• 농촌의학ㆍ지역보건
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• 제29권1호
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• pp.177-184
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• 2004

Objectives: Tsutsugamushi disease is one of the most significant acute febrile illnesses, increasing in frequency of occurrence during the late autumn in rural areas of Korea. Methods: I have conducted a case-control study on 30 cases who had the fever as a chief complaint, then had been ruled out as having the Tsutsugamushi disease. Data was collected retrospectively by review of chart regarding their general characteristics, clinical and laboratory findings, then was analysed by chi-test. Results: Of 30 cases, 16 cases were seropositive and 14 cases were seronegative against O. tsutsugamushi. Of seropositive for tsutsugamushi disease, 56.3% were female; 37.5% were in their seventies; 50.0% were farmers; 62,6% had chances of exposure to fields or mountains. And 75.0% occurred in November. The main symptoms and signs were fever and chill(100.0%), headache(75.0%). weakness and fatigue(93.8%), and eschar(68.8%). The characteristic laboratory findings were elevated AST(50.0%), ALT(62.5%), and abnormal urinalysis(56.3%). On the other hand, of seronegative cases, 57.1% were male; 50.0% were in their fifties; 42.9% were farmers; 57.2% had chances of exposure to fields or mountains. And 71.4% occurred in November. The symptoms and signs were fever and chill(100.0%), headache(85.7%), eschar(64.3%). weakness, fatigue and skin(57.1%). The laboratory findings were elevated AST(71.4%) and ALT(64.3%), and abnormal urinalysis(42.9%). However, there were no significant differences between the seropositive and seronegative cases(P>.05). Conclusions: Acute febrile community inhabitants who have the epidemiological, clinical as well as laboratory features should be focused upon for the early diagnosis and treatment for tsutsugamushi disease whether or not possessing the serological antibody against O. tsutsugamushi.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7725-7730
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• 2014

Hepatocellular carcinoma (HCC) is the third most common cause for cancer death in the world, now being especially linked to chronic hepatitis C virus (HCV) infection. This case-control study consisting of 65 HCC patients and 82 patients with other malignant tumours as controls was conducted to determine the association of HCV markers with HCC. Serum of each participant was obtained for detection of HCV Ab and RNA by DNA enzyme immunoassay (DEIA). Twenty six per cent (26.0%) of HCC patients had positive anti-HCV which was significantly greater than the control group (p=0.001). HCC patients significantly have a risk of exposure to HCV infection almost 3 times than the control group (OR=2.87, 95% C.I=1.1-7). Anti-HCV seropositive rate was significantly (p=0.03) higher among old age HCC patients and increases with age. Males with HCC significantly showed to have more than 9 times risk of exposure to HCV infection (OR=9.375, 95 % CI=1.299-67.647) than females. HCV-RNA seropositive rate was (70.8%) significantly higher among HCC patients compared to (22.2%) the control group (p=0.019). The most prevalent genotype (as a single or mixed pattern of infection) was HCV-1b. This study detected a significantly higher HCV seropositive rate of antibodies and RNA in HCC patients.

• Parasites, Hosts and Diseases
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• 제37권1호
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• pp.27-32
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• 1999

A total of 542 children under 10 years of age, admitted to the Seoul National University Children's Hospital, was examined for antibody titers of Toxoplasma gondii using indirect latex agglutination (ILA) test. Among them, 7.7% showed positive titers higher than 1:32, without significant difference between males (7.3%) and females (8.5%). The seropositive rate increased with age although the statistical significance was negligible (0.05

• 대한수의학회지
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• 제45권2호
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• pp.239-244
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• 2005

Hematologic investigations were made on the blood samples taken from bovine leukemia virus (BLV)-seropositive Holstein-Friesian cattle in Korea, and their absolute lymphocyte count was compared with that of BLV-seronegative cattle. The incidence of persistent lymphocytosis (PL) was also determined. The normal bovine lymphocyte count was established on the basis of studies of 656 blood samples taken three times from 297 seronegative animals aged from 0~6 months to over 5 years at 5~6-month intervals. The data were examined according to 7 age groups of samples placed into their respective age groups. A peak in average total count was reached at 6~12 months ($5.36{\times}10^3/{\mu}l$) and thereafter the count declined continuously until over 5 years ($3.17{\times}10^3/{\mu}l$). From the results, 99.74 percent limits were calculated, and the upper limit of the range was chosen as the cutoff point for lymphocytosis. A PL was defined as a lymphocyte count that exceeded the above 99.74 percent limits and persisted over an interval of at least three months. The criterion for PL was applied to classifying 515 blood samples obtained four times from 189 seropositive animals without clinical signs at 5~7-month intervals. It was found that 54 (28.5%) of seropositive animals were with PL; cattle with PL were in age groups of 2~3 years to over 5 years.

