concentration of serum Zn in 1st trimester was 86.4${\pm}$10.5$\mu\textrm{g}$/dl, was 72.4${\pm}$10.3$\mu\textrm{g}$/dl in trimester and 65.1${\pm}$10.8$\mu\textrm{g}$/dl in 3rd trimester and was declined significantly by gestational age during pregnancy. In was concluded that a decline in serum Zn by gestional age was not influenced by amount of Zn intake. However ALP activity and urinary zinc excretion increased significantly by gestational age. Zinc nutritional status of pregnant women was not confirmed yet due to the physiological changes during pregnancy. However, the pregnant woman may be in a marginal zinc deficient status because of low amount of Zn intake and low bioavailability of Zn from dietary sources. (Korean J Nutrition 33(8) : 848-856, 2000)