• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.12
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• pp.4275-4291
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• 2021

With the unprecedented growth of textual information on the Internet, an efficient automatic summarization system has become an urgent need. Recently, the neural network models based on the encoder-decoder with an attention mechanism have demonstrated powerful capabilities in the sentence summarization task. However, for paragraphs or longer document summarization, these models fail to mine the core information in the input text, which leads to information loss and repetitions. In this paper, we propose an abstractive document summarization method by applying guidance signals of key sentences to the encoder based on the hierarchical encoder-decoder architecture, denoted as KI-HABS. Specifically, we first train an extractor to extract key sentences in the input document by the hierarchical bidirectional GRU. Then, we encode the key sentences to the key information representation in the sentence level. Finally, we adopt key information representation guided selective encoding strategies to filter source information, which establishes a connection between the key sentences and the document. We use the CNN/Daily Mail and Gigaword datasets to evaluate our model. The experimental results demonstrate that our method generates more informative and concise summaries, achieving better performance than the competitive models.

• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.1-15
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• 2023

Autophagy is a process of eliminating damaged or unnecessary proteins and organelles, thereby maintaining intracellular homeostasis. Deregulation of autophagy is associated with several diseases including cancer. Contradictory dual roles of autophagy have been well established in cancer. Cytoprotective mechanism of autophagy has been extensively investigated for overcoming resistance to cancer therapies including radiotherapy, targeted therapy, immunotherapy, and chemotherapy. Selective autophagy inhibitors that directly target autophagic process have been developed for cancer treatment. Efficacies of autophagy inhibitors have been tested in various pre-clinical cancer animal models. Combination therapies of autophagy inhibitors with chemotherapeutics are being evaluated in clinal trials. In this review, we will focus on genetical and pharmacological perturbations of autophagy-related proteins in different steps of autophagic process and their therapeutic benefits. We will also summarize combination therapies of autophagy inhibitors with chemotherapies and their outcomes in pre-clinical and clinical studies. Understanding of current knowledge of development, progress, and application of cytoprotective autophagy inhibitors in combination therapies will open new possibilities for overcoming drug resistance and improving clinical outcomes.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1997.04a
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• pp.119-119
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• 1997

Valacyclovir is a L-valyl ester prodrug of acyclovir which is a highly effective and selective antiviral agent in the treatment of herpes virus diseases. Valacyclovir is rapidly and almost completely converted to acyclovir and increases the oral bioavailability of acyclovir three to five fold. However, the intestinal absorption mechanism of valacyclovir is not clear. If the improved absorption mechanism of valacyclovir is fully understood, it will provide a rationale of designing the amino acid ester prodrugs of polar drugs containing hydroxyl group. The main objective of our present study is to characterize the membrane transport mechanism of valacyclovir. Methods : Intestinal absorption of valacyclovir was investigated by using in-situ rat perfusion study and its wall permeability was estimated by modified boundary layer model. The membrane transport mechanism was also investigated through the uptake study in Caco-2 cells and in CHO-hPepTl cells. Results : In the rat perfusion study, the wall permeability of valacyclovir was ten times higher than acyclovir and showed concentration dependency, Valacyclovir also demonstrated a D,L stereo-selectivity with L-isomer having an approximately five-fold higher permeability than D-isomer. Mixed dipeptides and cephalexin, which are transported by dipeptide carriers, strongly competed with valacyclovir for the intestinal absorption, while L-valine did not show any competition with valacyclovir. This indicated that the intestinal absorption of valacyclovir could be dipeptide carrier-mediated. In addition, the competitive uptake study in Caco-2 cells presented that dipeptides reduced the valacyclovir uptake but valine did not. Also, in IC$\sub$50/ study, valacyclovir showed strong inhibition on the $^3$H-gly-sar uptake in CHO-hPepTl cells over-expressing a human intestinal peptide transporter. Taken together, the result from our present study indicated that valacyclovir utilized the peptide transporter for the intestinal absorption.

