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Amino Acid-Based Material for the Complementary Therapy of Decubitus Ulcers

  • Nogueira, Frederico;Gouveia, Isabel C.
    • Journal of Microbiology and Biotechnology
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    • v.27 no.4
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    • pp.747-758
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    • 2017
  • Chronic wounds, pressure sores, lesions, and infections of microbial origin in bedridden, paralyzed, or malnutrition patients remain the object of study of many researchers. A variety of factors behind the development of these disorders are related to the patient's immune system, making it unable to respond effectively to the treatment of the wound. These factors can be properly controlled, giving particular importance to the ethiology and stage of the wound, as well as the time periods corresponding to the replacement of the dressings. The present research reports a novel foam/soft material, ${{\small}L}$-Cys-g-PCL, with an application for decubitus/pressure ulcers, especially for wounds with a difficult healing process due to infections and constant oxidation of the soft tissues. During this work, the interactions between S. aureus and ${{\small}L}$-Cys-g-PCL foam were studied under conditions that simulate decubitus ulcers; namely, pH and exudate. The effects of duration of grafting (1 or 8 h) and pH (7.0 and 8.9) on wettability, surface energy, swelling, and porosity were also evaluated. Results showed an effective microbicidal activity exhibiting an inhibition ratio of 99.73% against S. aureus. This new ${{\small}L}$-Cys-g-PCL soft material showed saftey to contact skin, ability to be shaped to fill in sunken holes (craters) - pressure ulcers stage III - and to act as a smart material responsive to pH, which can be tailored to develop better swelling properties at alkaline pH where exudates are normally higher, so as to address exudate self-cleaning and prevention of desiccation.

Effects of foot pressure using the elastic band with rings during sit-to-stand in persons with stroke

  • Hwang, Young-In;Kim, Ki-Song
    • Physical Therapy Rehabilitation Science
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    • v.6 no.4
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    • pp.159-163
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    • 2017
  • Objective: Persons with stroke have a tendency to exhibit asymmetric weight-bearing during sit-to-stand because due to the attempt to support themselves with the non-paretic foot. However, there are few devices that can assist with sit-to-stand (STS) performance. This study was designed to investigate the use of the elastic band with rings (EBR) in improving weight-bearing effectively in persons with stroke during STS training. Design: Cross-sectional study. Methods: Thirteen stroke survivors participated in the study. An EBR was applied onto the patient during STS activity. The foot pressure was measured before and after wearing the EBR, with a 5-minute rest period between measurements. Subjects were asked to perform each test twice with and without the EBR. Bilateral feet pressures were measured with standing posture being divided into the forward and backward aspects. The foot contact pressure during STS activity was measured with the CONFORMat System. Results: With EBR, the forward pressure of the affected foot significantly increased while the less-affected forward foot pressure significantly decreased (p=0.015 and p=0.023, respectively). The backward foot pressure did not differ significantly in the two limbs, and there was no difference with and without the EBR in terms of the total pressure of the affected foot. There was a significant difference with and without the EBR in the total pressure of the less-affected foot (p<0.05). Conclusions: STS training with the EBR has been shown to improve weight-bearing of both feet while decreasing the total pressure of the less-affected foot in stroke survivors. Therefore, we suggest that the EBR is a useful tool for STS training for persons with stroke in the clinic.

Stabilization of Dry Immuno-Diagnostic Kit with Immobilized Antibody and Determination of Its Shelf-Life (항체가 건조상태로 고정된 면역진단키트의 안정화와 Shelf-Life 결정)

  • 이창우;조정환;육순학;권오협;박영남;박세환
    • KSBB Journal
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    • v.13 no.5
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    • pp.502-510
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    • 1998
  • Stabilization of antibody, which is specific to Salmonella typhimurium antigens, present in dry states on membranes was accomplished, and its shelf-life, i.e., duration for maintaining minimum 90% of the initial activity, under optimal conditions was determined. To prepare two major components of an immuno-strip, the antibody was not only immobilized on nitrocellulose membrane surfaces but also placed within the pores of glass fiber membrane after conjugating it with old colloids as signal generator. Among potential stabilizers of the immuno-components, a disaccharide, trehalose, showed a significant protection effect of immunoglobulin structure from thermal energy. Optimal concentrations of trehalose for the respective component were significantly different (8-fold higher for the antibody-gold conjugate than for the immobilized antibody), which probably resulted from distinct densities and configurations of antibody present on the membranes. An additional requirement for the gold conjugate was freeze-drying of this substance such that the conjugate can be readily resolubilized upon contact with aqueous medium. By using the components prepared under optimal conditions, immuno-strips were constructed and exposed to thermal energy. Signals with less than 10% decrease in the intensity were maintained for approximately 21 days at 60$^{\circ}C$. Compared to previous reports, this result represented a 2-year shelf-life at room temperature. it was, however, two times longer if determined from thermal acceleration tests based on the theory of inactivation rate of protein. Such discrepancy between the two estimates could be mainly attributed to errors in accurately controlling temperatures and also to changes in the physical properties of membranes due to a high thermal energy.