• 한국동물위생학회지
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• 제43권2호
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• pp.59-65
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• 2020

The aim of the study was to investigate the seroprevalence of equine herpesvirus type 1 (EHV-1) and type 4 (EHV-4), equine influenza virus (EIV), and Streptococcus (S.) equi subspecies equi in the horse population of Jeju. Serum samples were taken from 71 horses, regularly vaccinated with EHV-1 and strangles twice (April and November) a year. In April 2014, seropositive rates of EHV-1 and strangles were 24.5% and 84.5%, while in November, were 26.8% and 62.0%, respectively. A total of 1,144 serum samples, including Jeju native horses, Halla horses, and Thoroughbred horses were collected from slaughter house for 4 years (2014 to 2017) and it is unclear the animals were vaccinated or not. The seropositive rates in Jeju was 21.9% (250/l,144) for EHV-1, 96.4% (1,103/1,144) for EHV-4, 14.6% (129/882) for EIV, and 79.3% (879/1,108) for strangles. The seropositive rate was the highest in Thoroughbred, but lowest in Hala horse.

• Parasites, Hosts and Diseases
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• 제53권5호
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• pp.605-610
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• 2015

Toxoplasmosis is considered as an important risk factor for bad obstetric history (BOH) and one of the major causes of congenitally acquired infections. The present study aimed to estimate the seropositivity of T. gondii infection and associated risk factors among the attendees of high risk pregnancy and low risk antenatal care clinic of Minia Maternity and Pediatric University Hospital, Minia, Egypt. The study was carried out from April 2013 to April 2014 through 2 phases, the first phase was case-control study, and the second phase was follow-up with intervention. A total of 120 high risk pregnant and 120 normal pregnant females were submitted to clinical examinations, serological screening for anti-Toxoplasma IgM and IgG antibodies by ELISA, and an interview questionnaire. Seropositive cases were subjected to spiramycin course treatment. The results showed that the seroprevalence of toxoplasmosis in high-risk pregnancy group was 50.8%, which was significantly different from that of normal pregnancy group (P<0.05). Analysis of seropositive women in relation to BOH showed that abortion was the commonest form of the pregnancy wastage (56.5%). The high prevalence of T. gondii seropositive cases was observed in the age group of 21-30 years. Post-delivery adverse outcome was observed in 80.3% of high-risk pregnancy group compared to 20% of normal pregnancy group. There was a statistically significant relationship between seropositivity and living in rural area, low socioeconomic level, and undercooked meat consumption (P<0.05). Serological screening for anti-Toxoplasma antibodies should be routine tests especially among high-risk pregnant women.

• Pediatric Infection and Vaccine
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• 제27권2호
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• pp.117-126
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• 2020

목적: Epstein-Barr virus (EBV)는 초감염 연령이 사회, 문화 및 경제적인 환경에 따라 다르게 나타나며, 이에 따른 임상 양상도 다르다. 우리나라도 점차 EBV 감염의 발생 시기가 늦어짐에 따라 초감염시 전형적인 양상의 전염성 단핵구증 임상증상을 보이는 환자들의 수가 증가하고 있다. 이 연구의 목적은 전 연령의 EBV 항체검사 결과를 분석함으로써 현재 우리나라 항체 보유율 현황을 파악하는 것이다. 방법: 2000년부터 2017년까지 삼성서울병원에서 EBV 항체검사를 시행한 전 연령의 환자들의 성별, 거주지, 검사 시행 당시 환자의 나이 및 검사 시행 년도에 따른 항체 양성률을 분석하였다. EBV-viral capsid antigen (VCA) IgG 혹은 EBV-VCA IgM이 양성인 경우를 항체 보유율이 양성인 환자로 분류하였다. 결과: 전체 환자 26,527명을 대상으로 한 EBV 항체 양성률은 81.0% (21,485/26,527)였으며 0-9세의 EBV 항체 양성률이 44.4% (2,716/6,122), 10-19세의 경우 75.8% (2,077/2,739), 만 20세 이후부터는 94.5% (16,692/17,666)이상으로 확인되었다. 검사 시행 시기에 따라 EBV 항체 양성률의 변화는 2000-2008년에 비해 2009-2017년 사이의 항체 양성률이 89.4%, 76.2%로 통계학적으로 유의미하게 감소하였다(P<0.001). 특히 0-19세 사이의 소아청소년의 경우 2000-2008년에 비해 2009-2017년 사이의 EBV 항체 양성률이 두드러지게 감소하였다(0-9세: 2000-2008년 62.8% [1,172/1,866], 2009-2017년 36.3%[1,544/4,256]; 10-19세: 2000-2008년 83.8% [745/858], 2009-2017년 70.8% [1,332/1,881]) (P<0.001). 결론: 2000년 이후 전체 인구의 EBV 항체 보유율은 81.0%로 높게 유지되고 있으나, 초감염이 발생하는 소아청소년기의 항체 보유율은 감소추세를 보이고 있어 EBV 초감염이 발생하는 연령이 늦어지고 있음을 시사하고 있다. 따라서 EBV 초감염 발생 연령의 증가에 따른 청소년 및 젊은 성인에서의 전염성 단핵구증과 같은 임상 양상 발현에 대한 관심이 필요하다.

