• The Korean Journal of Nuclear Medicine Technology
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• v.17 no.1
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• pp.80-84
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• 2013

Purpose: The Immunotech AFP is a widely used test in 14 hospitals(RIA QC establishments: 46) as a liver tumor marker. Normally, the test takes 45 minutes including complicated 2 step method. We evaluated the possibility of 1 step method and suitable test time. Materials and Methods: Samples of 31 patients in SNUBH were used as subject. We evaluated the sensitivity, intra and inter assay precision, recovery rate, linearity between 1 step and 2 step method (45 min. and 60 min.). Results: Both of 45 minutes and 60 minutes test showed 0.1 ng/mL sensitivity. In 45 minutes test, the intra assay coefficients of variation were 3.05%, 3.43%, 1.68%. Also, inter assay coefficients of variation were 3.91%, 2.38%, 0.82%. In 60 minutes test, the intra assay were 5.00%, 3.69%, 1.97%, inter assay were 3.14%, 3.71%, 1.85%.The correlation coefficient of each 2 step and 1 step (45 min.), 2 step and 1 step(60 min.), 1 step (45 min.) and 1 step (60 min.) were y=0.9293x+2.7356 ($R^{2}=0.9999$), y=0.9193x+4.1002 ($R^{2}=0.9993$), y=0.9894x+1.3805 ($R^{2}=0.9997$). Conclusion: Compared 1step method to 2 step method, both method showed very reasonable precision, recovery rate and correlation coefficient. Also, 1 step method(45 min.) of correlation coefficient ($R^2$) was 0.999. We suggest that 1 step method test can reduce the test time and is useful for AFP test.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.293-296
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• 2008

Creep and shrinkage in concrete structures are very complex phenomena in which various uncertainties exist with regard to inherent material variations as well as modeling uncertainties. The creep and shrinkage models which are capable of predicting long-term structural response are specified in design codes such as ACI 209-92, CEB-FIP Model Code 90, etc. However, in the prediction formulas of creep and shrinkage effects of concrete, various kinds of parameters are involved to express the characteristics of concrete under consideration (i.e. the proportion of concrete, the shape of the structure, relative humidity, etc.). And the predicted values from each design code under same environment differ from each other. To predict the characteristics of concrete, the long-term experiments of creep and shrinkage is necessary but this is not suitable for a construction field. In this study, adjustment method of creep coefficient using sensitivity analysis is proposed to predict creep coefficient of concrete exactly and it is checked up on the validity of the predicting method by comparing to the assumed value and predicted one.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6571-6574
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• 2014

Background: Alcohol is well established as a risk factor for cancer development in many organ sites. To assess the reliability and validity of the Alcohol Use Disorders Identification Test - Consumption (AUDIT-C) for detecting alcohol use disorders or risky drinking in Japanese adults the present study was conducted. Materials and Methods: A test-retest method was applied with a 2-week interval with 113 health care employees. The k coefficient, Cronbach's coefficient alpha, Spearman's correlation coefficient, and intraclass correlation coefficient (ICC) were determined and the validity of the AUDIT-C was analyzed using the data from a nationwide survey on adult alcohol use conducted in 2008 (n=4,123). Results: The reliability of the AUDIT-C score was high (${\kappa}$ coefficient=0.63, Cronbach's alpha=0.98, correlation coefficient=0.95, and ICC=0.95). According to the likelihood ratio and Youden index, appropriate cutoffs for the AUDIT-C were ${\geq}5points$ in men and ${\geq}4$ points in women. The sensitivity and specificity of these cutoffs for identifying ${\geq}8$ points on the AUDIT were 0.88 and 0.80, respectively, for men (positive likelihood ratio [LR+]=4.5) and 0.96 and 0.87, respectively, for women (LR+=7.7). The sensitivity and specificity of the cutoffs for identifying ${\geq}12$ points on the AUDIT were 0.90 and 0.84, respectively, for men (LR+=5.8) and 0.93 and 0.94, respectively, for women (LR+=15.8). The sensitivity and specificity of the cutoffs for identifying ${\geq}16$ points on the AUDIT were 0.93 and 0.80, respectively, for men (LR+=4.7) and 0.92 and 0.98, respectively, for women (LR+=55.6). With higher scores on the AUDIT, the specificity decreased and false-positives increased. The appropriate cutoffs for identifying risky drinking were the same for both genders. Conclusions: The reliability and validity of the AUDIT-C are high, indicating that it is useful for identifying alcohol use disorders or risky drinking among the general population in Japan, a group at high risk of cancer development.