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Effect of the Education on AIDS for Korean Health Care Workers (건강 관리자의 에이즈 교육 효과)

  • 장순복;이창우
    • Journal of Korean Academy of Nursing
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    • v.27 no.1
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    • pp.201-211
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    • 1997
  • This study was an evaluation study of AIDS education program. The purpose of this study was to clarify the education effects on AIDS for health care workers to develop a better next education program. This study was done by self reporting with a 67 items of structured questionnaire by 431 health care workers included doctors, nurses, laboratory technicians, and health educators. Data were collected at the time of completion of each AIDS education with the help of education program manager. Both the AIDS related knowledge score and the acceptance attitudes score were significantly higher in the male group, in the medical institution employer group, in the group who have met the HIV infected person, who has known the HIV positive person, and the group of laboratory technician, but the AIDS prevention intention score was statistically higher in the group of female and laboratory technician group. The post education scores of AIDS related knowledge. acceptance attitudes, and preventive intention were statistically higher than those of the preeducation. The most increased item among AIDS prevention intention list was 'I will provide the meeting between the HIV infected persons and the public (+21.9%)'. But even the decreased item among AIDS prevention intention list was 'I will advice to female not to have extra marital sexual contact to avoid AIDS(-3.1%)'. It could be concluded that the health care workers were ignorant of vertical transmission of AIDS, they were afraid of disclosing the infection status, and have less AIDS prevention intention. Therefore it is needed to take an assessment process before each new education trategy to increase AIDS related the effect of the education on AIDS.

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A Qualitative Study on Social Work Applicants' Impression Management Tactics in Job Interviews (사회복지 지원자의 채용면접 인상관리전략에 관한 질적 연구)

  • Jang, Yeon-Jin;Jeong, Sun-Wuk
    • Korean Journal of Social Welfare
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    • v.60 no.1
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    • pp.77-102
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    • 2008
  • The purpose of this study is to know what impression management(IM) tactics social work applicants use in their job interviews and what relation between their IM tactics and interviewers' evaluation exists. To accomplish this purpose, we reviewed the precedent researches about IM and conducted a qualitative study with the applicants in a community welfare center which adopted open approach in recruitment process. We analyzed the applicants' IM tactics through observing video-taped interview sessions and reviewing interviewers' rating paper. The results showed that the social work applicants mainly used self-promotion tactic for emphasizing their strengths and justification tactics for expressing their weaknesses. Some applicants often used fit-with-organization and other-enhancement belonged to ingratiation tactics. According to interviewers' rating results, the applicants with deep eye contact, calm attitude or smiling face gave a good impression to the interviewers. In the final discussion, an applicant who adopted diverse verbal and non-verbal tactics and expressed her point clearly was perceived attractive by the interviewers and accepted as the best choice. Based on this qualitative analysis, we have made several practical suggestions for social work applicants, social work researchers and social work organizations.

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Predictors of Local Legislators' Support for Tobacco Control Policies in Seoul Metropolitan City (서울특별시 기초의회 의원들의 흡연규제정책 지지도 및 관련 요인)

