• Nuclear Engineering and Technology
• /
• v.13 no.1
• /
• pp.22-35
• /
• 1981

The U$_3$O$_{8}$ requirements are estimated for the high, intermediate, and low growth projections of nuclear power in Korea. To each projection, four illustrative reactor-mix strategies and four fuel cycle options are applied for estimating the requirements. The reactor types considered are PWR, PHWR. and FBR. The fuel cycles considered are once-through cycle, U/Pu recycle, and improved once-through cycle. Also the amount of Pu-fissile recovered from U recycle is estimated. The maximum cumulative (to the year 2000) requirements of U$_3$O$_{8}$ occupy about 4 to 5 percent of the WOCA requirements and are about 23 times larger than the U$_3$O$_{8}$ resources in Korea. For the high nuclear power growth projection, the cumulative amount of Pu-fissile recovered from U recycle is sufficient for the startup of 2 units of 1200 MWe fast reactors by the year 2000. 2000.

• Journal of Radiopharmaceuticals and Molecular Probes
• /
• v.5 no.2
• /
• pp.101-112
• /
• 2019

Herein, 2-nitroimidazole-fluorophore conjugates were synthesized by linking 2-nitroimidazole and FITC or RITC via thiourea bonds. The prepared derivatives were stable for 2 h in Dulbecco's modified Eagle's medium (DMEM) at 37 ℃. The novel conjugates were studied for their in vitro uptake under hypoxic conditions using U87MG and CT-26 cell lines, showing significantly higher uptakes in hypoxic than normoxic cells. Immunohistochemical analysis confirmed hypoxia in U87MG and CT-26 xenografted tumor tissues. Moreover, the prepared conjugates were evaluated by in vivo experiments after intravenous injection in U87MG and CT-26 xenografted mice. Hypoxia was confirmed by immunohistochemistry of the prepared derivatives with co-injected pimonidazole. Confocal microscopy of the prepared derivatives showed strong fluorescence in hypoxic tumor tissues correlated with the pimonidazole distribution. This suggested that the 2-nitroimidazole-fluorophore conjugates are promising optical imaging probes for tumor hypoxia and are promising substitutes for pimonidazole immunohistochemistry, which requires a multi-step procedure of incubation involving antibody, second antibody, dye, hydrogen peroxide, and multiple washing steps.

• Molecules and Cells
• /
• v.43 no.8
• /
• pp.694-704
• /
• 2020

HslUV is a bacterial heat shock protein complex consisting of the AAA+ ATPase component HslU and the protease component HslV. HslV is a threonine (Thr) protease employing the N-terminal Thr residue in the mature protein as the catalytic residue. To date, HslUV from Gram-negative bacteria has been extensively studied. However, the mechanisms of action and activation of HslUV from Gram-positive bacteria, which have an additional N-terminal sequence before the catalytic Thr residue, remain to be revealed. In this study, we determined the crystal structures of HslV from the Gram-positive bacterium Staphylococcus aureus with and without HslU in the crystallization conditions. The structural comparison suggested that a structural transition to the symmetric form of HslV was triggered by ATP-bound HslU. More importantly, the additional N-terminal sequence was cleaved in the presence of HslU and ATP, exposing the Thr9 residue at the N-terminus and activating the ATP-dependent protease activity. Further biochemical studies demonstrated that the exposed N-terminal Thr residue is critical for catalysis with binding to the symmetric HslU hexamer. Since eukaryotic proteasomes have a similar additional N-terminal sequence, our results will improve our understanding of the common molecular mechanisms for the activation of proteasomes.

