• Journal of Nutrition and Health
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• 제31권4호
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• pp.777-786
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• 1998

The purpose of this study to investigate the relationship between nutrient intake and serum lipid levels in 165 healthy women in Taegu. A convenient method was to assess nutritional intake. Anthropometric measurement of body weight and height were measured and average energy expenditure calculated . The mean body mass index (BMI) was 23.4$\pm$3.1 and it was higher than the mean BMI of Korean women. Obesity rates for the study subjects were 15.7% by RBW (relative body weight : >120%) and 28.5% by BMI(body mass index) ; >25). Daily energy intake was sufficient at 106% of recommended dietary allowances and the energy percentage ration of carbohydrate , fat and protein was 68 : 18 : 14. Mean intake of vitamin A, B1 , niacin , and Ca were higher than RDA. The incidence of hypertension(>140mmHg) and hypercholoesterolemia(>240mg/dl) as 18.2% and 23.6% of the subjects, respectively . Postmenopasusal women showed significantly higher blood pressure, RBW, and ALP (alkaline phosphatase) than premenopausal women. The concentration of cholesterol and average blood pressure in the irregular meal eater group were significantly higher than in the regular meal eater group. Skipping meals and unenvendurnal distribution(no breakfast, or no lunch , and large evening meals) are associated with high total cholesterol level in this population . Especially, the atherogenic index was significantly lower in the regular meal eater group than that in irregular meal eaters. The values for serum cholesterol, triglyceride, blood pressure, BMI, and atherogenic index increased with age in middle-aged women. There was a highly significant correlation between body weight and plasma lipids. HDL -cholesterol was inversely correlated with BMI. The above dta provides valuable information for community program planning and health providers who work with individual female and adults to meet their nutrietional needs to control blood lipids.

• Asian-Australasian Journal of Animal Sciences
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• 제25권2호
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• pp.248-255
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• 2012

Three levels of boron (0, 30, 60 ppm) were supplemented in practical corn-soybean based starter and grower diets, containing either adequate or inadequate Ca or P. A total of 1,800, 1-day-old sexed broiler chicks were assigned to six dietary treatments and fed with the experimental diets for 42 days. Boron improved the overall feed conversion ratio, but increased body weight only at 21 days of age (p<0.01). Boron decreased feed intake in the case of feeding on a diet deficient in Ca and P, and tended to increase feed intake when birds received a diet adequate in Ca and P, signifying significant boron by Ca-P interaction (p<0.01). Mortality was not influenced by boron (p>0.05). Dietary Ca and P deprivation reduced body weight and feed consumption significantly, but did not influence the feed conversion ratio and mortality (p>0.05). Serum Ca level, ALP and ALT activities were not influenced either by dietary Ca and P deficiency or boron supplementation. Serum P content increased with respect to boron at 30 ppm. Bone breakage strength was not affected by dietary variables. Tibia ash, Ca and P were increased in response to the supplementation diet with 30 ppm boron, whereas 60 ppm showed no effect in most cases. Accordingly, the dietary boron supplementation of 30 ppm significantly decreased fecal Ca and P excretion, while there was a numerical decline in the 60 ppm boron as compared to the 0 ppm boron group. Data presented herein indicated that boron, either at the 30 ppm or 60 ppm supplementation level, was effective in conversion of feed to body weight, whereas only boron at 30 ppm contributed to the mineralization of bone thereby augmenting more Ca and P while excreting less through faeces.

