• Molecules and Cells
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• v.38 no.12
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• pp.1079-1085
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• 2015

Originally, activins were identified as stimulators of FSH release in reproduction. Other activities, including secondary axis formation in development, have since been revealed. Here, we investigated the influence of activin ${\beta}_A$ on the body, including the gastro-intestinal (GI) tract. Initially, the activin ${\beta}_A$ protein was detected in the serum proportional to the amount of pCMV-rAct plasmid injected. The induced level of activin ${\beta}_A$ in muscle was higher in female than male mice. Subsequent results revealed that stomach and intestine were severely damaged in pCMV-rAct-injected mice. At the cellular level, loss of parietal cells was observed, resulting in increased pH within the stomach. This phenomenon was more severe in male than female mice. Consistent with damage of the stomach and intestine, activin ${\beta}_A$ often led to necrosis in the tip of the tail or foot, and loss of body weight was observed in pCMV-rAct-injected male but not female mice. Finally, in pCMV-rAct-injected mice, circulating activin ${\beta}_A$ led to death at supraphysiological doses, and this was dependent on the strain of mice used. Taken together, these results indicate that activin ${\beta}_A$ has an important role outside of reproduction and development, specifically in digestion. These data also indicate that activin ${\beta}_A$ must be controlled within a narrow range because of latent lethal activity. In addition, our approach can be used effectively for functional analysis of secreted proteins.

• Nuclear Medicine and Molecular Imaging
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• v.41 no.2
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• pp.141-151
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• 2007

Parkinson's disease is one of the most frequent neurodegenerative diseases, which mainly affects the elderly. Parkinson's disease is often difficult to differentiate from atypical parkinson diorder such as progressive supranuclear palsy, multiple system atrophy, dementia with Lewy body, and corticobasal ganglionic degeneration, based on the clinical findings because of the similarity of phenotypes and lack of diagnostic markers. The accurate diagnosis of Parkinson's disease and atypical Parkinson disorders is not only important for deciding on treatment regimens and providing prognosis, but also it is critical for studies designed to investigate etiology and pathogenesis of parkinsonism and to develop new therapeutic strategies. Although degeneration of the nigrostriatal dopamine system results in marked loss of striatal dopamine content in most of the diseases causing parkinsonism, pathologic studies revealed different topographies of the neuronal cell loss in Parkisonism. Since the regional cerebral glucose metabolism is a marker of integrated local synaptic activity and as such is sensitive to both direct neuronal/synaptic damage and secondary functional disruption at synapses distant from the primary site of pathology, an assessment of the regional cerebral glucose metabolism with F-18 FDG PET is useful in the differential diagnosis of parkinsonism and evaluating the pathophysiology of parkisonism.

• Journal of Conservation Science
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• v.11 no.1 s.14
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• pp.28-37
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• 2002

The cleaning in conservation treatment of cultural heritage is very important process. For the best conservation treatment of cultural heritage, except having a good detergency, the cleaning agent must be able to keep the heritage from the secondary deposition and re-soiling, damage and etc. In this paper, the dust (lichen, algae, dust, etc.) on the surface of stone made heritage was treated with some kinds of solvents and analyzed with FT-IR to develop a cleaning agent for stone made cultural heritage. And the cleaning ability to the dust and the corrosion ratio to the granite of the cleaning agent was investigated. Nonionic surfactants were good for treatment of stone-made cultural heritage. The reason is that nonionic surfactants are stable in acidic solution, and possess low reactivity with the compound of stone and low possibility to the second contamination, and build up the reactivities of acids and oxidants. A new cleaning agent composed with $H_2O_2/HF/NP-10$ shows a good cleaning ability for the conservation treatment of stone made cultural heritage.

