• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권12호
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• pp.4275-4291
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• 2021

With the unprecedented growth of textual information on the Internet, an efficient automatic summarization system has become an urgent need. Recently, the neural network models based on the encoder-decoder with an attention mechanism have demonstrated powerful capabilities in the sentence summarization task. However, for paragraphs or longer document summarization, these models fail to mine the core information in the input text, which leads to information loss and repetitions. In this paper, we propose an abstractive document summarization method by applying guidance signals of key sentences to the encoder based on the hierarchical encoder-decoder architecture, denoted as KI-HABS. Specifically, we first train an extractor to extract key sentences in the input document by the hierarchical bidirectional GRU. Then, we encode the key sentences to the key information representation in the sentence level. Finally, we adopt key information representation guided selective encoding strategies to filter source information, which establishes a connection between the key sentences and the document. We use the CNN/Daily Mail and Gigaword datasets to evaluate our model. The experimental results demonstrate that our method generates more informative and concise summaries, achieving better performance than the competitive models.

• Biomolecules & Therapeutics
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• 제31권1호
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• pp.1-15
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• 2023

Autophagy is a process of eliminating damaged or unnecessary proteins and organelles, thereby maintaining intracellular homeostasis. Deregulation of autophagy is associated with several diseases including cancer. Contradictory dual roles of autophagy have been well established in cancer. Cytoprotective mechanism of autophagy has been extensively investigated for overcoming resistance to cancer therapies including radiotherapy, targeted therapy, immunotherapy, and chemotherapy. Selective autophagy inhibitors that directly target autophagic process have been developed for cancer treatment. Efficacies of autophagy inhibitors have been tested in various pre-clinical cancer animal models. Combination therapies of autophagy inhibitors with chemotherapeutics are being evaluated in clinal trials. In this review, we will focus on genetical and pharmacological perturbations of autophagy-related proteins in different steps of autophagic process and their therapeutic benefits. We will also summarize combination therapies of autophagy inhibitors with chemotherapies and their outcomes in pre-clinical and clinical studies. Understanding of current knowledge of development, progress, and application of cytoprotective autophagy inhibitors in combination therapies will open new possibilities for overcoming drug resistance and improving clinical outcomes.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1997년도 춘계학술대회
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• pp.119-119
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• 1997

Valacyclovir is a L-valyl ester prodrug of acyclovir which is a highly effective and selective antiviral agent in the treatment of herpes virus diseases. Valacyclovir is rapidly and almost completely converted to acyclovir and increases the oral bioavailability of acyclovir three to five fold. However, the intestinal absorption mechanism of valacyclovir is not clear. If the improved absorption mechanism of valacyclovir is fully understood, it will provide a rationale of designing the amino acid ester prodrugs of polar drugs containing hydroxyl group. The main objective of our present study is to characterize the membrane transport mechanism of valacyclovir. Methods : Intestinal absorption of valacyclovir was investigated by using in-situ rat perfusion study and its wall permeability was estimated by modified boundary layer model. The membrane transport mechanism was also investigated through the uptake study in Caco-2 cells and in CHO-hPepTl cells. Results : In the rat perfusion study, the wall permeability of valacyclovir was ten times higher than acyclovir and showed concentration dependency, Valacyclovir also demonstrated a D,L stereo-selectivity with L-isomer having an approximately five-fold higher permeability than D-isomer. Mixed dipeptides and cephalexin, which are transported by dipeptide carriers, strongly competed with valacyclovir for the intestinal absorption, while L-valine did not show any competition with valacyclovir. This indicated that the intestinal absorption of valacyclovir could be dipeptide carrier-mediated. In addition, the competitive uptake study in Caco-2 cells presented that dipeptides reduced the valacyclovir uptake but valine did not. Also, in IC$\sub$50/ study, valacyclovir showed strong inhibition on the $^3$H-gly-sar uptake in CHO-hPepTl cells over-expressing a human intestinal peptide transporter. Taken together, the result from our present study indicated that valacyclovir utilized the peptide transporter for the intestinal absorption.

• 정보처리학회논문지C
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• 제12C권7호
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• pp.1039-1046
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• 2005