• 동의생리병리학회지
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• 제22권1호
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• pp.183-188
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• 2008

여성의 폐경에 의한 estrogen의 감소는 골다공증을 유발시킨다고 알려져 있다. 최근 새로운 식품으로 각광받고 있는 도라지 추출물을 인위적 갱년기 장애를 유발시킨 흰쥐에 투여하여 혈 중 ALP활성 변화와 골 중의 collagen의 함량 및 collagen 가교물질 pyridinoline과 deoxypyridinoline 함량 변화를 측정하여 그 효과를 검토해 보았다. 도라지 추출물을 갱년기를 유도한 흰쥐에 투여하여 혈 중 ALP활성 변화에 미치는 영향을 검토한 결과 난소절제에 의하여 ALP활성이 증가하였으나, 도라지 추출물 투여한 군에서 ALP활성이 억제되는 것을 확인할 수 있었다. 또한 난소 절제에 의해 연골의 collagen 함량이 감소되었는데, 이는 도라지 추출물을 투여함으로써 정상적인 수치로 증가하는 경향을 나타내어 도라지 추출물이 골 대사와 관련된 골 대사 질환에 유효한 효과를 나타낼 것으로 추측된다. 또한 collagen 가교물질로써 골대사의 biomaker인 pyridinoline 및 deoxypyridinoline의 골 중의 함량은 난소절제에 의해 감소하였고, 도라지 추출물 투여에 의해 증가하여 estrogen부족으로 인한 골 손실에 도라지 추출물이 유익한 효과를 가지는 것으로 보이며, 이는 도라지 중에 함유되어 있는 phytoestrogen에 의한 것으로 추측되어 앞으로 구체적인 검토가 필요한 것으로 사료된다.

• 한국임상수의학회지
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• 제29권6호
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• pp.435-440
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• 2012

이번 연구는 만성신부전이 있는 개에서 대황 추출물($Rubenal^{(R)}$)의 치료적 효과와 부작용을 평가하기 위해서 실시되었다. 보호자가 있는 만성신부전 IRIS II-III 단계의 개 40마리가 이번 연구에서 사용되었다. 개들에게 동일한 모양의 대황 추출물과 위약을 투여한 후 0, 30, 90, 180일 동안 관찰, 평가하였다: BSC, 임상적 평가(식욕, 다음/다뇨, QOL), 혈액 검사(WBC, RBC, PCV), 혈청화학검사(ALT/AST, ALP, Creatinine /BUN, Total protein, albumin), 전해질검사(Na, K, Cl, Ca, iCa, P), 혈압, 요검사(UPC, 요비중) 그리고 IRIS 단계를 평가하였다. 이번 연구에서 개들에게 대황 추출물을 적용하였을 때 부작용 없이 잘 받아들이는 것을 확인하였다. 또한, 통계학적으로 임상적 평가(수의사와 보호자의 QOL)와 혈청 BUN, creatinine 수치, 혈청 인 농도, 단백뇨의 양, 그리고 만성신부전의 IRIS 점수가 루비날치료 6개월 후에 유의성 있게 개선되었다. 이러한 발견은 대황의 추출물은 만성신부적의 임상증상(i.e., azotemia, hypertension, proteinuria, hyperphosphoremia)과 삶의 질(i.e., body condition score, appetite and PD/PU)을 향상시키고, 개에서 만성신부전의 진행을 늦출 수 있다는 것을 보여준다. 그러므로 대황 추출물은 준임상적, 그리고 임상적으로 신장 질환을 치료하고 있는 개에게 좋은 보조제가 될 수 있다. 하지만 본 연구는 작은 규모의 파일럿 연구이므로 이중 맹검법의 대규모 실험을 통해 보다 정확한 실험결과의 재현이 요구된다.

• 동아시아식생활학회지
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• 제9권2호
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• pp.161-168
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• 1999

