• Archives of Pharmacal Research
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• 제23권4호
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• pp.385-390
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• 2000

To demonstrate the effect of formulation conditions on the controlled release of protein from poly(lactide-co-glycolide) (PLGA) microspheres for use as a parenteral drug carrier, ovalbumin (OVA) microspheres were prepared using the W/O/W multiple emulsion solvent evaporation and extraction method. Methylene chloride or ethyl acetate was applied as an organic phase and poly(vinyl alcohol) as a secondary emulsion stabilizer. Low loading efficiencies of less than 20％ were observed and the in vitro release of OVA showed a burst effect in all batches of different microspheres, followed by a gradual release over the next 6 weeks. Formulation processes affected the size and morphology, drug content, and the controlled release of OVA from PLGA microspheres.

• 대한두개안면성형외과학회지
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• 제23권5호
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• pp.193-204
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• 2022

Tongue reconstruction remains a major aspect of head and neck reconstructive procedures. Surgeons planning tongue reconstruction should consider several factors to optimize the overall outcomes. Specifically, various technical aspects related to tongue reconstruction have been found to affect the outcomes. Multidisciplinary teams dedicated to oncologic, reconstructive, and rehabilitative approaches play an essential role in the reconstructive process. Moreover, operative planning addressing certain patient-related and defect-related factors is crucial for optimizing functional speech and swallowing, as well as quality of life outcomes. Furthermore, tongue reconstruction is a delicate process, in which overall functional outcomes result from proper flap selection and shaping, recipient vessel preparation and anastomosis, surgical approaches to flap insetting, and postoperative management. The second part of this review summarizes these factors in relation to tongue reconstruction.

• Archives of Reconstructive Microsurgery
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• 제23권2호
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• pp.45-50
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• 2014

Palmar soft tissue defects are best reconstructed using a replacement flap of proper size with adequate soft tissue stability for mechanical resistance as well as with protective sensation. Reconstructive approaches are dictated by injury mechanism, defect size and location, and the status of the wound bed and tendino-skeletal structure. While uninjured portions of the hand can be used as a source for local flaps, the use of free flaps allows for maximal access for selection of the most ideal replacement tissue for the defect to be restored as close to the initial state as possible. Here, we review the garden variety of free flaps used in reconstruction of palmar soft tissue defects.

• Archives of Pharmacal Research
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• 제5권2호
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• pp.71-77
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• 1982

Improvements in the analytical methodology used in the gas chromatographic/mass spectral analysis of phenolic compounds from cigarette smoke are described. For the direct analysis of crude samples, pyridine extraction and the glass capillary column GC was used for the separation of phenolics as trimethylsilyl derivativatives. The separations of cigarette smoke on Carbowax 20M and SE-54 wall coated open tubular columns are given. Improved methodology for the routine quantitation of the identified components using the computer-controlled multiple ion selection technique of MS presented. Considerations pertaining to routine analyses of a multitude of complex smoke samples are also discussed.

• 비만대사연구학술지
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• 제1권1호
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• pp.33-38
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• 2022

Although it has been confirmed that excessive body fat increases health risks and all-cause mortality, several epidemiological studies have reported that overweight or obesity in patients with chronic diseases and in older adults is advantageous with respect to mortality. Several mechanisms have been proposed to explain the biological basis of this obesity paradox. The marked heterogeneity of findings observed across studies and the possibility of systematic errors in these studies have cast doubt on the actual existence of the obesity paradox. However, the obesity paradox questioned the validity of body mass index as the best indicator for obesity in terms of predicting its comorbidities and urges clinicians to focus more on changes in body composition and related metabolic derangements, rather than body weight per se.

• 대한두개안면성형외과학회지
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• 제23권2호
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• pp.53-58
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• 2022

Alveolar cleft belongs to the spectrum of cleft lip and/or palate, affecting 75% of cleft lip/palate patients. The goals of alveolar cleft treatment are stabilizing the maxillary arch, separating the nasal and oral cavities, and providing bony support for both erupting teeth and the nasal base via the piriform aperture. Secondary alveolar bone grafting is a well-established treatment option for alveolar cleft. Secondary alveolar bone grafting is performed during the period of mixed dentition using autologous bone from various donor sites. There are several issues relevant to maximizing the success of secondary alveolar bone grafting, including the surgical timing, graft material, and surgical technique. In this study, we reviewed issues related to surgical timing, graft materials, and evaluation methods in secondary alveolar bone grafting.

