Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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Real-time identification of the separated lanthanides by ion-exchange chromatography for no-carrier-added Ho-166 production

  • Aran Kim (Radioisotope Research Division, Korea Atomic Energy Research Institute) ;
  • Kanghyuk Choi (Radioisotope Research Division, Korea Atomic Energy Research Institute)
  • Received : 2021.12.02
  • Accepted : 2021.12.28
  • Published : 2021.12.30
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Abstract

No-carrier-added holmium-166 (n.c.a 166Ho) separation is performed based on the results of separation conditions using stable isotopes dysprosium (Dy) and holmium (Ho) to minimize radioactive waste from separation optimization procedures. Successful separation of two adjacent lanthanides was achieved by cation-exchange chromatography using a sulfonated resin in the H+ form (BP-800) and α-hydroxyisobutyric acid (α-HIBA) as eluent. For the identification process after separation of stable isotopes, the use of chromogenic reagents alternatively enables on-line detection because the lanthanides are hardly absorb light in the UV-vis region or exhibit radioactivity. Four different chromogenic reagents were pre-tested to evaluate suitable coloring reagents, of which 4-(2-Pyridylazo)resorcinol is the most recommendable considering the sensitivity and specificity for lanthanides. Lanthanide radioisotopes (RI) were monitored for separation with an RI detector using a lab-made separation LC system. Under the proper separation conditions, the n.c.a 166Ho was effectively obtained from a large amount of 100 mg dysprosium target within 2 hrs.

Keywords

Acknowledgement

This study was supported by Nuclear R&D Program, Development of Production Standardized Production Technology for Theranostic RI (57831-21) and KAERI Major Project, Development of Radioisotope Production and Application Technology (524430-20).

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