• Journal of Medicine and Life Science
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• v.20 no.1
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• pp.1-7
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• 2023

Transient receptor potential ankyrin 1 (TRPA1) receptors are major polymodal nociceptors that generate primary pain responses in the peripheral nerve endings of the dorsal root ganglion neurons. Recently, we reported that the activation of TRPA1 receptors by reactive oxygen species (ROS) signaling, which is triggered by Ca²⁺ influx through T-type Ca²⁺ channels, contributes to prolonged pain responses induced by jellyfish toxin. In this review, we focus on the characteristics of the TRPA1 receptor involved in intracellular signaling as a secondary pain modulator. Unlike other transient receptor potential receptors, TRPA1 receptors can induce membrane depolarization by ROS without exogenous stimuli in peripheral and central sensory neurons. Therefore, it is important to identify the functional characteristics of TRPA1 receptors to understand pain modulation under several pathogenic conditions such as neuropathic pain syndromes and autoimmune diseases, which are mediated by oxidative signaling to cause chronic pain in the sensory system.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.27 no.2
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• pp.249-260
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• 2009

The georeferencing accuracy of the sensory data acquired by an aerial monitoring system heavily depends on the performance of the GPS/IMU mounted on the system. The employment of a high performance but expensive GPS/IMU unit causes to increase the developmental cost of the overall system. In this study, we simulate the images and GPS/IMU data acquired by an UAV-based aerial monitoring system using an inexpensive integrated GPS/IMU of a MEMS type, and perform the image georeferencing by applying the aerial triangulation to the simulated sensory data without any GCP. The image georeferencing results are then analyzed to assess the accuracy of the estimated exterior orientation parameters of the images and ground points coordinates. The analysis indicates that the RMSEs of the exterior orientation parameters and ground point coordinates is significantly decreased by about 90% in comparison with those resulted from the direct georeferencing without the aerial triangulation. From this study, we confirmed the high possibility to develop a low-cost real-time aerial monitoring system.

• Archives of design research
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• v.20 no.3 s.71
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• pp.39-48
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• 2007

This study explored the Eye Movement, the horizontal and vertical flow of vision, and genetic, cultural and empirical schema, and the differentiation of the visual system of the cerebrum through the engineering psychological or the cognitive neuroscientific experiments measuring Eye Movement to maximize the efficiency of the Public Sign System in the urban environment. Accordingly, the study derived an algorithm that can bring out the most efficient visual design measurement by using EMR test and bitmap counting method. The scientific test data in this study will show the existence of the momentum of differentiation and visual sampling by the Schema and Sensory Qualia of the human.

• Korean Institute of Interior Design Journal
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• v.20 no.3
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• pp.143-151
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• 2011

With today's new media environment throughout Ubiquitous information innovation, live and dynamic fluid space is being created by integrating organic integration between electronic space and physical space and transplanting intelligence to materials. In other words, perception occurs in fluid space itself in a new media environment so has complicatedly organic relationship with environment and humans. In addition, emotion, time and movement have actively attempted to enter the space so designs appealing to humans' emotions are made through stimulation of synaesthetic sensory organs. This can be understood in the same context that media is eventually expansion of human body. Fluid space has characteristics of a live organism with factors such as sensor, perception and behavior so it needs to interpret perceptual system relationally and synthetically through an organic study method. This study looks into characteristics of organic perceptual system in terms of the meaning that fluid space with movements have as the sensory-perceptive subject and accordingly makes the world more sufficient as the third space, prepares a possibility to get out of limited five senses, and will develop fluid space as the organic environment making stimulation by itself.

• The Journal of Korean Physical Therapy
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• v.13 no.1
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• pp.219-227
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• 2001

Capsaicin. a vanillyl amide(8-methy1-N-vanilly1-6-nonenamide) with a molecular weight of 305.42, was substance, interrupting the pain conducting pathway Until recently the neurotoxic effects of Capsaicin to adult animals were thought to be limited to the peripheral nervous system. But several reports suggest the possibility of central nervous system changes after Capsaicin administration to the adult rat. Capsaicin desensitization is defined as long lasting, reversible suppression of sensory neuron activity. How fast and for how long the desensitization develops is related to the dose and time of exposure to Capsaicin, and the interval between consecutive dosing. In the long term Capsaicin treatment can lead to morphological degeneration and changes in some small sensory neurons, predominantly unmyelinated C fiber afferent nerve fibers. Clinical interest has recently been roused by evidence that Capsaicin's desensitizing action may be of therapeutic value and that an endogenous Capsaicin-1 ike substance may exist. This study summarizes the fundamental knowledge(mechanism, receptors, et al of Capsaicin) of Capsaicin for physical therapists.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.6
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• pp.511-519
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• 2001

