• 제목/요약/키워드: Senile

검색결과 257건 처리시간 0.024초

Recombinant Human HAPLN1 Mitigates Pulmonary Emphysema by Increasing TGF-β Receptor I and Sirtuins Levels in Human Alveolar Epithelial Cells

  • Yongwei Piao;So Yoon Yun;Zhicheng Fu;Ji Min Jang;Moon Jung Back;Ha Hyung Kim;Dae Kyong Kim
    • Molecules and Cells
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    • 제46권9호
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    • pp.558-572
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    • 2023
  • Chronic obstructive pulmonary disease (COPD) will be the third leading cause of death worldwide by 2030. One of its components, emphysema, has been defined as a lung disease that irreversibly damages the lungs' alveoli. Treatment is currently unavailable for emphysema symptoms and complete cure of the disease. Hyaluronan (HA) and proteoglycan link protein 1 (HAPLN1), an HA-binding protein linking HA in the extracellular matrix to stabilize the proteoglycan structure, forms a bulky hydrogel-like aggregate. Studies on the biological role of the full-length HAPLN1, a simple structure-stabilizing protein, are limited. Here, we demonstrated for the first time that treating human alveolar epithelial type 2 cells with recombinant human HAPLN1 (rhHAPLN1) increased TGF-β receptor 1 (TGF-β RI) protein levels, but not TGF-β RII, in a CD44-dependent manner with concurrent enhancement of the phosphorylated Smad3 (p-Smad3), but not p-Smad2, upon TGF-β1 stimulation. Furthermore, rhHAPLN1 significantly increased sirtuins levels (i.e., SIRT1/2/6) without TGF-β1 and inhibited acetylated p300 levels that were increased by TGF-β1. rhHAPLN1 is crucial in regulating cellular senescence, including p53, p21, and p16, and inflammation markers such as p-NF-κB and Nrf2. Both senile emphysema mouse model induced via intraperitoneal rhHAPLN1 injections and porcine pancreatic elastase (PPE)-induced COPD mouse model generated via rhHAPLN1-containing aerosols inhalations showed a significantly potent efficacy in reducing alveolar spaces enlargement. Preclinical trials are underway to investigate the effects of inhaled rhHAPLN1-containing aerosols on several COPD animal models.

노인성 치매 환자의 돌봄경험에 대한 문화기술지 (Ethnography of Caring Experience for the Senile Dementia)

  • 김귀분;이경희
    • 대한간호학회지
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    • 제28권4호
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    • pp.1047-1059
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    • 1998
  • Senile Dementia is one of the dispositional mental disorder which has been known to the world since Hippocratic age. It has become a wide-spread social problem all over the world because of chronic disease processes and the demands of dependent care for several years as well as improbability of treatment of it at the causal level. Essentially, life styles of the older generation differ from those of the younger generation. While the fomer is used to the patriarchal system and the spirit of filial piet and respect, the latter is pragmatized and individualized under the effects of the Western material civilization. These differences between the two generations cause conflict between family members. In particular, the pain and conflict of care-givers who take care of a totally dependent dementia patient not only is inciting to the collapse of the family union, but is expanding into a serious social problem. According to this practical difficulty, this study has tried to compare dementia care-givers' experiences inter-culturally and to help set up more proper nursing interventions, describing and explaining them through ethnographies by participant observation and in-depth interviews that enable seeing them in a more close, honest and certain way. It also tries to provide a theoetical model of nusing care for dementia patients which is proper to Korean culture. This study is composed of 12 participants (4 males, 8 females) whose ages range from 37-71 years. The relations of patients are 5 spouses(3 husbands, 2 wives), 4 daughters-in-law, 2 daughters, and 1 son-in-law. The following are the care-givers' meaning of experiences that results of the study shows. The first is "psychological conflict". It contains the minds of getting angry, reproaching, being driven to dispair, blaming oneself, giving up lives, and being afraid, hopeless, and resigned. The second is "physical, social and psychological pressure" . At this stage, care-givers are shown to be under stress of both body and soul for the lack of freedom and tiredness. They also feel constraint because they hardly cope with the care and live through others' eyes. The third is "isolation". It makes the relationship of patient care-giver to be estranged, without understanding each other. They, also, experience indifference such as being upset and left alone. The forth is "acceptance" They gradually have compassion, bear up and then adapt themselves to the circumstances they are in. The fifth is "love". Now they learn to reward the other with love. It is also shown that this stage contains the process of winning others' recognition. The final is "hope". In this stage they really want situations to go smoothly and hope everything will be O.K. These consequences enable us to summarize the principles of cue experience such as, in the early stage, negative response such as physical·psychological confusion, pain and conflict are primary. Then the stage of acceptance emerges. It is an initial positive response phase when care-givers may admit their situations. As time passes by a positive response stage emerges. At last they have love and hope. Three stages we noted above : however, there are never consistent situations. Rather it gradually comes into the stage of acceptance, repeating continuous conflict, pressure and isolation. If any interest and understanding of families or the support of surrounding society lack, it will again be converted to negative responses sooner or later. Otherwise, positive responses like hope and love can be encouraged if the family and the surroundings give active aids and understanding. After all, the principles of dementia care experiences neither stay at any stage, nor develop from negative stages to positive stages steadily. They are cycling systems in which negative responses and positive responses are constantly being converted. I would like to suggest the following based on the above conclusions : First, the systematic and planned education of dementia should be performed in order to enhance public relations. Second, a special medical treatment center which deals with dementia, under government's charge, should be managed. Third, the various studies approaching dementia care experiences result in the development of more reasonable and useful nursing guidelines.

