Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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Esthesioneuroblastoma(Olfactory Neuroblastoma) : Report of Six Cases and Review of the Literature

감각신경모세포종: 증례 보고와 문헌 고찰

  • Shim Byoung-Yong (Division of Medical Oncology, Department of Internal Medicine, The Catholic University of Korea) ;
  • Park Jin-No (Division of Medical Oncology, Department of Internal Medicine, The Catholic University of Korea) ;
  • Han Ji-Youn (Division of Medical Oncology, Department of Internal Medicine, The Catholic University of Korea) ;
  • Hong Young-Sun (Division of Medical Oncology, Department of Internal Medicine, The Catholic University of Korea) ;
  • Kim Hoon-Kyo (Division of Medical Oncology, Department of Internal Medicine, The Catholic University of Korea) ;
  • Lee Kyung-Shick (Division of Medical Oncology, Department of Internal Medicine, The Catholic University of Korea) ;
  • Kim Min-Sik (Department of Otolaryngology- Head and Neck Surgery, The Catholic University of Korea) ;
  • Cho Seung-Ho (Department of Otolaryngology- Head and Neck Surgery, The Catholic University of Korea) ;
  • Chung Su-Mi (Department of Therapeutic Radiology, The Catholic University of Korea) ;
  • Lee Youn-Soo (Department of Clinical Pathology, The Catholic University of Korea) ;
  • Kang Jin-Hyoung (Division of Medical Oncology, Department of Internal Medicine, The Catholic University of Korea)
  • 심병용 (가톨릭대학교 의과대학 내과학교실) ;
  • 박진노 (가톨릭대학교 의과대학 내과학교실) ;
  • 한지연 (가톨릭대학교 의과대학 내과학교실) ;
  • 홍영선 (가톨릭대학교 의과대학 내과학교실) ;
  • 김훈교 (가톨릭대학교 의과대학 내과학교실) ;
  • 이경식 (가톨릭대학교 의과대학 내과학교실) ;
  • 김민식 (가톨릭대학교 의과대학 이비인후과학교실) ;
  • 조승호 (가톨릭대학교 의과대학 이비인후과학교실) ;
  • 정수미 (가톨릭대학교 의과대학 치료방사선과학교실) ;
  • 이연수 (가톨릭대학교 의과대학 임상병리학교실) ;
  • 강진형 (가톨릭대학교 의과대학 내과학교실)
  • Published : 2000.11.01
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Abstract

Objectives: Esthesioneuroblastoma is a rare malignant neoplasm that originates from the olfactory sensory cells. This tumor grows from the upper nasal cavity and ethmoid sinus and invades surrounding structures through the cribriform plate into intracranium or orbit in advanced stage. Even though there has been some controversies in determining standard treatment due to rarity of this tumor, the combination treatment of surgery and adjuvant radiation has been recommended for the locally advanced esthesioneuroblastomas. However, the recent clinical experiences of advanced cases showed that combination chemotherapy is highly effective to reduce tumor mass and improve clinical outcomes. Materials and Methods: The authors conducted a retrospective analysis of 6 esthesioneuroblastoma patients who were treated in our hospital from 1986. Results: The age of these patients was between 19 and 86 year-old. Among the 6 cases, 2 were diagnosed at stage B and 4 at stage C, according to Kadish classification. Anti-tumor treatments were performed in 5 patients. One patient refused active treatment and was lost to follow-up. Better survival outcome were observed in 3 patients who were treated with combination chemotherapy alone or combined modality treatment including chemotherapy. Conclusion: Based on our retrospective study, the combined treatment consisting of surgery, radiotherapy, and combination chemotherapy should be used to improve treatment results. And furthermore, innovative clinical approaches such as neoadjuvant chemotherapy, high-dose chemotherapy and autologous peripheral stem cell transplantation, which have been reported to have good therapeutic results, should be considered and applied actively.

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