• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 1994년도 Proceedings of International Symposium on BIOLOGICAL CONTROL OF PLANT DISEASES Korean Society of Plant Pathology
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• pp.75-85
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• 1994

Biocontrol is playing a more and more important role in plant disease management. Evidences show that there are optimum prospects for people to apply biocontrol approach to control plant disease or to study the mechanism of antagonism.“The study of Antagonistic Protein of Bacillus spp.to Xanthomonas oryzae pv. oryzae”has been worked in our laboratory since 1986. One hundred and thirty antagonistics bacteria were screened out, most of them belonged to Bacillus spp., and showed very strong inhibitive effect to various plant pathogens. Nine antagonistic proteins (peptides) were purified (P11-I, P11-II, B8, B826-I, B826-II, A30-I, A30-II, G35). Two antagonistic protein related DNA fragments (B826-I, A30-II) were cloned and sequenced. B826-I DNA fragment composed by 905 bp, and it contained two ORF encoding 95, and 54 amino acids, respectively. By using Rifr and Kamr as the selective markers, we found the bacteria could colonize on rice leaf for at least 40 days. In greenhouse the antagonistic bacteria showed certain degree of control efficiency.

• 대한음성학회:학술대회논문집
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• 대한음성학회 2005년도 추계 학술대회 발표논문집
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• pp.137-140
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• 2005

In this study we investigated the cognitive neuropsychological characteristics and the underlying mechanism in a letter-by-letter reading dyslexic patient after cerebral infarct of left posterior cerebral artery using fMRl, The results of cognitive neuropsychological assesment are visual perception was appropriate, and semantic categorization, picture naming and picture-word matching tasks were above83% correct, respectively. However, she was very poor in lexical decision task. The selective reading impairment is thought to result from the disruption of the left occipitotemporal region included fusiform gyrus. In fMRl results, the activation level increase din the right occipitotemporal region included fusiform gyrus compared with normal group in compensation for left impairment and more increased in pseudo word reading task than word reading on account of familiarity.

• Food Science and Biotechnology
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• 제17권6호
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• pp.1305-1309
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• 2008

Baicalein, one of the major flavonoid in Scutellaria baicalensis, has been known for its effects on proliferation and apoptosis of many tumor cell lines. Most biological effects of baicalein are thought to be from its antioxidant and prooxidant activities. In this report, baicalein was found to induce apoptosis in HL60 human promyelocytic leukemia cell line. Baicalein treatment induced DNA fragmentation and typical morphological features of apoptosis. To elucidate the mechanism of baicalein-induced apoptosis, the activities of the members of caspase family were measured. Interestingly caspase 2, 3, and 6 were significantly activated whereas caspase 1, 8, and 9 were not activated, suggesting selective involvement of specific caspases. Further, treatment with caspase inhibitors also supports the involvement of caspase 2 in apoptosis process. Although it has been reported that baicalein can induce apoptosis through many caspase pathways, the present study indicates that caspase 2 not caspase 9 pathway may be the important step in apoptosis on HL60 cell line.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2002년도 가을 학술발표논문집 Vol.29 No.2 (1)
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• pp.715-717
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• 2002

최신의 프로세서는 분기명령에 의한 파이프라인 지연을 피하기 위해 분기 예상 기법을 사용하고 있다. 그러나 예측기에서 예상이 잘못된 경우에는 예상한 분기 방향의 명령어들을 무효화시키고 올바른 분기 방향의 명령어들을 다시 반입하여 수행시키므로 서 수행 사이클과 하드웨어 자원을 낭비하게된다. 본 논문에서는 컴파일 시 프로파일링을 통한 정적인 방법과 프로그램상의 제어 흐름을 통해 동적으로 제어 독립적인 명령어를 탐지해서 분기 명령어의 잘못된 예상으로 인해 무효화되는 명령어를 효과적으로 감소시켜 프로세서의 성능을 향상시키는 메커니즘을 제안한다. SPECint95 벤치마크 프로그램에 대해 기존의 방법과 본 논문에서 제안한 방법 사이의 사이클 당 수행된 명령어 수를 분석한 결과, 4-이슈 프로세서에서 2%-7%, 8-이슈 프로세서에서 4%-l5%, 16-이슈 프로세서에서 18%-28%의 성능 향상을 보이고 있다.

• The Korean Journal of Physiology and Pharmacology
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• 제25권3호
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• pp.197-206
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• 2021

Carnosol is a phenolic diterpene phytochemical found in rosemary and sage with reported anti-microbial, anti-oxidant, anti-inflammatory, and anti-carcinogenic activities. This study aimed to investigate the effect of carnosol on the lineage commitment of mouse bone marrow-derived mesenchymal stem cells (mBMSCs) into osteoblasts and adipocytes. Interestingly, carnosol stimulated the early commitment of mBMSCs into osteoblasts in dose-dependent manner as demonstrated by increased levels of alkaline phosphatase activity and Alizarin red staining for matrix mineralization. On the other hand, carnosol significantly suppressed adipogenesis of mBMSCs and downregulated both early and late markers of adipogenesis. Carnosol showed to induce osteogenesis in a mechanism mediated by activating BMP signaling pathway and subsequently upregulating the expression of BMPs downstream osteogenic target genes. In this context, treatment of mBMSCs with LDN-193189, BMPR1 selective inhibitor showed to abolish the stimulatory effect of carnosol on BMP2-induced osteogenesis. In conclusion, our data identified carnosol as a novel osteoanabolic phytochemical that can promote the differentiation of mBMSCs into osteoblasts versus adipocytes by activating BMP-signaling.