• Journal of Trauma and Injury
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• 제28권1호
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• pp.9-14
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• 2015

Purpose: The aim of this study was to estimate the seropositive prevalence of blood-borne infection in neurotrauma patients who underwent emergent surgical intervention, especially patients with hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis and human immunodefIciency virus (HIV). Methods: A retrospective review identified 559 patients with traumatic brain injury and spinal trauma who underwent emergent surgery between 2007 and 2014. We reviewed the medical records and extracted data, including age, sex, location of lesion, result of serologic tests, time interval of admission and surgery after presenting to emergency room. Serologic tests for HBV, HCV, syphilis and HIV were performed and analyzed to determine whether the seropositive results were confirmed by the surgeon before surgery. Results: The majority of the patients were male (74.6%), and the mean age was $55.4{\pm}20.2years$. Most patients underwent surgery due to traumatic brain injury (90.0%). Fifty-three patients (10.0%) showed a positive result on at least one serologic test. Seropositive rates according to pathogens were 0.5% for syphilis, 5.2% for HBV and 3.9% for HCV. No positive results were noted on the serologic tests for HIV. HBV in patients with spinal cord injury and age from 40 to 49 years were associated with high serologic positive rate, and that result was statistically significant. However, no statistically significant differences were found in the other variables. Serologic results could not confirmed before surgery in the majority of the cases (62.1%), and 10.4% of these patients showed seropositive results. Conclusion: The results of this study emphasize the importance of taking precautions and conducting rapid serologic testing in preventing the occupational transmission of blood-borne viruses to health-care workers.

• 한국동물위생학회지
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• 제36권3호
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• pp.151-155
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• 2013

Since a large number of Akabane and bovine ephemeral fever (BEF) infection occurred in the southern part of Korea in 2010, recent information about seroprevalence of Akabane virus (AKAV) and bovine ephemeral fever virus (BEFV) has been required for preventing both diseases. In this study, serological assay against AKAV and BEFV using virus neutralization assay was conducted using 1,743 bovine sera collected from Namwon, Miryang, Yeongju and Uljin which located in Southern part of Korea from March to May in 2012. The overall seropositive rates for AKAV and BEFV were found to be 49.8% and 1.2%, respectively. The regional distribution of seroprevalence for AKAV ranged from 18.1% to 63.7%. Seroprevalences of AKAV were 63.7% in Miryang, 62.3% in Uljin, 50.7% in Namwon, and 18.1% in Yeongju. The seropositive rates for AKAV in southern part of Korea were higher than the annual average at the national level. On the other hand, seropositive rates of BEFV in four regions were from 0.3 to 3.1%. In detail, regional seroprevalences were 3.1% in Miryang, 2.0% in Uljin, and 1.7% in Yeongju, and 0.3% in Namwon. Even only one year after massive outbreaks, overall seropositive rates were very low, similar to the annual average at the nation level. This result indicates that many number of cattle infected with BEFV may be replaced by new born calf or cattle in farm may not be immunized with vaccines. To prevent another epidemic, a national wide warning should be issued and more aggressive control measure must be implied. Recent global warming phenomenon could lead to more vigorous activity of haematophagous vectors and it is possible that arboviral diseases such as AKAV and BEFV are increased. Therefore, continuous sero-monitoring and extensive vaccination combined with control of haematophagous vectors are important to effectively prevent and control diseases caused by AKAV and BEFV.

• 한국동물위생학회지
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• 제41권3호
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• pp.185-190
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• 2018

This survey was carried out to investigate the seroprevalence of Neospora caninum in Korean indigenous cattle that was raised in the southern area of Gyenongbuk and Ulleung-gun. A total of 3,162 cattle from 984 farms were tested for the presence of antibodies against N. caninum using a commercial ELISA (IDEXX Switzerland AG, Liebefeld-bern) test kit. The Seropositive ratio of cattle was 1.38% (40/2,901), 0.77% (2/261) in the southern area of Gyeongbuk and Ulleung-gun, respectively. Regional seropositive rates of farms were 5.31% (11/207), 3.45% (4/116), 1.48% (2/135), 2.13% (2/94), 2.78% (3/108), 3.91% (95/128), 4.17% (4/96), 4.35% (3/69), 6.45% (2/31) at Gumi, Yeongcheon, Gyeongsan, Gunwi, Chengdo, Goryeong, Senogju, Chilgor and Ulleung-gun, respectively. A herd of cattle under 4 years old was 1.4% (28 heads), and above the age of 5 years was 1.1% (14 heads). and in seroprevalenec cattles by herd size farms raising under 100 heads were 39 heads.