• Nuclear Medicine and Molecular Imaging
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• 제40권4호
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• pp.193-199
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• 2006

Infectious and inflammatory bone diseases include a wide range of disease process, depending on the patient's age, location of infection, various causative organisms, duration from symtom onset, accompanied fracture or prior surgery, prosthesis insertion, and underlying systemic disease such as diabetes, etc. Bone infection may induce massive destruction of bones and joints, results in functional reduction and disability. The key to successful management is early diagnosis and proper treatment. Various radionuclide imaging methods including three phase bone scan, Ga-67 scan, WBC scan, and combined imaging techniques such as bone/Ga-67 scan, WBC/bone marrow scan add complementary role to the radiologic imaging modalities including plain radiography, CT and MRI. F-18 FDG PET imaging also has recently been introduced in diagnosis of infected prosthesis and chronic active osteomyelitis. Selection of proper nuclear medicine imaging method will improve the diagnostic accuracy of infections and inflammatory bone diseases, based on understading of pathogenesis and radiologic imaging findings.

• Journal of mucopolysaccharidosis and rare diseases
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• 제4권1호
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• pp.11-13
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• 2018

In Malaysia, diagnosis and treatment of patients with mucopolysaccharidoses (MPS) is mainly localized at Hospital Kuala Lumpur, which is the national referral center for rare diseases. To date there are 83 patients diagnosed with MPS in our center, with MPS II being the commonest. The Malaysian National Medicines Policy second edition has a specific section on the orphan drugs which includes recombinant human enzyme for enzyme replacement therapy (ERT) in MPS. So far, National Pharmaceutical Regulatory Agency Malaysia has approved recombinant human enzyme for MPS types I (Loranidase), II (idursulfase), IVA (elosulfase alfa), and VI (Galsufase). Access to Idursulfase beta (another recombinant human enzyme for MPS II) and vestronidase alfa-vjbk (MPS VII) required special authorization on named patient basic. Currently there are 25 patients receiving ERT, 70% of the funding are from Ministry of Health (MOH), the remaining 30% are from various charitable funds and humanitarian programs. Thirteen newly diagnosed patients have to queue for an additional fund. Four patients have been treated with Hematopoietic stem cell transplant. MOH has also published guidelines regarding the patient selection criteria for ERT and treatment monitoring schedule.

• 대한한의학원전학회지
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• 제29권3호
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• pp.13-40
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• 2016

Objectives : The practice of bloodletting therapy has taken place for several millenia all over the world. The therapy is still one of the most popular oriental treatments in Korea. This paper studies bloodletting therapy in Huangdineijing to provide the Korean Medicine doctors with knowledge of the therapy to effectively utilize it in their clinics. Methods : The author studied all of the diseases treated by bloodletting therapy in Huangdineijing, and placed them into three categories: the visceral and bowel diseases, the meridian diseases, and miscellaneous diseases. The author reviewed reference documents that show clinical experiences of using the therapy and the results from the research on the therapy's therapeutic dynamics. Results : The treatment principals such as diagnostic methods, meridian points selection, acupuncture methods, and tools for the bloodletting therapy were provided. Most of the diseases treated by the therapy were identified by the visceral pattern identification or meridian pattern identification except miscellaneous diseases. The characteristics of the diseases treated by the therapy were studied and the diseases were placed into categories such as fever, pain, qi counterflow, first-aid, mental disease, and deep-seated disease. Theoretical basis of the mechanism of bloodletting therapy was drawn from several researches and a number of clinical theses related to bloodletting therapy. Conclusions : Results of this study on bloodletting therapy in Huangdineijing could be a useful knowledge for the Korean medicine doctors to be utilized their clinics. Future studies on this type of therapy should be performed to identify the diseases that may be effectively treated by bloodletting therapy.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1998년도 Advances in Ginseng Research - Proceedings of the 7th International Symposium on Ginseng -
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• pp.103-108
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• 1998