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[유산균] 프로바이오틱 유산균 ([Lactic Acid Bacteria] Probiotic Lactic Acid Bacteria)

  • 안용근
    • 한국식품영양학회지
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    • 제24권4호
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    • pp.817-832
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    • 2011
  • 불가리아 사람들이 장수하는 것은 요구르트를 많이 섭취하여 유산균이 장내의 독소 생성 세균을 억제하기 때문이라고 한다. 젊을 때는 사람의 장 내용물 1 g당 100억 마리 이상의 $Bifidobacterium$이 살지만 노쇠하거나 병들면서 줄어들고 $Clostridium$ 등의 유해균이 많아진다. 그래서 인공적으로 장내의 비피도박테리움을 증가시키면 유해세균이 억제되어 건강하고 장수한다고 한다. 이를 위하여 섭취하는 미생물을 probiotic 미생물이라고 하며, 주로 유산균이 사용된다. 프로바이오틱 미생물은 항생제와 같이 유해균을 죽이는 것이 아니라 유해균과 공생하면서 유해균을 억제하여 건강을 증진, 즉 숙주(사람)를 증생(增生)시킨다. 그래서 유산균을 주체로 하는 프로바이오틱 미생물과 그 제품은 변비, 설사, 장염, 혈중 콜레스테롤, 암 등을 예방 내지 치료하고 정장(淨腸) 작용으로 건강을 향상시킨다고 하여 시장이 계속 확대되고 있다. 그러나 국내 프로바이오틱스 제품은 종균을 대부분(90%) 수입하여 사용하므로 한국인의 체질에 적합하지 않을 가능성이 있다. 그래서 E사는 자체 개발한 미생물로 제품을 생산하고 있다. 본 논문에서는 유산균을 주체로 하는 프로바이오틱 미생물과 제품의 효과와 특성, 종류, 시장 등 전반적인 면을 살펴 보았다.

치매환자를 위한 u-Health Care 시스템 개발 (Development of u-Health Care System for Dementia Patients)

  • 신동민;신동일;신동규
    • 한국통신학회논문지
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    • 제38C권12호
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    • pp.1106-1113
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    • 2013
  • 치매와 같은 노인성 정신질환 환자들에게 운동량과 일광량은 환자의 투약량과 조절과 진료에 있어 중요한 단서가 된다. 따라서 환자들의 안전과 건강한 삶을 위해 일상생활의 건강정보 모니터링이 필수적이다. 이러한 서비스를 제공하기 위해 환자에게는 휴대가 간편하고 항상 착용 가능한 센서 디바이스와 데이터를 모니터링할 서버의 구성이 필요하다. 본 논문에서는 치매환자의 건강정보를 실시간으로 모니터링하고 관리하기 위해 환자가 착욕하는 시계형 디바이스(스마트 시계)와 서버시스템을 개발했다. 본 논문에서 개발한 스마트시계는 GPS, 가속도센서, 조도센서를 포함하며 환자의 위치 추적, 운동량, 일광량을 측정해 환자의 실시간 건강정보를 취득 할 수 있다. 서버시스템은 스마트시계를 통해 취득한 센서 데이터를 통해 의사, 보호자가 모니터링 할 수 있는 웹 서버와 센서 데이터의 분석 알고리즘을 포함한다. 본 논문에서 제안한 데이터 분석 알고리즘은 가속도센서를 통해 취득한 환자의 움직임에서 걸음 수를 검출해 운동량 정보를 취득하며 이를 검증하기 위해 빠른 걸음, 느린 걸음, 보통 걸음에 해당하는 3가지 경우로 실험한 결과 96%의 정확도를 보였다. 본 논문을 통해 개발된 치매환자를 위한 u-Health Care 시스템을 적용한다면 치매환자들에게 더 질 높은 의료서비스를 제공할 수 있을 것이다.

