• Archives of Reconstructive Microsurgery
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• 제5권1호
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• pp.121-127
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• 1996

Peripheral nerve injury occurs mostly by trauma and is usually associated with fracture of bone and joint, muscular injury and tendon injury and it also evokes paralysis and anesthesia. When treatment of peripheral nerve injury is considered,, the modality of treatment is decided by the general condition of the patient, type of injury, associated injuries and the condition of wound. To get the maximum results, surgical treatment and reconstruction and rehabilitation should all go in hand-in-hand. From January 1985 to December 1994, we observed 61 patients that had operation without reconstruction due to peripheral nerve injury with a follow-up period of more than 1 year. Among the 61 patients, 44 were men(72%) and 17 were women(28%). Follow-up period was average 19 months. Age distribution was mostly in their twenties with a mean age of 28 years. Time interval of operation after injury was average 11 months. Trauma was the main cause of peripheral nerve injuries with a proportion of 87%. 31 patients had neurorrhaphy, in which case 14 patients had stay suture and 17 patients did not. 14 patients had nerve graft, and 16 patients had neurolysis. We used our scales to compare the results of surgery on the basis of British Research Council System. We gave scores to every sensory and motor scale to estimate functional improvement and emphasized on motor functional improvement. The total score = sensory score + ($2{\times}motor$ score). We considered 8-9 points as excellent, 6-7 points as good, 2-5 points as fair, 0-1 points as poor result. We considered excellent and good as much improved. Excellent and good results were obtained in 13 out of 14 neurorrhaphy with stay suture(93%), 12 out of 17 neurorrhaphy without stay suture(71%), 6 out of 14 nerve graft(43%), 12 out of 16 neurolysis(75%). Among the patients with neurorrhaphy done within 3 months, 11 out of 14(86%) showed improvement, but among the patients after 4 months 3 out of 17(76%) showed improvement. 84% of improvement was observed in the patients with time interval from injury to surgery within 3 months, and 64% in the patients with time interval after 4 months. In the aspect of age, 77% with the age below 20 years, 70% with the age between 21 and 30 years, 66% with the age above 31 years showed improvement. We conclude that considering degree of injury, time interval from injury and age with the adequate method of treatment, we can obtain good results from surgery.

• The Korean Journal of Physiology and Pharmacology
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• 제2권2호
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• pp.165-172
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• 1998

Under certain pathophysiological conditions, such as inflammation and ischemia, the concentration of H^+$ ion in the tissue surrounding neurons is changed. Variations in H^+$ concentration are known to alter the conduction and/of the gating properties of several types of ion channels. Several types of K^+$ channels are modulated by pH. In this study, the whole cell configuration of the patch clamp technique has been applied to the recording of the responses of change of external pH on the delayed rectifier K^+$ current of cultured DRG neurons of rat. Outward K^+$ currents were examined in DRG cells, and the Charybdotoxin and Mn^{2+}$ could eliminate Ca^{2+}-dependent$ K^+$ currents from outward K^+$ currents. This outward K^+$ current was activated around -60 mV by step depolarizing pulses from holding potential -70 mV. Outward K^+$ currents were decreased by low external pH. Activation and steady-state inactivation curve were shifted to the right by acidification, while there was small change by alkalization. These results suggest that H^+$ could be alter the sensory modality by changing and modifying voltage-dependent K^+$ currents, which participated in repolarization.

• The Korean Journal of Pain
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• 제13권2호
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• pp.191-195
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• 2000