• 디자인학연구
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• 제19권3호
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• pp.155-166
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• 2006

Color selection plays a vitally important role in creating impressions of individuals or companies. This is largely because colors have sensibility aspects, which relate, in part, to images and, in part, to associations. Based on theories of color harmony and sensibility ergonomics, we have developed quantitative and systematic metrics for color images. In this paper, we suggest a color coordinate system that supports color analysis and color harmony functions using color images, which can be captured by corresponding adjectival words. We focus on a prototype system for graphical logo design to exemplify our concepts. The system can be applied to a wide variety of design domains.

• Archives of Plastic Surgery
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• 제39권1호
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• pp.3-10
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• 2012

The free muscle-sparing transverse rectus abdominis myocutaneous (MS-TRAM) and deep inferior epigastric perforator (DIEP) flaps involve transferring skin and subcutaneous tissue from the lower abdominal area and have many features that make them well suited for breast reconstruction. The robust blood supply of the free flap reduces the risk of fat necrosis and also enables aggressive shaping of the flap for breast reconstruction to optimize the aesthetic outcome. In addition, the free MS-TRAM flap and DIEP flap require minimal donor-site sacrifice in most cases. With proper patient selection and safe surgical technique, the free MS-TRAM flap and DIEP flap can transfer the lower abdominal skin and subcutaneous tissue to provide an aesthetically pleasing breast reconstruction with minimal donor-site morbidity.

• Archives of Reconstructive Microsurgery
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• 제21권1호
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• pp.76-80
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• 2012

Various soft tissue defects can be occurred in the hand. In determining the most suitable means of reconstruction a defect, the benefit of the reconstruction has to outweigh the risk of donor morbidity. Flap selection will be based on the size of the defect, the requirements for sensibility, the surgeon's comfort level, and the patient profile such as gender, age, or systemic disease. The hand is the most important tactile sensory organ, hence sensory restoration is critical. Neurosensory free flaps can provide sensibility, vascularity, and soft tissue coverage to an injured hand. This paper will discuss free flaps which can be used for soft tissue reconstruction of the hand.

• 기록학연구
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• 제79호
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• pp.343-387
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• 2024

전자기록물은 그 특성상 휘발성과 불안정성이 높으며, 이를 장기간 이용할 수 있도록 유지하는 것은 중요하다. 국가기록원은 이를 위해 전자기록물 보존포맷 선정체계를 수립하였으나, 현재 보존포맷 선정체계는 문서 유형의 전자기록물만을 그 범위로 하고 있어 시청각기록물 등 다른 유형의 기록물에 적용하기에 적합하지 않다. 본 논문은 이미지 유형 전자기록물을 중심으로 기존 체계의 적용 범위 확장과 이미지 유형 전자기록물의 보존에 대한 기초적인 가이드라인 구축을 목적으로 한다. 국내에서 이미지 유형 전자기록물은 문서 유형 전자기록물 다음으로 가장 많은 수량을 가진 유형이다. 이미지 유형은 시청각기록물의 가장 기본적인 형태로, 이에 대한 연구는 향후 다른 시청각기록물에 관한 논의의 기반을 마련한다. 이에 본 연구는 이미지 유형 전자기록물에 대한 보존포맷 선정체계를 구축하였다. 이를 통해 향후 새로운 이미지 포맷의 등장에도 해당 체계를 활용하여 보존포맷의 적합성을 신속하고 효율적으로 평가할 수 있다. 이를 검증하기 위해 연구에서 제안된 보존포맷 선정체계를 실제 이미지 포맷에 적용하여 평가를 진행하였으며, 그 결과로 TIFF, JFIF, PNG 포맷이 보존포맷으로 선정되었다. 이러한 결과는 향후 포맷 평가의 실질적인 참고 자료로써 활용될 수 있다.