중완(中脘)($CV_{12}$) 황기약침이 노화촉진 생쥐의 골다공증 개선에 미치는 영향 (The Effects of Astragali Radix Pharmacopuncture at $CV_{12}$ on Osteoporosis of Senescence Accelerated Mice (SAM) P6)

  • 김성필;김승만;류혜선;신정철;이동근;이욱재;이주희;김재홍
    • Journal of Acupuncture Research
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    • 제29권2호
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    • pp.59-71
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    • 2012
  • Objectives : The purpose of this study was to examine the effects of the Astragali radix Pharmacopuncture on improvement of senile osteoporosis (Type 2) in SAM P6. Methods : At 10 weeks after birth, Astragali radix Pharmacopunctures were given 100mL, 200mL/kg/day, i.p. 3times a week for 4 weeks at $CV_{12}$ in SAM P6 mice. We measured complete blood cells (CBC) such as RBC, HGB, Hct, PLT, MPB and MCHC. And we analyzed the plasma concentrations of blood urea nitrogen, creatinine, inorganic phosphate and total iron. In addition, we tested bone mineral density (BMD) using the soft X-ray. Results : The results were as follows. 1. At $CV_{12}$ in SAM P6, treatments of Astragali radix Pharmacopuncture were showed a trend of increase in bone mineral density (BMD) of the vertebrae lumbales, femurand tibia in P6 mice. 2. At $CV_{12}$ in SAM P6, treatment of Astragali radix Pharmacopuncture increased in RBC, HB, HCT and PLT, in comparison with control group. It was also found that the inorganic phosphate levels increased in the treatment on groups of the Astragali radix Pharmacopuncture from that of the control group, but blood urea nitrogen was no significant. Conclusions : These results are suggested that at $CV_{12}$ the Astragali radix Pharmacopuncture help on improvement of osteoporosis in SAMs.

치매모델 쥐의 과제지향 훈련이 인지기능 회복과 중추신경계 가소성에 미치는 영향 (Effect of Task-oriented Training on Cognitive Function Recovery and CNS Plasticity in Scopolamine-induced Dementia Rats)

  • 김석범;김동현
    • 대한지역사회작업치료학회지
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    • 제9권2호
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    • pp.23-31
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    • 2019
  • 목적 : 본 연구는 치매모델 쥐에게 과제지향 훈련을 반복적으로 실시하고 그 결과로 인지기능과 중추신경계 가소성의 한 지표 물질인 아세틸콜린의 함량 변화를 관찰하여 치매의 개선 효과를 확인하는데 그 목적이 있다. 연구방법 : 스코폴라민을 투여한 치매모델 쥐에게 과제지향 훈련을 수행하지 않은 실험군I과 과제지향 훈련을 수행한 실험군II으로 구성하였다. 과제지향 훈련은 앞발의 뻗기, 잡기, 옮기기를 적용하였고 장애물 보행을 실시하였다. 인지기능은 기억력의 측정에 정량화된 수동회피검사를 실시하였고 중추신경계 가소성의 변화는 아세틸콜린의 함량의 변화를 비교하였다. 결과 : 연구의 결과는 다음과 같다. 첫째, 스코폴라민을 투여한 치매모델 쥐의 과제지향 훈련을 실시한 후 4일부터 인지 기능의 유의미한 향상이 있었다(.00). 둘째, 스코폴라민을 투여한 치매모델 쥐에 적용한 과제지향 훈련은 아세틸콜린 함량의 유의미한 증가를 보였다(.00). 결론 : 본 연구에서는 작업치료 중재 중 임상에서 노인성 치매환자에게 많이 수행하고 있는 과제지향 훈련을 치매모델 쥐에게 수행함으로서 기억력 개선을 통한 인지기능 향상과 중추신경계 가소성을 확인할 수 있는 아세틸콜린의 함량 증가를 과학적으로 입증하였다.

