• Analytical Science and Technology
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• v.19 no.6
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• pp.455-459
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• 2006

The extraction and separation of glabridin from licorice root by HPLC was performed in this work. First, by investigating the different extraction solvents, extraction methods and extraction times, a one-hour ultrasonic extraction procedure with ethyl acetate as the extraction solvent was optimized. Then the ethyl acetate extraction was applied to RP-HPLC for separation of glabridin. The column efficiencies and resolutions were experimentally investigated with different mobile phase compositions. Baseline separation of glabridin was obtained under the mobile phase composition of 50/50 vol.% (ACN/water). The retention time of glabridin was 20.3 min. The peak of glabridin was collected from the HPLC elution for several times and identified by LC/MS. Under the optimum extraction and HPLC separation methods, 1.26 g of glabridin per kg licorice root could be extracted.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.20 no.7
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• pp.2347-2355
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• 1996

Purpose of the present study is to develop a computational design program for shape optimization, combining the numerical optimization technique with the flow analysis code. The present methodology is then validated in three cases of aerodynamic shape optimization. In the numerical optimization, a feasible direction optimization algorithm and shape functions are considered. In the flow analysis, the Navier-Stokes equations are discretized by a cell-centered finite volume method, and Roe's flux difference splitting TVD scheme and ADI method are used. The developed design code is applied to a transonic channel flow over a bump, and an external flow over a NACA0012 airfoil to minimize the wave drag induced by shock waves. Also a separated subsonic flow over a NACA0024 airfoil is considered to determine a maximum allowable thickness of the airfoil without separation.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.2
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• pp.69-77
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• 2021

No-carrier-added holmium-166 (n.c.a ¹⁶⁶Ho) separation is performed based on the results of separation conditions using stable isotopes dysprosium (Dy) and holmium (Ho) to minimize radioactive waste from separation optimization procedures. Successful separation of two adjacent lanthanides was achieved by cation-exchange chromatography using a sulfonated resin in the H+ form (BP-800) and α-hydroxyisobutyric acid (α-HIBA) as eluent. For the identification process after separation of stable isotopes, the use of chromogenic reagents alternatively enables on-line detection because the lanthanides are hardly absorb light in the UV-vis region or exhibit radioactivity. Four different chromogenic reagents were pre-tested to evaluate suitable coloring reagents, of which 4-(2-Pyridylazo)resorcinol is the most recommendable considering the sensitivity and specificity for lanthanides. Lanthanide radioisotopes (RI) were monitored for separation with an RI detector using a lab-made separation LC system. Under the proper separation conditions, the n.c.a ¹⁶⁶Ho was effectively obtained from a large amount of 100 mg dysprosium target within 2 hrs.

• Food Science of Animal Resources
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• v.35 no.4
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• pp.431-440
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• 2015

Chicken bone is not adequately utilized despite its high nutritional value and protein content. Although not a common raw material, chicken bone can be used in many different ways besides manufacturing of collagen products. In this study, a multi-step procedure was optimized to isolate chicken bone collagen for higher yield and quality for manufacture of collagen products. The chemical composition of chicken bone was 2.9% nitrogen corresponding to about 15.6% protein, 9.5% fat, 14.7% mineral and 57.5% moisture. The lowest amount of protein loss was aimed along with the separation of the highest amount of visible impurities, non-collagen proteins, minerals and fats. Treatments under optimum conditions removed 57.1% of fats and 87.5% of minerals with respect to their initial concentrations. Meanwhile, 18.6% of protein and 14.9% of hydroxyproline were lost, suggesting that a selective separation of non-collagen components and isolation of collagen were achieved. A significant part of impurities were selectively removed and over 80% of the original collagen was preserved during the treatments.

• 한국전산유체공학회:학술대회논문집
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• 2008.03b
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• pp.185-188
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• 2008

In this study, we experimentally investigated that the optimization of pulsating jet to reduce the separated flow region behind the vertical fence. The vertical fence was submerged in the turbulent boundary layer in the circulating water channel and we applied phase averaged PIV method to measure the instantaneous velocity fields around the fence. One cycle of pulsating jet is divided into 20 phases and grabbed total 200 instantaneous velocity fields at each phase. The experiments were performed by varying the frequency, maximum jet velocity and the shape of pulsating jet wave. Pulsating jet was precisely made by piston-type pump controlled by the computer. The obtained results were compared with normal fence flow. From this study, we found there is the specific frequency which is effective in reducing the reattachment region.

• Transactions of the Society of Information Storage Systems
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• v.1 no.2
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• pp.161-168
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• 2005

This paper optimizes the optical flying head(OFH) suspension using the integrated optimization frame, which automatically integrates the analysis with the optimization and effectively implements the repetitive works between them. The problem formulation for the optimization is suggested to improve the dynamic compliance of OFH and to shift the resonant frequencies caused tracking errors to high frequency domain. Furthermore, the minimization of the effective suspension mass that leads to decrease the so-called 'lift-off' as the disk-head separation acceleration divided by the suspension load is taken into consideration. In particular, this study is carried out the optimal design considering the process of modes tracking through the entire optimization processes. The advanced suspension that reduces the effective mass of the suspension and increases the resonant frequencies of sway and $2^{nd}$ torsion over 10kHz is achieved by using the integrated optimization frame.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.11b
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• pp.571-576
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• 1996

The 3-stage cascade composed of the multisection-type bithermal $H_2$/$H_2O$-exchange columns was suggested for heavy water separation. In order to study the separation characteristics for the cascade, a matrix equation with 18 simultaneous equations was composed and the concentrations and flow rates were calculated for the all parts of the cascade. Product D-concentration decreases and extraction yield increases with increasing cut in each stage, which is one of the principal parameters of the separation characteristics. The optimization of the 3-stage cascade can be made by case study using the matrix equation.

• Proceedings of the Membrane Society of Korea Conference
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• 1999.10b
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• pp.108-110
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• 1999

• 한국전산유체공학회:학술대회논문집
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• 2005.04a
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• pp.191-196
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• 2005

For the improvement of aerodynamic performance of the turbine blade in a turbopump for the liquid rocket engine, the optimization of turbine profile shape has been studied. The turbine in a turbopump in this study is a partial admission of impulse type, which has twelve nozzles and supersonic inflow. Due to the separated nozzles and supersonic expansion, the flow field becomes complicates and shows oblique shocks and flow separation. To increase the blade power, redesign of the blade shape using CFD and optimization method was attempted. The turbine cascade shape was represented by four design parameters. For optimization, genetic algorithm based upon non-gradient search has been selected as a optimizer. As a result, the final blade has about 4 percent more blade power than the initial shape.

• Journal of computational fluids engineering
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• v.10 no.2
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• pp.54-59
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• 2005

For the improvement of aerodynamic performance of the turbine blade in a turbopump for the liquid rocket engine, the optimization of turbine profile shape has been studied. The turbine in a turbopump in this study is a partial admission of impulse type, which has twelve nozzles and supersonic inflow. Due to the separated nozzles and supersonic expansion, the flow field becomes complicate and shows oblique shocks and flow separation. To increase the blade power, redesign ol the blade shape using CFD and optimization methods was attempted. The turbine cascade shape was represented by four design parameters. For optimization, a genetic algorithm based upon non-gradient search hue been selected as an optimizer. As a result, the final blade has about 4 percent more blade power than the initial shape.