• Korean Journal of Fisheries and Aquatic Sciences
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• v.36 no.4
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• pp.321-326
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• 2003

Antioxidative activities of low molecular weight biocompounds purified from anchovy (Engraulis japonicus) sauce fermented at $15\pm3^{\circ}C$ for 5 years were investigated. The fermented anchovy sauce showed 5 peaks on gel chromatography pattern. Antioxidant activity of peak 2 was $82.7\%$ followed by $42.6\%$ of peak 1. Main antioxidant compounds of peak 1 were glutamic acid and lysine, but those of peak 2 were not confirmed by amino acid sequence analysis.

• Journal of Microbiology and Biotechnology
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• v.11 no.2
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• pp.275-280
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• 2001

Bacteriocin J105 is a proteinaceous inhibitory substance produced by Latococcus latis subsp. lactis j105 isolated from Kimchi. Bacteriocin J105 was purified to homogeneity by the pH-dependent adsorption-desorption method and reverse-phase HPLC from the culture broth of Lactococcus lactis subsp. lactis J105. Purification of bacteriocin J105 resulted in a 1.47-fold increase in the specific activity and the recovery was 1.5%. Its molecular mass measured by the electrophoretic pattern in the sodium, dodecyl sulfate polyacrylamide gel was about 3.4 kDa. It was stable at $121^{\circ}C$ for 15 min at pH between 2 and 4. However, at pH above 5, bacteriocin was rapidly inactivated. Twenty-one residues from the N-terminal portion of bacteriocin J105 were sequenced using sequence analysis of lantibiotics. Bacteriocin J105 showed significant homology with known nisin A from lactic acid bacteria.

• Journal of Microbiology
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• v.44 no.3
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• pp.311-319
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• 2006

Bud6p is a component of a polarisome that controls cell polarity in Saccharomyces cerevisiae. In this study, we investigated the role of the Candide albicans Bud6 protein (CaBud6p) in cell polarity and hyphal development. CaBud6p, which consists of 703 amino acids, had 37% amino-acid sequence identity with the Bud6 protein of S. cerevisiae. The homozygous knock-out of CaBUD6 resulted in several abnormal phenotypes, such as a round and enlarged cells, widened bud necks, and a random budding pattern. In hypha-inducing media, the mutant cells had markedly swollen tips and a reduced ability to switch from yeast to hypha. In addition, a yeast two-Hybrid analysis showed a physical interaction between CaBud6p and CaAct1p, which suggests that CaBud6p may be involved in actin cable organization, like Bud6p in S. cerevisiae. Taken together, these results indicate that CaBud6 plays an important role in the polarized growth of C. albicans.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.28 no.3
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• pp.166-171
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• 2005

With development of the database, there are too many data on process variables and the manufacturing process for the traditional statistical process control methods to identify the process variables related with assignable causes. Data mining is useful in this situation and provides variety of approaches for improving the process. In this paper, we applied control charts to monitor the process and if assignable causes are detected, then we applied the SVM technique and the sequence pattern analysis to find out the process variables suspected. These techniques made possible to predict the behavior of process variables. We illustrated our proposed methods with real manufacturing process data.

• Proceedings of the Korean Information Science Society Conference
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• 2001.04a
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• pp.748-750
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• 2001

최근 Human Genome Project(HGP)에서 사람의 염기 서열의 초안이 발표되었다. 생물체의 염기 서열을 분석하는 방법은 매우 많은데, 그 중 하나가 k-mer 분석이다. k-mer는 유전자의 염기 서열내의 길이가 k인 연속된 염기 서열이다. k-mer 분석은 염기서열이 가진 k-mer들의 빈도의 분포나 대칭성 등을 탐색하는 것이다. 그런데 유전자의 염기 서열은 대용량 텍스트이고 k가 줄 때 기존의 온메모리 알고리즘으로는 처리가 불가능하므로 효율적인 자료구조와 알고리즘이 필요하다. 본 논문에서는 패턴 일치(pattern matching)에 적합하고 외부 메모리를 지원하는 스트링 B-트리(string B-tree)를 이용한 k-mer 분석 방법을 제시하고, 그것을 구현하였으며 몇 가지 실험 결과에 대하여 기술한다.

