• Journal of KIISE
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• v.43 no.6
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• pp.627-635
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• 2016

When many processes issue write operations alternately on Log-structured File System (LFS), the created files can be fragmented on the file system layer although LFS sequentially allocates new blocks of each process. Unfortunately, this file fragmentation degrades read performance because it increases the number of block I/Os. Additionally, read-ahead operations which increase the number of data to request at a time exacerbates the performance degradation. In this paper, we suggest a new cleaning method on LFS that minimizes file fragmentation. During a cleaning process of LFS, our method sorts valid data blocks by inode numbers before copying the valid blocks to a new segment. This sorting re-locates fragmented blocks contiguously. Our cleaning method experimentally eliminates 60% of file fragmentation as compared to file fragmentation before cleaning. Consequently, our cleaning method improves sequential read throughput by 21% when read-ahead is applied.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.12
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• pp.2387-2394
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• 2016

It is important to select the most appropriate channel for efficient transmission of massive data in wireless sensor network. In the fixed channel method for wireless sensor node, shortage of frequency may be a major constraint to support a variety of environments. In this paper, the method that seeks common channels between two nodes without common control channels in the existing wireless cognitive radio network is introduced in order to use efficiently the channel of wireless sensor network. The problem of existing method shows the severe degradation of performance that is caused by interference of linkage between selected channels, so that the sequential algorithm is suggested to improve the performance. From the results of computer simulation, the suggested method shows that the link can be set 50% faster than the other methods as the number of links increases because the beacon packet waiting time caused by the interference decreases remarkably.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.33 no.6
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• pp.636-642
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• 2007

Background: CpG DNA plays an important role in immune cell function. This study examined whether the temporal control of toll-like receptor (TLR)9 by CpG DNA can regulate the expression of matrix metalloproteinase-9(MMP-9). Methods and materials: Macrophages were cultured in the presence of 10% FBS. For the various MMP genes analysis, RT-PCR and real-time PCR were performed. In addition, zymography assay performed for the MMP activity. The phosphorylation assay did for the ERK1/2 and NF${\kappa}B$ activation, and luciferase promoter assay was for the NF${\kappa}B$ activity. Results: CpG DNA induced the mRNA expression of MMP-2, MMP-9, and MMP-13, but not of MMP-7, MMP-8, and MMP-12, in a time-dependent manner. Especially, the mRNA expression of MMP-9 was strongly induced by CpG DNA using real-time RT-PCR. The TLR9 inhibitor, chloroquine, suppressed CpG DNA-induced MMP-9 expression and its activity. Moreover, CpG DNA induced the phosphorylation of ERK and the inhibition of ERK by U0126 suppressed CpG DNA-induced MMP-9 expression and its activity. CpG DNA stimulated $I{\kappa}B-{\alpha}$ degradation and luciferase activity. In addition, pretreatment of SN-50, the inhibitor of NF${\kappa}B$, strongly blocked the CpG DNA-induced MMP-9 expression and activity. Conclusion: These observations suggest that CpG DNA may play important roles in the activation of macrophages by regulating the production of MMP-9 via the sequential TLR9-ERK-NF${\kappa}B$ signaling pathway.

• 한국지구물리탐사학회:학술대회논문집
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• 2003.11a
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• pp.493-500
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• 2003

The effect of reductive treatment with elemental iron on the extent of mineralization by Fenton oxidation was studied for the explosive 2,4,6-trinitrotoluene (TNT) and hexahydro-l,3,5-trinitro-l,3,5-triazine (RDX) using a completely-stirred tank reactor (CSTR). The results support the hypothesis that TNT and RDX are reduced with elemental iron to products that are oxidized more rapidly and completely by Fenton's reagent. Iron pretreatment enhanced the extent of TOC removal by approximately $20\%\;and\;60\%$ for TNT and RDX, respectively. Complete TOC removal was achieved for TNT and RDX solutions with iron pretreatment under optimal conditions. On the other hand, without iron pretreatment, complete mineralization of TNT and RDX solutions were not achieved even with much higher $H_2O_2$ and $Fe^{2+}$ concentrations. The bench-scale iron treatment-Fenton oxidation integrated system showed more than $95\%$ TOC removal for TNT and RDX solutions under optimal conditions. The proposed zero-valent iron-Fenton process was evaluated with pink water from the Iowa Army ammunition plant. Results from batch and column experiments show that TNT, RDX, and octahydro-l,3,5,7-tetranitro-l,3,5,7-tetrazocine (HMX) were completely removed from the pink water and that triaminotoluene (TAT) and ${NH_4}^+$ were recovered as products in reduction with zero-valent iron. By using an integrated system, $83.3\pm4.2\%$ of TOC was removed in a CSTR with 10 mM of $Fe^{2+}$ and 50 mM of $H_2O_2$. These results suggest that the reduction products of TNT and RDX are more rapidly and completely mineralized by Fenton oxidation and that a sequential iron treatment-Fenton oxidation process may be a viable technology for pink water treatment.