• Proceedings of the KSR Conference
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• 2007.11a
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• pp.953-958
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• 2007

To assess the derailment safety of the Samaeul Train, We developed a fleet analysis model and carried out sensitivity analysis of the variables related to derailment factors with ADAMS/Rail computing analysis method. Depending on the variation of the running speed in curve section, derailment coefficient and wheel load reduction rate are high at right side wheels in slow running speed section and low at left side wheel in high running speed. According to decreasing the radius of curve, derailment coefficient and wheel load decreasing rate are increased. Derailment coefficient is proportional to transition curve length and wheel load decreasing rate is constant. Cant value rising causes wheel load deduction rate rising.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.9
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• pp.517-524
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• 2019

The overdrive hub clutch is attached to a 6-speed automatic transmission to reduce fuel consumption by using the additional power of the engine. This paper proposes a means to minimize the load and roll-over ratio on the punch during the piercing process for the overdrive hub clutch product. Die clearance, shear angle, and friction coefficient, which can affect the load and roll-over ratio of the punch during processing, were set as the design variables. Sensitivity analysis was also conducted to determine the influence of each design variable on the punch load and roll-over ratio. As a result, shear angle, friction coefficient and die clearance were found to be sensitive to load and roll-over ratio. The punch load and roll-over ratio were set as the objective function and the equation of each design variable and objective function was derives using the Response Surface Method. Finally, the optimal value of the design variables was derived using the Response Surface Method. Application of this model to finite element analysis resulted in 22.14% improvement in the roll-over ratio of the punch load and material.

• Journal of Biomedical Engineering Research
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• v.31 no.1
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• pp.14-19
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• 2010

Baroreflex sensitivity (BRS) is a parameter of the cardiovascular system that is reflected in changes in pulse interval (PD and systolic blood pressure (SBP). BRS contains information about how the autonomic nervous system regulates hemodynamic homeostasis. Normally the beat-to-beat SBP measurement and the pulse interval measured from the electrocardiogram (ECG) are required to estimate the BRS. We investigated the possibility of measuring BRS in the absence of a beat-to-beat SBP measurement device. Pulse arrival time (PAT), defined as the time between the R-peak of the ECG and a single characteristic point on the pulse wave recorded from any arterial location was measured by photoplethysmography. By comparing the BRS obtained from conventional measurements with our method during controlled breathing, we confirmed again that PAT and SBP are closely correlated, with a correlation coefficient of -0.82 to -0.95. The coherence between SBP and PI at a respiration frequency of 0.07-0.12 Hz was similar to the coherence between PAT and PI. Although the ranges and units of measurement are different (ms/mmHg vs. ms/ms) for BRS measured conventionally and by our method, the correlation is very strong. Following further investigation under various conditions, BRS can be reliably estimated without the inconvenient and expensive beat-to-beat SBP measurement.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.7
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• pp.873-879
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• 2010

It is common to predict structural dynamic design parameters due to the change of design parameter, but to predict the amount of changed design parameter where the mass and stiffness are being modified are rarely found in previous literature. In this study, the changed design parameter in a proportional damping system is predicted by using sensitivity coefficients and an iterative method. The sensitivity coefficients are determined from the changes in eigenvectors; these changes are due to modification. This method is applied to a three-story shear structure. To validate the prediction of the changed design parameter, the results are compared to the reanalysis results; both results are in good agreement.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.59 no.4
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• pp.793-796
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• 2010

The equalizer compensates a signal distorted by transmission lines and amplifying stages, so the signal can have uniform characteristics over all frequency range. The equalizer in ODD(Optical Disc Drive) improves the stability of the extracted clock from a received signal and the readability of an inserted disc by suppressing noise and ISI(Inter-Symbol Inference). The length of marks-spaces and track pitch on discs becomes shorter as the recording density of an optical media is higher, which causes noise and ISI. And, the sensitivity about the fluctuation of physical systems is higher as the optical devices become more complicate. This paper proposes a method to select the coefficient of built-in equalizer of ODD in order to maintain the quality of signals against noise and ISI caused by system fluctuation.

• Journal of Korea Water Resources Association
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• v.46 no.11
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• pp.1103-1113
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• 2013

In this study, determination methods of the pressure monitoring location in water distribution system were introduced and applied to sample pipe network. The best determination method of the pressure monitoring location was suggested and applied to the real city pipe network. Three kinds of determination methods of pressure monitoring locations are categorized such as the sensitivity analysis according to changing roughness coefficient, pressure contribution analysis, and sensitivity analysis according to changing demand. Further-more, pressure contribution analysis and sensitivity analysis from the results of unsteady analysis were conducted and compared each other. From the results, the most accurate and simplest method was selected in this study. Therefore, the best method can be applied for the pressure management or leakage detection as a determination method of pressure monitoring location in water distribution system.

• Journal of the Microelectronics and Packaging Society
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• v.26 no.4
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• pp.141-148
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• 2019

Electronic substrates used in a mobile device is composed of various materials, and when the temperature is changed during manufacturing or operating, thermal deformation and stress concentration occur due to the difference in thermal expansion coefficient of each material. The shadow moiré technique is a non-contact optical method that measures shape or out-of-plane displacement over the entire area, but it is necessary to overcome the Talbot effect for high sensitivity applications. In this paper, LED light sources of various wavelengths was used to overcome the Talbot effect caused in the shadow moiré technique. By using the phase shift method, an experimental method to retain the measurement sensitivity within 10 ㎛/fringe was proposed and evaluated, and this method is applied to the thermal deformation measurement of the mobile electronic substrate. In the case of using white light, there were several areas that could not be measured due to the Talbot effect, but in the case of using blue LED light, it was shown that a precise moiré pattern with a sensitivity of 6.25 ㎛/fringe could be obtained in most areas.