• Proceedings of the Korea Information Processing Society Conference
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• 2015.04a
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• pp.501-503
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• 2015

Malicious(악의적인) + Code 즉, 악의적인코드를 포함한 소프트웨어라는 의미로 줄여 Malware(Malicious + Software) 라고 불리는 악성코드는 최근 네트워크와 컴퓨터의 급속한 발전에 따라 기하급수적으로 증가하고 있는 추세이다. 폭발적인 증가율 추세를 보이고 있는 악성코드의 위협을 대비하기 위해 악성코드에 대한 분석이 필요한데 그 분석의 종류로는 초기분석, 동적 분석, 정적분석으로 나누고 장, 단점을 정리하였다. 또한 악성코드 대량화에 따른 효율적인 분석과 빠른 의사결정을 위한 악성코드 유사도에 대한 연구를 소개하고 API Call Sequence와 분류된 API를 이용한 악성행위 유사도 판별법을 제시하고 실험하였다.

• Journal of the Semiconductor & Display Technology
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• v.21 no.4
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• pp.86-91
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• 2022

Cache bypassing is a scheme to prevent unnecessary cache blocks from occupying the capacity of the cache for avoiding cache contamination. This method is introduced to alleviate the problems of non-volatile memories (NVMs)-based memory system. However, the prior works have been studied without considering wear-out attack. Malicious writing to a small area in NVMs leads to the failure of the system due to the limited write endurance of NVMs. This paper proposes a novel scheme to prolong the lifetime with higher resistance for the wear-out attack. First, the memory reference pattern is found by modified reuse distance calculation for each cache block. If a cache block is determined as the target of the attack, it is forwarded to higher level cache or main memory without updating the NVM-based cache. The experimental results show that the write endurance is improved by 14% on average and 36% on maximum.

• Proceedings of the Korea Information Processing Society Conference
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• 2011.11a
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• pp.33-35
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• 2011

최근 안드로이드 플랫폼은 성능 개선의 많은 이슈를 가지고 있다. 그 중 안드로이드 부팅 시퀀스부분이 중요한 부분으로 차지하고 있다. 안드로이드 플랫폼 부팅 과정의 속도 저하가 발생 되는 부분은 블록 I/O 시스템이다. 본 논문에서는 리눅스 블록 레이어의 I/O를 tracing 해주는 blktrace에 대해 소개를 하고 그 기법을 통해 안드로이드 부팅 시퀀스의 I/O 패턴을 분석하고, 개선 방안을 고찰한다.

• Proceedings of the Korea Information Processing Society Conference
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• 2007.05a
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• pp.10-13
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• 2007

모티프는 진화과정을 거치면서 단백질 서열상에서 부분적으로 높게 보존된 지역을 의미한다. 이러한 모티프는 단백질의 기능과 구조를 예측하거나 생물학적으로 관련성이 있는 단백질의 공통적인 특성을 기술하는데 사용된다. 또한, 모티프와 단백질 서열의 상관관계는 생물학적 기능 예측에 필수적이며, 이러한 예측 문제는 모티프 검색을 통해 서열에 존재하는 빈발한 서열패턴과 구조패턴을 통해 단백질 서열에 대한 분석이 가능하다. 이 논문에서는 단백질 서열에 존재하는 2차 구조 특성과 빈발패턴을 검색하고 추출된 정보를 이용하여 단백질 기능 분류에 활용하고자 한다.

• Pediatric Infection and Vaccine
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• v.6 no.2
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• pp.219-233
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• 1999

Purpose : Respiratory syncytial virus(RSV) is the major cause of lower respiratory tract infection in infants and young children. This study was performed to analyze antigenic and genetic variation of G protein of subgroup A RSV. Methods : One hundred seventy-nine strains isolated at the Seoul National University Children's Hospital over 8 years-period from 1990 through 1998 were analysed for antigenic and genetic variability. Analysis was made by reactivity with monoclonal antibodies raised against RSV, and by restriction mapping and, for selected strains, nucleotide sequencing following amplification of full sequence of G gene by reverse transcription-polymerase chain reaction. Results : Restriction fragment analysis of the amplified G protein gene revealed 23 restriction patterns, 12 of which included more than 2 isolate, and the most frequent genetic type comprised 30% of the strains. Indirect immunofluorescent staining with monoclonal antibodies revealed 6 antigenic types with one predominant pattern accounting for 91% of the total strains. The most frequent antigenic type had 21 restriction patterns, and some viruses with same restiction pattern had different monoclonal antibody reaction pattern. Nucleotide sequence homology of subgroup A was 91~93% between reference(A2, Long) and Korean isolates, 93~99% among Korean isolates. Maximum-parsimony analysis demonstrated that Korean isolates were distinct from reference strains and subgroup A strains were clustered in 4 groups. Conclusion : The restriction analysis pattern of G protein gene identified greater diversity within subgroup A than was seen with the monoclonal analysis and a variety of antigenic and genetic types of RSV are circulating in Korea which are different from reference strains or strains isolated from other countries.