• 센서학회지
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• 제28권4호
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• pp.231-235
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• 2019

We investigated the facile and effective strategy for sensitive and selective $C_2H_5OH$ sensors based on the In-decorated NiO nanoigloos. The In-decorated NiO nanoigloos is fabricated by RF sputtering using 750 nm-diameter polystyrene beads using a soft-template. The morphological evolution based on the Van der Drift model was generated through a heterojunction between In metal and NiO, resulting in a pyramidal rough surface. Upon decorating the In on the NiO surface, high sensitivity and selectivity to $C_2H_5OH$ were observed, and gas sensing mechanism was demonstrated by a high surface-to-volume and double Schottky barrier. We are confident that the method presented in this study will have a significant impact on the fabrication of effective nanostructures and their application for the gas sensors.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.217.1-217.1
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• 2003

In previous study, we investigated the mechanism of suppression of inducible nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2) by ergolide, sesquiterpene lactone from Inula Britannica. In this study, the suppression of iNOS and COX-2 by ergolide might be attributed to selective inhibition of NF-$\_$K/B signaling pathways. Here, we investigated the suppressionmechanism of NF-$\_$K/B signaling pathways by ergolide in TPA-stimulated HeLa cells. (omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.149.1-149.1
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• 2003

We have previously shown that 2,4,3',5'-tetramethoxystilbene (TMS), a synthetic trans-stilbene analogue, is one of the most potently selective inhibitor of human cytochrome P450 1B1 in vitro and in vivo. In the present studies, the apoptotic effects of TMS were investigated in HL-60 cells. The effects of TMS on the proliferation of HL-60 cells were determined with MTT assay. TMS exhibited cytotoxicity with an $IC_50$ value of 37 nM. Cotreatment with TMS and etoposide, a well-known anticancer drug significantly enhanced the cytotoxicity. (omitted)

• 대한지리학회지
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• 제49권5호
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• pp.705-715
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• 2014

강화 지역에 감리교 개신교가 1903년 선교사에 의하여 전래되어 10년이라고 하는 짧은 시간 내 교인과 교회의 수가 급증하여 순조로운 정착을 보였다. 초기에는 해상루트를 따라 이주 전파가, 중기에는 계층에 따른 내륙에의 계층전파가, 후기에는 부근 지역으로의 접촉전파가 주를 이루었다. 이러한 전파는 초기에 서양 선교사의 직접적인 선교와 유학자에 의한 자연스러운 채택이었기 때문에 하곡 양명학과의 문화접변(acculturation)이 이루어질 수 있게 된다. 하곡학과 감리교는 문화요소 중 교육, 사회적 관계, 사상, 정신적 목표, 실천분야가 서로 일치하는 양상을 보이게 되어 하곡학자들은 감리교 수용에 큰 어려움이 없었다. 활동장소나 전수전략이 달랐지만 이들 요소는 오히려 감리교의 수용에 유리하게 작용하였다. 전래된 감리교는 초기에는 저항이 있었지만 하곡학의 선택적 메카니즘에 의하여 재해석되어 지위와 역할의 변화가 있은 다음 강화지역의 우세종교로 자리 잡았다. 강화지역의 대다수의 법정리에 감리교 교회당이 들어서고 25개 법정리에는 2개 이상의 교회당이 들어서게 된 것이다. 이는 특정 씨족 중심의 교회가 많아 가족관계를 더욱 중시하는 방향으로 변동하였음을 말해준다. 100세대 정도의 마을마다 교회당이 들어서 있다는 사실은 전래된 감리교가 특정 성씨 중심의 가족관계를 강화시키는 역할을 하였다고 볼 수 있다. 종교가 서로 다른 성씨 집단을 통합하기 보다는 이질성을 심화시키는 기능이 컸다고 보겠다. 강화지역은 가법을 중시하는 문화적 전통을 타파하지 못하고 혼합주의(syncretism) 양상을 띠어 완전히 동화되었다고는 보기 어렵다.

• Molecules and Cells
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• 제27권5호
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• pp.525-531
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• 2009

We studied the effect of carbachol on pacemaker currents in cultured interstitial cells of Cajal (ICC) from the mouse small intestine by muscarinic stimulation using a whole cell patch clamp technique and $Ca^{2+}$-imaging. ICC generated periodic pacemaker potentials in the current-clamp mode and generated spontaneous inward pacemaker currents at a holding potential of -70 mV. Exposure to carbachol depolarized the membrane and produced tonic inward pacemaker currents with a decrease in the frequency and amplitude of the pacemaker currents. The effects of carbachol were blocked by 1-dimethyl-4-diphenylacetoxypiperidinium, a muscarinic $M_3$ receptor antagonist, but not by methotramine, a muscarinic $M_2$ receptor antagonist. Intracellular $GDP-{\beta}-S$ suppressed the carbachol-induced effects. Carbachol-induced effects were blocked by external $Na^+$-free solution and by flufenamic acid, a non-selective cation channel blocker, and in the presence of thapsigargin, a $Ca^{2+}$-ATPase inhibitor in the endoplasmic reticulum. However, carbachol still produced tonic inward pacemaker currents with the removal of external $Ca^{2+}$. In recording of intracellular $Ca^{2+}$ concentrations using fluo 3-AM dye, carbachol increased intracellular $Ca^{2+}$ concentrations with increasing of $Ca^{2+}$ oscillations. These results suggest that carbachol modulates the pacemaker activity of ICC through the activation of non-selective cation channels via muscarinic $M_3$ receptors by a G-protein dependent intracellular $Ca^{2+}$ release mechanism.