  • Lee, Weon-Young
    • Korean Journal of Health Education and Promotion
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    • v.22 no.2
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    • pp.77-95
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    • 2005
  • Objectives: This study measured the extent of local legislators' support for tobacco control policies and identified the predictors of that. Methods: Local legislators, from 21 Gu in Seoul Metropolitan City, underwent a self-administrated questionaire during the 6-week period from December 1, 2004 to January 15, 2005. Multiple linear regression model was used to assess relationships between five groups of variables(political factors including political ideology, personal characteristics, tobacco experiences, tobacco knowledge, contact with local health officers) and support for tobacco control policies based on an 11-item scale. Results: The rates of support for 'penalizing merchants who sell cigarettes to minors' and 'instituting a law mandating that parents should not smoke in a car when children are present' were highest as 87.5% and 82.0% respectively, and those for 'increasing price of cigarettes' and 'regulating stores that sell cigarettes' were lowest as 52.2% and 51.7% respectively. Support was higher among local legislators who thought government had a duty to promote healthy life styles, knew second-hand smoke could cause lung cancer, knew tobacco caused more deaths than alcohol. Support among ex-smokers and nonsmokers was higher than current smokers. Conclusions: The findings indicate that local legislators who oppose tobacco control measures may not be opposed to tobacco control per se, but are more generally opposed to a government role in health promotion, Thus, Tobacco control advocates need to be more attentive to the way tobacco control issues are framed for particular legislators. Further, they could work to increase tobacco knowledge among local legislators.

A Study on the Relation of the Later Personality Adjustment Types and the Aged Perception of the Conflict with their Married Children -Focus on the Relationships with their Eldest Sons and Wives- (노후 성격적응성향과 노인이 지각하는 기혼자녀와의 갈등관계연구 -장남부부와의 관계를 중심으로-)

  • 유영주
    • Journal of Families and Better Life
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    • v.15 no.2
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    • pp.155-172
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    • 1997
  • The purpose of this study is to examine the relation between the later personality adjustment types and the elderly percepted conflict with their married children. The subjects for this study are the aged over 60 years in Seoul both having the eldest sons' couples and perceiving their own economics level as the middle-upper. The results based on this are as followed: 1) The Active Integrated Coper is appeared in the higher educational level group in the better health condition in the 11-30 thousand won of personal expense in the professional and management occupation and in the more vigorous for social activity. The Failing Overcoper the Dependent Passive Coper and the Self-negating Undercoper is appeared in th female elder group in the later group of the older age in the lower educational level in the worse health condition in the group without spouse in one without income in the below 10 thousand won in the less preparation for the later life. 2) The problems of emotion and iew of values bring about the conflicts between them and theirs rather than the financial problem. when they are in the worse health condition in the group without religion in the group not cohabiting their eldest sons' couples and in the group not well-prepared for their later life as the socio-demographic variables the old recognized the seriousness of the conflict with their eldest sons' couples. 3) The lower the Active Integrated Coper is and the higher the Failing Overcoper is the more intense the conflict between them and their eldest sons' couples is. 4) The t-test to examine the difference in the old's conflict with their eldest sons' couples among the later groups shows that it is in the less the Active Integrated Coper and in the more the Failing Overcoper that the conflict is more surfaced. 5) The educational level the level of the later life preparation the contact frequency with their daughter the level of their social activity as the socio-demographic variables and the Failing Overcoper as the later personality adjustment type answer for 22 percentage of the conflict.

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The structure Optimization Research of the Automation Welding Equipment of the Large L-type Using the Response Surface Method (반응표면법을 이용한 대형 L-type 자동화용접장치의 구조최적화 연구)

  • Jang, Junho;Jung, Wonjee;Lee, Dongsun;Jung, Jangsik;Jung, Sung Ho
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.22 no.1
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    • pp.138-144
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    • 2013
  • The automation technology for overlay welding is needed due to the occurrence of severe corrosion and abrasion on the surface of internal contact in different shape of fittings. In Korea, different shapes of fittings have been manufactured by using the imported equipment of overlay welding automation at some companies. Thus the research on the development of overlay welding automation system (in short, OWAS) for a large L-type tube is urgently needed. In this paper, the investigation is focused on the optimal design of a supporting base for the (currently developing) OWAS of large L-type tube. Specifically we assume that the base which supports the equipment during the process of overlay welding is loaded as self-weight in the direction of gravity through static analysis especially when it is rotated 180 degree on the OWAS. For optimal design of a supporting base for OWAS of large L-type tube, Solidworks(R) (for 3-dimensional modelling) and ANASYS Workbench(R) (for structural analysis) are incorporated so as to proceed an optimization routines based on Response Surface Method (RSM) and Design of Experiment (DOE). In more specific, DOE finds out major factors (or dimensions) of the supporting base by using MINITAB(R). Then the regression equations between design variables (the major factors of supporting base) and response variables (deformation, stress and safety factor for the supporting base), which will be resulted in by RSM, verify the major factors of DOE. In the next step, Central Composite Design (CCD) plans 20 simulations of ANASYS Workbench(R) and then figures out the optimal values of design variables which will be reflected on the manufacturing of supporting base. Finally welding experiment is conducted to figure out the influence of overlay welding quality in applying the optimized design values of supporting base to the actual OWAS.