치매노인 문제행동과 간호제공자의 대처행동 관계 (Coping with dementia related behavior problems of the elderly and care providers)

  • 임동영
    • 한국산학기술학회논문지
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    • 제16권7호
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    • pp.4805-4815
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    • 2015
  • 치매노인과 부양가족, 간호제공자를 대상으로 치매노인의 문제행동의 유형과 이에 따른 간호제공자의 대처방법과의 관계를 규명하기 위한 분석은 기술통계, t-test, ANOVA, discrete variable를 이용하여 상관 분석하였다. 연구결과는 부양가족 및 간호제공자가 경험한 치매노인 문제행동으로 초조행동이 가장 높게 나타났고, 세부영역별로는 '같은 질문을 반복하거나 같은 요구를 반복한다.' 와, '이상한 소리를 내거나 소음을 낸다.' 그리고 '.간호제공자의 말을 안 듣고 고집을 부린다.'등으로 나타났다. 또한 본 연구에서 나타난 치매노인의 문제행동에 따른 대처행동으로는 '언어적토론', '발생요인제거', '행동제한'이 순 상관관계가 있는 것으로 나타났다. 이에 본 연구자는 치매노인을 돌보는 관련 기관 및 재가에서는 간호제공자에게 치매노인의 문제행동 중 빈번하게 나타나는 문제행동별로 대처 할 수 있도록 정기적인 교육이 필요하다고 사료되고, 치매노인의 문제행동에 대한 개별화된 간호중재프로그램이 개발되는데 기초자료로 제공될 것이다.

노인성 치매환자 가족간호 향상을 위한 교육프로그램 효과에 관한 연구 (Study on the Effectiveness of Care Giver Education Program on the Home Care of Senile Dementia Patients)

  • 홍여신;이선자;박현애;조남옥;오진주
    • 대한간호학회지
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    • 제25권1호
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    • pp.45-60
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    • 1995
  • This study investigated the effects of education program conducted through individual home visit by CHPs, which was developed ,by the operational re-search technique for families of dementia patients. (Yeo Shin Hong et at,1994) The study was conducted in the form of a primary experimental design with 43 people as subjects, including dementia patients and family member in several Myon areas of Chungcheong Namdo between June 10 and August 20, 1994. The data was collected by questionnaires through the home visit by the CHPs. The results of study are as follows. 1. There is no difference in the quality of life between before and after the education program. 2. Role stress 'before the education program' was significantly different than 'after the education program'. 3. There was no difference in the feeling of burden between before and after the education program. 4. There was a significant difference in the abnormal behaviors of patients between before and after the education program. 5. The knowledge of dementia by the patient's family increased significantly after the education program, compared to that of 'before the education program'. 6. There was a significant difference in the attitude of family members toward the education program on dementia between before and after the education program. 7. The results of analysis on the coefficient relationship of various variables showed that the age of patients and family members have a significant correlation with role stress(p=.01). 8. In the subjective evaluation of family members on changes in actual nursing actions and the improvement of knowledge and technique in terms of daily living, (including abnormal behavior of patients, adjustment of environment for patients, activity programs for patients, communication technique with patients, ensuring the safety of patients, clothing, meals and elimination, 60-65% of family members responded that their knowledge had increased. As for improvement in techniques for each item, the technique for communication with patients showed the greatest improvement while the action program method for patients showed the least change. As for the nursing service provided to patients, most respondents showed a positive change. The specific items for which more than 80% respondents answered positively were as follows : recognizing the demand of patients, getting patients to do simple house works, talking softly and gently, removing dangerous things, preparing comfortable clothes that are easy to put on and take off, and limiting water consumption at night. As a result of study, the following suggestions can be made. The purpose of the study was to examine the effect of an education program developed and applied for dementia patients and family members in the community. This needs to be compared with a similar study conducted in the urban setting. In addition, a community service program (ex : nursing hem and shelter) including the application of the education program should be developed and the study done to investigate its effect.