차전초는 무병 장수의 식물로 잘 알려져 있으며 주로 잎과 씨가 약재로 쓰이는데 잎은 여름에 채취하여 햇볕에 말렸다가 잘게 썰어서 사용하고 씨는 익는 대로 채취하여 햇볕에 말려 그대로 사용하였다. 차전초에는 plantagnin과 aucubin이라는 성분을 함유하고 있어 호흡기에 작용하여 기침에 특효약으로 이용되며, 또한 체내의 분비신경을 자극하여 기관지의 점액이나 소화액 분비를 촉진하는 할로겐 화합물로 단백질의 불활성, 효소활성 감소 또는 막의 구조와 기능을 파괴함으로써 간장을 표적장기로 독작용을 일으킨다고 알려져 있는 사염화탄소를 투여하여 인위적으로 간장해를 유발한 흰쥐에게 차전초 열수 추출액을 투여하여 혈청 중의 효소활성도와 지질 함량을 분석하여 얻은 결과는 다음과 같다. 1. 간 손상의 대표적인 지표로 사용되고 있는 효소인 ALT, AST, LDH와 ALP 활성도는 사염화탄소를 투여함으로써 증가하여 간 손상이 초래되었음을 알 수 있었으며, 증가한 효소활성도는 차전초 열수 추출액을 투여함으로써 양호하게 감소하였다. 2. 혈청 중의 total cholesterol LDL-cholesterol 함량은 사염화탄소 투여에 의해서 증가하였으나 차전초 열수추출액 투여로 양호하게 감소하였다. 또한 HDL-cholesterol은 사염화탄소 단독투여로 인해 감소되었으나 차전초 열수 추출액을 병행투여함으로써 증가하였다. 3. 혈청 중의 total lipid, triglyceride 및 phospholipid 함량은 사염화탄소 단독투여군에 비해 차전초 열수 추출액 단독투여군은 양호하게 감소하였고 차전초 열수 추출액과 병행 투여군 또한 유의적으로 감소하는 경향을 보였다. 이러한 결과로 보아 차전초 열수 추출액이 간기능을 증강시키며 지질성분과 효소활성에 좋은 효과를 나타내어 차전초의 함유성분이 보간작용에 중요한 역할을 할 수 있을 것이라 사료되어진다.

• 한국임상수의학회지
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• 제30권1호
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• pp.12-16
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• 2013

This study was performed to investigate hepatoprotective effect of rutin on acute hepatic damage induced by carbon tetrachloride in rats. Twenty-four male Sprague-Dawley rats were randomly divided into four groups; normal control group, $CCl_4$ control group, two rutin treatment groups (rutin 200+$CCl_4$ and rutin 400+$CCl_4$). Dissolving vehicles were applied to the rats in the normal control group. The rutin was administrated to the rats in rutin 200+$CCl_4$ and rutin 400+$CCl_4$ groups at the levels of 200 mg/kg and 400 mg/kg, 3 consecutive days orally, with 24 hours interval before inoculating $CCl_4$. $CCl_4$ was intraperitoneally administered an hour after the last treatment of rutin to the rats in every group except the normal control group. The body weight of rats in $CCl_4$ control group were significantly lower than other groups (p < 0.05), but the liver weight and relative liver weight were higher than normal control group (p < 0.05). The activities of ALT, AST, ALP, GTP, LDH and the level of total bilirubin in sera of rats in $CCl_4$ control group were higher and the levels of total protein, albumin and globulin were lower than the normal group (p < 0.05). The activities of ALT, AST, ALP, GTP, LDH and the level of total bilirubin in rutin 200+$CCl_4$ and rutin 400+$CCl_4$ groups were lower than $CCl_4$ control group (p < 0.05). Therefore the pre-treatment of rutin before $CCl_4$ inoculation in rats effectively inhibited the elevation of serum ALT, AST and total bilirubin which are the parameters of hepatic damage.

• 한국지역사회생활과학회지
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• 제16권1호
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• pp.59-64
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• 2005