• Journal of mucopolysaccharidosis and rare diseases
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• v.4 no.1
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• pp.14-20
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• 2018

Mucopolysaccharidoses (MPSs) are a group of rare inherited metabolic disorders caused by specific lysosomal enzyme deficiencies leading to the sequential degradation of glycosaminoglycans, causing substrate accumulation in various cells and tissues and progressive multiple organ dysfunction. The rare disease medical care team at Mackay Memorial Hospital in Taiwan has been dedicated to the study of MPSs for more than 20 years. Since 1999, more than 50 academic papers focusing on MPSs have been published in international medical journals. Topics of research include the following items regarding MPSs: incidence, natural history, clinical manifestations, gene mutation characteristics, cardiac function, bone mineral density, sleep studies, pulmonary function tests, hearing assessments, percutaneous endoscopic gastrostomy, anesthetic experience, imaging analysis, special biochemical tests, laboratory diagnostics, global expert consensus conferences, prenatal diagnosis, new drug clinical trials, newborn screening, and treatment outcomes. Of these published academic research papers, more than half were cross-domain, cross-industry, and international studies with results in cooperation with experts from European, American and other Asian countries. A cross-specialty collaboration platform was established based on high-risk population screening criteria with the acronym "BECARE" (Bone and joints, Eyes, Cardiac and central nervous system, Abdomen and appearance, Respiratory system, and Ear, nose, and throat involvement). Through this platform, orthopedic surgeons, rheumatologists, ophthalmologists, cardiologists, rehabilitation physicians, gastroenterologists, otorhinolaryngologists, and medical geneticists have been educated with regards to awareness of suspected cases of MPSs patients to allow for a further confirmative diagnosis of MPSs. Because of the progressive nature of the disease, an early diagnosis and early multidisciplinary therapeutic interventions including surgery, rehabilitation programs, symptom-based treatments, hematopoietic stem cell transplantation, and enzyme replacement therapy, are very important.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37 no.7A
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• pp.535-544
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• 2012

Multi-Input Multi-Output (MIMO) transmission is now considered as one of essential techniques enabling high rate data transmissions in wireless communication systems. In addition, severe channel impairments in wireless systems should be compensated by using highly efficient forward error correction (FEC) codes. Turbo codes or low density parity check (LDPC) codes, using iterative decoding with soft decision detection information (SDDI), are the most common examples. The excellent performance of these codes should be conditioned on accurate estimation of SDDI from the MIMO detection process. In this paper, we propose a soft MIMO detection scheme using QR decomposition of channel matrices as an efficient means to provide accurate SDDI to the iterative decoder. The proposed method employed a two sequential soft MIMO detection process in order to reduce computational complexity. Compared to the soft ZF method calculating the direct inverse of the channel matrix, the complexity of the proposed method can be further reduced as the number of antennas is increased, without any performance degradation.

• Journal of the Korean Wood Science and Technology
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• v.26 no.3
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• pp.53-62
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• 1998