• Journal of the Korean Society for Marine Environment & Energy
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• v.6 no.2
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• pp.16-27
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• 2003

For the last decade, some 400 small and large oil spill accidents have occurred every year. Such accident blow a serious damage to the marine resource and ecosystem, which can't be estimated in terms of economic and environmental losses. The physical/chemical methods used currently may be effective at the initial stage of accidents, but they can't serve to remove the spilled oil completely. Moreover, the dispersant may lead to a secondary contamination detrimental to the lives inhabiting wet lands, beaches and tidal zone. Thus, a new decomposing technology Is required for the environmentally sensitive areas. Bioremediation is the active use of biological techniques to mitigate the consequences of a spill using biological processes and refers both of stimulation of pollutant biodegradation and/or to enhance ecosystem recovery Bioremediation is an economically attractive method for the clean-up of oil-contaminated area. Bioremediation has been demonstrated to be an effective oil spill countermeasure for use in cobble, sand beach, salt marsh, and mud flat environment.

• Korean Journal of Remote Sensing
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• v.32 no.1
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• pp.1-11
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• 2016

Since forest is an important part of ecological system, the deforestation is one of global substantive issues. It is generally accepted that the climate change is related to the deforestation. The issue is worse in developing countries because the forest is one of important natural resources. In the case of North Korea, the deforestation is on the rise from forest reclamation for firewood collection and food production. Moreover, a secondary effect from flood intensifies the damage. Also, the political situation in North Korea presents difficulty to have in-situ measurements. It means that the accurate information of North Korea is nearly impossible to obtain. Thus, assessing the current situation of the forest in North Korea by indirect method is required. The objective of this study is to monitor the forest status of North Korea using multitemporal Landsat images, from 1980s to 2010s. Since the deforestation in North Korea is caused by local residents, we selected two study areas of high population density: Pyeongyang and Hyesan. In North Korea, most of clean Landsat images are acquired in fall season. The fall images have an advantage that we can easily distinguish agriculture areas from forest areas, also have an disadvantage that the forests cannot be easily identified because some of trees have turned red. To identify the forests exactly, we proposed a modified Normalized Difference Vegetation Index (mNDVI) value. The deforestation in Pyeongyang and Hyesan was analyzed by using mNDVI. The dimension of forest has decreased approximately 36% in Pyeongyang for 27 years and approximately 25% in Hyesan for 16 years. The results show that the forest areas in Pyeongyang and Hyesan have been steadily reduced.

• Korea-Australia Rheology Journal
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• v.12 no.1
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• pp.55-67
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• 2000

In this paper, an experimental study of the rheological behavior of granular flow in a new type of storage silo is presented. The main characteristic of the new design is a hexagonal shape chosen with the objective of minimizing the stresses applied to the stored grains, and to reduce grain damage during the filling and emptying processes. Measurements of stress distribution and flow patterns are shown for a variety of granular materials. Because of the design of the silo, the granular material adopts its natural rest angle at all times eliminating collisional stresses and impacts between grains. A homogeneous, low friction flow is naturally achieved which provides a controlled stress distribution throughout the silo during filling and emptying. Secondary dynamic stresses, which are responsible for wall failure in conventional silos of the vertical type, are completely eliminated. A comparison between the two geometries is presented with data obtained for these silos and a number of granular materials. The discharge pattern inhibits powder formation in the silo and the filling system virtually eliminates unwanted material packing. Finally, notwithstanding the rheological advantages of this new design, the hexagonal cells that constitute the silo have many other advantages, such as the possible use of solar energy to control the humidity inside them. The cell type design allows for versatile storage capabilities and the elevation above the ground provides unlimited transportation facilities during emptying.