• The KIPS Transactions:PartC
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• v.12C no.7 s.103
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• pp.1039-1046
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• 2005

TCP SACK is the unique mechanism to reflect the situation of sink's sequence space, some TCP variants and proposals can perform in conjunction with SACK mechanism for achieving optimal performance. By definition of RFC 2018, however, each contiguous block of data queued at the data receiver is defined in the SACK option by two 32-bit unsigned integers in network byte order. Since TCP Options field has a 40-byte maximum length, when error bursts now, we note that the available option space may not be sufficient to report all blocks present in the receiver's queue and lead to unnecessarily force the TCP sender to retransmit Packets that have actually been received by TCP sink. For overcoming this restriction, in this thesis, a new solution named 'one-byte offset based SACK mechanism' is designed to further improve the performance or TCP SACK and prevent those unwanted retransmissions. The results or both theory analysis and simulation also show that his proposed scheme operates simply and more effectively than the other existing schemes by means of the least bytes and most robust mechanism to the high packet error rates often seen in networks environment.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.4
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• pp.385-395
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• 2017

Vasoconstrictive properties of sympathomimetic drugs are the basis of their widespread use as decongestants and possible source of adverse responses. Insufficiently substantiated practice of combining decongestants in some marketed preparations, such are those containing phenylephrine and lerimazoline, may affect the overall contractile activity, and thus their therapeutic utility. This study aimed to examine the interaction between lerimazoline and phenylephrine in isolated rat aortic rings, and also to assess the substrate of the obtained lerimazoline-induced attenuation of phenylephrine contraction. Namely, while lower concentrations of lerimazoline ($10^{-6}M$ and especially $10^{-7}M$) expectedly tended to potentiate the phenylephrine-induced contractions, lerimazoline in higher concentrations ($10^{-4}M$ and above) unexpectedly and profoundly depleted the phenylephrine concentration-response curve. Suppression of NO with NO synthase (NOS) inhibitor $N^w$-nitro-L-arginine methyl ester (L-NAME; $10^{-4}M$) or NO scavanger $OHB_{12}$ ($10^{-3}M$), as well as non-specific inhibition of $K^+$-channels with tetraethylammonium (TEA; $10^{-3}M$), have reversed lerimazoline-induced relaxation of phenylephrine contractions, while cyclooxygenase inhibitor indomethacin ($10^{-5}M$) did not affect the interaction between two vasoconstrictors. At the receptor level, non-selective 5-HT receptor antagonist methiothepin reversed the attenuating effect of lerimazoline on phenylephrine contraction when applied at $3{\times}10^{-7}$ and $10^{-6}M$, but not at the highest concentration ($10^{-4}M$). Neither the 5-$HT_{1D}$-receptor selective antagonist BRL 15572 ($10^{-6}M$) nor 5-$HT_7$ receptor selective antagonist SB 269970 ($10^{-6}M$) affected the lerimazoline-induced attenuation of phenylephrine activity. The mechanism of lerimazoline-induced suppression of phenylephrine contractions may involve potentiation of activity of NO and $K^+$-channels and activation of some methiothepin-sensitive receptors, possibly of the 5-$HT_{2B}$ subtype.

• Transactions of the Korean Society of Automotive Engineers
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• v.20 no.6
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• pp.73-82
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• 2012

The main and side reactions of the three selective catalytic reduction (SCR) reactions with ammonia over a vanadium-based catalyst have been investigated using synthetic gas mixtures in the temperature range of $170{\sim}590^{\circ}C$. The three SCR reactions are standard SCR with pure NO, fast SCR with an equimolar mixture of NO and $NO_2$, and $NO_2$ SCR with pure $NO_2$. Vanadium based catalyst has no significant activity in NO oxidation to $NO_2$, while it has high activity for $NO_2$ decomposition at high temperatures. The selective catalytic oxidation of ammonia and the formation of nitrous oxide compete with the SCR reactions at the high temperatures. Water strongly inhibits the selective catalytic oxidation of ammonia and the formation of nitrous oxide, thus increasing the selectivity of the SCR reactions. However, the presence of water inhibits the SCR activity, most pronounced at low temperatures. In this study, the experimental results are analyzed by means of a dynamic one-dimensional isothermal heterogeneous plug-flow reactor (PFR) model according to the Eley-Rideal mechanism.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.1
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• pp.39-47
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• 2009