This study is to find out effects of hot water soluble extract from green tea, one of the Korean favorites, on the calcium metabolism and bone strength in body. To do so, calcium, phosphate, creatinine concentration and ALP activity in blood and the content of calcium and ash in the organ, the length, weight, strength in bone were measured. In addition, to find the calcium metabolism, the level of calcium intake, excretion, retention were measured. Twenty male Sprague-Dawley rats were divided into two groups and isoloated soy protein was provided as the source of protein and CaCO₃ was provided as the source of calcium. 0.5% hot water soluble extract from green tea was provided to the green tea groups and for the control group deionized water was provided. The results are as follows ; 1. There is no difference between the experimental groups in diet intake, weight gain, and the feed intake. 2. Feed efficiency ratio was low in the group which hot water soluble extract from green tea was provided. 3. There is no difference between groups the level of calcium, phosphorus, creatinine and ALP activity in serum. 4. There is no difference between groups weight, contents of ash and calcium in kidney and liver. 5. There is no difference between groups in calcium intake, absorption, excretion, and retention. 6. There is no difference between groups weight, length and strength in bone. In summary, when hot water soluble extract from green tea was provided with the amount of 150-200mg, which is taken when people generally drink as favorite tea, weight gain was reduced due to the decrease of feed efficiency ratio. However, it did not affect the availability of calcium in body at all. Thus, even if a big quantity of green tea powder or solid of hot green tea extract is not provided, the quantity obtained when people drink green tea lowers the feed efficiency ratio without reducing availability of calcium in body.

• 대한의생명과학회지
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• 제15권2호
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• pp.135-139
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• 2009

The CA(carbohydrate antigen)19-9 is complex protein that can be used as an important marker which aids the clinical diagnosis and prognosis of various pancreaticobiliary tumors. However, it was also reported that there were some CA19-9 positive patients with benign disease as using RIA method. The purpose of this study is to evaluate the clinical usefulness of serum level of CA19-9 with RIA(radioimmuno assay), CIA(chemiluminescence immuno assay), and conventional liver function tests. The correlation between CIA and RIA in CA19-9 of pancreatobiliary disease was 0.9833(P<0.01). Also, the correlations between CIA and RIA in CA19-9 of benign and malignant pancreaticobiliary tumor patients was 0.8714(P<0.01) and 0.9727(P<0.01) respectively. The correlation between CA19-9 and ALP was 0.5140(P<0.01) and CEA was 0.3385(P<0.05) as using CIA. The measurement of serum CA19-9 levels by CIA method may be useful in differentiating patients with malignant disease from those with benign disease in pancreaticobiliary tumors.

• Nutrition Research and Practice
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• 제3권2호
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• pp.108-113
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• 2009

Taurine supplementation has been shown to have a beneficial effect on femur bone mineral content in ovariectomized rats. It therefore seemed desirable to find out whether the beneficial effect of taurine on ovariectomized rats fed calcium deficient diet could also be reproduced. Forty female Sprague-Dawley rats were divided into two groups, One group was OVX and the other group received sham operation (SHAM), and received either control diet or a taurine supplemented diet for 6 weeks. All rats were fed on calcium deficient diet (AIN-93: 50% level of calcium) and deionized water. Bone mineral density (BMD) and bone mineral content (BMC) were measured in spine and femur. The serum and urine concentrations of calcium and phosphorus were determined, Bone formation was measured by serum osteocalcin and alkaline phosphatase (ALP) concentrations, Bone resorption rate was measured by deoxypyridinoline (DPD) crosslinks immunoassay and corrected for creatinine. Urinary calcium and phosphorus excretion, osteocalcin in blood and cross link value were not significantly different among the groups. Within the OVX group, the taurine supplemented group had not higher femur bone mineral content than the control group. This study established the need for a study on the taurine effect on bone with different calcium levels.

• Food Science and Biotechnology
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• 제15권2호
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• pp.238-243
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• 2006

The methanol extract of waxy brown rice fermented with Agrocybe cylindracea was prepared. The extract was then freeze dried and fed to rats at the level of 0.5, 1.0, 2.0 g/kg body weight for 14 days, followed by the treatment with carbon tetrachloride for three consecutive days to induce hepatotoxicity. After sacrificing the rats, the enzyme activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and ${\gamma}$-glutamyl transpeptidase (${\gamma}$-GTP) in serum was determined. Biochemical analysis on serum for albumin, total protein, triglyceride, and total as well as HDL-cholesterol were carried out along with a histopathological study of liver tissues. Based on these data, we suggest that the waxy brown rice cultured with A. cylindracea may exert hepatoprotective activity against hepatotoxicity caused by chemicals such as carbon tetrachloride.