• Proceedings of the Zoological Society Korea Conference
• /
• 1996.10a
• /
• pp.192.2-192
• /
• 1996

No Abstract, See Full Text

• Journal of Korean Neurosurgical Society
• /
• v.46 no.4
• /
• pp.292-299
• /
• 2009

Objective : Clinical and radiological results of posterior dynamic stabilization using interspinous U (ISU, $Coflex^{TM}$, Paradigm Spine $Inc.^{(R)}$, NY, USA) were analyzed in comparison with posterior lumbar interbody fusion (PLIF) in degenerative lumbar spinal stenosis (LSS). Methods : A retrospective study was conducted for a consecutive series of 61 patients with degenerative LSS between May 2003 and December 2005. We included only the patients completed minimum 24 months follow up evaluation. Among them, 30 patients were treated with implantation of ISU after decompressive laminectomy (Group ISU) and 31 patients were treated with wide decompressive laminectomy and posterior lumbar interbody fusion (PLIF; Group PLIF). We evaluated visual analogue scale (VAS) and Oswestry Disability Index (ODI) for clinical outcomes (VAS, ODI), disc height ratio disc height (DH), disc height/vertebral body length ${\times}100$), static vertebral slip (VS) and depth of maximal radiolucent gap between ISU and spinous process) in preoperative, immediate postoperative and last follow up. Results : The mean age of group ISU ($66.2{\pm}6.7$ years) was 6.2 years older than the mean age of group PLIF ($60.4{\pm}8.1$ years; p=0.003). In both groups, clinical measures improved significantly than preoperative values (p<0.001). Operation time and blood loss was significantly shorter and lower in group ISU than group PLIF (p<0.001). In group ISU, the DH increased transiently in immediate postoperative period ($15.7{\pm}4.5%{\rightarrow}18.6{\pm}5.9%$), however decreased significantly in last follow up ($13.8{\pm}6.6%$, p=0.027). Vertebral slip (VS) of spondylolisthesis in group ISU increased during postoperative follow-up ($2.3{\pm}3.3{\rightarrow}8.7{\pm}6.2$, p=0.040). Meanwhile, the postoperatively improved DH and VS was maintained in group PLIF in last follow up. Conclusion : According to our result, implantation of ISU after decompressive laminectomy in degenerative LSS is less invasive and provides similar clinical outcome in comparison with the instrumented fusion. However, the device has only transient effect on the postoperative restoration of disc height and reduction of slip in spondylolisthesis. Therefore, in the biomechanical standpoint, it is hard to expect that use of Interspinous U in decompressive laminectomy for degenerative LSS had long term beneficial effect.

• Journal of The Korean Astronomical Society
• /
• v.10 no.1
• /
• pp.3-12
• /
• 1977

$Str\ddot{o}mgren$-system colors for 23 OV stars compiled by Crawford have been compared with colors calculated by Mihalas from non-LTE model atmospheres. In this way, effective temperatures of these stars have been determined and plotted against spectral type, $c_1$ (u-b), (b-y), (U-B), and (B-V). Within the accuracy of the observations, effective temperatures derived from the photometry for these 23 main-sequence stars are found to be in good agreement with Contiis spectroscopical temperatures.

• 한국초전도학회:학술대회논문집
• /
• v.12
• /
• pp.16-16
• /
• 2002

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.7 no.3
• /
• pp.365-372
• /
• 2006

We expect u-Education based on ubiquitous information and technology will be the next generation education system. We performed a comparative study of well designed school homepage at H elementary school and the other case of homepage at C elementary school in Seoul. We conclude the former shows better performance and educational achievement under U-Learning environment and we propose a next generation U-Learning system architecture.

• Proceedings of the PSK Conference
• /
• 2000.10a
• /
• pp.127.3-128
• /
• 2000

• Journal of the Korean Mathematical Society
• /
• v.35 no.4
• /
• pp.1019-1043
• /
• 1998

In this paper we study some asymptotics for solutions of the Ginzburg-Landau equations with Dirichlet boundary conditions. We consider the solutions ( $u_{\in}$, $A_{\in}$) which minimize the Ginzburg-Landau energy functional $E_{\in}$(u, A). We show that the solutions ( $u_{\in$}$ , $A_{\in}$) converge to some ( $u_{*}$, $A_{*}$) in various norms as the coupling parameter $\in$longrightarrow0.ow0.