A Study on the Development of Computer Assisted Instruction for Definite Integral (정적분 단원에 관한 CAI프로그램 개발 연구)

  • 우제환
    • Journal of the Korean School Mathematics Society
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    • v.1 no.1
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    • pp.97-109
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    • 1998
  • The activities of teaching and learning are to try to reach the lesson object most closely in many ways. Considering that the lesson objects are to get the principle or law of a concept, to acquire the mathematical function, to master it through repeated exercises and to solve mathematical problems, we need many ways to reach such objects. Among the many ways, we can first think of one: the students will learn with curiosity and according to their own ability or advancing level in learning when teachers study and prepare necessary contents enough in advance by using computers, showing the right program to learners' needs. For example, defining definite integral by measuration by parts will help understand measuration by parts well and know the meaning of definite integral correctly, In teaching and learning by the use of this program, the educational effects are expected as follows. 1. It is thought that this program will stimulate the desire for and interest in learning because it used animation and acoustic effect. And voluntary and positive thinking activity will be shown. 2. It is expected that the conviction of formulas will be got and the concept of definite integral will be remembered firmly by showing how to measure the width of circle with the use of measuration by parts in various other ways instead of the ways used at present. 3. It is expected that students will feel the pleasure of mathematics in life when they recognize mathematical facts scattered really in our life rather than mathematical difficulties. 4. It is expected that the repeated review of programs already designed will remove the fear of incomplete parts and help review again. 5. It is certain that positive attitude in life will be formed as teacher-centered class is changed into learner-centered class and unwilling study is changed into self-oriented study. However, I think this program is insufficient for humanbeing-centered education given directly in contact with students on the ground of the variety in mathematical education and applications in many ways. And mechanically inhuman computers leave some solutions to be desired

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Effect of a 4-week Theraband Exercise with PNF Pattern on Improving Mobility, Balance and Fear of Fall in Community-Dwelling Elderly

  • Candace, Wong YH;Kennis, Cheung KW;Evelyn, Ko YC;Jeffrey, Tse HC;Margaret, Law YL;Hwang, Seong-Soo;Shirley, Ngai PC
    • Journal of the Korean Society of Physical Medicine
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    • v.12 no.4
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    • pp.73-82
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    • 2017
  • PURPOSE: Proprioceptive Neuromuscular Facilitation (PNF) has been shown to improve body function and activity/participation in people with functional dysfunctions. This study evaluates if active exercise using theraband in PNF pattern may induce similar benefits as exercise using manual PNF pattern performed by physiotherapists on promoting mobility, balance and fear of fall in community-dwelling elderly. METHODS: Twenty-three community-dwelling elderly with independent activities of daily living were recruited and randomly allocated into either PNF group - exercise in PNF pattern by trained physiotherapists or Theraband-PNF (T-PNF) group - exercise using theraband in PNF pattern, for an hour, twice weekly for 4 weeks. Functional outcomes such as Timed Up and Go test, Elderly Mobility Scale, Berg balance scale, functional reach and subjective measures including fear of fall (FOF) scale, bodily pain in visual analogue scale were measured pre and post-program. RESULTS: Twenty-one participants completed the program. PNF group demonstrated significant within-group improvements in all subjective measures and objective measures. Similar within-group improvements were demonstrated in all outcome measures except FOFS in T-PNF group. However, no between-group differences were found in any of the outcome measures. CONCLUSION: Comparable improvements in functional outcomes in community dwelling elderly were demonstrated in both groups. As manual PNF exercise traditionally need clinicians' contact and feedback on patient which limit the training to be carried out extensively in community setting. The current findings suggest that exercise using theraband in PNF pattern is feasible to be adopted as self-practice exercise for community-dwelling elderly to induce beneficial effects on functional outcomes.