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일본의 재가간호 및 방문간호 -새로운 개호보험제도의 실시를 앞두고- (A Study on Home Care and Home Visiting Nursing in Japan)

  • 김증임
    • 지역사회간호학회지
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    • 제10권1호
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    • pp.106-120
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    • 1999
  • Japan has been prepared for aging society from 1970. In 1970, the percentage of distribution of population of 65 years old and over was 7.1%. It is similar to present percentile of the elderly in Korea. Therefore, it will be needed to study about home care and home visiting nursing in Japan at present. This study was aimed to prepare the fundamental documents for home care nursing in Korea and to know the background of new health care system of Long-term Care Insurance in Japan, by studying home care and home visiting nursing in Japan. With the continuing aging of the population, especially the increase in the number of latter stage elderly, it is predicted that there will be an increase in the number of the elderly who are bedridden and suffering senile dementia. To ensure that these people will be able to continue living in the communities and homes they are accustomed to, surrounded by their families and neighbors, Japan substantially improve and expand in-home services. There were also long-term effort to reach the level of services outlined in the Gold Plan and the New Gold Plan within the decade between FY 1991 and FY 1999 in the field of health care and welfare. Under this plan, the most noticeable change was occurred in home care, home was permitted as the field of care and visiting nursing was established in law. Through this 10- Year Strategy for Promotion of Health and Welfare Services for the Aged, many problems have been improved and solved, but some problems remained such as inadequate service supply and consumption of medical insurance for the elderly. Japan will be a society composed 25% of elderly people of total population in 2020, and it will be soon faced with a shortage of welfare and medical facilities and manpower. As for equalizing the benefits and cost burdens, and other future arrangements for health care and welfare, Long-term Care insurance system was established in 1994. This system will be enforced from April 2000 and use present facilities and services. To know home care and home visiting nursing in Japan, we need to consider present conditions well and to take notice of changes and measures to cope with an aging society continuously.

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허혈성 뇌손상 모델 당뇨쥐의 복합운동프로그램의 효과 (The Effect of Complex Exercise Program of Diabetic Rats with Ischemic Brain Injury Model)

  • 김동현;방현수
    • 대한지역사회작업치료학회지
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    • 제6권1호
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    • pp.41-48
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    • 2016
  • 목적 : 본 연구의 목적은 허혈성 뇌손상시 회복의 지연을 초래하는 당뇨에 복합운동프로그램을 적용하였을 때, 신경학적 효과와 당뇨의 개선효과를 확인하고자 하였다. 연구방법 : 본 연구는 경상북도 소재의 동물실험 연구실에서 실시하였고 허혈성 뇌손상 모델의 흰쥐에게 STZ(streptozotocin)를 투여하고 당뇨를 유발한 흰쥐 10마리를 사용하였다. 흰쥐에게는 4주간 복합운동프로그램을 실시하여 뇌기능회복을 확인하기 위해 미로검사(maze test)를 실시하였고, 당뇨의 개선효과를 보기위해서 혈당을 확인하였다. 결과 : 허혈성 뇌손상 모델 당뇨쥐에게 복합운동프로그램을 적용한 결과, 뇌기능회복을 확인하기 위한 미로검사에서는 실패횟수(error)가 3주 후부터 유의하게 감소하였고(p<.05) 탈출시간은 1주 후부터 유의하게 감소하였다(p<.05). 그리고 당뇨의 개선효과를 확인하기 위한 혈당 검사에서는 대조군에서는 유의한 변화가 없었고 복합운동프로그램을 적용한 실험군에서는 4주 후부터 유의한 효과가 있음을 알 수 있었다(p<.05). 결론 : 뇌졸중, 당뇨 등의 성인, 노인성 질환이 증가되고 있는 현 시점에서 환자들에게 재활은 여명수명동안 삶의 질 개선에 매우 중요하다. 본 연구는 허혈성 뇌졸중과 당뇨를 모두 가지고 있는 동물모델에게 치료사가 쉽게 시행할 수 있는 복합운동프로그램 적용을 통하여 뇌기능회복과 당뇨 개선효과를 확인할 수 있었다.