Background: Vascular occlusive event is one of the etiologies of sudden sensorineural hearing loss (SNHL). Stellate ganglion block (SGB) induces dramatic and intense vasodilatation in head and neck. Based on this principle, SGB has used as one of the treatment modalities in SNHL. This study was performed to evaluate immediate response of SGB on pure tone audiogram (PTA) in SNHL. Methods: Forty patients were studied. Each patient received daily ipsilateral SGB in paratracheal approach using 0.2% bupivacaine for 2 weeks. On first, third, and fifth day of treatment, we checked their PTA twice 1 hour before (Pre-PTA) and after (Post-PTA) SGB. Pre- and Post-PTA were compared. Several factors were analyzed as a prognostic factor of therapeutic results. Results: Eleven of 40 patients revealed decreased PTA after SGB. Degree of decreased PTA were insignificant ($2.5{\pm}1.6$ dB). Initial and final PTA results was $76.2{\pm}22.5$ and $49.8{\pm}28.3$ dB, respectively. Thirty-one of 40 patients were improved their PTA over 10 dB. The recovery was mainly influenced by the severity of initial hearing loss (P<0.001) and slightly by age (P<0.05). However, the change of PTA after SGB, time interval to receive SGB, sex, site, and number of SGB were not correlated to therapeutic outcome. Conclusions: These results suggest that vasodilatation by SGB has no immediate improvement in SNHL. Therefore, we question whether SGB is beneficial to all patients with SNHL as a therapeutic modality.

• 인간행동과 음악연구
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• 제7권1호
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• pp.1-15
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• 2010

본 연구는 지적장애영유아의 수학개념 발달을 위한 음악활동의 이론적 배경을 고찰하는 데에 그 목적이 있다. 음악은 청각, 시각, 촉각을 자극할 수 있는 다감각적 매체로써 다양한 경로를 통해 인지능력을 향상 할 수 있는 방법을 제공할 수 있고, 영유아의 집중을 유도할 수 있는 요소를 가지고 있으며, 학습에 필요한 기본적 정보를 기억하는 것을 돕는 보조적 역할 및 동기부여의 도구로 사용될 수 있으므로, 지적장애영유아 치료 교육현장에서 효과적으로 사용될 수 있다. 음악의 각 요소들과 특성들을 파악하는 것은 수학개념 발달에 사용될 수 있는 음악활동의 종류에 대한 이론적 배경을 제공하며, 적절한 음악활동을 구성할 수 있는 방향을 제시할 수 있는 기초를 마련한다. 본 연구는 지적장애영유아 수학교육의 현장에서 음악활동이 적극적으로 활용되어야 한다는 필요성을 제시하며, 수학개념 발달을 위한 다양한 음악활동 개발의 필요성을 논의하였다.

• 대한두경부종양학회지
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• 제16권2호
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• pp.228-234
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• 2000

Objectives: Esthesioneuroblastoma is a rare malignant neoplasm that originates from the olfactory sensory cells. This tumor grows from the upper nasal cavity and ethmoid sinus and invades surrounding structures through the cribriform plate into intracranium or orbit in advanced stage. Even though there has been some controversies in determining standard treatment due to rarity of this tumor, the combination treatment of surgery and adjuvant radiation has been recommended for the locally advanced esthesioneuroblastomas. However, the recent clinical experiences of advanced cases showed that combination chemotherapy is highly effective to reduce tumor mass and improve clinical outcomes. Materials and Methods: The authors conducted a retrospective analysis of 6 esthesioneuroblastoma patients who were treated in our hospital from 1986. Results: The age of these patients was between 19 and 86 year-old. Among the 6 cases, 2 were diagnosed at stage B and 4 at stage C, according to Kadish classification. Anti-tumor treatments were performed in 5 patients. One patient refused active treatment and was lost to follow-up. Better survival outcome were observed in 3 patients who were treated with combination chemotherapy alone or combined modality treatment including chemotherapy. Conclusion: Based on our retrospective study, the combined treatment consisting of surgery, radiotherapy, and combination chemotherapy should be used to improve treatment results. And furthermore, innovative clinical approaches such as neoadjuvant chemotherapy, high-dose chemotherapy and autologous peripheral stem cell transplantation, which have been reported to have good therapeutic results, should be considered and applied actively.