• Proceedings of the Korean Vacuum Society Conference
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• 2000.02a
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• pp.180-180
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• 2000

Plasma source ion implantation is a new doping technique for the formation of shallow junction with the merits of high dose rate, low-cost and minimal wafer charging damage. In plasma source ion implantation process, the wafer is placed directly in the plasma of the appropriate dopant ions. Negative pulse bias is applied to the wafer, causing the dopant ions to be accelerated toward the wafer and implanted below the surface. In this work, inductively couples plasma was generated by anodized Al antenna that was located inside the vacuum chamber. The outside wall of Al chamber was surrounded by Nd-Fe-B permanent magnets to confine the plasma and to enhance the uniformity. Before implantation, the wafer was pre-sputtered using DC bias of 300B in Ar plasma in order to eliminate the native oxide. After cleaning, B2H6 (5%)/H2 plasma and negative pulse bias of -1kV to 5 kV were used to form shallow p+/n junction at the boron dose of 1$\times$1015 to 5$\times$1016 #/cm2. The as-implanted samples were annealed at 90$0^{\circ}C$, 95$0^{\circ}C$ and 100$0^{\circ}C$during various annealing time with rapid thermal process. After annealing, the sheet resistance and the junction depth were measured with four point probe and secondary ion mass spectroscopy, respectively. The doping uniformity was also investigated. In addition, the electrical characteristics were measured for Schottky diode with a current-voltage meter.

• Journal of the Korean Society for Nondestructive Testing
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• v.32 no.5
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• pp.545-550
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• 2012

Steam generator is one of the major components of nuclear power plant and steam generator tubes are the pressure boundary between primary and secondary side, which makes them critical for nuclear safety. As the operating time of nuclear power plant increases, not only damage mechanisms but also scaled deposits on steam generator tubes are known to be problematic causing tube support flow hole blockage and heat fouling. The ability to assess the extent and location of scaled deposits on tubes became essential for management and maintenance of steam generator and eddy current bobbin data can be utilized to measure thickness of scale on tubes. In this paper, tube reference standards with various thickness of scaled deposit has been set up to provide information about the overall deposit condition of steam generator tubes, providing essential tool for steam generator management and maintenance to predict and prevent future damages. Also, methodology to automatically measure scale thickness on tubes has been developed and applied to field data to estimate overall scale amount.

• Journal of KIBIM
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• v.9 no.1
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• pp.11-21
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• 2019

Recently, there is an increase in fire incidents in building structures. Due to this, the importance of fire-damaged buildings' safety diagnosis and evaluation after fire is growing. However, the existing fire-damaged safety diagnosis and evaluation methods are personnel-oriented, so the diagnostic results are intervened by investigators' subjectivity and unquantified. Thus, improper repair and reinforcement can result in secondary damage accidents and economic losses. In order to overcome these limitations, this study proposes using 3D laser scanning technology. The case analysis of fire-damaged building structures was conducted to verify the effectiveness of accuracy and manpowering by comparing the existing method and the proposed method. The proposed method using 3D laser scanning technology to obtain point cloud data of fire-damaged field. The point cloud data and BIM model is combined to inspect the fire-damaged area and depth. From inspection, quantified repair and reinforcement quantity take-off can be acquired. Also, the proposed method saves half of the manpowering within same time period compared to the existing method. Therefore, it seems that using 3D laser scanning technology in fire-damaged safety diagnosis and evaluation will improve in accuracy and saving time and manpowering.

• Journal of the Korean Society of Hazard Mitigation
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• v.11 no.3
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• pp.191-200
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• 2011

Levee failure cause the huge amount of damage to human and property. Overflow and erosion of levee are primary cause of a break in a levee but the analysis of breach pattern and impact is partially inadequate. The flow characteristics of meandering rivers are very important in field of river hydraulics that should be studied in practical viewpoints relating to river levee. In meandering the secondary flow that rotary direction is changed reciprocally occurs in three dimension is known. In this study flow characteristics of local river are considered and of meandering channels are analyzed using CCHE2D and FLOW3D. The stability and accuracy of models are examined comparing the measuring and analyzed data for the experimental channel and natural river(Namgang). Consequently, the flow characteristics in a meandering river are suggested precisely and it is essential that river levees having meandering river should be analyzed.