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Two Minor Furanocoumarins of Angelica dahurica

  • Shin, Kuk-Hyun;Moon, Ki-Ho;Woo, Woo-Sick
    • Archives of Pharmacal Research
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    • v.14 no.2
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    • pp.165-166
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    • 1991
  • Two minor constituents were isolated from the roots of Angelica dahurica and identified as isooxypeucedanin and gosferol, respectively.

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Central Nervous Depressant Activity of Piperine

  • Woo, Won-Sick;Lee, Eun-Bang;Shin, Kuk-Hyun
    • Archives of Pharmacal Research
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    • v.2 no.2
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    • pp.121-125
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    • 1979
  • Piperine showed a central nervous system depressant activity which was characterized by the antagonistic effect against chemoshock seizure as well as potent muscular incoordination in mice.

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A Novel Synthetic Method for 3-Hydroxyhomoisoflavanone

  • Jew, Sang-Sup;Kim, Hyun-Ah;Park, Hyeung-Geun
    • Archives of Pharmacal Research
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    • v.20 no.2
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    • pp.144-147
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    • 1997
  • A novel synthetic method was developed for 3-hydroxyhomoisoflavanone. Treatment of aryllithium 14 to aldehyde 13 which was obtained from dihydroxylation of 10, followed by cycloetherification to give 3-hydroxyhomoisoflavanones.

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Total Synthesis of Fentanyl

  • Suh, Young-Ger;Cho, Kyung-Ho;Shin, Dong-Yoon
    • Archives of Pharmacal Research
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    • v.21 no.1
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    • pp.70-72
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    • 1998
  • Fentanyl of a potent anilidopiperidine analgesic has been synthesized from a simple phenyle-thylamine by four step sequence. The key part of this synthesis involves an efficient construc-tion of phenylethylpiperidone skeleton via aminomethano desilyation-cyclization followed by Swern oxidation.

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