• 한국콘텐츠학회논문지
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• 제19권11호
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• pp.144-152
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• 2019

학습양식은 정보를 습득하고 처리하며 해석하고 조직화하는 도구를 의미한다. VARK(Visual Auditory Read Kinesthetic, VARK) 학습양식은 사용하는 감각양식에 따라 시각, 청각, 읽기/쓰기, 운동감각으로 구분된다. 국내 의과대학에서는 학습자 중심의 학습이 강조되지만 학습자의 VARK 학습양식에 대한 연구는 거의 없다. 본 연구에서는 국내 의과대학 학생을 대상으로 VARK 학습양식을 조사하여 각 학습유형과 성별, 학업성취 수준이 어떤 관계를 가지고 있는지 파악하고자 하였다. 본 연구의 대상은 전북지역 C의과대학·의학전문대학원에 재학 중인 394명의 학생이다. 학습양식검사는 VARK 웹 사이트에서 제공하는 Fleming이 개발한 VARK 검사지© 7.0 한국어버전, 총 16문항이다. 학업성취도는 표준화점수(t점수)로 변환하여 사용하였으며 학습유형에 대한 빈도분석과 집단별 비교를 위한 교차분석 및 분산분석(t-test, ANOVA)을 실시하였다. 연구 결과 학습선호 양식은 단일형이 87명(22.1%), 다중형이 307명(77.9%)이다. 남학생과 여학생 모두 4개 연합형인 VARK를 가장 선호하였다. 성별에 따른 전체 학습양식의 유의미한 차이는 없었다. 의학과 1학년은 단일형이 가장 낮고(8.8%), VARK 유형이 가장 높은 반면(47.8%), 의학과 4학년은 단일형이 가장 높고(30.7%), VARK 4개 연합유형(19.8%)과 3개 연합유형(19.8%)이 가장 낮았다. 모든 학습유형에서 학업성취도 차이는 확인되지 않았다(F=1.09, p=0.37). 의과대학 학생의 학습양식의 선호 결과는 추후 학습자 중심의 다양한 교수전략을 적용하는 기초 자료로서 의미가 있다.

• 기호학연구
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• 제56호
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• pp.7-44
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• 2018

본 연구의 목적은 인지과학의 관점에 근거하여 한국어 맛 어휘, 특히 한국어 맛 형용사의 분류 체계를 제안하는데 있다. 이때 한국어 맛 형용사의 분류는 인지과학의 분과 학문들이 수용하는 '미각'과 '향미'와 '맛'의 정의에 근거하여 이루어진다. 국내에서는 맛 어휘와 관련하여 많은 연구가 이루어져 왔다. 그래서 맛 어휘의 분류와 관련된 연구 결과물들이 꾸준히 발표되었으나, 연구자에 따라 크고 작은 차이를 보인다. 이는 연구자들이 맛 어휘를 범주화하는데 있어 객관적이고 보편적인 기준보다는 주관적이고 직관적인 기준을 적용했기 때문이다. 우리가 일상생활에서 흔히 말하는 '맛'은 미각 수용기 세포가 지각하는 감각 이상의 것을 포괄한다. 게다가 우리 인간이 지각하는 맛의 80~90%는 냄새에 좌우되어, 맛의 지각에 있어 후각의 중요성이 강조된다. 한편 음식의 식감과 색상과 온도, 음식을 먹는 주변 환경, 음식을 먹는 사람의 개인적 사회문화적 기호척도 등이 맛 지각에 큰 영향을 미친다. 먹는 것과 맛을 보는 것은 우리의 일상생활에서 중요한 부분을 차지한다. 그래서 맛 지각에 대한 언어학적 접근은 결코 간과할 수 없는 연구 영역이다. 본 연구자는 인지과학의 관점에 따른 맛 어휘의 분류가 맛 지각의 인지 메커니즘을 이해하는데 도움을 줄 수 있다는 가정에서 출발한다. 본 연구는 우리 인간의 심상어휘집에 '존재할 혹은 존재할지 모르는' 맛 어휘 낱말밭의 모습을 기하학적 모델로 형상화하고자 하는 후속 연구의 사전 작업임을 이 자리를 빌려 밝혀둔다.