TCP SACK은 sink의 순차적인 필드 상태를 나타내는 유일한 메커니즘이며, 여러 가지 변형된 TCP들은 최적의 성능을 위해서 SACK 메커니즘을 적용할 수 있다. RFC 2018에서 SACK 옵션은 수신자 측에 쌓여진 데이터 큐 각각의 연속된 블록으로 2개의 32비트로 정의되어 있다. TCP 옵션 필드는 최대 40바이트 길이를 가지기 때문에 에러가 발생하였을 때, TCP 수신자 큐에 있는 모든 데이터 블록들을 알려줄 수 있는 사용 가능한 옵션 공간이 충분하지 않으며, TCP 송신자가 TCP sink에 의해서 수신된 패킷들을 불필요하게 재 전송하게 된다. 이러한 문제들을 해결하기 위해서 본 논문에서는 TCP SACK의 성능을 향상시키고 불필요한 재전송을 제거하기 위해서 "one-byte offset based SACK mechanism" 이라는 새로운 방식을 제시한다. 제안된 방식의 분석과 시뮬레이션 결과 제안된 방식은 최소한의 바이트를 사용하기 때문에 다른 메커니즘들보다 오버헤드를 줄였고, 유무선 통합 환경에서 에러율이 적은 효율적인 메커니즘임을 입증하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제21권4호
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• pp.385-395
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• 2017

Vasoconstrictive properties of sympathomimetic drugs are the basis of their widespread use as decongestants and possible source of adverse responses. Insufficiently substantiated practice of combining decongestants in some marketed preparations, such are those containing phenylephrine and lerimazoline, may affect the overall contractile activity, and thus their therapeutic utility. This study aimed to examine the interaction between lerimazoline and phenylephrine in isolated rat aortic rings, and also to assess the substrate of the obtained lerimazoline-induced attenuation of phenylephrine contraction. Namely, while lower concentrations of lerimazoline ($10^{-6}M$ and especially $10^{-7}M$) expectedly tended to potentiate the phenylephrine-induced contractions, lerimazoline in higher concentrations ($10^{-4}M$ and above) unexpectedly and profoundly depleted the phenylephrine concentration-response curve. Suppression of NO with NO synthase (NOS) inhibitor $N^w$-nitro-L-arginine methyl ester (L-NAME; $10^{-4}M$) or NO scavanger $OHB_{12}$ ($10^{-3}M$), as well as non-specific inhibition of $K^+$-channels with tetraethylammonium (TEA; $10^{-3}M$), have reversed lerimazoline-induced relaxation of phenylephrine contractions, while cyclooxygenase inhibitor indomethacin ($10^{-5}M$) did not affect the interaction between two vasoconstrictors. At the receptor level, non-selective 5-HT receptor antagonist methiothepin reversed the attenuating effect of lerimazoline on phenylephrine contraction when applied at $3{\times}10^{-7}$ and $10^{-6}M$, but not at the highest concentration ($10^{-4}M$). Neither the 5-$HT_{1D}$-receptor selective antagonist BRL 15572 ($10^{-6}M$) nor 5-$HT_7$ receptor selective antagonist SB 269970 ($10^{-6}M$) affected the lerimazoline-induced attenuation of phenylephrine activity. The mechanism of lerimazoline-induced suppression of phenylephrine contractions may involve potentiation of activity of NO and $K^+$-channels and activation of some methiothepin-sensitive receptors, possibly of the 5-$HT_{2B}$ subtype.

• 한국자동차공학회논문집
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• 제20권6호
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• pp.73-82
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• 2012

The main and side reactions of the three selective catalytic reduction (SCR) reactions with ammonia over a vanadium-based catalyst have been investigated using synthetic gas mixtures in the temperature range of $170{\sim}590^{\circ}C$. The three SCR reactions are standard SCR with pure NO, fast SCR with an equimolar mixture of NO and $NO_2$, and $NO_2$ SCR with pure $NO_2$. Vanadium based catalyst has no significant activity in NO oxidation to $NO_2$, while it has high activity for $NO_2$ decomposition at high temperatures. The selective catalytic oxidation of ammonia and the formation of nitrous oxide compete with the SCR reactions at the high temperatures. Water strongly inhibits the selective catalytic oxidation of ammonia and the formation of nitrous oxide, thus increasing the selectivity of the SCR reactions. However, the presence of water inhibits the SCR activity, most pronounced at low temperatures. In this study, the experimental results are analyzed by means of a dynamic one-dimensional isothermal heterogeneous plug-flow reactor (PFR) model according to the Eley-Rideal mechanism.

• The Korean Journal of Physiology and Pharmacology
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• 제13권1호
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• pp.39-47
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• 2009