The Canadian production of American ginseng (Panax quinquefolius L.) occurs mainly in Ontario, British Columbia and the Atlantic provinces. Although ginseng is a profitable crop, its successful production is dependent on careful consideration of cultural management f include site selection, site preparation, seed selection and handling, shading actors which and mulching, pest and nutritional management, and handling of harvested crops. Diseases of particular concern in Atlantic Canada are root rots caused by Phytopkthora cactorum, Cylindrocarpon destructans and Fusarium sp. Recently two systemic fungicides (metalaxyl and fosetylal) were registered; however, growers in Atlantic Canada have experienced metalaxyl resistance resulting from the reliance on this single compound for the control of Phytophthora sap. Current research being conducted on alternative control of these diseases will be discussed. In weed control research, 2, 4-D, MCPA, clopyralid have continued to show promise for weed contro1 at low rates. In trials to evaluate non-selective herbicides as post-senescence or pre-emergence in ginseng, glyphosate (Round-up) provided control of perennials as well as willowherb and lambsquarters. In phytoxicity trials, ginseng significantly tolerated grass herbicides, including clethodim, rimsulfuron, trakloxydim, nicosulfuron and fenoxyprop. For broadleaf herbicides, significant tolerance was shown for bromoxynil, thifensulfuron methyl, flumetulam/clopyralid, thifensulfuro/tribenuron. Disease and weed management of ginseng in Atlantic Canada will be discussed.

• Genomics & Informatics
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• 제4권1호
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• pp.45-47
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• 2006

D2GSNP is a web-based server for the selection of single nucleotide polymorph isms (SNPs) within genes related to human diseases. The D2GSNP is based on a relational database created by downloading and parsing OMIM, GAD, and dbSNP, and merging it with positional information of UCSC Golden Path. Totally our server provides 5,142 and 1,932 non-redundant disease genes from OMIM and GAD, respectively. With the D2GSNP web interface, users can select SNPs within genes responding to certain diseases and get their flanking sequences for further genotyping experiments such as association studies.

• 식물병연구
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• 제9권1호
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• pp.1-9
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• 2003

The occurrence of potato(Sotanum tuberosum) viral diseases caused by Potato virus X(PVX), Potato virus Y (PVY), Potato leafroll virus(PLRV), Potato vims S(PVS), Potato virus M(PVM), Potato virus A(PVA), Potato virus T(PVT), Alfalfa mosic virus(AIMV), Tobacco mosic virus(TMV), Potato mop top virus(PMTV) Tobacco rattle virus(TRV) and Potato spindle tuber viroid(PSTVd), potato witches' broom phytoplasma, have been identified so far in Korea. Major viral diseases such as PVX, PVY and PLRV had been studied more deeply, however, the others are just identified and only partially characterized since the first study on the relation between PVX nucleic acid and virus protein by Kim in 1961. The most studies on potato viral diseases are mainly focused on the problems of seed potato production. The National Alpine Agricultural Experiment Station(NAAES), since it began its activities in 1961, has given special attention to this problem by doing studies to identify, characterize and control potato virus diseases. This effort resulted in the development of new potato virus detection methods as a basis for elaborating new method of control, such as the production of seed potato free of virus and the selection of new virus-resistant transgenic potatoes. The further studies of potato viral diseases required would be fallowings: the continuous monitoring for the occurrence of identified or not identified potato viruses in Korea, the isolation of resistant viral genes, the development of control method for the non-persistently transmitted viruses like PVY, special vectors such as nematode and fungus transmitted viruses, TRV and PMTV and the development of control methods against potato viral diseases by viral cross protection, therapy, transgenic plant, and the use of the agents or molecules, such as virus inhibitors and antiviral proteins, etc., blocking viral replication.

• Korean Journal of Acupuncture
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• 제26권2호
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• pp.165-175
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• 2009

Objectives : The aim of this study was to show the rationale of point-selection on the methods of acupuncture and moxibustion in the Internal Injury section(in the Naegyeong chapter) of the Donguibogam. Methods : First, we summarized the cause of each disease in the Internal Injury section(in the Naegyeong chapter) of the Donguibogam. Then we explained the rationale of acupuncture point-selection referring to the cause of disease, physiology of the oriental medicine, other uses of each acupuncture points in the Donguibogam and other literature, character of each acupuncture points and specific acupuncture points etc. Results and Conclusions : Total 9 acupuncture points were used in the Internal Injury section(in the Naegyeong chapter) of the Donguibogam. Most of rationale of acupuncture point-selection were explained by specific acupuncture points, character of each acupuncture points, physiology of the oriental medicine and flow of meridian pathways etc. Each acupuncture points has practical application of specific diseases.

