• Proceedings of the Korean Society of Plant Pathology Conference
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• 1994.06a
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• pp.75-85
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• 1994

Biocontrol is playing a more and more important role in plant disease management. Evidences show that there are optimum prospects for people to apply biocontrol approach to control plant disease or to study the mechanism of antagonism.“The study of Antagonistic Protein of Bacillus spp.to Xanthomonas oryzae pv. oryzae”has been worked in our laboratory since 1986. One hundred and thirty antagonistics bacteria were screened out, most of them belonged to Bacillus spp., and showed very strong inhibitive effect to various plant pathogens. Nine antagonistic proteins (peptides) were purified (P11-I, P11-II, B8, B826-I, B826-II, A30-I, A30-II, G35). Two antagonistic protein related DNA fragments (B826-I, A30-II) were cloned and sequenced. B826-I DNA fragment composed by 905 bp, and it contained two ORF encoding 95, and 54 amino acids, respectively. By using Rifr and Kamr as the selective markers, we found the bacteria could colonize on rice leaf for at least 40 days. In greenhouse the antagonistic bacteria showed certain degree of control efficiency.

• Proceedings of the KSPS conference
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• 2005.11a
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• pp.137-140
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• 2005

In this study we investigated the cognitive neuropsychological characteristics and the underlying mechanism in a letter-by-letter reading dyslexic patient after cerebral infarct of left posterior cerebral artery using fMRl, The results of cognitive neuropsychological assesment are visual perception was appropriate, and semantic categorization, picture naming and picture-word matching tasks were above83% correct, respectively. However, she was very poor in lexical decision task. The selective reading impairment is thought to result from the disruption of the left occipitotemporal region included fusiform gyrus. In fMRl results, the activation level increase din the right occipitotemporal region included fusiform gyrus compared with normal group in compensation for left impairment and more increased in pseudo word reading task than word reading on account of familiarity.

• Food Science and Biotechnology
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• v.17 no.6
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• pp.1305-1309
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• 2008

Baicalein, one of the major flavonoid in Scutellaria baicalensis, has been known for its effects on proliferation and apoptosis of many tumor cell lines. Most biological effects of baicalein are thought to be from its antioxidant and prooxidant activities. In this report, baicalein was found to induce apoptosis in HL60 human promyelocytic leukemia cell line. Baicalein treatment induced DNA fragmentation and typical morphological features of apoptosis. To elucidate the mechanism of baicalein-induced apoptosis, the activities of the members of caspase family were measured. Interestingly caspase 2, 3, and 6 were significantly activated whereas caspase 1, 8, and 9 were not activated, suggesting selective involvement of specific caspases. Further, treatment with caspase inhibitors also supports the involvement of caspase 2 in apoptosis process. Although it has been reported that baicalein can induce apoptosis through many caspase pathways, the present study indicates that caspase 2 not caspase 9 pathway may be the important step in apoptosis on HL60 cell line.

• Proceedings of the Korean Information Science Society Conference
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• 2002.10c
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• pp.715-717
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• 2002

최신의 프로세서는 분기명령에 의한 파이프라인 지연을 피하기 위해 분기 예상 기법을 사용하고 있다. 그러나 예측기에서 예상이 잘못된 경우에는 예상한 분기 방향의 명령어들을 무효화시키고 올바른 분기 방향의 명령어들을 다시 반입하여 수행시키므로 서 수행 사이클과 하드웨어 자원을 낭비하게된다. 본 논문에서는 컴파일 시 프로파일링을 통한 정적인 방법과 프로그램상의 제어 흐름을 통해 동적으로 제어 독립적인 명령어를 탐지해서 분기 명령어의 잘못된 예상으로 인해 무효화되는 명령어를 효과적으로 감소시켜 프로세서의 성능을 향상시키는 메커니즘을 제안한다. SPECint95 벤치마크 프로그램에 대해 기존의 방법과 본 논문에서 제안한 방법 사이의 사이클 당 수행된 명령어 수를 분석한 결과, 4-이슈 프로세서에서 2%-7%, 8-이슈 프로세서에서 4%-l5%, 16-이슈 프로세서에서 18%-28%의 성능 향상을 보이고 있다.

• The Korean Journal of Physiology and Pharmacology
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• v.25 no.3
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• pp.197-206
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• 2021

Carnosol is a phenolic diterpene phytochemical found in rosemary and sage with reported anti-microbial, anti-oxidant, anti-inflammatory, and anti-carcinogenic activities. This study aimed to investigate the effect of carnosol on the lineage commitment of mouse bone marrow-derived mesenchymal stem cells (mBMSCs) into osteoblasts and adipocytes. Interestingly, carnosol stimulated the early commitment of mBMSCs into osteoblasts in dose-dependent manner as demonstrated by increased levels of alkaline phosphatase activity and Alizarin red staining for matrix mineralization. On the other hand, carnosol significantly suppressed adipogenesis of mBMSCs and downregulated both early and late markers of adipogenesis. Carnosol showed to induce osteogenesis in a mechanism mediated by activating BMP signaling pathway and subsequently upregulating the expression of BMPs downstream osteogenic target genes. In this context, treatment of mBMSCs with LDN-193189, BMPR1 selective inhibitor showed to abolish the stimulatory effect of carnosol on BMP2-induced osteogenesis. In conclusion, our data identified carnosol as a novel osteoanabolic phytochemical that can promote the differentiation of mBMSCs into osteoblasts versus adipocytes by activating BMP-signaling.