Gaegurin 4(GGN 4), an antimicrobial peptide isolated from a Korean frog, is five times more potent against Gram-positive than Gram-negative bacteria, but has little hemolytic activity. To understand the mechanism of such cell selectivity, we examined GGN4-induced $K^+$ efflux from target cells, and membrane conductances in planar lipid bilayers. The $K^+$ efflux from Gram-positive M. luteus(2.5 ${\mu}g/ml$) was faster and larger than that from Gram-negative E. coli(75 ${\mu}g/ml$), while that from RBC was negligible even at higher concentration(100 ${\mu}g/ml$). GGN4 induced larger conductances in the planar bilayers which were formed with lipids extracted from Gram-positive B. subtilis than in those from E. coli(p<0.01), however, the effects of GGN4 were not selective in the bilayers formed with lipids from E. coli and red blood cells. Addition of an acidic phospholipid, phosphatidylserine to planar bilayers increased the GGN4-induced membrane conductance(p<0.05), but addition of phosphatidylcholine or cholesterol reduced it(p<0.05). Transmission electron microscopy revealed that GGN4 induced pore-like damages in M. luteus and dis-layering damages on the outer wall of E. coli. Taken together, the present results indicate that the selectivity of GGN4 toward Gram-positive over Gram-negative bacteria is due to negative surface charges, and interaction of GGN4 with outer walls. The selectivity toward bacteria over RBC is due to the presence of phosphatidylcholine and cholesterol, and the trans-bilayer lipid asymmetry in RBC. The results suggest that design of selective antimicrobial peptides should be based on the composition and topology of membrane lipids in the target cells.

• 한국통신학회논문지
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• 제36권8C호
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• pp.489-496
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• 2011

무선 센서 네트워크에서 넓은 지역의 현상 및 움직임을 지속적으로 추적, 관찰하기 위해 에너지 효율성은 가장 중요한 요소이다. 이러한 망에서 에너지를 절약하기 위해 센서노드들에 대한 선택적 활성화 기법은 효과적인 방법이다. 그러나 이러한 선택적 활성화 기법을 적용한 기존의 대부분의 연구들은 침입자, 탱크와 같은 개별객체에 대해서만 고려했기 때문에 산불, 유독가스와 같은 연속객체에 대해서는 기존 기법을 적용하기 어렵다. 이는 연속객체들은 주변 환경의 영향에 상당히 민감하기 때문에 매우 유동적이고 불안정하여 이동할 다음 위치를 단순히 시공간 기법만을 가지고 예상할 수 없지 때문이다. 따라서 본 논문에서는 망의 센서노드들이 충분히 밀집한 경우 보다 정밀한 예측을 위해 객체가 퍼지거나 수축될 것으로 예상되는 지역의 센서들을 클러스터 단위로 활성화 시키는 클러스터 기반의 선택적 활성화 기법을 제안한다. 또한, 본 방안은 예측을 위한 계산이 동시에 수행될 필요가 없기 때문에 예측을 함에 있어 비동기식 기법을 적용한다.

• 대한기계학회논문집B
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• 제38권5호
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• pp.437-441
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• 2014

본 논문은 미세유체 시스템에서 농도차에 의한 역전기투석을 이용하여 에너지발전을 할 수 있는 장치를 제안한다. 역전기투석을 위한 이온교환막은 미세유체칩의 적정 위치에 자기조립화된 나노입자 사이의 공극으로 이루어지며, 이는 마이크로 용량의 나노입자가 분산된 용액 방울을 제어함으로써 쉽고 저렴한 방법으로 제작이 가능하다. 본 제안 시스템은 미세유체칩의 형상을 변형하거나 나노입자의 사이즈, 혹은 나노입자의 종류를 손쉽게 바꿔가며 최대 파워와 에너지 변환 효율을 향상 시킬 수 있다는 장점이 있다. 앞으로, 본 연구에서 제안하는 디바이스는 랩온어칩 시스템에서 다른 미세장치로 에너지를 공급하는 매개체로 이용 될 수 있을 뿐 아니라 더 다양한 재료를 이용함으로써 이온 교환현상 및 에너지 발전의 기초 연구에 활용될 수 있을 것이라 기대한다.

• 한국자동차공학회논문집
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• 제17권1호
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• pp.137-145
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• 2009

The steady-state kinetics of the selective catalytic reduction (SCR) of $NO_X$ with $NH_3$ has been investigated over a commercial ${V_2}{O_5}/TiO_2$ catalyst. In order to account for the influence of transport effects the kinetics are coupled with a fully transient two-phase 1D+1D monolith channel model. The Langmuir-Hinshelwood (L-H) mechanism is adopted to describe the steady-state kinetic behavior of the ${V_2}{O_5}/TiO_2$ catalyst. The reaction rate expressions are based on previously reported papers and are modified to fit the experimental data. The steady-state chemical reaction scheme used in the present mathematical model has been validated extensively with experimental data of selective $NO_X$ reduction efficiency for a wide range of inlet conditions such as space velocity, oxygen concentrations, water concentration, and $NO_2/NO$ ratio. The parametric investigations are performed to examine how the $NH_3$ slip from a SCR $DeNO_X$ catalyst and the conversion of $NO_X$ are affected by the reaction temperature, $NH_3/NO_X$ feed ratio, and space velocity for feed gas compositions with $NO_2/NO_X$ ratios of 0 and 0.5.