• 한국인구학
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• 제34권1호
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• pp.179-198
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• 2011

본 논문의 목적은 연령과 교육수준이 한국인의 만성질환에 미치는 영향을 분석하는 데 있다. 이를 위해 한국노동연구원이 2006년에 수집한 '고령화연구패널조사(KLoSA: Korean Longitudinal Study of Ageing)'에 참여한 45세 이상의 한국인을 분석하였다. 분석결과는 먼저 연령과 만성질환이 비선형 관계를 갖고 있음을 보여준다. 연령이 증가함에 따라 응답자가 만성질환을 앓고 있을 확률도 증가하나 약 74세를 기준으로 다시 감소한다. 또한 이러한 연령과 만성질환의 관계는 교육수준에 따라 다르게 나타났다. 교육수준이 낮을수록 상대적으로 이른 나이에 만성질환이 발현하여 70대 초까지 상대적으로 만성질환에 노출될 확률이 높게 나타난다. 그러나 이러한 교육수준에 따른 건강격차는 수렴현상(convergence)을 보이다가 70대 초반 이후부터 역전되어 다시 분기(divergence)한다. 즉, 고령층에서는 오히려 교육수준이 높을수록 만성질환을 가질 확률이 높게 나타나는 것이다. 이러한 결과는 교육수준이 낮은 사람들이 만성질환에 상대적으로 더 젊은 나이에 노출되고 결국에는 이른 사망으로 이어질 수 있다는 점을 함의한다.

• 응용통계연구
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• 제35권5호
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• pp.667-684
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• 2022

유전자 발현 데이터는 각 유전자에 대해 mRNA 양의 정도를 나타내고, 그러한 유전자 발현량에 대한 분석은 질병 발생에 대한 메커니즘을 이해하고 새로운 치료제와 치료 방법을 개발하는데 중요한 아이디어를 제공해오고 있다. 오늘날 DNA 마이크로어레이와 RNA-시퀀싱과 같은 고출력 기술은 수천 개의 유전자 발현량을 동시에 측정하는 것을 가능하게 하여 고차원성이라는 유전자 발현 데이터의 특징을 발생시켰다. 이러한 고차원성으로 인해 유전자 발현 데이터를 분석하기 위한 학습 모형들은 과적합 문제에 부딪히기 쉽고, 이를 해결하기 위해 차원 축소 또는 변수 선택 기술들이 사전 분석 단계로써 보통 사용된다. 특히, 사전 분석 단계에서 우리는 유전자 선택법을 이용하여 부적절하거나 중복된 유전자를 제거할 수 있고 중요한 유전자를 찾아낼 수도 있다. 현재까지 다양한 유전자 선택 방법들이 기계학습의 맥락에서 개발되어왔다. 본 논문에서는 기계학습 접근법을 사용하는 최근의 유전자 선택 방법들을 집중적으로 살펴보고자 한다. 또한, 현재까지 개발된 유전자 선택 방법들의 근본적인 문제점과 앞으로의 연구 방향에 대해 논의하고자 한다.

• Korean Journal of Acupuncture
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• 제19권2호
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• pp.119-131
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• 2002

In this paper, we studied Dongssi' acupuncture therapy via the consideration of development process of Oriental medicine in history. We investigated the distribution chart and naming of Dongssi' acupuncture point in human body, artificial selection principle of Dongssi' acupuncture point to therapy (選穴原則) on the various diseases, the therapy of pyo-bon (標本理論) and the therapy of Geun-Gyeal (根結理論) and compared GeoZa-principle (巨刺法) and MuZa-principle (繆刺法) with artificial selection principle of Dongssi' acupuncture point. And we also studied the acupuncture therapy of DongGi (動氣鍼法), DoMa (倒馬鍼法) and SaeIn (索引鍼法), which is the unique principle in Dongssi' acupuncture theraphy, to consider with the other Oriental medicine theory which is the theory of ZangSang (臟象學說) and BiWi (脾胃學說) etc. Our desire in this study is the giving aid to treatment diseases with the acupuncture therapy in Oriental medicine.