Gaegurin 4(GGN 4), an antimicrobial peptide isolated from a Korean frog, is five times more potent against Gram-positive than Gram-negative bacteria, but has little hemolytic activity. To understand the mechanism of such cell selectivity, we examined GGN4-induced $K^+$ efflux from target cells, and membrane conductances in planar lipid bilayers. The $K^+$ efflux from Gram-positive M. luteus(2.5 ${\mu}g/ml$) was faster and larger than that from Gram-negative E. coli(75 ${\mu}g/ml$), while that from RBC was negligible even at higher concentration(100 ${\mu}g/ml$). GGN4 induced larger conductances in the planar bilayers which were formed with lipids extracted from Gram-positive B. subtilis than in those from E. coli(p<0.01), however, the effects of GGN4 were not selective in the bilayers formed with lipids from E. coli and red blood cells. Addition of an acidic phospholipid, phosphatidylserine to planar bilayers increased the GGN4-induced membrane conductance(p<0.05), but addition of phosphatidylcholine or cholesterol reduced it(p<0.05). Transmission electron microscopy revealed that GGN4 induced pore-like damages in M. luteus and dis-layering damages on the outer wall of E. coli. Taken together, the present results indicate that the selectivity of GGN4 toward Gram-positive over Gram-negative bacteria is due to negative surface charges, and interaction of GGN4 with outer walls. The selectivity toward bacteria over RBC is due to the presence of phosphatidylcholine and cholesterol, and the trans-bilayer lipid asymmetry in RBC. The results suggest that design of selective antimicrobial peptides should be based on the composition and topology of membrane lipids in the target cells.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.8C
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• pp.489-496
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• 2011

Energy efficiency in wireless sensor networks is a principal issue to prolong applications to track the movement of the large-scale phenomena. It is a selective wakeup approach that is an effective way to save energy in the networks. However, most previous studies with the selective wakeup scheme are concentrated on individual objects such as intruders and tanks, and thus cannot be applied for tracking continuous objects such as wild fire and poison gas. This is because the continuous object is pretty flexible and volatile due to its sensitiveness to surrounding circumferences so that movable area cannot be estimated by the just spatiotemporal mechanism. Therefore, we propose a cluster-based algorithm for applying the efficient and more accurate technique to the continuous object tracking in enough dense sensor networks. Proposed algorithm wakes up the sensors in unit cluster where target objects may be diffused or shrunken. Moreover, our scheme is asynchronous because it does not need to calculate the next area at the same time.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.38 no.5
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• pp.437-441
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• 2014

This paper presents a novel microplatform for high power generation based on reverse electrodialysis. The ideal cation-selective membrane for power generation was realized using geometrically controlled in situ self-assembled nanoparticles. Our proposed membranes can be constructed through a simple and cost-effective process that uses microdroplet control with nanoparticles in a microchannel. Another advantage of our system is that the maximum power and energy conversion efficiency can be improved by changing the geometry of the microchannel and proper selection of the nanoparticle size and material. This proposed platform can be used to supply power sources to other microdevices and contribute to a fundamental understanding of ion transport behavior and the power generation mechanism.

• Transactions of the Korean Society of Automotive Engineers
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• v.17 no.1
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• pp.137-145
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• 2009

The steady-state kinetics of the selective catalytic reduction (SCR) of $NO_X$ with $NH_3$ has been investigated over a commercial ${V_2}{O_5}/TiO_2$ catalyst. In order to account for the influence of transport effects the kinetics are coupled with a fully transient two-phase 1D+1D monolith channel model. The Langmuir-Hinshelwood (L-H) mechanism is adopted to describe the steady-state kinetic behavior of the ${V_2}{O_5}/TiO_2$ catalyst. The reaction rate expressions are based on previously reported papers and are modified to fit the experimental data. The steady-state chemical reaction scheme used in the present mathematical model has been validated extensively with experimental data of selective $NO_X$ reduction efficiency for a wide range of inlet conditions such as space velocity, oxygen concentrations, water concentration, and $NO_2/NO$ ratio. The parametric investigations are performed to examine how the $NH_3$ slip from a SCR $DeNO_X$ catalyst and the conversion of $NO_X$ are affected by the reaction temperature, $NH_3/NO_X$ feed ratio, and space velocity for feed gas compositions with $NO_2/NO_X$ ratios of 0 and 0.5.