• Journal of Sensor Science and Technology
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• v.28 no.4
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• pp.231-235
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• 2019

We investigated the facile and effective strategy for sensitive and selective $C_2H_5OH$ sensors based on the In-decorated NiO nanoigloos. The In-decorated NiO nanoigloos is fabricated by RF sputtering using 750 nm-diameter polystyrene beads using a soft-template. The morphological evolution based on the Van der Drift model was generated through a heterojunction between In metal and NiO, resulting in a pyramidal rough surface. Upon decorating the In on the NiO surface, high sensitivity and selectivity to $C_2H_5OH$ were observed, and gas sensing mechanism was demonstrated by a high surface-to-volume and double Schottky barrier. We are confident that the method presented in this study will have a significant impact on the fabrication of effective nanostructures and their application for the gas sensors.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.217.1-217.1
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• 2003

In previous study, we investigated the mechanism of suppression of inducible nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2) by ergolide, sesquiterpene lactone from Inula Britannica. In this study, the suppression of iNOS and COX-2 by ergolide might be attributed to selective inhibition of NF-$\_$K/B signaling pathways. Here, we investigated the suppressionmechanism of NF-$\_$K/B signaling pathways by ergolide in TPA-stimulated HeLa cells. (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.149.1-149.1
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• 2003

We have previously shown that 2,4,3',5'-tetramethoxystilbene (TMS), a synthetic trans-stilbene analogue, is one of the most potently selective inhibitor of human cytochrome P450 1B1 in vitro and in vivo. In the present studies, the apoptotic effects of TMS were investigated in HL-60 cells. The effects of TMS on the proliferation of HL-60 cells were determined with MTT assay. TMS exhibited cytotoxicity with an $IC_50$ value of 37 nM. Cotreatment with TMS and etoposide, a well-known anticancer drug significantly enhanced the cytotoxicity. (omitted)

• Journal of the Korean Geographical Society
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• v.49 no.5
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• pp.705-715
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• 2014

Acculturation is caused with contact by two different cultures. This study investigates a cultural change of Gangwha society with Hagok confusianism influenced by implantation of methodism. At early periods methodism diffused rapidly and relocated toward marine routes. Lately hierarchical diffusion and contagious diffusion was typical, centering on the Gangwha Jungang Church. This successful acception was influenced with confusianism's acculturation. One of the reason why Gangwha people could accept the Christianity was reinterpretation and selective strategy by Hagok fraction that became one of confusinism, It seemed that several cultural elements of Hagok fraction was coincided with some elements of methodism. However, A methodist church transferred by clan's shrine, which family relationship was coerced, was split into it's members. This segregation other than social intergretation influenced establishment of a or more church per each village.

• Molecules and Cells
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• v.27 no.5
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• pp.525-531
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• 2009

We studied the effect of carbachol on pacemaker currents in cultured interstitial cells of Cajal (ICC) from the mouse small intestine by muscarinic stimulation using a whole cell patch clamp technique and $Ca^{2+}$-imaging. ICC generated periodic pacemaker potentials in the current-clamp mode and generated spontaneous inward pacemaker currents at a holding potential of -70 mV. Exposure to carbachol depolarized the membrane and produced tonic inward pacemaker currents with a decrease in the frequency and amplitude of the pacemaker currents. The effects of carbachol were blocked by 1-dimethyl-4-diphenylacetoxypiperidinium, a muscarinic $M_3$ receptor antagonist, but not by methotramine, a muscarinic $M_2$ receptor antagonist. Intracellular $GDP-{\beta}-S$ suppressed the carbachol-induced effects. Carbachol-induced effects were blocked by external $Na^+$-free solution and by flufenamic acid, a non-selective cation channel blocker, and in the presence of thapsigargin, a $Ca^{2+}$-ATPase inhibitor in the endoplasmic reticulum. However, carbachol still produced tonic inward pacemaker currents with the removal of external $Ca^{2+}$. In recording of intracellular $Ca^{2+}$ concentrations using fluo 3-AM dye, carbachol increased intracellular $Ca^{2+}$ concentrations with increasing of $Ca^{2+}$ oscillations. These results suggest that carbachol modulates the pacemaker activity of ICC through the activation of non-selective cation channels via muscarinic $M_3$ receptors by a G-protein dependent intracellular $Ca^{2+}$ release mechanism.