In this research, 7 species of white rot fungi were used for determining the resistance against pentachlorophenol (PCP). Three fungi with good PCP resistance were selected for evaluating the biodegradability, and biodegradation mechanism by HPLC and GC/MS spectrometry. Among 7 fungi, there were significant differences on PCP resistance on 4 different PCP concentrations. In the concentrations of 50 and 100ppm ($\mu$g of PCP per g of 2% malt extract agar), most fungi were easily able to grow, and well suited to newly PCP-added condition, but in that of more than 250ppm, the mycelia growths of Ganoderma lucidum 20435, G. lucidum 20432, Pleurotus ostreatus, and Daldinia concentrica were significantly inhibited or even stopped by the addition of PCP to the culture. However, Trametes versicolor, Phanerochaete chrysosporium, and Inonotus cuticularis still kept growing at 250ppm, indicating the potential utilization of wood rot fungi to high concentrated PCP biodegradation. Particularly, P. chrysosporium even showed very rapid growth rate at more than 500ppm of PCP concentration. Three selected fungi based on the above results showed an excellent biodegradability against PCP. P. chrysosporium degraded PCP up to 84% on the first day of incubation, and during 7 days, most of added PCP were degraded. T. versicolor also showed more than 90% of biodegradability at 7th day, and even though the initial stage of degradation was very slow, I. cuticularis has been approached to 90% at 21 st day after incubation with dense growing pattern of mycelia. Therefore, the PCP biodegradability was definitely dependent on the rapid suitability of fungi to newly PCP-added condition. In addition, the PCP biodegradation by filtrates of P. chrysosporium, T. versicolor, and I. cuticularis was very minimal or limited, suggesting that the extracellular enzyme system may be not so significantly related to the PCP biodegradation. Among the biodegradation metabolites of PCP, the most abundant one was pentachloroanisole which resulted in a little weaker toxicity than PCP, and others were tetrachlorophenol, tetrachloro-hydroquinone, benzoic acid, and salicylic acid, suggesting that PCP may be biodegraded by several sequential reactions such as methylation, radical-induced oxidation, dechlorination, and hydroxylation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.12B
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• pp.1574-1585
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• 2011

This paper proposes a real-time algorithm for speed limit sign recognition for advanced safety vehicle system. The proposed algorithm uses Block-DCT in extracting features from a given ROI(Region Of Interest) instead of using entire pixel values as in previous works. The proposed algorithm chooses parts of the DCT coefficients according to the proposed discriminant factor, uses correlation coefficients and variances among ROIs from training samples to reduce amount of arithmetic operations without performance degradation in classification process. The algorithm recognizes the speed limit signs using the information obtained during training process by calculating LDA and Mahalanobis Distance. To increase the hit rate of recognition, it uses accumulated classification results computed for a sequence of frames. Experimental results show that the hit rate of recognition for sequential frames reaches up to 100 %. When compared with previous works, numbers of multiply and add operations are reduced by 69.3 % and 67.9 %, respectively. Start after striking space key 2 times.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.12
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• pp.130-139
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• 2014

Undesired camera shaking can make a blur effect, which causes a degradation of video quality. We propose an efficient method of removing the blur effects on video captured from a single camera. The proposed method has a sequential process that is applied to each frame. The first stage is to estimate the camera motion for each frame. In order to estimate the camera motion, we compute the optical flow using 3 consecutive frames. Then a patch-wise image deconvolution is applied. During the deconvolution, edge prediction is used to improve the quality of image deconvolution. After patch-wise image deconvolution, deblurred patches are integrated into an image to produce a deblurred frame. The above process is performed for each frame. The experimental result shows that the proposed method removes the blur effect efficiently.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.45 no.3
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• pp.123-128
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• 2019

Demineralized dentin matrix (DDM) has been used as a recombinant human bone morphogenetic protein-2 (rhBMP-2) carrier in many clinical trials. To optimize the clinical safety and efficacy of rhBMP-2 with DDM, efforts have been made to improve the delivery of rhBMP-2 by 1) lowering the administered dose, 2) localizing the protein, and 3) prolonging its retention time at the action site as well as the bone forming capacity of the carrier itself. The release profile of rhBMP-2 that is associated with endogenous BMP in dentin has been postulated according to the type of incorporation, which is attributed to the loosened interfibrillar space and nanoporous dentinal tubule pores. Physically adsorbed and modified, physically entrapped rhBMP-2 is sequentially released from the DDM surface during the early stage of implantation. As DDM degradation progresses, the loosened interfibrillar space and enlarged dentinal tubules release the entrapped rhBMP-2. Finally, the endogenous BMP in dentin is released with osteoclastic dentin resorption. According to the postulated release profile, DDM can therefore be used in a controlled manner as a sequential delivery scaffold for rhBMP-2, thus sustaining the rhBMP-2 concentration for a prolonged period due to localization. In addition, we attempted to determine how to lower the rhBMP-2 concentration to 0.2 mg/mL, which is lower than the approved 1.5 mg/mL.