Nimopidine, one of dihydropyridine derivatives, has been widely used to pharmacologically identify L-type Ca currents. In this study, it was tested if nimodipine is a selective blocker for L-type Ca currents in sensory neurons and heterologous system. In mouse dorsal root ganglion neurons (DRG), low concentrations of nimodipine $(<10\;{\mu}M),$ mainly targeting L-type Ca currents, blocked high-voltage-activated calcium channel currents by ${\sim}38%.$ Interestingly, high concentrations of nimodipine $(>10\;{\mu}M)$ further reduced the 'residual' currents in DRG neurons from ${\alpha}_{1E}$ knock-out mice, after blocking L-, N- and P/Q-type Ca currents with $10\;{\mu}M$ nimodipine, $1\;{\mu}M\;{\omega}-conotoxin$ GVIA and 200 nM ${\omega-agatoxin$ IVA, indicating inhibitory effects of nimodipine on R-type Ca currents. Nimodipine $(>10\;{\mu}M)$ also produced the inhibition of both low-voltage-activated calcium channel currents in DRG neurons and ${\alpha}_{1B}\;and\;{\alpha}_{1E}$ subunit based Ca channel currents in heterologous system. These results suggest that higher nimodipine $(>10\;{\mu}M)$ is not necessarily selective for L-type Ca currents. While care should be taken in using nimodipine for pharmacologically defining L-type Ca currents from native macroscopic Ca currents, nimodipine $(>10\;{\mu}M)$ could be a useful pharmacological tool for characterizing R-type Ca currents when combined with toxins blocking other types of Ca channels.

• The Research Journal of the Costume Culture
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• v.20 no.2
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• pp.144-153
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• 2012

This study performed a simultaneous sensory evaluation and color measurement, targeting 136 female university students who live in the Dae-Jeon region. the study measured participants'facial coloration under the condition of available light between 11 AM and 3 PM from Spring (May) to Autumn (October) in 2009. For statistical analysis, descriptive statistics, a member variate analysis, and discriminant analysis were executed using SPSS version 18.0 of the statistics program. The results of this study are as follows. First, as a result of the sensory evaluation, the blue undertone well matched to face type was dominantly distributed among the female university student participants. Second, the forehead showed a type of yellowish coloration and was relatively dark to cheeks. However the cheek displayed a reddish coloration and was relatively bright compared to the forehead from an evaluation of a cheek and forehead color measurement. Third, due to the investigation the of facial coloration variable, a yellowish and reddish chromaticity on the cheek were evident as a variable of facial coloration, which has an influence on the classification of the types of facial color. As a result of the induced discriminant through these two color variables, the yellowish chromaticity appeared as a color variable to have a greater influence than the reddish chromaticity on the cheek.

• Journal of the Korean Society of Food Culture
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• v.33 no.5
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• pp.426-436
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• 2018

This study assessed effective strategies to reduce the sodium intake among consumers using pork cutlet sauce as a model food system. Original pork cutlet sauce and sodium-reduced sauce (29% reduced by a salt substitute) were analyzed to characterize the sensory properties using descriptive analysis. The effects of sodium-reduction of the sauce, consumer type (nutrition teachers vs. general consumers), information related to the sodium content, serving method, and consumer's health, taste and sodium-related attitudes on the consumer's preference, perception, and intake of the sauce were analyzed using a consumer test. In descriptive analysis, the original and sodium-reduced sauce showed similar sensory characteristics but did not differ in saltiness. In the consumer test, there were no significant differences in the overall preference levels between the two sauces. On the other hand, there were significant differences in preference and perception between nutrition teachers and general consumer groups, which were due largely to their age as well as the health and sodium-related attitudes and nutritional knowledge differences. Sodium-reduced information decreased the perceived saltiness intensity. In addition, reducing sodium intake by serving pork cutlet sauce in a bottle can be an effective strategy because this serving method increased the acceptance and induced the smaller intake of sauce.

• Archives of Craniofacial Surgery
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• v.21 no.6
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• pp.380-383
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• 2020

Schwannomas, which originate from Schwann cells in the peripheral nervous system, are slowg-rowing and uncommon benign tumors. Most schwannomas (90%) occur in isolation, and multiple occurrences are a characteristic feature of neurofibromas. Schwannomas of the nose and nasal tip are particularly unusual. Although a few cases of schwannomas of the sinusoidal tract and nasal septum have been reported, schwannomas arising from the nasal dorsum area and tip are extremely rare. Sensory abnormalities are also a very rare symptom. We excised a schwannoma on the nasal dorsum through direct incision and a schwannoma on the nasal tip through open rhinoplasty. No postoperative complications involving recurrence, hematoma, or infection occurred. The possibility of neurological changes should be considered in cases of an abnormality in the peripheral nervous system. Schwannoma must be kept in mind as a possible cause of neurological changes localized to a specific dermatome, and should always be considered in the differential diagnosis of a mass on the nose.

• International Journal of Computer Science & Network Security
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• v.23 no.2
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• pp.47-54
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• 2023

This article reviews recent advances and perspectives in neuroscience related to consciousness, cognition, and neural networks in the brain. The neural mechanisms underlying cognitive processes, such as perception, attention, memory, and decision-making, are explored. The article also examines how these processes give rise to our experience of consciousness. The implications of these findings for our understanding of the brain and its functions are presented, as well as potential applications of this knowledge in fields such as medicine, psychology, and artificial intelligence. Additionally, the article explores the concept of a quantum viewpoint concerning consciousness, cognition, and creativity and how incorporating DNA as a key element could reconcile classical and quantum perspectives on human behaviour, consciousness, and cognition, as explained by genomic psychological theory. Furthermore, the article explains how the human brain processes external stimuli through the sensory nervous system and how it can be simulated using an artificial neural network (ANN) consisting of one input layer, multiple hidden layers, and an output layer. The law of learning is also discussed, explaining how ANNs work and how the modification of weight values affects the output and input values. The article concludes with a discussion of future research directions in this field, highlighting the potential for further discoveries and advancements in our understanding of the brain and its functions.